Autophagosome requires specific early sec proteins for its formation and NSF/SNARE for vacuolar fusion

Molecular Biology of the Cell

Volumn 12, Issue 11, 2001, Pages 3690-3702

  Ishihara, N ^a   Hamasaki, M ^a   Yokota, S ^a   Suzuki, K ^a   Kamada, Y ^a   Kihara, A ^a   Yoshimori, T ^a   Noda, T ^a   Ohsumi, Y ^a  

^a GRADUATE UNIVERSITY FOR ADVANCED STUDIES   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

HYBRID PROTEIN; N ETHYLMALEIMIDE; PROTEIN NSF; PROTEIN SEC; SNARE PROTEIN; UNCLASSIFIED DRUG;

ANIMAL CELL; ARTICLE; AUTOPHAGOSOME; AUTOPHAGY; CELL FRACTIONATION; CELL LABELING; ELECTRON MICROSCOPY; IMMUNOPRECIPITATION; NONHUMAN; PHAGOSOME; PRIORITY JOURNAL; PROTEIN ANALYSIS; YEAST;

ANIMALIA; SACCHAROMYCES CEREVISIAE;

EID: 0035192612     PISSN: 10591524     EISSN: None     Source Type: Journal    
DOI: 10.1091/mbc.12.11.3690     Document Type: Article

References (54)

1. Cytoplasm to vacuole trafficking of aminopeptidase I requires a t-SNARE-Sec1p complex composed of Tlg2p and Vps45p
2. Two distinct pathways for targeting proteins from the cytoplasm to the vacuole/lysosome
3. Ultrastrucrural analysis of the autophagic process in yeast: Detection of autophagosomes and their characterization
4. COPII: A membrane coat formed by Sec proteins that drive vesicle budding from the endoplasmic reticulum
5. Vesicular transport between the endoplasmic reticulum and Golgi stack requires the NEM sensitive fusion protein
6. A multispecificity syntaxin homologue, Vam3p, essential for autophagic and biosynthetic protein transport to the vacuole
7. Studies on the mechanisms of autophagy: Formation of the autophagic vacuole
8. Yeast SEC16 gene encodes a multidomain vesicle coat protein that interact with Sec23p
9. The yeast v-SNARE Vti1p mediates two vesicle transport pathways through interaction with t-SNAREs Sed5p and Pep12p
10. The Sccharomyces cerevisiae v-SNARE Vti1p is required for multiple membrane transport pathways to the vacuole
11. Compartmental organization of Golgi-specific protein modification and vacuolar protein sorting event defined in a yeast sec18 (NSF) mutant
12. Genetic and phenotypic overlap between autophagy and the cytoplasm to vacuole targeting pathway
13. Isolation and characterization of yeast mutants in cytoplasm to vacuole protein targeting pathway
14. Transport through the yeast endocytic pathway occurs through morphologically distinct compartments and requires an active secretory pathway and Sec18p/N-ethylmaleimide-sensitive fusion protein
15. Two syntaxin homologues in the TGN/endosomal system of yeast
16. A ubiquitin-like system mediates protein lipidation
17. Distinct sets of SEC genes govern transport vesicle formation and fusion early in the secretory pathway
18. Tor-mediated induction of autophagy via an Apg1 protein kinase complex
19. Two distinct Vps34 phosphatidylinositol 3-kinase complexes function in autophagy and carboxypeptidase Y sorting in Saccharomyces cerevisiae
20. Apg7p/Cvt2p is required for the cytoplasm-to-vacuole targeting, macroautophagy, and peroxisome degradation pathways
21. Cvt9/Gsa9 functions in sequestering selective cytosolic cargo destined for the vacuole
22. Formation process of autophagosome is traced with Apg8p/Aut7p in yeast
23. Aminopeptidase I of Sccharomyces cerevisiae is localized to the vacuole independent of the secretory pathway
24. Vacuolar import of proteins and organelles from the cytoplasm
25. Sec24p and Iss1p function interchangeably in transport vesicle formation from the endoplasmic reticulum in Saccharomyces cerevisiae
26. Membrane fusion and the cell cycle: Cdc48p participates in the fusion of ER membranes
27. The SNARE machinery is involved in apical plasma membrane trafficking in MDCK cells
28. Sec18p (NSF)-driven release of Sec17p (α-SNAP) can precede docking and fusion of yeast vacuoles
29. A protein conjugation system essential for autophagy
30. Continued functioning of the secretory pathway is essential for ribosome synthesis
31. A novel GTP-binding protein, Sar1p, is involved in transport from the endoplasmic reticulum to the Golgi apparatus
32. An unexpected link between the secretory path and the organization of the nucleus
33. Novel system for monitoring autophagy in the yeast Ssccharomyces cerevisiae
34. Tor, a phosphatidylinositol kinase homologue, controls autophagy in yeast
35. Identification of 23 complementation groups required for post-translational events in the yeast secretory pathway
36. Intracellular aspects of the process of protein synthesis
37. An NSF-like ATPase, p97, and NSF mediate cisternal regrowth from mitotic Golgi fragments
38. A novel RING finger protein complex essential for a late step in protein transport to the yeast vacuole
39. Control of amino acid permease sorting in the late secretory pathway of Saccharomyces cerevisiae by SEC13, LST4, LST7 and LST8
40. LST1 is a SEC24 homologue used for selective export of the plasma membrane ATPase from the endoplasmic reticulum
41. Physiological regulation of membrane protein sorting late in the secretory pathway of Saccharomyces cerevisiae
42. Sec31 encodes an essential component of the COPII coat required for transport vesicle budding from the endoplasmic reticulum
43. Vam7p, a SNAP-25-like molecule, and Vam3p, a syntaxin homolog, function together in yeast vacuolar protein trafficking
44. Cytoplasm-to-vacuole targeting and autophagy employ the same machinery to deliver proteins to the yeast vacuole
45. Apg13p and Vac8p are part of a complex of phosphoproteins that are required for cytoplasm to vacuole targeting
46. Purification and characterization of autophagosomes from rat hepatocytes
47. Apg7/Cvt2p: A novel protein-activating enzyme essential for autophagy
48. Isolation of autophagocytosis mutants of Saccharomyces cerevisiae
49. Isolation and characterization of autophagy-defective mutant of Saccharomyces cerevisiae
50. Membrane markers of endoplasmic reticulum preserved in autophagic vacuolar membranes isolated from leupeptin-administered rat liver
51. A cell-free assay allows reconstitution of Vps33p-dependent transport to the yeast vacuole/lysosome
52. Absence of cytochrome P-450 and presence of autophagosomal membrane antigens on the isolation membranes and autophagosomal membranes in rat hepatocytes
53. Different biosynthetic transport routes to the plasma membrane in BHK and CHO cells