메뉴 건너뛰기




Volumn 185, Issue 9, 2010, Pages 5336-5347

Error-prone DNA repair activity during somatic hypermutation in shark B lymphocytes

Author keywords

[No Author keywords available]

Indexed keywords

CYTIDINE DEAMINASE; DNA POLYMERASE;

EID: 78149476860     PISSN: 00221767     EISSN: 15506606     Source Type: Journal    
DOI: 10.4049/jimmunol.1000779     Document Type: Article
Times cited : (22)

References (76)
  • 3
    • 0034268780 scopus 로고    scopus 로고
    • Class switch recombination and hypermutation require activation-induced cytidine deaminase (AID), a potential RNA editing enzyme
    • Muramatsu, M., K. Kinoshita, S. Fagarasan, S. Yamada, Y. Shinkai, and T. Honjo. 2000. Class switch recombination and hypermutation require activation-induced cytidine deaminase (AID), a potential RNA editing enzyme. Cell 102:553-563.
    • (2000) Cell. , vol.102 , pp. 553-563
    • Muramatsu, M.1    Kinoshita, K.2    Fagarasan, S.3    Yamada, S.4    Shinkai, Y.5    Honjo, T.6
  • 4
    • 0037083364 scopus 로고    scopus 로고
    • Requirement of the activation-induced deaminase (AID) gene for immunoglobulin gene conversion
    • Arakawa, H., J. Hauschild, and J. M. Buerstedde. 2002. Requirement of the activation-induced deaminase (AID) gene for immunoglobulin gene conversion. Science 295:1301-1306.
    • (2002) Science , vol.295 , pp. 1301-1306
    • Arakawa, H.1    Hauschild, J.2    Buerstedde, J.M.3
  • 5
    • 0037022540 scopus 로고    scopus 로고
    • AID is essential for immunoglobulin V gene conversion in a cultured B cell line
    • Harris, R. S., J. E. Sale, S. K. Petersen-Mahrt, and M. S. Neuberger. 2002. AID is essential for immunoglobulin V gene conversion in a cultured B cell line. Curr. Biol. 12:435-438.
    • (2002) Curr. Biol. , vol.12 , pp. 435-438
    • Harris, R.S.1    Sale, J.E.2    Petersen-Mahrt, S.K.3    Neuberger, M.S.4
  • 6
    • 11844269804 scopus 로고    scopus 로고
    • Evolution of the AID/APOBEC family of polynucleotide (deoxy) cytidine deaminases
    • Conticello, S. G., C. J. Thomas, S. K. Petersen-Mahrt, and M. S. Neuberger. 2005. Evolution of the AID/APOBEC family of polynucleotide (deoxy) cytidine deaminases. Mol. Biol. Evol. 22:367-377.
    • (2005) Mol. Biol. Evol. , vol.22 , pp. 367-377
    • Conticello, S.G.1    Thomas, C.J.2    Petersen-Mahrt, S.K.3    Neuberger, M.S.4
  • 7
    • 34249790004 scopus 로고    scopus 로고
    • Molecular mechanisms of antibody somatic hypermutation
    • Di Noia, J. M., and M. S. Neuberger. 2007. Molecular mechanisms of antibody somatic hypermutation. Annu. Rev. Biochem. 76:1-22.
    • (2007) Annu. Rev. Biochem. , vol.76 , pp. 1-22
    • Di Noia, J.M.1    Neuberger, M.S.2
  • 9
    • 41149153412 scopus 로고    scopus 로고
    • DNA polymerases in adaptive immunity
    • Weill, J. C., and C. A. Reynaud. 2008. DNA polymerases in adaptive immunity. Nat. Rev. Immunol. 8:302-312.
    • (2008) Nat. Rev. Immunol. , vol.8 , pp. 302-312
    • Weill, J.C.1    Reynaud, C.A.2
  • 11
    • 0026470596 scopus 로고
    • What limits affinity maturation of antibodies in Xenopus-the rate of somatic mutation or the ability to select mutants?
    • Wilson, M., E. Hsu, A. Marcuz, M. Courtet, L. Du Pasquier, and C. Steinberg. 1992. What limits affinity maturation of antibodies in Xenopus-the rate of somatic mutation or the ability to select mutants? EMBO J. 11:4337-4347.
    • (1992) EMBO J. , vol.11 , pp. 4337-4347
    • Wilson, M.1    Hsu, E.2    Marcuz, A.3    Courtet, M.4    Pasquier, L.D.5    Steinberg, C.6
  • 12
    • 33846900907 scopus 로고    scopus 로고
    • Known components of the immunoglobulin A:T mutational machinery are intact in Burkitt lymphoma cell lines with G:C bias
    • Xiao, Z., M. Ray, C. Jiang, A. B. Clark, I. B. Rogozin, and M. Diaz. 2007. Known components of the immunoglobulin A:T mutational machinery are intact in Burkitt lymphoma cell lines with G:C bias. Mol. Immunol. 44:2659-2666.
    • (2007) Mol. Immunol. , vol.44 , pp. 2659-2666
    • Xiao, Z.1    Ray, M.2    Jiang, C.3    Clark, A.B.4    Rogozin, I.B.5    Diaz, M.6
  • 13
    • 0032911308 scopus 로고    scopus 로고
    • Mutational pattern of the nurse shark antigen receptor gene (NAR) is similar to that of mammalian Ig genes and to spontaneous mutations in evolution: The translesion synthesis model of somatic hypermutation
    • Diaz, M., J. Velez, M. Singh, J. Cerny, and M. F. Flajnik. 1999. Mutational pattern of the nurse shark antigen receptor gene (NAR) is similar to that of mammalian Ig genes and to spontaneous mutations in evolution: the translesion synthesis model of somatic hypermutation. Int. Immunol. 11:825-833.
    • (1999) Int. Immunol. , vol.11 , pp. 825-833
    • Diaz, M.1    Velez, J.2    Singh, M.3    Cerny, J.4    Flajnik, M.F.5
  • 14
    • 0036224829 scopus 로고    scopus 로고
    • Hypermutation in shark immunoglobulin light chain genes results in contiguous substitutions
    • Lee, S. S., D. S. Tranchina, Y. Ohta, M. F. Flajnik, and E. Hsu. 2002. Hypermutation in shark immunoglobulin light chain genes results in contiguous substitutions. Immunity 16:571-582.
    • (2002) Immunity , vol.16 , pp. 571-582
    • Lee, S.S.1    Tranchina, D.S.2    Ohta, Y.3    Flajnik, M.F.4    Hsu, E.5
  • 16
    • 0027499308 scopus 로고
    • Passenger transgenes reveal intrinsic specificity of the antibody hypermutation mechanism: Clustering, polarity, and specific hot spots
    • Betz, A. G., C. Rada, R. Pannell, C. Milstein, and M. S. Neuberger. 1993. Passenger transgenes reveal intrinsic specificity of the antibody hypermutation mechanism: clustering, polarity, and specific hot spots. Proc. Natl. Acad. Sci. USA 90:2385-2388.
    • (1993) Proc. Natl. Acad. Sci. USA , vol.90 , pp. 2385-2388
    • Betz, A.G.1    Rada, C.2    Pannell, R.3    Milstein, C.4    Neuberger, M.S.5
  • 17
    • 0031569118 scopus 로고    scopus 로고
    • Analysis of the frequency and pattern of somatic mutations within nonproductively rearranged human variable heavy chain genes
    • Dörner, T., H.-P. Brezinschek, R. I. Brezinschek, S. J. Foster, R. Domiati-Saad, and P. E. Lipsky. 1997. Analysis of the frequency and pattern of somatic mutations within nonproductively rearranged human variable heavy chain genes. J. Immunol. 158:2779-2789.
    • (1997) J. Immunol. , vol.158 , pp. 2779-2789
    • Dörner, T.1    Brezinschek, H.-P.2    Brezinschek, R.I.3    Foster, S.J.4    Domiati-Saad, R.5    Lipsky, P.E.6
  • 18
    • 0032848321 scopus 로고    scopus 로고
    • Targeting and subsequent selection of somatic hypermutations in the human V κ repertoire
    • Foster, S. J., T. Dörner, and P. E. Lipsky. 1999. Targeting and subsequent selection of somatic hypermutations in the human V κ repertoire. Eur. J. Immunol. 29:3122-3132.
    • (1999) Eur. J. Immunol. , vol.29 , pp. 3122-3132
    • Foster, S.J.1    Dörner, T.2    Lipsky, P.E.3
  • 19
    • 0343618461 scopus 로고    scopus 로고
    • Targeting and selection of mutations in human Vλ rearrangements
    • Monson, N. L., T. Dörner, and P. E. Lipsky. 2000. Targeting and selection of mutations in human Vλ rearrangements. Eur. J. Immunol. 30:1597-1605.
    • (2000) Eur. J. Immunol. , vol.30 , pp. 1597-1605
    • Monson, N.L.1    Dörner, T.2    Lipsky, P.E.3
  • 20
    • 33645301314 scopus 로고    scopus 로고
    • The plasticity of immunoglobulin gene systems in evolution
    • Hsu, E., N. Pulham, L. L. Rumfelt, and M. F. Flajnik. 2006. The plasticity of immunoglobulin gene systems in evolution. Immunol. Rev. 210:8-26.
    • (2006) Immunol. Rev. , vol.210 , pp. 8-26
    • Hsu, E.1    Pulham, N.2    Rumfelt, L.L.3    Flajnik, M.F.4
  • 21
    • 45849106307 scopus 로고    scopus 로고
    • The evolution of multiple isotypic IgM heavy chain genes in the shark
    • Lee, V., J. L. Huang, M. F. Lui, K. Malecek, Y. Ohta, A. Mooers, and E. Hsu. 2008. The evolution of multiple isotypic IgM heavy chain genes in the shark. J. Immunol. 180:7461-7470.
    • (2008) J. Immunol. , vol.180 , pp. 7461-7470
    • Lee, V.1    Huang, J.L.2    Lui, M.F.3    Malecek, K.4    Ohta, Y.5    Mooers, A.6    Hsu, E.7
  • 22
    • 6344269702 scopus 로고    scopus 로고
    • Shark Ig light chain junctions are as diverse as in heavy chains
    • Fleurant, M., L. Changchien, C. T. Chen, M. F. Flajnik, and E. Hsu. 2004. Shark Ig light chain junctions are as diverse as in heavy chains. J. Immunol. 173:5574-5582.
    • (2004) J. Immunol. , vol.173 , pp. 5574-5582
    • Fleurant, M.1    Changchien, L.2    Chen, C.T.3    Flajnik, M.F.4    Hsu, E.5
  • 23
    • 29144433461 scopus 로고    scopus 로고
    • Somatic hypermutation and junctional diversification at Ig heavy chain loci in the nurse shark
    • Malecek, K., J. Brandman, J. E. Brodsky, Y. Ohta, M. F. Flajnik, and E. Hsu. 2005. Somatic hypermutation and junctional diversification at Ig heavy chain loci in the nurse shark. J. Immunol. 175:8105-8115.
    • (2005) J. Immunol. , vol.175 , pp. 8105-8115
    • Malecek, K.1    Brandman, J.2    Brodsky, J.E.3    Ohta, Y.4    Flajnik, M.F.5    Hsu, E.6
  • 25
    • 0020541348 scopus 로고
    • Molecular characterization of a nonsecreting myeloma mutant
    • Argon, Y., O. R. Burrone, and C. Milstein. 1983. Molecular characterization of a nonsecreting myeloma mutant. Eur. J. Immunol. 13:301-305.
    • (1983) Eur. J. Immunol. , vol.13 , pp. 301-305
    • Argon, Y.1    Burrone, O.R.2    Milstein, C.3
  • 26
    • 0026443954 scopus 로고
    • Somatic hypermutagenesis in immunoglobulin genes. II. Influence of neighbouring base sequences on mutagenesis
    • Rogozin, I. B., and N. A. Kolchanov. 1992. Somatic hypermutagenesis in immunoglobulin genes. II. Influence of neighbouring base sequences on mutagenesis. Biochim. Biophys. Acta 1171:11-18.
    • (1992) Biochim. Biophys. Acta , vol.1171 , pp. 11-18
    • Rogozin, I.B.1    Kolchanov, N.A.2
  • 28
    • 0025630537 scopus 로고
    • Boundaries of somatic mutation in rearranged immunoglobulin genes: 5′ boundary is near the promoter, and 3′ boundary is approximately 1 kb from V (D) J gene
    • Lebecque, S. G., and P. J. Gearhart. 1990. Boundaries of somatic mutation in rearranged immunoglobulin genes: 5′ boundary is near the promoter, and 3′ boundary is approximately 1 kb from V (D) J gene. J. Exp. Med. 172:1717-1727.
    • (1990) J. Exp. Med. , vol.172 , pp. 1717-1727
    • Lebecque, S.G.1    Gearhart, P.J.2
  • 29
    • 0343953047 scopus 로고    scopus 로고
    • Follicular lymphomas' BCL-2/IgH junctions contain templated nucleotide insertions: Novel insights into the mechanism of t (14;18) translocation
    • Jäger, U., S. Böcskör, T. Le, G. Mitterbauer, I. Bolz, A. Chott, M. Kneba, C. Mannhalter, and B. Nadel. 2000. Follicular lymphomas' BCL-2/IgH junctions contain templated nucleotide insertions: novel insights into the mechanism of t (14;18) translocation. Blood 95:3520-3529.
    • (2000) Blood , vol.95 , pp. 3520-3529
    • Jäger, U.1    Böcskör, S.2    Le, T.3    Mitterbauer, G.4    Bolz, I.5    Chott, A.6    Kneba, M.7    Mannhalter, C.8    Nadel, B.9
  • 32
    • 0035158355 scopus 로고    scopus 로고
    • Highly frequent frameshift DNA synthesis by human DNA polymerase μ
    • Zhang, Y., X. Wu, F. Yuan, Z. Xie, and Z. Wang. 2001. Highly frequent frameshift DNA synthesis by human DNA polymerase μ. Mol. Cell. Biol. 21:7995-8006.
    • (2001) Mol. Cell. Biol. , vol.21 , pp. 7995-8006
    • Zhang, Y.1    Wu, X.2    Yuan, F.3    Xie, Z.4    Wang, Z.5
  • 33
    • 8544254763 scopus 로고    scopus 로고
    • To slip or skip, visualizing frameshift mutation dynamics for error-prone DNA polymerases
    • Tippin, B., S. Kobayashi, J. G. Bertram, and M. F. Goodman. 2004. To slip or skip, visualizing frameshift mutation dynamics for error-prone DNA polymerases. J. Biol. Chem. 279:45360-45368.
    • (2004) J. Biol. Chem. , vol.279 , pp. 45360-45368
    • Tippin, B.1    Kobayashi, S.2    Bertram, J.G.3    Goodman, M.F.4
  • 34
    • 0023790391 scopus 로고
    • Mutagenesis by transient misalignment
    • Kunkel, T. A., and A. Soni. 1988. Mutagenesis by transient misalignment. J. Biol. Chem. 263:14784-14789.
    • (1988) J. Biol. Chem. , vol.263 , pp. 14784-14789
    • Kunkel, T.A.1    Soni, A.2
  • 35
    • 33646490558 scopus 로고    scopus 로고
    • Mechanism of a genetic glissando: Structural biology of indel mutations
    • Garcia-Diaz, M., and T. A. Kunkel. 2006. Mechanism of a genetic glissando: structural biology of indel mutations. Trends Biochem. Sci. 31:206-214.
    • (2006) Trends Biochem. Sci. , vol.31 , pp. 206-214
    • Garcia-Diaz, M.1    Kunkel, T.A.2
  • 36
    • 0022518316 scopus 로고
    • H segmental elements during vertebrate evolution
    • H segmental elements during vertebrate evolution. Nature 320:546-549.
    • (1986) Nature , vol.320 , pp. 546-549
    • Hinds, K.R.1    Litman, G.W.2
  • 37
    • 0028962371 scopus 로고
    • A new antigen receptor gene family that undergoes rearrangement and extensive somatic diversification in sharks
    • Greenberg, A. S., D. Avila, M. Hughes, A. Hughes, E. C. McKinney, and M. F. Flajnik. 1995. A new antigen receptor gene family that undergoes rearrangement and extensive somatic diversification in sharks. Nature 374:168-173.
    • (1995) Nature , vol.374 , pp. 168-173
    • Greenberg, A.S.1    Avila, D.2    Hughes, M.3    Hughes, A.4    McKinney, E.C.5    Flajnik, M.F.6
  • 39
    • 0033963813 scopus 로고    scopus 로고
    • Phylogeny of lower vertebrates and their immunological structures
    • Zapata, A., and C. T. Amemiya. 2000. Phylogeny of lower vertebrates and their immunological structures. Curr. Top. Microbiol. Immunol. 248:67-107.
    • (2000) Curr. Top. Microbiol. Immunol. , vol.248 , pp. 67-107
    • Zapata, A.1    Amemiya, C.T.2
  • 40
    • 15844403109 scopus 로고    scopus 로고
    • Shark immunity bites back: Affinity maturation and memory response in the nurse shark, Ginglymostoma cirratum
    • Dooley, H., and M. F. Flajnik. 2005. Shark immunity bites back: affinity maturation and memory response in the nurse shark, Ginglymostoma cirratum. Eur. J. Immunol. 35:936-945.
    • (2005) Eur. J. Immunol. , vol.35 , pp. 936-945
    • Dooley, H.1    Flajnik, M.F.2
  • 41
    • 0031944925 scopus 로고    scopus 로고
    • Mutation, selection, and memory in B lymphocytes of exothermic vertebrates
    • Hsu, E. 1998. Mutation, selection, and memory in B lymphocytes of exothermic vertebrates. Immunol. Rev. 162:25-36.
    • (1998) Immunol. Rev. , vol.162 , pp. 25-36
    • Hsu, E.1
  • 42
    • 0032564347 scopus 로고    scopus 로고
    • Somatic hypermutation of the new antigen receptor gene (NAR) in the nurse shark does not generate the repertoire: Possible role in antigen-driven reactions in the absence of germinal centers
    • Diaz, M., A. S. Greenberg, and M. F. Flajnik. 1998. Somatic hypermutation of the new antigen receptor gene (NAR) in the nurse shark does not generate the repertoire: possible role in antigen-driven reactions in the absence of germinal centers. Proc. Natl. Acad. Sci. USA 95:14343-14348.
    • (1998) Proc. Natl. Acad. Sci. USA , vol.95 , pp. 14343-14348
    • Diaz, M.1    Greenberg, A.S.2    Flajnik, M.F.3
  • 43
    • 32444436434 scopus 로고    scopus 로고
    • First molecular and biochemical analysis of in vivo affinity maturation in an ectothermic vertebrate
    • Dooley, H., R. L. Stanfield, R. A. Brady, and M. F. Flajnik. 2006. First molecular and biochemical analysis of in vivo affinity maturation in an ectothermic vertebrate. Proc. Natl. Acad. Sci. USA 103:1846-1851.
    • (2006) Proc. Natl. Acad. Sci. USA , vol.103 , pp. 1846-1851
    • Dooley, H.1    Stanfield, R.L.2    Brady, R.A.3    Flajnik, M.F.4
  • 44
    • 33745862755 scopus 로고    scopus 로고
    • Why do B cells mutate their immunoglobulin receptors?
    • Longo, N. S., and P. E. Lipsky. 2006. Why do B cells mutate their immunoglobulin receptors? Trends Immunol. 27:374-380.
    • (2006) Trends Immunol. , vol.27 , pp. 374-380
    • Longo, N.S.1    Lipsky, P.E.2
  • 45
    • 2642652230 scopus 로고    scopus 로고
    • The 5′ hypermutation boundary of kappa chains is independent of local and neighbouring sequences and related to the distance from the initiation of transcription
    • Rada, C., J. Yélamos, W. Dean, and C. Milstein. 1997. The 5′ hypermutation boundary of kappa chains is independent of local and neighbouring sequences and related to the distance from the initiation of transcription. Eur. J. Immunol. 27:3115-3120.
    • (1997) Eur. J. Immunol. , vol.27 , pp. 3115-3120
    • Rada, C.1    Yélamos, J.2    Dean, W.3    Milstein, C.4
  • 46
    • 27944493275 scopus 로고    scopus 로고
    • The very 5′ end and the constant region of Ig genes are spared from somatic mutation because AID does not access these regions
    • Longerich, S., A. Tanaka, G. Bozek, D. Nicolae, and U. Storb. 2005. The very 5′ end and the constant region of Ig genes are spared from somatic mutation because AID does not access these regions. J. Exp. Med. 202:1443-1454.
    • (2005) J. Exp. Med. , vol.202 , pp. 1443-1454
    • Longerich, S.1    Tanaka, A.2    Bozek, G.3    Nicolae, D.4    Storb, U.5
  • 47
    • 0030063726 scopus 로고    scopus 로고
    • Somatic hypermutation of immunoglobulin genes is linked to transcription initiation
    • Peters, A., and U. Storb. 1996. Somatic hypermutation of immunoglobulin genes is linked to transcription initiation. Immunity 4:57-65.
    • (1996) Immunity , vol.4 , pp. 57-65
    • Peters, A.1    Storb, U.2
  • 48
    • 0031920676 scopus 로고    scopus 로고
    • Dual enigma of somatic hypermutation of immunoglobulin variable genes: Targeting and mechanism
    • Winter, D. B., and P. J. Gearhart. 1998. Dual enigma of somatic hypermutation of immunoglobulin variable genes: targeting and mechanism. Immunol. Rev. 162:89-96.
    • (1998) Immunol. Rev. , vol.162 , pp. 89-96
    • Winter, D.B.1    Gearhart, P.J.2
  • 49
    • 0035881820 scopus 로고    scopus 로고
    • The intrinsic hypermutability of antibody heavy and light chain genes decays exponentially
    • Rada, C., and C. Milstein. 2001. The intrinsic hypermutability of antibody heavy and light chain genes decays exponentially. EMBO J. 20:4570-4576.
    • (2001) EMBO J. , vol.20 , pp. 4570-4576
    • Rada, C.1    Milstein, C.2
  • 51
    • 67449161835 scopus 로고    scopus 로고
    • Immunoglobulin switch μ sequence causes RNA polymerase II accumulation and reduces dA hypermutation
    • Rajagopal, D., R. W. Maul, A. Ghosh, T. Chakraborty, A. A. Khamlichi, R. Sen, and P. J. Gearhart. 2009. Immunoglobulin switch μ sequence causes RNA polymerase II accumulation and reduces dA hypermutation. J. Exp. Med. 206:1237-1244.
    • (2009) J. Exp. Med. , vol.206 , pp. 1237-1244
    • Rajagopal, D.1    Maul, R.W.2    Ghosh, A.3    Chakraborty, T.4    Khamlichi, A.A.5    Sen, R.6    Gearhart, P.J.7
  • 52
    • 33646862623 scopus 로고    scopus 로고
    • The transcription elongation complex directs activation-induced cytidine deaminase-mediated DNA deamination
    • Besmer, E., E. Market, and F. N. Papavasiliou. 2006. The transcription elongation complex directs activation-induced cytidine deaminase-mediated DNA deamination. Mol. Cell. Biol. 26:4378-4385.
    • (2006) Mol. Cell. Biol. , vol.26 , pp. 4378-4385
    • Besmer, E.1    Market, E.2    Papavasiliou, F.N.3
  • 53
    • 0032478071 scopus 로고    scopus 로고
    • Frequent occurrence of deletions and duplications during somatic hypermutation: Implications for oncogene translocations and heavy chain disease
    • Goossens, T., U. Klein, and R. Küppers. 1998. Frequent occurrence of deletions and duplications during somatic hypermutation: implications for oncogene translocations and heavy chain disease. Proc. Natl. Acad. Sci. USA 95:2463-2468.
    • (1998) Proc. Natl. Acad. Sci. USA , vol.95 , pp. 2463-2468
    • Goossens, T.1    Klein, U.2    Küppers, R.3
  • 54
    • 0032435650 scopus 로고    scopus 로고
    • TdT-accessible breaks are scattered over the immunoglobulin V domain in a constitutively hypermutating B cell line
    • Sale, J. E., and M. S. Neuberger. 1998. TdT-accessible breaks are scattered over the immunoglobulin V domain in a constitutively hypermutating B cell line. Immunity 9:859-869.
    • (1998) Immunity , vol.9 , pp. 859-869
    • Sale, J.E.1    Neuberger, M.S.2
  • 56
    • 0031567975 scopus 로고    scopus 로고
    • Constitutive expression of terminal deoxynucleotidyl transferase in transgenic mice is sufficient for N region diversity to occur at any Ig locus throughout B cell differentiation
    • Bentolila, L. A., G. E. Wu, F. Nourrit, M. Fanton d'Andon, F. Rougeon, and N. Doyen. 1997. Constitutive expression of terminal deoxynucleotidyl transferase in transgenic mice is sufficient for N region diversity to occur at any Ig locus throughout B cell differentiation. J. Immunol. 158:715-723.
    • (1997) J. Immunol. , vol.158 , pp. 715-723
    • Bentolila, L.A.1    Wu, G.E.2    Nourrit, F.3    D'Andon, F.M.4    Rougeon, F.5    Doyen, N.6
  • 57
    • 0033136298 scopus 로고    scopus 로고
    • Increased junctional diversity in fetal B cells results in a loss of protective anti-phosphorylcholine antibodies in adult mice
    • Benedict, C. L., and J. F. Kearney. 1999. Increased junctional diversity in fetal B cells results in a loss of protective anti-phosphorylcholine antibodies in adult mice. Immunity 10:607-617.
    • (1999) Immunity , vol.10 , pp. 607-617
    • Benedict, C.L.1    Kearney, J.F.2
  • 58
    • 34548682354 scopus 로고    scopus 로고
    • Characterization of terminal deoxynucleotidyl transferase and polymerase mu in zebrafish
    • Beetz, S., D. Diekhoff, and L. A. Steiner. 2007. Characterization of terminal deoxynucleotidyl transferase and polymerase mu in zebrafish. Immunogenetics 59:735-744.
    • (2007) Immunogenetics , vol.59 , pp. 735-744
    • Beetz, S.1    Diekhoff, D.2    Steiner, L.A.3
  • 61
    • 7444228703 scopus 로고    scopus 로고
    • Overexpression of human DNA polymerase μ (Pol μ) in a Burkitt's lymphoma cell line affects the somatic hypermutation rate
    • Ruiz, J. F., D. Lucas, E. García-Palomero, A. I. Saez, M. A. González, M. A. Piris, A. Bernad, and L. Blanco. 2004. Overexpression of human DNA polymerase μ (Pol μ) in a Burkitt's lymphoma cell line affects the somatic hypermutation rate. Nucleic Acids Res. 32:5861-5873.
    • (2004) Nucleic Acids Res. , vol.32 , pp. 5861-5873
    • Ruiz, J.F.1    Lucas, D.2    García-Palomero, E.3    Saez, A.I.4    González, M.A.5    Piris, M.A.6    Bernad, A.7    Blanco, L.8
  • 63
    • 34548526067 scopus 로고    scopus 로고
    • Strand-biased spreading of mutations during somatic hypermutation
    • Unniraman, S., and D. G. Schatz. 2007. Strand-biased spreading of mutations during somatic hypermutation. Science 317:1227-1230.
    • (2007) Science , vol.317 , pp. 1227-1230
    • Unniraman, S.1    Schatz, D.G.2
  • 64
    • 34547114028 scopus 로고    scopus 로고
    • DNA polymerases η and θ function in the same genetic pathway to generate mutations at A/T during somatic hypermutation of Ig genes
    • Masuda, K., R. Ouchida, M. Hikida, T. Kurosaki, M. Yokoi, C. Masutani, M. Seki, R. D. Wood, F. Hanaoka, and J. O. Wang. 2007. DNA polymerases η and θ function in the same genetic pathway to generate mutations at A/T during somatic hypermutation of Ig genes. J. Biol. Chem. 282:17387-17394.
    • (2007) J. Biol. Chem. , vol.282 , pp. 17387-17394
    • Masuda, K.1    Ouchida, R.2    Hikida, M.3    Kurosaki, T.4    Yokoi, M.5    Masutani, C.6    Seki, M.7    Wood, R.D.8    Hanaoka, F.9    Wang, J.-O.10
  • 65
    • 0036682979 scopus 로고    scopus 로고
    • Translesion DNA synthesis in eukaryotes: A one-or two-polymerase affair
    • Prakash, S., and L. Prakash. 2002. Translesion DNA synthesis in eukaryotes: a one-or two-polymerase affair. Genes Dev. 16:1872-1883.
    • (2002) Genes Dev. , vol.16 , pp. 1872-1883
    • Prakash, S.1    Prakash, L.2
  • 66
    • 33750470385 scopus 로고    scopus 로고
    • Human DNA polymerase k forms nonproductive complexes with matched primer termini but not with mismatched primer termini
    • Carlson, K. D., R. E. Johnson, L. Prakash, S. Prakash, and M. T. Washington. 2006. Human DNA polymerase k forms nonproductive complexes with matched primer termini but not with mismatched primer termini. Proc. Natl. Acad. Sci. USA 103:15776-15781.
    • (2006) Proc. Natl. Acad. Sci. USA , vol.103 , pp. 15776-15781
    • Carlson, K.D.1    Johnson, R.E.2    Prakash, L.3    Prakash, S.4    Washington, M.T.5
  • 67
    • 2342419732 scopus 로고    scopus 로고
    • DNA replication fidelity
    • Kunkel, T. A. 2004. DNA replication fidelity. J. Biol. Chem. 279:16895-16898.
    • (2004) J. Biol. Chem. , vol.279 , pp. 16895-16898
    • Kunkel, T.A.1
  • 68
    • 0028867419 scopus 로고
    • New insights into V (D) J recombination and its role in the evolution of the immune system
    • Thompson, C. B. 1995. New insights into V (D) J recombination and its role in the evolution of the immune system. Immunity 3:531-539.
    • (1995) Immunity , vol.3 , pp. 531-539
    • Thompson, C.B.1
  • 69
    • 26044467886 scopus 로고    scopus 로고
    • Antibodies, immunoglobulin genes and the bursa of Fabricius in chicken B cell development
    • Ratcliffe, M. J. H. 2006. Antibodies, immunoglobulin genes and the bursa of Fabricius in chicken B cell development. Dev. Comp. Immunol. 30:101-118.
    • (2006) Dev. Comp. Immunol. , vol.30 , pp. 101-118
    • Ratcliffe, M.J.H.1
  • 70
    • 59249084046 scopus 로고    scopus 로고
    • Genetic evidence for single-strand lesions initiating Nbs1-dependent homologous recombination in diversification of Ig v in chicken B lymphocytes
    • Nakahara, M., E. Sonoda, K. Nojima, J. E. Sale, K. Takenaka, K. Kikuchi, Y. Taniguchi, K. Nakamura, Y. Sumitomo, R. T. Bree, et al. 2009. Genetic evidence for single-strand lesions initiating Nbs1-dependent homologous recombination in diversification of Ig v in chicken B lymphocytes. PLoS Genet. 5: e1000356.
    • (2009) PLoS Genet. , vol.5
    • Nakahara, M.1    Sonoda, E.2    Nojima, K.3    Sale, J.E.4    Takenaka, K.5    Kikuchi, K.6    Taniguchi, Y.7    Nakamura, K.8    Sumitomo, Y.9    Bree, R.T.10
  • 71
    • 70449715730 scopus 로고    scopus 로고
    • Temporal regulation of Ig gene diversification revealed by single-cell imaging
    • Ordinario, E. C., M. Yabuki, R. P. Larson, and N. Maizels. 2009. Temporal regulation of Ig gene diversification revealed by single-cell imaging. J. Immunol. 183:4545-4553.
    • (2009) J. Immunol. , vol.183 , pp. 4545-4553
    • Ordinario, E.C.1    Yabuki, M.2    Larson, R.P.3    Maizels, N.4
  • 72
    • 0025163907 scopus 로고
    • Base mispair extension kinetics. Comparison of DNA polymerase a and reverse transcriptase
    • Mendelman, L. V., J. Petruska, and M. F. Goodman. 1990. Base mispair extension kinetics. Comparison of DNA polymerase a and reverse transcriptase. J. Biol. Chem. 265:2338-2346.
    • (1990) J. Biol. Chem. , vol.265 , pp. 2338-2346
    • Mendelman, L.V.1    Petruska, J.2    Goodman, M.F.3
  • 74
    • 0035377269 scopus 로고    scopus 로고
    • DNA polymerase eta is an A-T mutator in somatic hypermutation of immunoglobulin variable genes
    • Zeng, X., D. B. Winter, C. Kasmer, K. H. Kraemer, A. R. Lehmann, and P. J. Gearhart. 2001. DNA polymerase eta is an A-T mutator in somatic hypermutation of immunoglobulin variable genes. Nat. Immunol. 2:537-541.
    • (2001) Nat. Immunol. , vol.2 , pp. 537-541
    • Zeng, X.1    Winter, D.B.2    Kasmer, C.3    Kraemer, K.H.4    Lehmann, A.R.5    Gearhart, P.J.6
  • 75
    • 33846404877 scopus 로고    scopus 로고
    • DNA polymerase eta is the sole contributor of A/T modifications during immunoglobulin gene hypermutation in the mouse
    • Delbos, F., S. Aoufouchi, A. Faili, J. C. Weill, and C. A. Reynaud. 2007. DNA polymerase eta is the sole contributor of A/T modifications during immunoglobulin gene hypermutation in the mouse. J. Exp. Med. 204:17-23.
    • (2007) J. Exp. Med. , vol.204 , pp. 17-23
    • Delbos, F.1    Aoufouchi, S.2    Faili, A.3    Weill, J.C.4    Reynaud, C.A.5


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.