Frequency and phenotypic implications of mitochondrial DNA mutations in human squamous cell cancers of the head and neck

Proceedings of the National Academy of Sciences of the United States of America

Volumn 104, Issue 18, 2007, Pages 7540-7545

  Zhou, Shaoyu ^a   Kachhap, Sushant ^a   Sun, Wenyue ^a   Wu, Guojun ^a,e   Chuang, Alice ^a   Poeta, Luana ^a,d   Grumbine, Lawson ^b   Mithani, Suhail K ^a   Chatterjee, Aditi ^a   Koch, Wayne ^a   Westra, William H ^a   Maitra, Anirban ^a   Glazer, Chad ^a   Carducci, Michael ^a   Sidransky, David ^a   McFate, Thomas ^c   Verma, Ajay ^c   Califano, Joseph A ^a  

^a DEPARTMENT OF PATHOLOGY   (United States)

^b THOMAS JEFFERSON UNIVERSITY   (United States)

^c Uniformed Services University of the Health Sciences and the Walter Reed National Military Medical Center   (United States)

^d UNIVERSITY CAMPUS BIO MEDICO   (Italy)

^e WAYNE STATE UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

MitoChip; p53; Reactive oxygen species

Indexed keywords

COMPLEMENTARY DNA; LACTIC ACID; MITOCHONDRIAL DNA; MITOCHONDRIAL ENZYME; PROTEIN P53; PYRUVIC ACID; REACTIVE OXYGEN METABOLITE; RNA; HIF1A PROTEIN, HUMAN; HYPOXIA INDUCIBLE FACTOR 1ALPHA; PYRUVIC ACID DERIVATIVE; UNCLASSIFIED DRUG;

ARTICLE; CONTROLLED STUDY; DNA SEQUENCE; FEMALE; GENE MUTATION; GENOTOXICITY; HEAD AND NECK CANCER; HELA CELL; HUMAN; HUMAN CELL; HUMAN TISSUE; MAJOR CLINICAL STUDY; MALE; PHENOTYPE; PRIORITY JOURNAL; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; SQUAMOUS CELL CARCINOMA; TUMOR SUPPRESSOR GENE; WESTERN BLOTTING; BIOSYNTHESIS; GENE EXPRESSION REGULATION; GENETICS; HEAD AND NECK TUMOR; METABOLISM; MUTATION; PATHOLOGY;

DNA, MITOCHONDRIAL; GENE EXPRESSION REGULATION, NEOPLASTIC; HEAD AND NECK NEOPLASMS; HELA CELLS; HUMANS; HYPOXIA-INDUCIBLE FACTOR 1, ALPHA SUBUNIT; LACTIC ACID; MUTATION; NEOPLASMS, SQUAMOUS CELL; PHENOTYPE; PYRUVATES; REACTIVE OXYGEN SPECIES; TUMOR SUPPRESSOR PROTEIN P53;

EID: 34250624498     PISSN: 00278424     EISSN: None     Source Type: Journal    
DOI: 10.1073/pnas.0610818104     Document Type: Article

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