-
1
-
-
8144228566
-
Why do cancers have high aerobic glycolysis?
-
Gatenby RA and Gillies RJ (2004). Why do cancers have high aerobic glycolysis? Nat Rev Cancer 4, 891-899.
-
(2004)
Nat Rev Cancer
, vol.4
, pp. 891-899
-
-
Gatenby, R.A.1
Gillies, R.J.2
-
2
-
-
0034614637
-
The hallmarks of cancer
-
Hanahan D and Weinberg RA (2000). The hallmarks of cancer. Cell 100, 57-70.
-
(2000)
Cell
, vol.100
, pp. 57-70
-
-
Hanahan, D.1
Weinberg, R.A.2
-
3
-
-
33745303045
-
Hypoxia signalling in cancer and approaches to enforce tumour regression
-
Pouyssegur J, Dayan F, and Mazure NM (2006). Hypoxia signalling in cancer and approaches to enforce tumour regression. Nature 441, 437-443.
-
(2006)
Nature
, vol.441
, pp. 437-443
-
-
Pouyssegur, J.1
Dayan, F.2
Mazure, N.M.3
-
4
-
-
8544271638
-
Hypoxia-inducible factors and hypoxic cell death in tumour physiology
-
Bacon AL and Harris AL (2004). Hypoxia-inducible factors and hypoxic cell death in tumour physiology. Ann Med 36, 530-539.
-
(2004)
Ann Med
, vol.36
, pp. 530-539
-
-
Bacon, A.L.1
Harris, A.L.2
-
5
-
-
33750108975
-
Hypoxia in head and neck cancer
-
Isa AY, Ward TH, West CM, Slevin NJ, and Homer JJ (2006). Hypoxia in head and neck cancer. Br J Radiol 79, 791-798.
-
(2006)
Br J Radiol
, vol.79
, pp. 791-798
-
-
Isa, A.Y.1
Ward, T.H.2
West, C.M.3
Slevin, N.J.4
Homer, J.J.5
-
6
-
-
21844455567
-
Hypoxia in head and neck cancer: How much, how important?
-
Janssen HL, Haustermans KM, Balm AJ, and Begg AC (2005). Hypoxia in head and neck cancer: how much, how important? Head Neck 27, 622-638.
-
(2005)
Head Neck
, vol.27
, pp. 622-638
-
-
Janssen, H.L.1
Haustermans, K.M.2
Balm, A.J.3
Begg, A.C.4
-
7
-
-
33747819801
-
mTOR and cancer: Insights into a complex relationship
-
Sabatini DM (2006). mTOR and cancer: insights into a complex relationship. Nat Rev Cancer 6, 729-734.
-
(2006)
Nat Rev Cancer
, vol.6
, pp. 729-734
-
-
Sabatini, D.M.1
-
8
-
-
33750044112
-
Stress and mTORture signaling
-
Reiling JH and Sabatini DM (2006). Stress and mTORture signaling. Oncogene 25, 6373-6383.
-
(2006)
Oncogene
, vol.25
, pp. 6373-6383
-
-
Reiling, J.H.1
Sabatini, D.M.2
-
9
-
-
0042031047
-
A novel hypoxia-inducible factor-independent hypoxic response regulating mammalian target of rapamycin and its targets
-
Arsham AM, Howell JJ, and Simon MC (2003). A novel hypoxia-inducible factor-independent hypoxic response regulating mammalian target of rapamycin and its targets. J Biol Chem 278, 29655-29660.
-
(2003)
J Biol Chem
, vol.278
, pp. 29655-29660
-
-
Arsham, A.M.1
Howell, J.J.2
Simon, M.C.3
-
10
-
-
33644852277
-
Gene expression during acute and prolonged hypoxia is regulated by distinct mechanisms of translational control
-
Koritzinsky M, Magagnin MG, van den Beucken T, Seigneuric R, Savelkouls K, Dostie J, Pyronnet S, Kaufman RJ, Weppler SA, Voncken JW, et al. (2006). Gene expression during acute and prolonged hypoxia is regulated by distinct mechanisms of translational control. EMBO J 25, 1114-1125.
-
(2006)
EMBO J
, vol.25
, pp. 1114-1125
-
-
Koritzinsky, M.1
Magagnin, M.G.2
van den Beucken, T.3
Seigneuric, R.4
Savelkouls, K.5
Dostie, J.6
Pyronnet, S.7
Kaufman, R.J.8
Weppler, S.A.9
Voncken, J.W.10
-
11
-
-
32444433450
-
Hypoxia-induced energy stress regulates mRNA translation and cell growth
-
Liu L, Cash TP, Jones RG, Keith B, Thompson CB, and Simon MC (2006). Hypoxia-induced energy stress regulates mRNA translation and cell growth. Mol Cell 21, 521-531.
-
(2006)
Mol Cell
, vol.21
, pp. 521-531
-
-
Liu, L.1
Cash, T.P.2
Jones, R.G.3
Keith, B.4
Thompson, C.B.5
Simon, M.C.6
-
12
-
-
27544505190
-
Mammalian target of rapamycin, a molecular target in squamous cell carcinomas of the head and neck
-
Amornphimoltham P, Patel V, Sodhi A, Nikitakis NG, Sauk JJ, Sausville EA, Molinolo AA, and Gutkind JS (2005). Mammalian target of rapamycin, a molecular target in squamous cell carcinomas of the head and neck. Cancer Res 65, 9953-9961.
-
(2005)
Cancer Res
, vol.65
, pp. 9953-9961
-
-
Amornphimoltham, P.1
Patel, V.2
Sodhi, A.3
Nikitakis, N.G.4
Sauk, J.J.5
Sausville, E.A.6
Molinolo, A.A.7
Gutkind, J.S.8
-
13
-
-
3042531148
-
Persistent activation of the Akt pathway in head and neck squamous cell carcinoma: A potential target for UCN-01
-
Amornphimoltham P, Sriuranpong V, Patel V, Benavides F, Conti CJ, Sauk J, Sausville EA, Molinolo AA, and Gutkind JS (2004). Persistent activation of the Akt pathway in head and neck squamous cell carcinoma: a potential target for UCN-01. Clin Cancer Res 10, 4029-4037.
-
(2004)
Clin Cancer Res
, vol.10
, pp. 4029-4037
-
-
Amornphimoltham, P.1
Sriuranpong, V.2
Patel, V.3
Benavides, F.4
Conti, C.J.5
Sauk, J.6
Sausville, E.A.7
Molinolo, A.A.8
Gutkind, J.S.9
-
14
-
-
33144489901
-
Hypoxia-inducible factor-1alpha polymorphisms and TSC1/2 mutations are complementary in head and neck cancers
-
Hebert C, Norris K, Parashar P, Ord RA, Nikitakis NG, and Sauk JJ (2006). Hypoxia-inducible factor-1alpha polymorphisms and TSC1/2 mutations are complementary in head and neck cancers. Mol Cancer 5, 3.
-
(2006)
Mol Cancer
, vol.5
, pp. 3
-
-
Hebert, C.1
Norris, K.2
Parashar, P.3
Ord, R.A.4
Nikitakis, N.G.5
Sauk, J.J.6
-
15
-
-
34548820978
-
Dissecting the Akt/mammalian target of rapamycin signaling network: Emerging results from the head and neck cancer tissue array initiative
-
Molinolo AA, Hewitt SM, Amornphimoltham P, Keelawat S, Rangdaeng S, Meneses Garcia A, Raimondi AR, Jufe R, Itoiz M, Gao Y, et al. (2007). Dissecting the Akt/mammalian target of rapamycin signaling network: emerging results from the head and neck cancer tissue array initiative. Clin Cancer Res 13, 4964-4973.
-
(2007)
Clin Cancer Res
, vol.13
, pp. 4964-4973
-
-
Molinolo, A.A.1
Hewitt, S.M.2
Amornphimoltham, P.3
Keelawat, S.4
Rangdaeng, S.5
Meneses Garcia, A.6
Raimondi, A.R.7
Jufe, R.8
Itoiz, M.9
Gao, Y.10
-
16
-
-
4444278397
-
Overexpressed eIF4E is functionally active in surgical margins of head and neck cancer patients via activation of the Akt/mammalian target of rapamycin pathway
-
Nathan CO, Amirghahari N, Abreo F, Rong X, Caldito G, Jones ML, Zhou H, Smith M, Kimberly D, and Glass J (2004). Overexpressed eIF4E is functionally active in surgical margins of head and neck cancer patients via activation of the Akt/mammalian target of rapamycin pathway. Clin Cancer Res 10, 5820-5827.
-
(2004)
Clin Cancer Res
, vol.10
, pp. 5820-5827
-
-
Nathan, C.O.1
Amirghahari, N.2
Abreo, F.3
Rong, X.4
Caldito, G.5
Jones, M.L.6
Zhou, H.7
Smith, M.8
Kimberly, D.9
Glass, J.10
-
17
-
-
10044276784
-
The hypoxia-induced paralogs Scylla and Charybdis inhibit growth by down-regulating S6K activity upstream of TSC in Drosophila
-
Reiling JH and Hafen E (2004). The hypoxia-induced paralogs Scylla and Charybdis inhibit growth by down-regulating S6K activity upstream of TSC in Drosophila. Genes Dev 18, 2879-2892.
-
(2004)
Genes Dev
, vol.18
, pp. 2879-2892
-
-
Reiling, J.H.1
Hafen, E.2
-
18
-
-
10044276783
-
Regulation of mTOR function in response to hypoxia by REDD1 and the TSC1/TSC2 tumor suppressor complex
-
Brugarolas J, Lei K, Hurley RL, Manning BD, Reiling JH, Hafen E, Witters LA, Ellisen LW, and Kaelin WG Jr (2004). Regulation of mTOR function in response to hypoxia by REDD1 and the TSC1/TSC2 tumor suppressor complex. Genes Dev 18, 2893-2904.
-
(2004)
Genes Dev
, vol.18
, pp. 2893-2904
-
-
Brugarolas, J.1
Lei, K.2
Hurley, R.L.3
Manning, B.D.4
Reiling, J.H.5
Hafen, E.6
Witters, L.A.7
Ellisen, L.W.8
Kaelin Jr, W.G.9
-
19
-
-
21744459535
-
Regulation of mTOR and cell growth in response to energy stress by REDD1
-
Sofer A, Lei K, Johannessen CM, and Ellisen LW (2005). Regulation of mTOR and cell growth in response to energy stress by REDD1. Mol Cell Biol 25, 5834-5845.
-
(2005)
Mol Cell Biol
, vol.25
, pp. 5834-5845
-
-
Sofer, A.1
Lei, K.2
Johannessen, C.M.3
Ellisen, L.W.4
-
20
-
-
15444362044
-
The stress-inducted proteins RTP801 and RTP801L are negative regulators of the mammalian target of rapamycin pathway
-
Corradetti MN, Inoki K, and Guan KL (2005). The stress-inducted proteins RTP801 and RTP801L are negative regulators of the mammalian target of rapamycin pathway. J Biol Chem 280, 9769-9772.
-
(2005)
J Biol Chem
, vol.280
, pp. 9769-9772
-
-
Corradetti, M.N.1
Inoki, K.2
Guan, K.L.3
-
21
-
-
0345167800
-
TSC2 mediates cellular energy response to control cell growth and survival
-
Inoki K, Zhu T, and Guan KL (2003). TSC2 mediates cellular energy response to control cell growth and survival. Cell 115, 577-590.
-
(2003)
Cell
, vol.115
, pp. 577-590
-
-
Inoki, K.1
Zhu, T.2
Guan, K.L.3
-
23
-
-
4544287424
-
Global gene expression profiles of human head and neck squamous carcinoma cell lines
-
Jeon GA, Lee JS, Patel V, Gutkind JS, Thorgeirsson SS, Kim EC, Chu IS, Amornphimoltham P, and Park MH (2004). Global gene expression profiles of human head and neck squamous carcinoma cell lines. Int J Cancer 112, 249-258.
-
(2004)
Int J Cancer
, vol.112
, pp. 249-258
-
-
Jeon, G.A.1
Lee, J.S.2
Patel, V.3
Gutkind, J.S.4
Thorgeirsson, S.S.5
Kim, E.C.6
Chu, I.S.7
Amornphimoltham, P.8
Park, M.H.9
-
24
-
-
38349056675
-
Hypoxia regulates TSC1/2-mTOR signaling and tumor suppression through REDD1-mediated 14-3-3 shuttling
-
DeYoung MP, Horak P, Sofer A, Sgroi D, and Ellisen LW (2008). Hypoxia regulates TSC1/2-mTOR signaling and tumor suppression through REDD1-mediated 14-3-3 shuttling. Genes Dev 22, 239-251.
-
(2008)
Genes Dev
, vol.22
, pp. 239-251
-
-
DeYoung, M.P.1
Horak, P.2
Sofer, A.3
Sgroi, D.4
Ellisen, L.W.5
-
25
-
-
0036118562
-
Identification of a novel hypoxia-inducible factor 1-responsive gene, RTP801, involved in apoptosis
-
Shoshani T, Faerman A, Mett I, Zelin E, Tenne T, Gorodin S, Moshel Y, Elbaz S, Budanov A, Chajut A, et al. (2002). Identification of a novel hypoxia-inducible factor 1-responsive gene, RTP801, involved in apoptosis. Mol Cell Biol 22, 2283-2293.
-
(2002)
Mol Cell Biol
, vol.22
, pp. 2283-2293
-
-
Shoshani, T.1
Faerman, A.2
Mett, I.3
Zelin, E.4
Tenne, T.5
Gorodin, S.6
Moshel, Y.7
Elbaz, S.8
Budanov, A.9
Chajut, A.10
-
26
-
-
14644395545
-
REDD1 integrates hypoxia-mediated survival signaling downstream of phosphatidylinositol 3-kinase
-
Schwarzer R, Tondera D, Arnold W, Giese K, Klippel A, and Kaufmann J (2005). REDD1 integrates hypoxia-mediated survival signaling downstream of phosphatidylinositol 3-kinase. Oncogene 24, 1138-1149.
-
(2005)
Oncogene
, vol.24
, pp. 1138-1149
-
-
Schwarzer, R.1
Tondera, D.2
Arnold, W.3
Giese, K.4
Klippel, A.5
Kaufmann, J.6
-
27
-
-
37449024702
-
The biology of cancer: Metabolic reprogramming fuels cell growth and proliferation
-
DeBerardinis RJ, Lum JJ, Hatzivassiliou G, and Thompson CB (2008). The biology of cancer: metabolic reprogramming fuels cell growth and proliferation. Cell Metab 7, 11-20.
-
(2008)
Cell Metab
, vol.7
, pp. 11-20
-
-
DeBerardinis, R.J.1
Lum, J.J.2
Hatzivassiliou, G.3
Thompson, C.B.4
-
28
-
-
20844451123
-
AMP-activated protein kinase: Ancient energy gauge provides clues to modern understanding of metabolism
-
Kahn BB, Alquier T, Carling D, and Hardie DG (2005). AMP-activated protein kinase: ancient energy gauge provides clues to modern understanding of metabolism. Cell Metab 1, 15-25.
-
(2005)
Cell Metab
, vol.1
, pp. 15-25
-
-
Kahn, B.B.1
Alquier, T.2
Carling, D.3
Hardie, D.G.4
-
29
-
-
0034141355
-
The regulation of AMP-activated protein kinase by phosphorylation
-
Stein SC, Woods A, Jones NA, Davison MD, and Carling D (2000). The regulation of AMP-activated protein kinase by phosphorylation. Biochem J 345 Pt 3, 437-443.
-
(2000)
Biochem J
, vol.345
, Issue.PART 3
, pp. 437-443
-
-
Stein, S.C.1
Woods, A.2
Jones, N.A.3
Davison, M.D.4
Carling, D.5
-
30
-
-
0035960866
-
Head and neck cancer
-
Forastiere A, Koch W, Trotti A, and Sidransky D (2001). Head and neck cancer. N Engl J Med 345, 1890-1900.
-
(2001)
N Engl J Med
, vol.345
, pp. 1890-1900
-
-
Forastiere, A.1
Koch, W.2
Trotti, A.3
Sidransky, D.4
-
31
-
-
36048990355
-
Molecular targeted therapy of head and neck cancer: Review and clinical development challenges
-
Le Tourneau C, Faivre S, and Siu LL (2007). Molecular targeted therapy of head and neck cancer: review and clinical development challenges. Eur J Cancer 43, 2457-2466.
-
(2007)
Eur J Cancer
, vol.43
, pp. 2457-2466
-
-
Le Tourneau, C.1
Faivre, S.2
Siu, L.L.3
-
32
-
-
40749094856
-
Activation of the PI3-K/ AKT pathway and implications for radioresistance mechanisms in head and neck cancer
-
Bussink J, van der Kogel AJ, and Kaanders JH (2008). Activation of the PI3-K/ AKT pathway and implications for radioresistance mechanisms in head and neck cancer. Lancet Oncol 9, 288-296.
-
(2008)
Lancet Oncol
, vol.9
, pp. 288-296
-
-
Bussink, J.1
van der Kogel, A.J.2
Kaanders, J.H.3
-
33
-
-
38749095570
-
Tissue microarray - a high-throughput molecular analysis in head and neck cancer
-
Radhakrishnan R, Solomon M, Satyamoorthy K, Martin LE, and Lingen MW (2008). Tissue microarray - a high-throughput molecular analysis in head and neck cancer. J Oral Pathol Med 37, 166-176.
-
(2008)
J Oral Pathol Med
, vol.37
, pp. 166-176
-
-
Radhakrishnan, R.1
Solomon, M.2
Satyamoorthy, K.3
Martin, L.E.4
Lingen, M.W.5
-
34
-
-
32944482803
-
Molecular context of the EGFR mutations: Evidence for the activation of mTOR/S6K signaling
-
Conde E, Angulo B, Tang M, Morente M, Torres-Lanzas J, Lopez-Encuentra A, Lopez-Rios F, and Sanchez-Cespedes M (2006). Molecular context of the EGFR mutations: evidence for the activation of mTOR/S6K signaling. Clin Cancer Res 12, 710-717.
-
(2006)
Clin Cancer Res
, vol.12
, pp. 710-717
-
-
Conde, E.1
Angulo, B.2
Tang, M.3
Morente, M.4
Torres-Lanzas, J.5
Lopez-Encuentra, A.6
Lopez-Rios, F.7
Sanchez-Cespedes, M.8
-
35
-
-
33748188459
-
Epidermal growth factor receptor biology in head and neck cancer
-
Kalyankrishna S and Grandis JR (2006). Epidermal growth factor receptor biology in head and neck cancer. J Clin Oncol 24, 2666-2672.
-
(2006)
J Clin Oncol
, vol.24
, pp. 2666-2672
-
-
Kalyankrishna, S.1
Grandis, J.R.2
-
36
-
-
33749035470
-
Mutant epidermal growth factor receptor (EGFRvIII) contributes to head and neck cancer growth and resistance to EGFR targeting
-
Sok JC, Coppelli FM, Thomas SM, Lango MN, Xi S, Hunt JL, Freilino ML, Graner MW, Wikstrand CJ, Bigner DD, et al. (2006). Mutant epidermal growth factor receptor (EGFRvIII) contributes to head and neck cancer growth and resistance to EGFR targeting. Clin Cancer Res 12, 5064-5073.
-
(2006)
Clin Cancer Res
, vol.12
, pp. 5064-5073
-
-
Sok, J.C.1
Coppelli, F.M.2
Thomas, S.M.3
Lango, M.N.4
Xi, S.5
Hunt, J.L.6
Freilino, M.L.7
Graner, M.W.8
Wikstrand, C.J.9
Bigner, D.D.10
-
37
-
-
13944276748
-
TOR signaling: An odyssey from cellular stress to the cell growth machinery
-
Abraham RT (2005). TOR signaling: an odyssey from cellular stress to the cell growth machinery. Curr Biol 15, R139-R141.
-
(2005)
Curr Biol
, vol.15
-
-
Abraham, R.T.1
-
38
-
-
34250193203
-
Tumor microenvironment in head and neck squamous cell carcinomas: Predictive value and clinical relevance of hypoxic markers. A review
-
Hoogsteen IJ, Marres HA, Bussink J, van der Kogel AJ, and Kaanders JH (2007). Tumor microenvironment in head and neck squamous cell carcinomas: predictive value and clinical relevance of hypoxic markers. A review. Head Neck 29, 591-604.
-
(2007)
Head Neck
, vol.29
, pp. 591-604
-
-
Hoogsteen, I.J.1
Marres, H.A.2
Bussink, J.3
van der Kogel, A.J.4
Kaanders, J.H.5
-
39
-
-
34547121206
-
Hypoxia in cancer: Significance and impact on clinical outcome
-
Vaupel P and Mayer A (2007). Hypoxia in cancer: significance and impact on clinical outcome. Cancer Metastasis Rev 26, 225-239.
-
(2007)
Cancer Metastasis Rev
, vol.26
, pp. 225-239
-
-
Vaupel, P.1
Mayer, A.2
-
40
-
-
37248999267
-
Bnip3 mediates the hypoxia-induced inhibition on mammalian target of rapamycin by interacting with Rheb
-
Li Y, Wang Y, Kim E, Beemiller P, Wang CY, Swanson J, You M, and Guan KL (2007). Bnip3 mediates the hypoxia-induced inhibition on mammalian target of rapamycin by interacting with Rheb. J Biol Chem 282, 35803-35813.
-
(2007)
J Biol Chem
, vol.282
, pp. 35803-35813
-
-
Li, Y.1
Wang, Y.2
Kim, E.3
Beemiller, P.4
Wang, C.Y.5
Swanson, J.6
You, M.7
Guan, K.L.8
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