Osteoblast expression of an engineered Gs-coupled receptor dramatically increases bone mass

Proceedings of the National Academy of Sciences of the United States of America

Volumn 105, Issue 4, 2008, Pages 1209-1214

  Hsiao, Edward C ^a,b   Boudignon, Benjamin M ^c   Chang, Wei C ^a,d   Bencsik, Margaret ^c   Peng, Jeffrey ^c   Nguyen, Trieu D ^a   Manalac, Carlota ^a   Halloran, Bernard P ^b,c   Conklin, Bruce R ^a,b   Nissenson, Robert A ^b,c  

^a GLADSTONE INSTITUTE OF CARDIOVASCULAR DISEASE   (United States)

^b UNIVERSITY OF CALIFORNIA   (United States)

^c VETERANS AFFAIRS MEDICAL CENTER   (United States)

^d UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

Bone formation; Constitutive Gs activity; Cyclic AMP; McCune Albright syndrome; RASSL

Indexed keywords

STIMULATORY GUANINE NUCLEOTIDE BINDING PROTEIN; LIGAND; SEROTONIN 4 RECEPTOR;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL TISSUE; BIOMEDICAL ENGINEERING; BONE DENSITY; BONE MASS; BONE TURNOVER; CONFERENCE PAPER; CONTROLLED STUDY; FEMUR; GENETIC MARKER; MOUSE; NONHUMAN; OSTEOBLAST; PERINATAL PERIOD; PHENOTYPE; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN FUNCTION; SIGNAL TRANSDUCTION; AMINO ACID SEQUENCE; ANIMAL; ARTICLE; BIOSYNTHESIS; CELL LINE; CHEMISTRY; DRUG POTENTIATION; FEMALE; GENETICS; HUMAN; MALE; METABOLISM; METHODOLOGY; MOLECULAR GENETICS; PHYSIOLOGY; PROTEIN ENGINEERING; TRANSGENIC MOUSE;

MURINAE; MUS;

AMINO ACID SEQUENCE; ANIMALS; BONE DENSITY; CELL LINE; FEMALE; GTP-BINDING PROTEIN ALPHA SUBUNITS, GS; HUMANS; LIGANDS; MALE; MICE; MICE, TRANSGENIC; MOLECULAR SEQUENCE DATA; OSTEOBLASTS; PROTEIN ENGINEERING; RECEPTORS, SEROTONIN, 5-HT4; SIGNAL TRANSDUCTION;

EID: 39549099297     PISSN: 00278424     EISSN: 10916490     Source Type: Journal    
DOI: 10.1073/pnas.0707457105     Document Type: Article

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