A minimal Bcl-x promoter is activated by Brn-3a and repressed by p53

Nucleic Acids Research

Volumn 29, Issue 22, 2001, Pages 4530-4540

  Sugars, Katharine L ^a   Budhram Mahadeo, Vishwanie ^a   Packham, Graham ^b   Latchman, David S ^a  

^a UNIVERSITY COLLEGE LONDON   (United Kingdom)

^b UNIVERSITY OF SOUTHAMPTON   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

PROTEIN BCL 2; PROTEIN BCL X; PROTEIN P53; TRANSCRIPTION FACTOR;

ANIMAL CELL; APOPTOSIS; ARTICLE; CELL PROTECTION; CONTROLLED STUDY; GENE ACTIVATION; GENE REPRESSION; MOUSE; NERVE CELL; NONHUMAN; PRIORITY JOURNAL; PROMOTER REGION; PROTEIN EXPRESSION;

ANIMALIA; STAPHYLOCOCCUS PHAGE 3A;

EID: 0035890849     PISSN: 03051048     EISSN: None     Source Type: Journal    
DOI: 10.1093/nar/29.22.4530     Document Type: Article

References (30)

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5. Requirement for Brn-3.0 in differentiation and survival of sensory and motor neurons
6. Targeted deletion of the mouse POU domain gene Brn-3a causes a selective loss of neurons in the brainstem and trigeminal ganglion, uncoordinated limb movement and impaired suckling
7. Role of transcription factors Brn-3.1 and Brn-3.2 in auditory and visual system development
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9. The Brn-3a transcription factor protects sensory but not sympathetic neurones from programmed cell death/apoptosis
10. L and promotes neuronal survival in vivo as well as in vitro
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18. Identification of a novel human BCL-X promoter and exon
19. Novel cell lines display the properties of nociceptive sensory neurons
20. High efficiency gene transfer into mammalian cells
21. Regulation of neurite outgrowth and SNAP-25 gene expression by the Brn-3a transcription factor
22. Regulation of NGFI-A (egr-1) gene expression by the POU domain transcription factor Brn-3a
23. Activation of the α-internexin promoter by the Brn-3a transcription factor is dependent on the N-terminal region of the protein
24. Co-ordinate induction of the three neurofilament genes by the Brn-3a transcription factor
25. The opposite and antagonistic effects of the closely related POU family transcription factors on the activity of a target promoter are dependent upon differences in the POU domain
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27. Alternative splicing of the Brn-3a and Brn-3b transcription factor mRNAs is regulated in neuronal cells
28. Transcriptional activation by p53 correlates with suppression of growth but not transformation
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30. The N-terminal domain unique to the long form of the Brn-3a transcription factor is essential to protect neuronal cells from apoptosis and for the activation of Bcl-2 gene expression