G protein and its signaling pathway in bone development and disease

Frontiers in Bioscience

Volumn 15, Issue 3, 2010, Pages 957-985

  Wu, Mengrui ^a,b   Deng, Lianfu ^b   Zhu, Guochun ^b   Li, Yi Ping ^a,b,c,d  

^a ZHEJIANG UNIVERSITY   (China)

^b SHANGHAI JIAO TONG UNIVERSITY   (China)

^c FORSYTH INSTITUTE   (United States)

^d HARVARD SCHOOL OF DENTAL MEDICINE   (United States)

Author keywords

Bone; Calcitonin; Cannabinoid; Cation sensing receptor; G protein coupled receptor; G 12 13; G i o; G q 11; G s; Heterometric G protein; Osteoblasts; Osteoclasts; PTH; PTHrP; Regulator of G protein signaling; Relaxin family peptide; Review

Indexed keywords

G PROTEIN COUPLED RECEPTOR; GUANINE NUCLEOTIDE BINDING PROTEIN;

ANIMAL; BONE DEVELOPMENT; BONE DISEASE; CELL PROLIFERATION; CYTOLOGY; GENETICS; HUMAN; METABOLISM; OSTEOBLAST; OSTEOCLAST; PATHOPHYSIOLOGY; PHYSIOLOGY; REVIEW; SIGNAL TRANSDUCTION;

ANIMALS; BONE DEVELOPMENT; BONE DISEASES; CELL PROLIFERATION; GTP-BINDING PROTEINS; HUMANS; OSTEOBLASTS; OSTEOCLASTS; RECEPTORS, G-PROTEIN-COUPLED; SIGNAL TRANSDUCTION;

EID: 77956627125     PISSN: 27686701     EISSN: 27686698     Source Type: Journal    
DOI: 10.2741/3656     Document Type: Article

References (270)

1. Ducy, P., T. Schinke & G. Karsenty: The osteoblast: a sophisticated fibroblast under central surveillance. Science, 289, 1501-4 (2000).
2. Ornitz, D. M. & P. J. Marie: FGF signaling pathways in endochondral and intramembranous bone development and human genetic disease. Genes Dev, 16, 1446-65 (2002). (Pubitemid 34686327)
3. Boyle, W. J., W. S. Simonet & D. L. Lacey: Osteoclast differentiation and activation. Nature, 423, 337-42 (2003). (Pubitemid 40852708)
4. Teitelbaum, S. L. & F. P. Ross: Genetic regulation of osteoclast development and function. Nat Rev Genet, 4, 638-49 (2003). (Pubitemid 36917505)
5. Zaidi, M., H. C. Blair, B. S. Moonga, E. Abe & C. L. Huang: Osteoclastogenesis, bone resorption, and osteoclast-based therapeutics. J Bone Miner Res, 18, 599-609 (2003). (Pubitemid 36899309)
6. Huang, W., S. Yang, J. Shao & Y. P. Li: Signaling and transcriptional regulation in osteoblast commitment and differentiation. Front Biosci, 12, 3068-92 (2007).
7. Malbon, C. C.: G protein in development. nature review molecular cell biology, 6, 689-701 (2005).
8. Kenakin, T.: Predicting therapeutic value in the lead optimization phase of drug discovery. Nat Rev Drug Discov, 2, 429-38 (2003). (Pubitemid 37361724)
9. Yu, S., D. Yu, E. Lee, M. Eckhaus, R. Lee, Z. Corria, D. Accili, H. Westphal & L. S. Weinstein: Variable and tissue-specific hormone resistance in heterotrimeric Gs protein alpha-subunit (Gsalpha) knockout mice is due to tissue-specific imprinting of the gsalpha gene. Proc Natl Acad Sci U S A, 95, 8715-20 (1998).
10. Castrop, H., M. Oppermann, D. Mizel, Y. Huang, R. Faulhaber-Walter, Y. Weiss, L. S. Weinstein, M. Chen, S. Germain, H. Lu, D. Ragland, D. M. Schimel & J. Schnermann: Skeletal abnormalities and extra-skeletal ossification in mice with restricted Gsalpha deletion caused by a renin promoter- Cre transgene. Cell Tissue Res, 330, 487-501 (2007). (Pubitemid 350098209)
11. Sakamoto, A., M. Chen, T. Nakamura, T. Xie, G. Karsenty & L. S. Weinstein: Deficiency of the G-protein alpha-subunit G (s)alpha in osteoblasts leads to differential effects on trabecular and cortical bone. J Biol Chem, 280, 21369-75 (2005). (Pubitemid 40805700)
12. Hsiao, E. C., B. M. Boudignon, W. C. Chang, M. Bencsik, J. Peng, T. D. Nguyen, C. Manalac, B. P. Halloran, B. R. Conklin & R. A. Nissenson: Osteoblast expression of an engineered Gs-coupled receptor dramatically increases bone mass. Proc Natl Acad Sci U S A, 105, 1209-14 (2008). (Pubitemid 351397032)
13. Sakamoto, A., M. Chen, T. Kobayashi, H. M. Kronenberg & L. S. Weinstein: Chondrocyte-specific knockout of the G protein G (s)alpha leads to epiphyseal and growth plate abnormalities and ectopic chondrocyte formation. J Bone Miner Res, 20, 663-71 (2005). (Pubitemid 40393075)
14. Ogata, N., H. Kawaguchi, U. I. Chung, S. I. Roth & G. V. Segre: Continuous activation of G alpha q in osteoblasts results in osteopenia through impaired osteoblast differentiation. J Biol Chem, 282, 35757-64 (2007). (Pubitemid 350277140)
15. Peng, J., M. Bencsik, A. Louie, W. Lu, S. Millard, P. Nguyen, A. Burghardt, S. Majumdar, T. J. Wronski, B. Halloran, B. R. Conklin & R. A. Nissenson: Conditional expression of a Gi-coupled receptor in osteoblasts results in trabecular osteopenia. Endocrinology, 149, 1329-37 (2008). (Pubitemid 351397956)
16. Miao, D., B. He, A. C. Karaplis & D. Goltzman: Parathyroid hormone is essential for normal fetal bone formation. J Clin Invest, 109, 1173-82 (2002). (Pubitemid 34496595)
17. Guo, J., U. I. Chung, H. Kondo, F. R. Bringhurst & H. M. Kronenberg: The PTH/PTHrP receptor can delay chondrocyte hypertrophy in vivo without activating phospholipase C. Dev Cell, 3, 183-94 (2002).
18. Miao, D., H. Su, B. He, J. Gao, Q. Xia, M. Zhu, Z. Gu, D. Goltzman & A. C. Karaplis: Severe growth retardation and early lethality in mice lacking the nuclear localization sequence and C-terminus of PTH-related protein. Proc Natl Acad Sci U S A, 105, 20309-14 (2008).
19. O'Brien, C. A., L. I. Plotkin, C. Galli, J. J. Goellner, A. R. Gortazar, M. R. Allen, A. G. Robling, M. Bouxsein, E. Schipani, C. H. Turner, R. L. Jilka, R. S. Weinstein, S. C. Manolagas & T. Bellido: Control of bone mass and remodeling by PTH receptor signaling in osteocytes. PLoS One, 3, e2942 (2008).
20. Davey, R. A., A. G. Turner, J. F. McManus, W. S. Chiu, F. Tjahyono, A. J. Moore, G. J. Atkins, P. H. Anderson, C. Ma, V. Glatt, H. E. MacLean, C. Vincent, M. Bouxsein, H. A. Morris, D. M. Findlay & J. D. Zajac: Calcitonin receptor plays a physiological role to protect against hypercalcemia in mice. J Bone Miner Res, 23, 1182-93 (2008). (Pubitemid 352040174)
21. Huebner, A. K., T. Schinke, M. Priemel, S. Schilling, A. F. Schilling, R. B. Emeson, J. M. Rueger & M. Amling: Calcitonin deficiency in mice progressively results in high bone turnover. J Bone Miner Res, 21, 1924-34 (2006). (Pubitemid 44851569)
22. Hoff, A. O., P. Catala-Lehnen, P. M. Thomas, M. Priemel, J. M. Rueger, I. Nasonkin, A. Bradley, M. R. Hughes, N. Ordonez, G. J. Cote, M. Amling & R. F. Gagel: Increased bone mass is an unexpected phenotype associated with deletion of the calcitonin gene. J Clin Invest, 110, 1849-57 (2002). (Pubitemid 36076492)
23. Woodrow, J. P., C. J. Sharpe, N. J. Fudge, A. O. Hoff, R. F. Gagel & C. S. Kovacs: Calcitonin plays a critical role in regulating skeletal mineral metabolism during lactation. Endocrinology, 147, 4010-21 (2006). (Pubitemid 44268353)
24. Schinke, T., S. Liese, M. Priemel, M. Haberland, A. F. Schilling, P. Catala-Lehnen, D. Blicharski, J. M. Rueger, R. F. Gagel, R. B. Emeson & M. Amling: Decreased bone formation and osteopenia in mice lacking alpha-calcitonin gene-related peptide. J Bone Miner Res, 19, 2049-56 (2004). (Pubitemid 41103420)
25. Wedemeyer, C., C. Neuerburg, A. Pfeiffer, A. Heckelei, D. Bylski, F. von Knoch, T. Schinke, G. Hilken, G. Gosheger, M. von Knoch, F. Loer & G. Saxler: Polyethylene particle-induced bone resorption in alphacalcitonin gene-related peptide-deficient mice. J Bone Miner Res, 22, 1011-9 (2007). (Pubitemid 351339723)
26. Dacquin, R., R. A. Davey, C. Laplace, R. Levasseur, H. A. Morris, S. R. Goldring, S. Gebre-Medhin, D. L. Galson, J. D. Zajac & G. Karsenty: Amylin inhibits bone resorption while the calcitonin receptor controls bone formation in vivo. J Cell Biol, 164, 509-14 (2004). (Pubitemid 38233312)
27. Garner, S. C., M. Pi, Q. Tu & L. D. Quarles: Rickets in cation-sensing receptor-deficient mice: an unexpected skeletal phenotype. Endocrinology, 142, 3996-4005 (2001). (Pubitemid 32802673)
28. Pi, M., L. Chen, M. Z. Huang, W. Zhu, B. Ringhofer, J. Luo, L. Christenson, B. Li, J. Zhang, P. D. Jackson, P. Faber, K. R. Brunden, J. J. Harrington & L. D. Quarles: GPRC6A null mice exhibit osteopenia, feminization and metabolic syndrome. PLoS One, 3, e3858 (2008).
29. Ofek, O., M. Karsak, N. Leclerc, M. Fogel, B. Frenkel, K. Wright, J. Tam, M. Attar-Namdar, V. Kram, E. Shohami, R. Mechoulam, A. Zimmer & I. Bab: Peripheral cannabinoid receptor, CB2, regulates bone mass. Proc Natl Acad Sci U S A, 103, 696-701 (2006). (Pubitemid 43153088)
30. Whyte, L. S., E. Ryberg, N. A. Sims, S. A. Ridge, K. Mackie, P. J. Greasley, R. A. Ross & M. J. Rogers: The putative cannabinoid receptor GPR55 affects osteoclast function in vitro and bone mass in vivo. Proc Natl Acad Sci U S A, 106, 16511-6 (2009).
31. Ferlin, A., A. Pepe, L. Gianesello, A. Garolla, S. Feng, A. Facciolli, R. Morello, A. I. Agoulnik & C. Foresta: New roles for INSL3 in adults. Ann N Y Acad Sci, 1160, 215-8 (2009).
32. Ferlin, A., A. Pepe, L. Gianesello, A. Garolla, S. Feng, S. Giannini, M. Zaccolo, A. Facciolli, R. Morello, A. I. Agoulnik & C. Foresta: Mutations in the insulin-like factor 3 receptor are associated with osteoporosis. J Bone Miner Res, 23, 683-93 (2008). (Pubitemid 351575022)
33. Yang, S., W. Chen, P. Stashenko & Y. P. Li: Specificity of RGS10A as a key component in the RANKL signaling mechanism for osteoclast differentiation. J Cell Sci, 120, 3362-71 (2007). (Pubitemid 350028344)
34. Yang, S. & Y. P. Li: RGS10-null mutation impairs osteoclast differentiation resulting from the loss of (Ca2+)i oscillation regulation. Genes Dev, 21, 1803-16 (2007). (Pubitemid 47076479)
35. Martensson, U. E., S. A. Salehi, S. Windahl, M. F. Gomez, K. Sward, J. Daszkiewicz-Nilsson, A. Wendt, N. Andersson, P. Hellstrand, P. O. Grande, C. Owman, C. J. Rosen, M. L. Adamo, I. Lundquist, P. Rorsman, B. O. Nilsson, C. Ohlsson, B. Olde & L. M. Leeb-Lundberg: Deletion of the G protein-coupled receptor 30 impairs glucose tolerance, reduces bone growth, increases blood pressure, and eliminates estradiol-stimulated insulin release in female mice. Endocrinology, 150, 687-98 (2009).
36. Windahl, S. H., N. Andersson, A. S. Chagin, U. E. Martensson, H. Carlsten, B. Olde, C. Swanson, S. Moverare-Skrtic, L. Savendahl, M. K. Lagerquist, L. M. Leeb-Lundberg & C. Ohlsson: The role of the G proteincoupled receptor GPR30 in the effects of estrogen in ovariectomized mice. Am J Physiol Endocrinol Metab, 296, E490-6 (2009).
37. Morris, A. J. & C. C. Malbon: Physiological regulation of G protein-linked signaling. Physiol Rev, 79, 1373-430 (1999). (Pubitemid 29473319)
38. Oldham, W. M. & H. E. Hamm: Heterotrimeric G protein activation by G-protein-coupled receptors. nature review molecular cell biology, 9, 60-71 (2008).
39. Milligan, G. & S. Rees: Chimaeric G (alpha) proteins: their potential use in drug discovery. Trends in Pharmacological Sciences, 20, 118-124 (1999). (Pubitemid 29306936)
40. Ritter, S. L. & R. A. Hall: Fine-tuning of GPCR activity by receptor-interacting proteins. Nat Rev Mol Cell Biol, 10, 819-30 (2009).
41. Neves, S. R., P. T. Ram & R. Iyengar: G protein pathways. Science, 296, 1636-9 (2002). (Pubitemid 34579147)
42. Hollinger, S. & J. R. Hepler: Cellular regulation of RGS proteins: modulators and integrators of G protein signaling. Pharmacol Rev, 54, 527-59 (2002).
43. Moore, C. A., S. K. Milano & J. L. Benovic: Regulation of receptor trafficking by GRKs and arrestins. Annu Rev Physiol, 69, 451-82 (2007). (Pubitemid 46457651)
44. Zheng, F., H. Liang, R. Liu, J. X. Quan, X. X. Li, C. L. Dai, G. Guo, J. Y. Zhang & B. L. Wang: Parathyroid hormone-related protein regulates osteoclast inhibitory lectin expression via multiple signaling pathways in osteoblast-like cells. Endocrine, 35, 47-56 (2009).
45. Mahon, M. J., M. Donowitz, C. C. Yun & G. V. Segre: Na (+)/H (+) exchanger regulatory factor 2 directs parathyroid hormone 1 receptor signalling. Nature, 417, 858-61 (2002). (Pubitemid 34670333)
46. Kindt, R. M. & A. D. Lander: Pertussis toxin specifically inhibits growth cone guidance by a mechanism independent of direct G protein inactivation. Neuron, 15, 79-88 (1995).
47. Nasim, S. & S. van Heyningen: Release of Gs alpha from rabbit intestinal cells following ADP-ribosylation by cholera toxin. Biochem Soc Trans, 22, 135S (1994). (Pubitemid 24166056)
48. Weinstein, L. S.: G (s)alpha mutations in fibrous dysplasia and McCune-Albright syndrome. J Bone Miner Res, 21 Suppl 2, P120-4 (2006).
49. Sakamoto, A., Y. Oda, Y. Iwamoto & M. Tsuneyoshi: A comparative study of fibrous dysplasia and osteofibrous dysplasia with regard to Gsalpha mutation at the Arg201 codon: polymerase chain reaction-restriction fragment length polymorphism analysis of paraffin-embedded tissues. J Mol Diagn, 2, 67-72 (2000).
50. Volkl, T. M. & H. G. Dorr: McCune-Albright syndrome: clinical picture and natural history in children and adolescents. J Pediatr Endocrinol Metab, 19 Suppl 2, 551-9 (2006).
51. Bianco, P., M. Riminucci, A. Majolagbe, S. A. Kuznetsov, M. T. Collins, M. H. Mankani, A. Corsi, H. G. Bone, S. Wientroub, A. M. Spiegel, L. W. Fisher & P. G. Robey: Mutations of the GNAS1 gene, stromal cell dysfunction, and osteomalacic changes in non-McCune- Albright fibrous dysplasia of bone. J Bone Miner Res, 15, 120-8 (2000). (Pubitemid 30026939)
52. Corsi, A., M. T. Collins, M. Riminucci, P. G. Howell, A. Boyde, P. G. Robey & P. Bianco: Osteomalacic and hyperparathyroid changes in fibrous dysplasia of bone: core biopsy studies and clinical correlations. J Bone Miner Res, 18, 1235-46 (2003). (Pubitemid 37294916)
53. Ish-Shalom, S., L. G. Rao, M. A. Levine, D. Fraser, S. W. Kooh, R. G. Josse, R. McBroom, M. M. Wong & T. M. Murray: Normal parathyroid hormone responsiveness of bone-derived cells from a patient with pseudohypoparathyroidism. J Bone Miner Res, 11, 8-14 (1996). (Pubitemid 26026738)
54. Mariot, V., S. Maupetit-Mehouas, C. Sinding, M. L. Kottler & A. Linglart: A maternal epimutation of GNAS leads to Albright osteodystrophy and parathyroid hormone resistance. J Clin Endocrinol Metab, 93, 661-5 (2008). (Pubitemid 351398535)
55. Yeh, G. L., S. Mathur, A. Wivel, M. Li, F. H. Gannon, A. Ulied, L. Audi, E. A. Olmstead, F. S. Kaplan & E. M. Shore: GNAS1 mutation and Cbfa1 misexpression in a child with severe congenital platelike osteoma cutis. J Bone Miner Res, 15, 2063-73 (2000).
56. Eddy, M. C., S. M. Jan De Beur, S. M. Yandow, W. H. McAlister, E. M. Shore, F. S. Kaplan, M. P. Whyte & M. A. Levine: Deficiency of the alpha-subunit of the stimulatory G protein and severe extraskeletal ossification. J Bone Miner Res, 15, 2074-83 (2000).
57. Aldred, M. A. & R. C. Trembath: Activating and inactivating mutations in the human GNAS1 gene. Hum Mutat, 16, 183-9 (2000).
58. Ahlstrom, M. & C. Lamberg-Allardt: Rapid protein kinase A-mediated activation of cyclic AMP-phosphodiesterase by parathyroid hormone in UMR-106 osteoblast-like cells. J Bone Miner Res, 12, 172-8 (1997). (Pubitemid 27086297)
59. Kronenberg, H. M.: PTHrP and skeletal development. Ann N Y Acad Sci, 1068, 1-13 (2006). (Pubitemid 43824131)
60. Billiard, J., S. S. Grewal, L. Lukaesko, P. J. Stork & P. Rotwein: Hormonal control of insulin-like growth factor I gene transcription in human osteoblasts: dual actions of cAMP-dependent protein kinase on CCAAT/enhancerbinding protein delta. J Biol Chem, 276, 31238-46 (2001). (Pubitemid 37384993)
61. Kaji, H., T. Sugimoto, M. Kanatani, M. Fukase, M. Kumegawa & K. Chihara: Prostaglandin E2 stimulates osteoclast-like cell formation and bone-resorbing activity via osteoblasts: role of cAMP-dependent protein kinase. J Bone Miner Res, 11, 62-71 (1996).
62. Drissi, H., F. Lasmoles, V. Le Mellay, P. J. Marie & M. Lieberherr: Activation of phospholipase C-beta1 via Galphaq/11 during calcium mobilization by calcitonin gene-related peptide. J Biol Chem, 273, 20168-74 (1998). (Pubitemid 28377575)
63. Evans, D. B., R. A. Hipskind & G. Bilbe: Analysis of signaling pathways used by parathyroid hormone to activate the c-fos gene in human SaOS2 osteoblast-like cells. J Bone Miner Res, 11, 1066-74 (1996). (Pubitemid 26321356)
64. Wang, B. L., C. L. Dai, J. X. Quan, Z. F. Zhu, F. Zheng, H. X. Zhang, S. Y. Guo, G. Guo, J. Y. Zhang & M. C. Qiu: Parathyroid hormone regulates osterix and Runx2 mRNA expression predominantly through protein kinase A signaling in osteoblast-like cells. J Endocrinol Invest, 29, 101-8 (2006).
65. Fu, L., M. S. Patel, A. Bradley, E. F. Wagner & G. Karsenty: The molecular clock mediates leptin-regulated bone formation. Cell, 122, 803-15 (2005). (Pubitemid 41242643)
66. Gutierrez, S., A. Javed, D. K. Tennant, M. van Rees, M. Montecino, G. S. Stein, J. L. Stein & J. B. Lian: CCAAT/enhancer-binding proteins (C/EBP) beta and delta activate osteocalcin gene transcription and synergize with Runx2 at the C/EBP element to regulate bone-specific expression. J Biol Chem, 277, 1316-23 (2002). (Pubitemid 34968885)
67. D'Alonzo, R. C., N. Selvamurugan, G. Karsenty & N. C. Partridge: Physical interaction of the activator protein- 1 factors c-Fos and c-Jun with Cbfa1 for collagenase-3 promoter activation. J Biol Chem, 277, 816-22 (2002). (Pubitemid 34952122)
68. Kobayashi, K., Y. Imanishi, H. Koshiyama, A. Miyauchi, K. Wakasa, T. Kawata, H. Goto, H. Ohashi, H. M. Koyano, R. Mochizuki, T. Miki, M. Inaba & Y. Nishizawa: Expression of FGF23 is correlated with serum phosphate level in isolated fibrous dysplasia. Life Sci, 78, 2295-301 (2006).
69. Shimada, T., H. Hasegawa, Y. Yamazaki, T. Muto, R. Hino, Y. Takeuchi, T. Fujita, K. Nakahara, S. Fukumoto & T. Yamashita: FGF-23 is a potent regulator of vitamin D metabolism and phosphate homeostasis. J Bone Miner Res, 19, 429-35 (2004). (Pubitemid 38787398)
70. Motomura, T., S. Kasayama, M. Takagi, S. Kurebayashi, H. Matsui, T. Hirose, Y. Miyashita, K. Yamauchi-Takihara, T. Yamamoto, S. Okada & T. Kishimoto: Increased interleukin-6 production in mouse osteoblastic MC3T3-E1 cells expressing activating mutant of the stimulatory G protein. J Bone Miner Res, 13, 1084-91 (1998). (Pubitemid 28311776)
71. Fu, Q., S. C. Manolagas & C. A. O'Brien: Parathyroid hormone controls receptor activator of NF-kappaB ligand gene expression via a distant transcriptional enhancer. Mol Cell Biol, 26, 6453-68 (2006). (Pubitemid 44277886)
72. Onyia, J. E., R. R. Miles, X. Yang, D. L. Halladay, J. Hale, A. Glasebrook, D. McClure, G. Seno, L. Churgay, S. Chandrasekhar & T. J. Martin: In vivo demonstration that human parathyroid hormone 1-38 inhibits the expression of osteoprotegerin in bone with the kinetics of an immediate early gene. J Bone Miner Res, 15, 863-71 (2000). (Pubitemid 30233409)
73. Kuznetsov, S. A., N. Cherman, M. Riminucci, M. T. Collins, P. G. Robey & P. Bianco: Age-dependent demise of GNAS-mutated skeletal stem cells and "normalization" of fibrous dysplasia of bone. J Bone Miner Res, 23, 1731-40 (2008).
74. Mendez-Ferrer, S. & P. S. Frenette: Galpha (s) uncouples hematopoietic stem cell homing and mobilization. Cell Stem Cell, 4, 379-80 (2009).
75. Adams, G. B., I. R. Alley, U. I. Chung, K. T. Chabner, N. T. Jeanson, C. Lo Celso, E. S. Marsters, M. Chen, L. S. Weinstein, C. P. Lin, H. M. Kronenberg & D. T. Scadden: Haematopoietic stem cells depend on Galpha (s)-mediated signalling to engraft bone marrow. Nature, 459, 103-7 (2009).
76. Le Mellay, V., F. Lasmoles & M. Lieberherr: Galpha (q/11) and gbetagamma proteins and membrane signaling of calcitriol and estradiol. J Cell Biochem, 75, 138-46 (1999). (Pubitemid 29402552)
77. Klein, R. F., R. A. Nissenson & G. J. Strewler: Pertussis toxin inhibits hormonal stimulation of bone resorption in fetal rat limb bones. J Pharmacol Exp Ther, 258, 877-81 (1991).
78. Zhang, X. & L. P. Zanello: Vitamin D receptordependent 1 alpha, 25 (OH)2 vitamin D3-induced antiapoptotic PI3K/AKT signaling in osteoblasts. J Bone Miner Res, 23, 1238-48 (2008). (Pubitemid 352040178)
79. Roman-Roman, S., D. L. Shi, V. Stiot, E. Hay, B. Vayssiere, T. Garcia, R. Baron & G. Rawadi: Murine Frizzled-1 behaves as an antagonist of the canonical Wnt/beta-catenin signaling. J Biol Chem, 279, 5725-33 (2004). (Pubitemid 38220602)
80. Godwin, S. L. & S. P. Soltoff: Calcium-sensing receptor-mediated activation of phospholipase Cgamma1 is downstream of phospholipase C-beta and protein kinase C in MC3T3-E1 osteoblasts. Bone, 30, 559-66 (2002). (Pubitemid 34270492)
81. Pi, M., P. Faber, G. Ekema, P. D. Jackson, A. Ting, N. Wang, M. Fontilla-Poole, R. W. Mays, K. R. Brunden, J. J. Harrington & L. D. Quarles: Identification of a novel extracellular cation-sensing G-protein-coupled receptor. J Biol Chem, 280, 40201-9 (2005). (Pubitemid 41779157)
82. Pi, M. & L. D. Quarles: A novel cation-sensing mechanism in osteoblasts is a molecular target for strontium. J Bone Miner Res, 19, 862-9 (2004). (Pubitemid 41094398)
83. Schwindinger, W. F., J. Fredericks, L. Watkins, H. Robinson, J. M. Bathon, M. Pines, L. J. Suva & M. A. Levine: Coupling of the PTH/PTHrP receptor to multiple G-proteins. Direct demonstration of receptor activation of Gs, Gq/11, and Gi (1) by (alpha-32P)GTP-gamma-azidoanilide photoaffinity labeling. Endocrine, 8, 201-9 (1998).
84. Miao, D., X. K. Tong, G. K. Chan, D. Panda, P. S. McPherson & D. Goltzman: Parathyroid hormone-related peptide stimulates osteogenic cell proliferation through protein kinase C activation of the Ras/mitogen-activated protein kinase signaling pathway. J Biol Chem, 276, 32204-13 (2001).
85. Caverzasio, J., G. Palmer, A. Suzuki & J. P. Bonjour: Evidence for the involvement of two pathways in activation of extracellular signal-regulated kinase (Erk) and cell proliferation by Gi and Gq protein-coupled receptors in osteoblast-like cells. J Bone Miner Res, 15, 1697-706 (2000). (Pubitemid 30666224)
86. Lax, A. J. & A. E. Grigoriadis: Pasteurella multocida toxin: the mitogenic toxin that stimulates signalling cascades to regulate growth and differentiation. Int J Med Microbiol, 291, 261-8 (2001). (Pubitemid 32948911)
87. Lax, A. J., G. D. Pullinger, M. R. Baldwin, D. Harmey, A. E. Grigoriadis & J. H. Lakey: The pasteurella multocida toxin interacts with signalling pathways to perturb cell growth and differentiation. Int J Med Microbiol, 293, 505-12 (2004). (Pubitemid 38667573)
88. Zhu, W., O. Boachie-Adjei, B. A. Rawlins, B. Frenkel, A. L. Boskey, L. B. Ivashkiv & C. P. Blobel: A novel regulatory role for stromal-derived factor-1 signaling in bone morphogenic protein-2 osteogenic differentiation of mesenchymal C2C12 cells. J Biol Chem, 282, 18676-85 (2007). (Pubitemid 47100177)
89. Roth, J. A., B. G. Kim, W. L. Lin & M. I. Cho: Melatonin promotes osteoblast differentiation and bone formation. J Biol Chem, 274, 22041-7 (1999).
90. Kaneki, H., M. Kurokawa & H. Ide: The receptor attributable to C-type natriuretic peptide-induced differentiation of osteoblasts is switched from type B- to type C-natriuretic peptide receptor with aging. J Cell Biochem, 103, 753-64 (2008). (Pubitemid 351240612)
91. Grey, A., T. Banovic, D. Naot, B. Hill, K. Callon, I. Reid & J. Cornish: Lysophosphatidic acid is an osteoblast mitogen whose proliferative actions involve G (i) proteins and protein kinase C, but not P42/44 mitogen-activated protein kinases. Endocrinology, 142, 1098-106 (2001). (Pubitemid 32202819)
92. Suzuki, A., G. Palmer, J. P. Bonjour & J. Caverzasio: Regulation of alkaline phosphatase activity by p38 MAP kinase in response to activation of Gi protein-coupled receptors by epinephrine in osteoblast-like cells. Endocrinology, 140, 3177-82 (1999). (Pubitemid 30650634)
93. de Wilde, A., C. Heberden, G. Chaumaz, C. Bordat & M. Lieberherr: Signaling networks from Gbeta1 subunit to transcription factors and actin remodeling via a membrane-located ER-beta-related protein in the rapid action of daidzein in osteoblasts. J Cell Physiol, 209, 786-801 (2006). (Pubitemid 44665701)
94. Chen, Y. J., C. J. Wang, K. D. Yang, P. R. Chang, H. C. Huang, Y. T. Huang, Y. C. Sun & F. S. Wang: Pertussis toxin-sensitive Galphai protein and ERK-dependent pathways mediate ultrasound promotion of osteogenic transcription in human osteoblasts. FEBS Lett, 554, 154-8 (2003). (Pubitemid 37324831)
95. Hsieh, Y. L.: Peripheral therapeutic ultrasound stimulation alters the distribution of spinal C-fos immunoreactivity induced by early or late phase of inflammation. Ultrasound Med Biol, 34, 475-86 (2008).
96. Caverzasio, J., G. Palmer, A. Suzuki & J. P. Bonjour: Mechanism of the mitogenic effect of fluoride on osteoblast-like cells: evidences for a G protein-dependent tyrosine phosphorylation process. J Bone Miner Res, 12, 1975-83 (1997). (Pubitemid 27524474)
97. Lajeunesse, D., R. Moreau, W. Hobbs, W. Qui, J. Lafond & S. E. Guggino: Influence of aluminum on the regulation of PTH- and 1, 25 (OH)2D3-dependent pathways in the rat osteosarcoma cell line ROS 17/2.8. J Bone Miner Res, 13, 962-9 (1998). (Pubitemid 28265274)
98. Kanno, S., C. D. Anuradha & S. Hirano: Chemotactic responses of osteoblastic MC3T3-E1 cells toward zinc chloride. Biol Trace Elem Res, 83, 49-55 (2001). (Pubitemid 32989387)
99. Wang, X., L. Yuan, J. Huang, T. L. Zhang & K. Wang: Lanthanum enhances in vitro osteoblast differentiation via pertussis toxin-sensitive gi protein and ERK signaling pathway. J Cell Biochem, 105, 1307-15 (2008).
100. Reich, K. M., T. N. McAllister, S. Gudi & J. A. Frangos: Activation of G proteins mediates flow-induced prostaglandin E2 production in osteoblasts. Endocrinology, 138, 1014-8 (1997). (Pubitemid 27089754)
101. Rawlinson, S. C., C. P. Wheeler-Jones & L. E. Lanyon: Arachidonic acid for loading induced prostacyclin and prostaglandin E (2) release from osteoblasts and osteocytes is derived from the activities of different forms of phospholipase A (2) Bone, 27, 241-7 (2000). (Pubitemid 30458817)
102. Hara, F., K. Fukuda, M. Ueno, C. Hamanishi & S. Tanaka: Pertussis toxin-sensitive G proteins as mediators of stretch-induced decrease in nitric-oxide release of osteoblast-like cells. J Orthop Res, 17, 593-7 (1999). (Pubitemid 29383622)
103. Singh, A. T., A. Gilchrist, T. Voyno-Yasenetskaya, J. M. Radeff-Huang & P. H. Stern: G alpha12/G alpha13 subunits of heterotrimeric G proteins mediate parathyroid hormone activation of phospholipase D in UMR-106 osteoblastic cells. Endocrinology, 146, 2171-5 (2005). (Pubitemid 40577502)
104. Nicholson, G. C., J. M. Moseley, A. J. Yates & T. J. Martin: Control of cyclic adenosine 3', 5'-monophosphate production in osteoclasts: calcitonin-induced persistent activation and homologous desensitization of adenylate cyclase. Endocrinology, 120, 1902-8 (1987). (Pubitemid 17069221)
105. Moonga, B. S., M. Pazianas, A. S. Alam, V. S. Shankar, C. L. Huang & M. Zaidi: Stimulation of a Gs-like G protein in the osteoclast inhibits bone resorption but enhances tartrate-resistant acid phosphatase secretion. Biochem Biophys Res Commun, 190, 496-501 (1993). (Pubitemid 23209638)
106. Suzuki, H., I. Nakamura, N. Takahashi, T. Ikuhara, K. Matsuzaki, Y. Isogai, M. Hori & T. Suda: Calcitonininduced changes in the cytoskeleton are mediated by a signal pathway associated with protein kinase A in osteoclasts. Endocrinology, 137, 4685-90 (1996). (Pubitemid 26403306)
107. Wada, S., N. Udagawa, N. Nagata, T. J. Martin & D. M. Findlay: Physiological levels of calcitonin regulate the mouse osteoclast calcitonin receptor by a protein kinase Alphamediated mechanism. Endocrinology, 137, 312-20 (1996). (Pubitemid 26005006)
108. Hofmann, G., P. A. Bernabei, O. Crociani, A. Cherubini, L. Guasti, S. Pillozzi, E. Lastraioli, S. Polvani, B. Bartolozzi, V. Solazzo, L. Gragnani, P. Defilippi, B. Rosati, E. Wanke, M. Olivotto & A. Arcangeli: HERG K+ channels activation during beta (1) integrin-mediated adhesion to fibronectin induces an up-regulation of alpha (v)beta (3) integrin in the preosteoclastic leukemia cell line FLG 29.1. J Biol Chem, 276, 4923-31 (2001).
109. Ishida, N., K. Hayashi, A. Hattori, K. Yogo, T. Kimura & T. Takeya: CCR1 acts downstream of NFAT2 in osteoclastogenesis and enhances cell migration. J Bone Miner Res, 21, 48-57 (2006). (Pubitemid 43023226)
110. Sun, L., Y. Peng, A. C. Sharrow, J. Iqbal, Z. Zhang, D. J. Papachristou, S. Zaidi, L. L. Zhu, B. B. Yaroslavskiy, H. Zhou, A. Zallone, M. R. Sairam, T. R. Kumar, W. Bo, J. Braun, L. Cardoso-Landa, M. B. Schaffler, B. S. Moonga, H. C. Blair & M. Zaidi: FSH directly regulates bone mass. Cell, 125, 247-60 (2006).
111. Park, Y. G., Y. H. Kim, S. K. Kang & C. H. Kim: cAMPPKA signaling pathway regulates bone resorption mediated by processing of cathepsin K in cultured mouse osteoclasts. Int Immunopharmacol, 6, 947-56 (2006).
112. Oldham, W. M. & H. E. Hamm: Heterotrimeric G protein activation by G-protein-coupled receptors. Nat Rev Mol Cell Biol, 9, 60-71 (2008).
113. Lagerstrom, M. C. & H. B. Schioth: Structural diversity of G protein-coupled receptors and significance for drug discovery. Nat Rev Drug Discov, 7, 339-57 (2008).
114. Pierce, K. L., R. T. Premont & R. J. Lefkowitz: Seven-transmembrane receptors. Nat Rev Mol Cell Biol, 3, 639-50 (2002). (Pubitemid 34987785)
115. Hull, K. L., K. Fathimani, P. Sharma & S. Harvey: Calcitropic peptides: neural perspectives. Comp Biochem Physiol C Pharmacol Toxicol Endocrinol, 119, 389-410 (1998). (Pubitemid 28434985)
116. Moseley, J. M., M. Kubota, H. Diefenbach-Jagger, R. E. Wettenhall, B. E. Kemp, L. J. Suva, C. P. Rodda, P. R. Ebeling, P. J. Hudson, J. D. Zajac & et al.: Parathyroid hormone-related protein purified from a human lung cancer cell line. Proc Natl Acad Sci U S A, 84, 5048-52 (1987). (Pubitemid 17095861)
117. Smith, E. P., J. Boyd, G. R. Frank, H. Takahashi, R. M. Cohen, B. Specker, T. C. Williams, D. B. Lubahn & K. S. Korach: Estrogen resistance caused by a mutation in the estrogen-receptor gene in a man. N Engl J Med, 331, 1056-61 (1994). (Pubitemid 24317698)
118. Decker, E., A. Stellzig-Eisenhauer, B. S. Fiebig, C. Rau, W. Kress, K. Saar, F. Ruschendorf, N. Hubner, T. Grimm & B. H. Weber: PTHR1 loss-of-function mutations in familial, nonsyndromic primary failure of tooth eruption. Am J Hum Genet, 83, 781-6 (2008).
119. Friedman, P. A.: Mechanisms of renal calcium transport. Exp Nephrol, 8, 343-50 (2000).
120. Bounoutas, G. S., H. Tawfeek, L. F. Frohlich, U. I. Chung & A. B. Abou-Samra: Impact of impaired receptor internalization on calcium homeostasis in knock-in mice expressing a phosphorylation-deficient parathyroid hormone (PTH)/PTH-related peptide receptor. Endocrinology, 147, 4674-9 (2006). (Pubitemid 44402173)
121. Aubin, J. E. & E. Bonnelye: Osteoprotegerin and its ligand: a new paradigm for regulation of osteoclastogenesis and bone resorption. Osteoporos Int, 11, 905-13 (2000). (Pubitemid 32044070)
122. Kano, J., T. Sugimoto, M. Kanatani, Y. Kuroki, T. Tsukamoto, M. Fukase & K. Chihara: Second messenger signaling of c-fos gene induction by parathyroid hormone (PTH) and PTH-related peptide in osteoblastic osteosarcoma cells: its role in osteoblast proliferation and osteoclast-like cell formation. J Cell Physiol, 161, 358-66 (1994).
123. Jilka, R. L.: Molecular and cellular mechanisms of the anabolic effect of intermittent PTH. Bone, 40, 1434-46 (2007). (Pubitemid 46756429)
124. Stewart, A. F.: PTHrP (1-36) as a skeletal anabolic agent for the treatment of osteoporosis. Bone, 19, 303-6 (1996). (Pubitemid 26370832)
125. Goltzman, D.: Discoveries, drugs and skeletal disorders. Nat Rev Drug Discov, 1, 784-96 (2002). (Pubitemid 37361562)
126. Chan, G. K., D. Miao, R. Deckelbaum, I. Bolivar, A. Karaplis & D. Goltzman: Parathyroid hormone-related peptide interacts with bone morphogenetic protein 2 to increase osteoblastogenesis and decrease adipogenesis in pluripotent C3H10T 1/2 mesenchymal cells. Endocrinology, 144, 5511-20 (2003). (Pubitemid 37476081)
127. Ju, W., A. Hoffmann, K. Verschueren, P. Tylzanowski, C. Kaps, G. Gross & D. Huylebroeck: The bone morphogenetic protein 2 signaling mediator Smad1 participates predominantly in osteogenic and not in chondrogenic differentiation in mesenchymal progenitors C3H10T1/2. J Bone Miner Res, 15, 1889-99 (2000).
128. Hollnagel, A., M. Ahrens & G. Gross: Parathyroid hormone enhances early and suppresses late stages of osteogenic and chondrogenic development in a BMP-dependent mesenchymal differentiation system (C3H10T1/2) J Bone Miner Res, 12, 1993-2004 (1997). (Pubitemid 27524476)
129. Krishnan, V., T. L. Moore, Y. L. Ma, L. M. Helvering, C. A. Frolik, K. M. Valasek, P. Ducy & A. G. Geiser: Parathyroid hormone bone anabolic action requires Cbfa1/Runx2-dependent signaling. Mol Endocrinol, 17, 423-35 (2003). (Pubitemid 36315636)
130. Ishida, K. & M. Yamaguchi: Albumin regulates Runx2 and alpha1 (I) collagen mRNA expression in osteoblastic cells: comparison with insulin-like growth factor-I. Int J Mol Med, 16, 689-94 (2005).
131. Gagiannis, S., M. Muller, S. Uhlemann, A. Koch, G. Melino, P. H. Krammer,
132. Datta, N. S., G. J. Pettway, C. Chen, A. J. Koh & L. K. McCauley: Cyclin D1 as a target for the proliferative effects of PTH and PTHrP in early osteoblastic cells. J Bone Miner Res, 22, 951-64 (2007). (Pubitemid 351339717)
133. Karaplis, A. C., A. Luz, J. Glowacki, R. T. Bronson, V. L. Tybulewicz, H. M. Kronenberg & R. C. Mulligan: Lethal skeletal dysplasia from targeted disruption of the parathyroid hormone-related peptide gene. Genes Dev, 8, 277-89 (1994). (Pubitemid 24065970)
134. Radeff, J. M., Z. Nagy & P. H. Stern: Rho and Rho kinase are involved in parathyroid hormone-stimulated protein kinase C alpha translocation and IL-6 promoter activity in osteoblastic cells. J Bone Miner Res, 19, 1882-91 (2004). (Pubitemid 41103440)
135. Kawane, T., J. Mimura, T. Yanagawa, Y. Fujii-Kuriyama & N. Horiuchi: Parathyroid hormone (PTH) down-regulates PTH/PTH-related protein receptor gene expression in UMR-106 osteoblast-like cells via a 3', 5'- cyclic adenosine monophosphate-dependent, protein kinase A-independent pathway. J Endocrinol, 178, 247-56 (2003). (Pubitemid 37063066)
136. Swarthout, J. T., T. A. Doggett, J. L. Lemker & N. C. Partridge: Stimulation of extracellular signal-regulated kinases and proliferation in rat osteoblastic cells by parathyroid hormone is protein kinase C-dependent. J Biol Chem, 276, 7586-92 (2001).
137. Rickard, D. J., F. L. Wang, A. M. Rodriguez-Rojas, Z. Wu, W. J. Trice, S. J. Hoffman, B. Votta, G. B. Stroup, S. Kumar & M. E. Nuttall: Intermittent treatment with parathyroid hormone (PTH) as well as a non-peptide small molecule agonist of the PTH1 receptor inhibits adipocyte differentiation in human bone marrow stromal cells. Bone, 39, 1361-72 (2006). (Pubitemid 44827918)
138. Yu, S., R. T. Franceschi, M. Luo, J. Fan, D. Jiang, H. Cao, T. G. Kwon, Y. Lai, J. Zhang, K. Patrene, K. Hankenson, G. D. Roodman & G. Xiao: Critical role of activating transcription factor 4 in the anabolic actions of parathyroid hormone in bone. PLoS One, 4, e7583 (2009).
139. Swarthout, J. T., R. C. D'Alonzo, N. Selvamurugan & N. C. Partridge: Parathyroid hormone-dependent signaling pathways regulating genes in bone cells. Gene, 282, 1-17 (2002). (Pubitemid 34117557)
140. Berry, J. E., E. L. Ealba, G. J. Pettway, N. S. Datta, E. C. Swanson, M. J. Somerman & L. K. McCauley: JunB as a downstream mediator of PTHrP actions in cementoblasts. J Bone Miner Res, 21, 246-57 (2006). (Pubitemid 43265290)
141. Huang, J. C., T. Sakata, L. L. Pfleger, M. Bencsik, B. P. Halloran, D. D. Bikle & R. A. Nissenson: PTH differentially regulates expression of RANKL and OPG. J Bone Miner Res, 19, 235-44 (2004). (Pubitemid 38116737)
142. Boguslawski, G., L. V. Hale, X. P. Yu, R. R. Miles, J. E. Onyia, R. F. Santerre & S. Chandrasekhar: Activation of osteocalcin transcription involves interaction of protein kinase A- and protein kinase C-dependent pathways. J Biol Chem, 275, 999-1006 (2000). (Pubitemid 30051146)
143. Redruello, B., M. D. Estevao, J. Rotllant, P. M. Guerreiro, L. I. Anjos, A. V. Canario & D. M. Power: Isolation and characterization of piscine osteonectin and down-regulation of its expression by PTH-related protein. J Bone Miner Res, 20, 682-92 (2005). (Pubitemid 40393077)
144. Araki, S., M. Mezawa, Y. Sasaki, L. Yang, Z. Li, H. Takai, Y. Nakayama & Y. Ogata: Parathyroid hormone regulation of the human bone sialoprotein gene transcription is mediated through two cAMP response elements. J Cell Biochem, 106, 618-25 (2009).
145. Martin, T. J., E. H. Allan, P. W. Ho, J. H. Gooi, J. M. Quinn, M. T. Gillespie, V. Krasnoperov & N. A. Sims: Communication Between EphrinB2 and EphB4 Within the Osteoblast Lineage. Adv Exp Med Biol, 658, 51-60.
146. Allan, E. H., K. D. Hausler, T. Wei, J. H. Gooi, J. M. Quinn, B. Crimeen-Irwin, S. Pompolo, N. A. Sims, M. T. Gillespie, J. E. Onyia & T. J. Martin: EphrinB2 regulation by PTH and PTHrP revealed by molecular profiling in differentiating osteoblasts. J Bone Miner Res, 23, 1170-81 (2008). (Pubitemid 352040173)
147. Qin, L., X. Li, J. K. Ko & N. C. Partridge: Parathyroid hormone uses multiple mechanisms to arrest the cell cycle progression of osteoblastic cells from G1 to S phase. J Biol Chem, 280, 3104-11 (2005). (Pubitemid 40189421)
148. Datta, N. S., C. Chen, J. E. Berry & L. K. McCauley: PTHrP signaling targets cyclin D1 and induces osteoblastic cell growth arrest. J Bone Miner Res, 20, 1051-64 (2005). (Pubitemid 40712830)
149. Bliziotes, M. M., A. J. Eshleman, X. W. Zhang & K. M. Wiren: Neurotransmitter action in osteoblasts: expression of a functional system for serotonin receptor activation and reuptake. Bone, 29, 477-86 (2001). (Pubitemid 33026469)
150. Onishi, T. & K. Hruska: Expression of p27Kip1 in osteoblast-like cells during differentiation with parathyroid hormone. Endocrinology, 138, 1995-2004 (1997). (Pubitemid 27180818)
151. Gopalakrishnan, R., S. Suttamanatwong, A. E. Carlson & R. T. Franceschi: Role of matrix Gla protein in parathyroid hormone inhibition of osteoblast mineralization. Cells Tissues Organs, 181, 166-75 (2005).
152. Yamamoto, T., F. Kambe, X. Cao, X. Lu, N. Ishiguro & H. Seo: Parathyroid hormone activates phosphoinositide 3-kinase-Akt-Bad cascade in osteoblast-like cells. Bone, 40, 354-9 (2007). (Pubitemid 46054557)
153. Inoue, Y., L. Canaff, G. N. Hendy, I. Hisa, T. Sugimoto, K. Chihara & H. Kaji: Role of Smad3, acting independently of transforming growth factor-beta, in the early induction of Wnt-beta-catenin signaling by parathyroid hormone in mouse osteoblastic cells. J Cell Biochem, 108, 285-94 (2009).
154. Chen, C., A. J. Koh, N. S. Datta, J. Zhang, E. T. Keller, G. Xiao, R. T. Franceschi, N. J. D'Silva & L. K. McCauley: Impact of the mitogen-activated protein kinase pathway on parathyroid hormone-related protein actions in osteoblasts. J Biol Chem, 279, 29121-9 (2004). (Pubitemid 38915784)
155. Nagy, Z., J. Radeff & P. H. Stern: Stimulation of interleukin-6 promoter by parathyroid hormone, tumor necrosis factor alpha, and interleukin-1beta in UMR-106 osteoblastic cells is inhibited by protein kinase C antagonists. J Bone Miner Res, 16, 1220-7 (2001). (Pubitemid 32574650)
156. Sanders, J. L. & P. H. Stern: Protein kinase C involvement in interleukin-6 production by parathyroid hormone and tumor necrosis factor-alpha in UMR-106 osteoblastic cells. J Bone Miner Res, 15, 885-93 (2000). (Pubitemid 30233412)
157. Li, X., L. Qin, M. Bergenstock, L. M. Bevelock, D. V. Novack & N. C. Partridge: Parathyroid hormone stimulates osteoblastic expression of MCP-1 to recruit and increase the fusion of pre/osteoclasts. J Biol Chem, 282, 33098-106 (2007). (Pubitemid 350159306)
158. Sabbieti, M. G., D. Agas, L. Xiao, L. Marchetti, J. D. Coffin, T. Doetschman & M. M. Hurley: Endogenous FGF-2 is critically important in PTH anabolic effects on bone. J Cell Physiol, 219, 143-51 (2009).
159. Okada, Y., A. Montero, X. Zhang, T. Sobue, J. Lorenzo, T. Doetschman, J. D. Coffin & M. M. Hurley: Impaired osteoclast formation in bone marrow cultures of Fgf2 null mice in response to parathyroid hormone. J Biol Chem, 278, 21258-66 (2003). (Pubitemid 36806441)
160. Wang, Y., S. Nishida, B. M. Boudignon, A. Burghardt, H. Z. Elalieh, M. M. Hamilton, S. Majumdar, B. P. Halloran, T. L. Clemens & D. D. Bikle: IGF-I receptor is required for the anabolic actions of parathyroid hormone on bone. J Bone Miner Res, 22, 1329-37 (2007). (Pubitemid 351339678)
161. Bikle, D. D., T. Sakata, C. Leary, H. Elalieh, D. Ginzinger, C. J. Rosen, W. Beamer, S. Majumdar & B. P. Halloran: Insulin-like growth factor I is required for the anabolic actions of parathyroid hormone on mouse bone. J Bone Miner Res, 17, 1570-8 (2002).
162. Kwok, S., L. Qin, N. C. Partridge & N. Selvamurugan: Parathyroid hormone stimulation and PKA signaling of latent transforming growth factor-beta binding protein-1 (LTBP-1) mRNA expression in osteoblastic cells. J Cell Biochem, 95, 1002-11 (2005). (Pubitemid 41420147)
163. Palcy, S., I. Bolivar & D. Goltzman: Role of activator protein 1 transcriptional activity in the regulation of gene expression by transforming growth factor beta1 and bone morphogenetic protein 2 in ROS 17/2.8 osteoblast-like cells. J Bone Miner Res, 15, 2352-61 (2000).
164. Sammons, J., N. Ahmed, M. El-Sheemy & H. T. Hassan: The role of BMP-6, IL-6, and BMP-4 in mesenchymal stem cell-dependent bone development: effects on osteoblastic differentiation induced by parathyroid hormone and vitamin D (3) Stem Cells Dev, 13, 273-80 (2004). (Pubitemid 38738369)
165. Tobimatsu, T., H. Kaji, H. Sowa, J. Naito, L. Canaff, G. N. Hendy, T. Sugimoto & K. Chihara: Parathyroid hormone increases beta-catenin levels through Smad3 in mouse osteoblastic cells. Endocrinology, 147, 2583-90 (2006).
166. Suzuki, A., K. Ozono, T. Kubota, H. Kondou, K. Tachikawa & T. Michigami: PTH/cAMP/PKA signaling facilitates canonical Wnt signaling via inactivation of glycogen synthase kinase-3beta in osteoblastic Saos-2 cells. J Cell Biochem, 104, 304-17 (2008).
167. Frutos, G., J. Y. Pastor, N. Martinez, M. R. Virto & S. Torrado: Influence of lactose addition to gentamicin-loaded acrylic bone cement on the kinetics of release of the antibiotic and the cement properties. Acta Biomater (2009).
168. Datta, N. S., R. Kolailat, A. Fite, G. Pettway & A. B. Abou-Samra: Distinct roles for mitogen-activated protein kinase phosphatase-1 (MKP-1) and ERK-MAPK in PTH1R signaling during osteoblast proliferation and differentiation. Cell Signal (2009).
169. Ma, Y. L., R. L. Cain, D. L. Halladay, X. Yang, Q. Zeng, R. R. Miles, S. Chandrasekhar, T. J. Martin & J. E. Onyia: Catabolic effects of continuous human PTH (1-38) in vivo is associated with sustained stimulation of RANKL and inhibition of osteoprotegerin and gene-associated bone formation. Endocrinology, 142, 4047-54 (2001). (Pubitemid 32802678)
170. Theman, T. A. & M. T. Collins: The role of the calcium-sensing receptor in bone biology and pathophysiology. Curr Pharm Biotechnol, 10, 289-301 (2009).
171. Chattopadhyay, N. & E. M. Brown: Cellular "sensing" of extracellular calcium (Ca (2+) (o)): emerging roles in regulating diverse physiological functions. Cell Signal, 12, 361-6 (2000). (Pubitemid 30417598)
172. Pollak, M. R., E. M. Brown, Y. H. Chou, S. C. Hebert, S. J. Marx, B. Steinmann, T. Levi, C. E. Seidman & J. G. Seidman: Mutations in the human Ca (2+)-sensing receptor gene cause familial hypocalciuric hypercalcemia and neonatal severe hyperparathyroidism. Cell, 75, 1297-303 (1993).
173. Brown, E. M., M. Pollak, Y. H. Chou, C. E. Seidman, J. G. Seidman & S. C. Hebert: Cloning and functional characterization of extracellular Ca (2+)-sensing receptors from parathyroid and kidney. Bone, 17, 7S-11S (1995).
174. Dvorak, M. M., T. H. Chen, B. Orwoll, C. Garvey, W. Chang, D. D. Bikle & D. M. Shoback: Constitutive activity of the osteoblast Ca2+-sensing receptor promotes loss of cancellous bone. Endocrinology, 148, 3156-63 (2007). (Pubitemid 46996999)
175. Buchs, N., D. Manen, J. P. Bonjour & R. Rizzoli: Calcium stimulates parathyroid hormone-related protein production in Leydig tumor cells through a putative cationsensing mechanism. Eur J Endocrinol, 142, 500-5 (2000). (Pubitemid 30341183)
176. Quarles, L. D., J. E. Hartle, 2nd, J. P. Middleton, J. Zhang, J. M. Arthur & J. R. Raymond: Aluminum-induced DNA synthesis in osteoblasts: mediation by a G-protein coupled cation sensing mechanism. J Cell Biochem, 56, 106-17 (1994). (Pubitemid 24288115)
177. Yamaguchi, T., N. Chattopadhyay, O. Kifor & E. M. Brown: Extracellular calcium (Ca2+ (o))-sensing receptor in a murine bone marrow-derived stromal cell line (ST2): potential mediator of the actions of Ca2+ (o) on the function of ST2 cells. Endocrinology, 139, 3561-8 (1998). (Pubitemid 28512314)
178. Kameda, T., H. Mano, Y. Yamada, H. Takai, N. Amizuka, M. Kobori, N. Izumi, H. Kawashima, H. Ozawa, K. Ikeda, A. Kameda, Y. Hakeda & M. Kumegawa: Calciumsensing receptor in mature osteoclasts, which are bone resorbing cells. Biochem Biophys Res Commun, 245, 419-22 (1998). (Pubitemid 28418516)
179. Chattopadhyay, N., S. J. Quinn, O. Kifor, C. Ye & E. M. Brown: The calcium-sensing receptor (CaR) is involved in strontium ranelate-induced osteoblast proliferation. Biochem Pharmacol, 74, 438-47 (2007). (Pubitemid 46970843)
180. Coulombe, J., H. Faure, B. Robin & M. Ruat: In vitro effects of strontium ranelate on the extracellular calciumG sensing receptor. Biochem Biophys Res Commun, 323, 1184-90 (2004). (Pubitemid 39296549)
181. Caverzasio, J.: Strontium ranelate promotes osteoblastic cell replication through at least two different mechanisms. Bone, 42, 1131-6 (2008).
182. Kanatani, M., T. Sugimoto, M. Kanzawa, S. Yano & K. Chihara: High extracellular calcium inhibits osteoclastlike cell formation by directly acting on the calciumsensing receptor existing in osteoclast precursor cells. Biochem Biophys Res Commun, 261, 144-8 (1999). (Pubitemid 29371632)
183. Lorget, F., S. Kamel, R. Mentaverri, A. Wattel, M. Naassila, M. Maamer & M. Brazier: High extracellular calcium concentrations directly stimulate osteoclast apoptosis. Biochem Biophys Res Commun, 268, 899-903 (2000). (Pubitemid 30150888)
184. Mentaverri, R., S. Yano, N. Chattopadhyay, L. Petit, O. Kifor, S. Kamel, E. F. Terwilliger, M. Brazier & E. M. Brown: The calcium sensing receptor is directly involved in both osteoclast differentiation and apoptosis. Faseb J, 20, 2562-4 (2006).
185. Hurtel-Lemaire, A. S., R. Mentaverri, A. Caudrillier, F. Cournarie, A. Wattel, S. Kamel, E. F. Terwilliger, E. M. Brown & M. Brazier: The calcium-sensing receptor is involved in strontium ranelate-induced osteoclast apoptosis. New insights into the associated signaling pathways. J Biol Chem, 284, 575-84 (2009).
186. Pi, M., S. C. Garner, P. Flannery, R. F. Spurney & L. D. Quarles: Sensing of extracellular cations in CasRdeficient osteoblasts. Evidence for a novel cation-sensing mechanism. J Biol Chem, 275, 3256-63 (2000). (Pubitemid 30083026)
187. Singer, F. R.: Human calcitonin treatment of Paget's disease of bone. Clin. Orthop, 127, 86-93 (1977). (Pubitemid 8192261)
188. Civitelli, R., S. Gonnelli, F. Zacchei, S. Bigazzi, A. Vattimo, L. V. Avioli & C. Gennari: Bone turnover in postmenopausal osteoporosis. Effect of calcitonin treatment. J Clin Invest, 82, 1268-1274 (1988).
189. Lerner, U. H.: Deletions of genes encoding calcitonin/·alpha-CGRP, amylin and calcitonin receptor have given new and unexpected insights into the function of calcitonin receptors and calcitonin receptor-like receptors in bone. J Musculoskelet Neuronal Interact 6, 87-95 (2006). (Pubitemid 43732831)
190. Gorn, A. H., H. Y. Lin, M. Yamin, P. E. Auron, M. R. Flannery, D. R. Tapp, C. A. Manning, H. F. Lodish, S. M. Krane & S. R. Goldring: Cloning, characterization, and expression of a human calcitonin receptor from an ovarian carcinoma cell line. J. Clin. Invest., 90, 1726-1735 (1992).
191. Ikegame, M., M. Rakopoulos, H. Zhou, S. Houssami, T. J. Martin, J. M. Moseley & D. M. Findlay: Calcitonin receptor isoforms in mouse and rat osteoclasts. J Bone Miner Res, 10, 59-65 (1995).
192. Granholm, S., P. Lundberg & U. H. Lerner: Expression of the calcitonin receptor, calcitonin receptorlike receptor, and receptor activity modifying proteins during osteoclast differentiation. J Cell Biochem, 104, 920-33 (2008). (Pubitemid 351830840)
193. Musumeci, M., G. Vadala, G. Tringali, E. Insirello, A. M. Roccazzello, J. Simpore & S. Musumeci: Genetic and environmental factors in human osteoporosis from Sub- Saharan to Mediterranean areas. J Bone Miner Metab, 27, 424-34 (2009).
194. Yerges, L. M., L. Klei, J. A. Cauley, K. Roeder, C. M. Kammerer, S. P. Moffett, K. E. Ensrud, C. S. Nestlerode, L. M. Marshall, A. R. Hoffman, C. Lewis, T. F. Lang, E. Barrett- Connor, R. E. Ferrell, E. S. Orwoll & J. M. Zmuda: A High-Density Association Study of 383 Candidate Genes for Volumetric Bone Density at the Femoral Neck and Lumbar Spine among Older Men. J Bone Miner Res (2009).
195. Zofkova, I., K. Zajickova, M. Hill & A. Krepelova: Does polymorphism C1377T of the calcitonin receptor gene determine bone mineral density in postmenopausal women? Exp Clin Endocrinol Diabetes, 111, 447-9 (2003). (Pubitemid 37486438)
196. Dayhoff, M. O.: Atlas of Protein Sequence and Structure. Hormones, active peptides and toxins. Washington: National Biomedical Research Foundation (1972).
197. LeMoullec, J. M., A. Jullienne, J. Chenais, F. Lasmoles, J. M. Guliana, G. Milhaud & M. S. Moukhtar: The complete sequence of human preprocalcitonin. FEBS Lett., 167, 93-97 (1984).
198. Horne, W. C., J. F. Shyu, M. Chakraborty & R. Baron: Signal transduction by calcitonin Multiple ligands, receptors, and signaling pathways. Trends Endocrinol Metab, 5, 395-401 (1994).
199. Ikegame, M., M. Rakopoulos, T. J. Martin, J. M. Moseley & D. M. Findlay: Effects of continuous calcitonin treatment on osteoclast-like cell development and calcitonin receptor expression in mouse bone marrow cultures. J Bone Miner Res, 11, 456-65 (1996). (Pubitemid 26109065)
200. Yang, M. & B. E. Kream: Calcitonin induces expression of the inducible cAMP early repressor in osteoclasts. Endocrine, 33, 245-53 (2008).
201. Naot, D., K. E. Callon, A. Grey, G. J. Cooper, I. R. Reid & J. Cornish: A potential role for adrenomedullin as a local regulator of bone growth. Endocrinology, 142, 1849-57 (2001). (Pubitemid 32405942)
202. Rosenfeld, M. G., J.-J. Mermod, S. G. Amara, L. W. Swanson, P. E. Sawchenk, J. Rivier, W. W. Vale & R. M. Evans: Production of a novel neuropeptide encoded by the calcitonin gene via tissue-specific RNA processing. Nature 304, 129-135 (1983). (Pubitemid 13079138)
203. Wang, L., D. Gesty-Palmer, T. A. Fields & R. F. Spurney: Inhibition of WNT signaling by G proteinG coupled receptor (GPCR) kinase 2 (GRK2) Mol Endocrinol, 23, 1455-65 (2009).
204. Cornish, J., K. Callon, D. Coy, N. Jiang, L. Xiao, G. Cooper & I. Reid: Adrenomedullin is a potent stimulator of osteoblastic activity in vitro and in vivo. Am J Physiol 273, 1113-1120 (1997).
205. Cornish, J., A. Grey, K. E. Callon, D. Naot, B. L. Hill, C. Q. Lin, L. M. Balchin & I. R. Reid: Shared pathways of osteoblast mitogenesis induced by amylin, adrenomedullin, and IGF-1. Biochem Biophys Res Commun, 318, 240-6 (2004). (Pubitemid 38526271)
206. Mackie, K.: Cannabinoid receptors: where they are and what they do. J Neuroendocrinol, 20 Suppl 1, 10-4 (2008). (Pubitemid 351552670)
207. Pacher, P., S. Batkai & G. Kunos: The endocannabinoid system as an emerging target of pharmacotherapy. Pharmacol Rev, 58, 389-462 (2006). (Pubitemid 44394908)
208. Bab, I., O. Ofek, J. Tam, J. Rehnelt & A. Zimmer: Endocannabinoids and the regulation of bone metabolism. J Neuroendocrinol, 20 Suppl 1, 69-74 (2008). (Pubitemid 351552679)
209. Brown, A. J.: Novel cannabinoid receptors. Br J Pharmacol, 152, 567-75 (2007). (Pubitemid 350041541)
210. Idris, A. I., R. J. van't Hof, I. R. Greig, S. A. Ridge, D. Baker, R. A. Ross & S. H. Ralston: Regulation of bone mass, bone loss and osteoclast activity by cannabinoid receptors. Nat Med, 11, 774-9 (2005). (Pubitemid 41021210)
211. Munro, S., K. L. Thomas & M. Abu-Shaar: Molecular characterization of a peripheral receptor for cannabinoids. Nature, 365, 61-5 (1993). (Pubitemid 23305569)
212. Steffens, S., N. R. Veillard, C. Arnaud, G. Pelli, F. Burger, C. Staub, M. Karsak, A. Zimmer, J. L. Frossard & F. Mach: Low dose oral cannabinoid therapy reduces progression of atherosclerosis in mice. Nature, 434, 782-6 (2005). (Pubitemid 44739523)
213. Whiteside, G. T., G. P. Lee & K. J. Valenzano: The role of the cannabinoid CB2 receptor in pain transmission and therapeutic potential of small molecule CB2 receptor agonists. Curr Med Chem, 14, 917-36 (2007). (Pubitemid 46863619)
214. Karsak, M., M. Cohen-Solal, J. Freudenberg, A. Ostertag, C. Morieux, U. Kornak, J. Essig, E. Erxlebe, I. Bab, C. Kubisch, M. C. de Vernejoul & A. Zimmer: Cannabinoid receptor type 2 gene is associated with human osteoporosis. Hum Mol Genet, 14, 3389-96 (2005). (Pubitemid 41672123)
215. T Dschietzig, C. B., G Baumann, K Stangl. : Relaxin-a pleiotropic hormone and its emerging role for experimental and clinical therapeutics Pharmacol Ther, 112, 38-56 (2006). (Pubitemid 44301484)
216. Ferlin, A., A. Pepe, A. Facciolli, L. Gianesello & C. Foresta: Relaxin stimulates osteoclast differentiation and activation. Bone (2009).
217. Facciolli, A., A. Ferlin, L. Gianesello, A. Pepe & C. Foresta: Role of relaxin in human osteoclastogenesis. Ann N Y Acad Sci, 1160, 221-5 (2009).
218. Figueiredo, K. A., G. Rossi & M. E. Cox: Relaxin promotes clustering, migration, and activation states of mononuclear myelocytic cells. Ann N Y Acad Sci, 1160, 353-60 (2009).
219. Klonisch, T., J. Bialek, Y. Radestock, C. Hoang-Vu & S. H.-K. Relaxin-like ligand-receptor systems are autocrine/paracrine effectors in tumor cells and modulate cancer progression and tissue invasiveness. Adv Exp Med Biol, 612, 104-118 (2007).
220. Halls, M. L., R. A. D. Bathgate & R. J. Summers: Relaxin Family Peptide Receptors RXFP1 and RXFP2 Modulate cAMP Signaling by Distinct Mechanisms. Molecular pharmacology, 70, 214-226 (2006).
221. Reya, T. & H. Clevers: Wnt signalling in stem cells and cancer. Nature, 434, 843-50 (2005). (Pubitemid 40558990)
222. Taipale, J. & P. A. Beachy: The Hedgehog and Wnt signalling pathways in cancer. Nature, 411, 349-54 (2001). (Pubitemid 32467044)
223. Bodine, P. V. & B. S. Komm: Wnt signaling and osteoblastogenesis. Rev Endocr Metab Disord, 7, 33-9 (2006). (Pubitemid 46049520)
224. Yavropoulou, M. P. & J. G. Yovos: The role of the Wnt signaling pathway in osteoblast commitment and differentiation. Hormones (Athens), 6, 279-94 (2007).
225. Chen, A. E., D. D. Ginty & C. M. Fan: Protein kinase A signalling via CREB controls myogenesis induced by Wnt proteins. Nature, 433, 317-22 (2005).
226. Kuhl, M., L. C. Sheldahl, C. C. Malbon & R. T. Moon: Ca (2+)/calmodulin-dependent protein kinase II is stimulated by Wnt and Frizzled homologs and promotes ventral cell fates in Xenopus. J Biol Chem, 275, 12701-11 (2000). (Pubitemid 30241421)
227. Tu, X., K. S. Joeng, K. I. Nakayama, K. Nakayama, J. Rajagopal, T. J. Carroll, A. P. McMahon & F. Long: Noncanonical Wnt signaling through G protein-linked PKCdelta activation promotes bone formation. Dev Cell, 12, 113-27 (2007). (Pubitemid 46002598)
228. Ludwig, M.-G., M. Vanek, D. Guerini, J. r. A. Gasser, C. E. Jones, U. Junker, H. Hofstetter, R. M. Wolf & K. Seuwen: Proton-sensing G-protein-coupled receptors. nature, 425, 94-98 (2003).
229. Tomura, H., C. Mogi, K. Sato & F. Okajima: Protonsensing and lysolipid-sensitive G-protein-coupled receptors: A novel type of multi-functional receptors cellular signaling, 17, 1466-1476 (2005).
230. Huang, C., L. M. Hydo, S. Liu & R. T. Miller: Activation of choline kinase by extracellular Ca2+ is Ca (2+)-sensing receptor, Galpha12 and Rho-dependent in breast cancer cells. Cell Signal, 21, 1894-900 (2009).
231. Heino, T. J., A. S. Chagin & L. Savendahl: The novel estrogen receptor G-protein-coupled receptor 30 is expressed in human bone. J Endocrinol, 197, R1-6 (2008). (Pubitemid 351696258)
232. Riggs, B. L., S. Khosla & L. J. Melton, 3rd: Sex steroids and the construction and conservation of the adult skeleton. Endocr Rev, 23, 279-302 (2002). (Pubitemid 34651948)
233. Lindberg, M. K., Z. Weihua, N. Andersson, S. Moverare, H. Gao, O. Vidal, M. Erlandsson, S. Windahl, G. Andersson, D. B. Lubahn, H. Carlsten, K. Dahlman- Wright, J. A. Gustafsson & C. Ohlsson: Estrogen receptor specificity for the effects of estrogen in ovariectomized mice. J Endocrinol, 174, 167-78 (2002). (Pubitemid 34965757)
234. Chagin, A. S. & L. Savendahl: GPR30 estrogen receptor expression in the growth plate declines as puberty progresses. J Clin Endocrinol Metab, 92, 4873-7 (2007). (Pubitemid 350223471)
235. Revankar, C. M., D. F. Cimino, L. A. Sklar, J. B. Arterburn & E. R. Prossnitz: A transmembrane intracellular estrogen receptor mediates rapid cell signaling. Science, 307, 1625-30 (2005). (Pubitemid 40354745)
236. Thomas, P., Y. Pang, E. J. Filardo & J. Dong: Identity of an estrogen membrane receptor coupled to a G protein in human breast cancer cells. Endocrinology, 146, 624-32 (2005). (Pubitemid 40129818)
237. Olde, B. & L. M. Leeb-Lundberg: GPR30/GPER1: searching for a role in estrogen physiology. Trends Endocrinol Metab, 20, 409-16 (2009).
238. De Vries, L., B. Zheng, T. Fischer, E. Elenko & M. G. Farquhar: The regulator of G protein signaling family. Annu Rev Pharmacol Toxicol, 40, 235-71 (2000). (Pubitemid 30340681)
239. Pierce, K. L., R. T. Premont & R. J. Lefkowitz: seven-transmembrane receptors. nature review molecular cell biology, 3, 630-650 (2002).
240. Hurst, J. H. & S. B. Hooks: Regulator of G-protein signaling (RGS) proteins in cancer biology. Biochem Pharmacol, 78, 1289-97 (2009).
241. Kehrl, J. H. & S. Sinnarajah: RGS2: a multifunctional regulator of G-protein signaling. Int J Biochem Cell Biol, 34, 432-8 (2002). (Pubitemid 34242757)
242. Tsingotjidou, A., J. M. Nervina, L. Pham, O. Bezouglaia & S. Tetradis: Parathyroid hormone induces RGS-2 expression by a cyclic adenosine 3', 5'- monophosphate-mediated pathway in primary neonatal murine osteoblasts. Bone, 30, 677-84 (2002). (Pubitemid 34467987)
243. Miles, R. R., J. P. Sluka, R. F. Santerre, L. V. Hale, L. Bloem, G. Boguslawski, K. Thirunavukkarasu, J. M. Hock & J. E. Onyia: Dynamic regulation of RGS2 in bone: potential new insights into parathyroid hormone signaling mechanisms. Endocrinology, 141, 28-36 (2000). (Pubitemid 32260342)
244. Homme, M., F. Schaefer, O. Mehls & C. P. Schmitt: Differential regulation of RGS-2 by constant and oscillating PTH concentrations. Calcif Tissue Int, 84, 305-12 (2009).
245. Ko, J. K., K. H. Choi, I. S. Kim, E. K. Jung & D. H. Park: Inducible RGS2 is a cross-talk regulator for parathyroid hormone signaling in rat osteoblast-like UMR106 cells. Biochem Biophys Res Commun, 287, 1025-33 (2001).
246. Thirunavukkarasu, K., D. L. Halladay, R. R. Miles, C. D. Geringer & J. E. Onyia: Analysis of regulator of Gprotein signaling-2 (RGS-2) expression and function in osteoblastic cells. J Cell Biochem, 85, 837-50 (2002). (Pubitemid 34462793)
247. Roy, A. A., C. Nunn, H. Ming, M. X. Zou, J. Penninger, L. A. Kirshenbaum, S. J. Dixon & P. Chidiac: Up-regulation of endogenous RGS2 mediates cross-desensitization between Gs and Gq signaling in osteoblasts. J Biol Chem, 281, 32684-93 (2006). (Pubitemid 46036824)
248. Yowe, D., N. Weich, M. Prabhudas, L. Poisson, P. Errada, R. Kapeller, K. Yu, L. Faron, M. Shen, J. Cleary, T. M. Wilkie, C. Gutierrez-Ramos & M. R. Hodge: RGS18 is a myeloerythroid lineage-specific regulator of G-proteinsignalling molecule highly expressed in megakaryocytes. Biochem J, 359, 109-18 (2001). (Pubitemid 32939212)
249. Park, I. K., C. A. Klug, K. Li, L. Jerabek, L. Li, M. Nanamori, R. R. Neubig, L. Hood, I. L. Weissman & M. F. Clarke: Molecular cloning and characterization of a novel regulator of G-protein signaling from mouse hematopoietic stem cells. J Biol Chem, 276, 915-23 (2001). (Pubitemid 32096509)
250. Iwai, K., M. Koike, S. Ohshima, K. Miyatake, Y. Uchiyama, Y. Saeki & M. Ishii: RGS18 acts as a negative regulator of osteoclastogenesis by modulating the acidsensing OGR1/NFAT signaling pathway. J Bone Miner Res, 22, 1612-20 (2007). (Pubitemid 351229331)
251. Yang, S. & Y. P. Li: RGS12 is essential for RANK-Levoked signaling for terminal differentiation of osteoclasts in vitro. J Bone Miner Res, 22, 45-54 (2007). (Pubitemid 46032596)
252. Spurney, R. F.: Regulated expression of G proteincoupled receptor kinases (GRK's) and beta-arrestins in osteoblasts. Calcif Tissue Int, 73, 153-60 (2003). (Pubitemid 37082362)
253. Bliziotes, M., J. Murtagh & K. Wiren: Beta-adrenergic receptor kinase-like activity and beta-arrestin are expressed in osteoblastic cells. J Bone Miner Res, 11, 820-6 (1996). (Pubitemid 26172806)
254. Fukayama, S., G. Kong, J. L. Benovic, E. Meurer & A. H. Tashjian, Jr.: Beta-adrenergic receptor kinase-1 acutely regulates PTH/PTHrP receptor signalling in human osteoblastlike cells. Cell Signal, 9, 469-74 (1997). (Pubitemid 27417174)
255. Spurney, R. F., P. J. Flannery, S. C. Garner, K. Athirakul, S. Liu, F. Guilak & L. D. Quarles: Anabolic effects of a G protein-coupled receptor kinase inhibitor expressed in osteoblasts. J Clin Invest, 109, 1361-71 (2002). (Pubitemid 34546901)
256. Wang, L., S. Liu, L. D. Quarles & R. F. Spurney: Targeted overexpression of G protein-coupled receptor kinase-2 in osteoblasts promotes bone loss. Am J Physiol Endocrinol Metab, 288, E826-34 (2005). (Pubitemid 40397221)
257. Wang, L., L. D. Quarles & R. F. Spurney: Unmasking the osteoinductive effects of a G-protein-coupled receptor (GPCR) kinase (GRK) inhibitor by treatment with PTH (1-34) J Bone Miner Res, 19, 1661-70 (2004). (Pubitemid 41094329)
258. Ferrari, S. L., D. D. Pierroz, V. Glatt, D. S. Goddard, E. N. Bianchi, F. T. Lin, D. Manen & M. L. Bouxsein: Bone response to intermittent parathyroid hormone is altered in mice null for {beta}-Arrestin2. Endocrinology, 146, 1854-62 (2005). (Pubitemid 40396895)
259. Bianchi, E. N. & S. L. Ferrari: Beta-arrestin2 regulates parathyroid hormone effects on a p38 MAPK and NF-kappaB gene expression network in osteoblasts. Bone, 45, 716-25 (2009).
260. Sneddon, W. B., C. A. Syme, A. Bisello, C. E. Magyar, M. D. Rochdi, J. L. Parent, E. J. Weinman, A. B. Abou-Samra & P. A. Friedman: Activation-independent parathyroid hormone receptor internalization is regulated by NHERF1 (EBP50) J Biol Chem, 278, 43787-96 (2003). (Pubitemid 37346007)
261. Wheeler, D. & W. B. Sneddon: Mutation of phenylalanine-34 of parathyroid hormone disrupts NHERF1 regulation of PTH type I receptor signaling. Endocrine, 30, 343-52 (2006). (Pubitemid 47010971)
262. Yasothan, U. & S. Kar: Osteoporosis: overview and pipeline. Nat Rev Drug Discov, 7, 725-6 (2008).
263. Opar, A.: Late-stage osteoporosis drugs illustrate challenges in the field. Nat Rev Drug Discov, 8, 757-8 (2009).
264. Lane, N. E.: Therapy Insight: osteoporosis and osteonecrosis in systemic lupus erythematosus. Nat Clin Pract Rheumatol, 2, 562-9 (2006). (Pubitemid 44489960)
265. Chesnut, C. H., 3rd, M. Azria, S. Silverman, M. Engelhardt, M. Olson & L. Mindeholm: Salmon calcitonin: a review of current and future therapeutic indications. Osteoporos Int, 19, 479-91 (2008).
266. Berg, C., K. Neumeyer & P. Kirkpatrick: Teriparatide. Nat Rev Drug Discov, 2, 257-8 (2003).
267. Compston, J.: Does parathyroid hormone treatment affect fracture risk or bone mineral density in patients with osteoporosis? Nat Clin Pract Rheumatol, 3, 324-5 (2007). (Pubitemid 46864885)
268. Geusens, P. P., C. H. Roux, D. M. Reid, W. F. Lems, S. Adami, J. D. Adachi, P. N. Sambrook, K. G. Saag, N. E. Lane & M. C. Hochberg: Drug Insight: choosing a drug treatment strategy for women with osteoporosis-an evidence-based clinical perspective. Nat Clin Pract Rheumatol, 4, 240-8 (2008). (Pubitemid 351638681)
269. Neuprez, A., M. Hiligsmann, S. Scholtissen, O. Bruyere & J. Y. Reginster: Strontium ranelate: the first agent of a new therapeutic class in osteoporosis. Adv Ther, 25, 1235-56 (2008).
270. Fonseca, J. E.: Rebalancing bone turnover in favour of formation with strontium ranelate: implications for bone strength. Rheumatology (Oxford), 47 Suppl 4, iv17-19 (2008). (Pubitemid 351865957)