Expression of beclin-1, an autophagy-related protein, in gastric and colorectal cancers

APMIS

Volumn 115, Issue 12, 2007, Pages 1344-1349

  Ahn, Chang Hyeok ^a   Jeong, Eun Goo ^a   Lee, Jong Woo ^a   Kim, Min Sung ^a   Kim, Sung Hee ^a   Kim, Sung Soo ^a   Yoo, Nam Jin ^a   Lee, Sug Hyung ^a  

^a The Catholic University of Korea   (South Korea)

Author keywords

Autophagy; Beclin 1; Colorectal cancer; Expression; Gastric cancer

Indexed keywords

BECLIN 1; TUMOR SUPPRESSOR PROTEIN;

ARTICLE; AUTOPHAGY; BECLIN 1 GENE; CANCER CELL; CANCER INVASION; CANCER STAGING; CARCINOGENESIS; CELL SURVIVAL; COLORECTAL CANCER; COLORECTAL CARCINOMA; CONTROLLED STUDY; GENE; HISTOPATHOLOGY; HUMAN; HUMAN CELL; HUMAN TISSUE; IMMUNOHISTOCHEMISTRY; METASTASIS; POINT MUTATION; PRIORITY JOURNAL; PROTEIN EXPRESSION; STOMACH CANCER; STOMACH CARCINOMA; TISSUE MICROARRAY;

ADENOCARCINOMA; APOPTOSIS REGULATORY PROTEINS; AUTOPHAGY; COLORECTAL NEOPLASMS; GENE EXPRESSION; HUMANS; IMMUNOHISTOCHEMISTRY; MEMBRANE PROTEINS; STOMACH NEOPLASMS; TISSUE ARRAY ANALYSIS;

EID: 37549063395     PISSN: 09034641     EISSN: 16000463     Source Type: Journal    
DOI: 10.1111/j.1600-0463.2007.00858.x     Document Type: Article

References (22)

1. Reed JC. Mechanisms of apoptosis. Am J Pathol 2000 39 : 1415 30.
2. Baehrecke EH. Autophagy: dual roles in life and death? Nat Rev Mol Cell Biol 2005 6 : 505 10.
3. Edinger AL, Thompson CB. Death by design: apoptosis, necrosis and autophagy. Curr Opin Cell Biol 2004 16 : 663 9.
4. Kondo Y, Kanzawa T, Sawaya R, Kondo S. The role of autophagy in cancer development and response to therapy. Nat Rev Cancer 2005 5 : 726 34.
5. Liang XH, Yu J, Brown K, Levine B. Beclin 1 contains a leucine-rich nuclear export signal that is required for its autophagy and tumor suppressor function. Cancer Res 2001 61 : 3443 9.
6. Liang XH, Kleeman LK, Jiang HH, Gordon G, Goldman JE, Berry G, et al. Protection against fatal Sindbis virus encephalitis by beclin, a novel Bcl-2-interacting protein. J Virol 1998 72 : 8586 96.
7. Hanahan D, Weinberg RA. The hallmarks of cancer. Cell 2000 100 : 57 70.
8. Kim HS, Lee JW, Soung YH, Park WS, Kim SY, Lee JH, et al. Inactivating mutations of caspase-8 gene in colorectal carcinomas. Gastroenterology 2003 125 : 708 15.
9. Lee SH, Shin MS, Park WS, Kim SY, Kim HS, Han JY, et al. Alterations of Fas (Apo-1/CD95) gene in non-small cell lung cancer. Oncogene 1999 18 : 3754 60.
10. Shin MS, Kim HS, Kang CS, Park WS, Kim SY, Lee SN, et al. Inactivating mutations of CASP10 gene in non-Hodgkin lymphomas. Blood 2002 99 : 4094 9.
11. Aita VM, Liang XH, Murty VV, Pincus DL, Yu W, Cayanis E, et al. Cloning and genomic organization of beclin 1, a candidate tumor suppressor gene on chromosome 17q21. Genomics 1999 59 : 59 65.
12. Yue Z, Jin S, Yang C, Levine AJ, Heintz N. Beclin 1, an autophagy gene essential for early embryonic development, is a haploinsufficient tumor suppressor. Proc Natl Acad Sci U S A 2003 100 : 15077 82.
13. Qu X, Yu J, Bhagat G, Furuya N, Hibshoosh H, Troxel A, et al. Promotion of tumorigenesis by heterozygous disruption of the beclin 1 autophagy gene. J Clin Invest 2003 112 : 1809 20.
14. Lee JW, Jeong EG, Lee SH, Yoo NJ, Lee SH. Somatic mutations of BECN1, an autophagy-related gene, in human cancers. APMIS 2007 115 : 750 6.
15. Liang XH, Jackson S, Seaman M, Brown K, Kempkes B, Hibshoosh H, et al. Induction of autophagy and inhibition of tumorigenesis by beclin 1. Nature 1999 402 : 672 6.
16. Yoo NJ, Lee SH, Jeong EG, Lee SH. Expression of phosphorylated caspase-9 in gastric carcinomas. APMIS 2007 115 : 354 9.
17. Marx J. Autophagy: is it cancer's friend or foe? Science 2006 312 : 1160 1.
18. Furuya D, Tsuji N, Yagihashi A, Watanabe N. Beclin 1 augmented cis-diamminedichloroplatinum induced apoptosis via enhancing caspase-9 activity. Exp Cell Res 2005 307 : 26 40.
19. Daniel F, Legrand A, Pessayre D, Vadrot N, Descatoire V, Bernuau D. Partial Beclin 1 silencing aggravates doxorubicin- and Fas-induced apoptosis in HepG2 cells. World J Gastroenterol 2006 12 : 2895 900.
20. Miracco C, Cosci E, Oliveri G, Luzi P, Pacenti L, Monciatti I, et al. Protein and mRNA expression of autophagy gene Beclin 1 in human brain tumours. Int J Oncol 2007 30 : 429 36.
21. Pattingre S, Tassa A, Qu X, Garuti R, Liang XH, Mizushima N, et al. Bcl-2 antiapoptotic proteins inhibit Beclin 1-dependent autophagy. Cell 2005 122 : 927 39.
22. Liang C, Feng P, Ku B, Dotan I, Canaani D, Oh BH, et al. Autophagic and tumour suppressor activity of a novel Beclin1-binding protein UVRAG. Nat Cell Biol 2006 8 : 688 99.