Parathyroid hormone bone anabolic action requires cbfa1/runx2-dependent signaling

Molecular Endocrinology

Volumn 17, Issue 3, 2003, Pages 423-435

  Krishnan, Venkatesh ^a   Moore, Terry L ^a   Ma, Yanfei L ^a   Helvering, Leah M ^a   Frolik, Charles A ^a   Valasek, Kathleen M ^a   Ducy, Patricia ^b   Geiser, Andrew G ^a  

^a ELI LILLY AND COMPANY   (United States)

^b BAYLOR COLLEGE OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ADENOVIRUS VECTOR; ANTISENSE OLIGONUCLEOTIDE; CYCLIC AMP DEPENDENT PROTEIN KINASE; MESSENGER RNA; PARATHYROID HORMONE; TRANSCRIPTION FACTOR; TRANSCRIPTION FACTOR RUNX2; UNCLASSIFIED DRUG;

ANIMAL TISSUE; ARTICLE; BONE METABOLISM; CANCER CELL CULTURE; CONTROLLED STUDY; FEMUR; GENE EXPRESSION REGULATION; IMMUNOHISTOCHEMISTRY; METATARSAL BONE; NONHUMAN; ORGAN CULTURE; OSTEOSARCOMA CELL; PARATHYROID GLAND; PRIORITY JOURNAL; RAT;

ANIMALS; ANIMALS, NEWBORN; BLOTTING, NORTHERN; BONE AND BONES; CORE BINDING FACTOR ALPHA 1 SUBUNIT; DOSE-RESPONSE RELATIONSHIP, DRUG; FEMALE; GENE EXPRESSION REGULATION; HUMANS; IMMUNOHISTOCHEMISTRY; METATARSAL BONES; NEOPLASM PROTEINS; OSTEOGENESIS; PARATHYROID HORMONE; RATS; RATS, SPRAGUE-DAWLEY; RESPONSE ELEMENTS; SIGNAL TRANSDUCTION; TIBIA; TRANS-ACTIVATION (GENETICS); TRANSCRIPTION FACTORS; TUMOR CELLS, CULTURED;

ADENOVIRIDAE; ANIMALIA;

EID: 0037340051     PISSN: 08888809     EISSN: None     Source Type: Journal    
DOI: 10.1210/me.2002-0225     Document Type: Article

References (54)

1. Potts JT, Bringhurst FR, Gardella T, Nussbaum S, Segre G, Krohenberg H 1995 Parathyroid hormone: physiology, chemistry, biosynthesis, secretion, metabolism, and mode of action. In: DeGroot LJ, ed. Endocrinology. 3rd ed., vol. 2. Philadelphia: W. B. Saunders; 920-966
2. Hock JM, Fonseca GJ, Raisz LG 1988 Human parathyroid hormone (1-34) increases bone mass in ovariectomized and orchidectomized rats. Endocrinology 122:2899-2904
3. Hock JM, Gera I 1992 Effects of continuous and intermittent administration and inhibition of resorption on the anabolic response of bone to parathyroid hormone. J Bone Miner Res 7:65-72
4. Dempster DW, Cosman F, Parisien M, Shen V, Lindsay R 1993 Anabolic actions of parathyroid hormone on bone. Endocr Rev 14:690-708
5. Cosman F, Lindsay R 1998 Is parathyroid hormone a therapeutic option for osteoporosis? A review of the clinical evidence. Calcif Tissue Int 62:475-480
6. Jerome CP, Johnson CS, Vafai HT, Kaplan KC, Bailey J, Capwell B, Fraser F, Hansen L, Ramsay H, Shadoan M, Lees CJ, Thomsen JS, Mosekilde L 1999 Effect of treatment for 6 months with human parathyroid hormone (1-34) peptide in ovariectomized Cynomolgus monkeys (Macaca fascicularis). Bone 25:301-309
7. Neer RM, Arnaud CD, Zanchetta JR, Prince R, Gaich GA, Reginster J-Y, Hodsman AB, Eriksen EF, Ish-Shalom S, Genant HK, Wang O, Mitlak BH 2001 Effect of parathyroid hormone (1-34) on fractures and bone mineral density in postmenopausal women with osteoporosis. N Engl J Med 344:1434-1441
8. Hock JM, Onyia JE, Miller B, Hulman J, Herring J, Chandrasekhar S, Harvey AK, Gunness M 1994 Anabolic PTH targets proliferating cells of the primary spongiosa in young rats, and increases the number differentiating into osteoblasts. J Bone Miner Res 9:S412 (Abstract)
9. Schmidt IU, Dobnig H, Tumer RT 1995 Intermittent parathyroid hormone treatment increases osteoblast number, steady state messenger ribonucleic acid levels for osteocalcin, and bone formation in tibial metaphysis of hypophysectomized female rats. Endocrinology 136:5127-5133
10. McClelland P, Onyia JE, Miles R, Tu Y, Liang J, Harvey AK, Chandrasekhar S, Hock J, Bidwell JP 1998 Intermittent administration of parathyroid hormone (1-34) stimulates matrix metalloproteinase-9 (MMP-9) expression in rat long bone. J Cell Biochem 70:391-401
11. Noda M, Yoon K, Rodan GA 1988 Cyclic AMP-mediated stabilization of osteocalcin mRNA in rat osteoblast-like cells treated with parathyroid hormone. J Biol Chem 263:18574-18577
12. Noda M, Rodan GA 1989 Transcriptional regulation of osteopontin production in rat osteoblast-like cells by parathyroid hormone. J Cell Biol 108:713-718
13. Lee K, Deeds JD, Chiba S, Un-No M, Bond AT, Segre GV 1994 Parathyroid hormone induces sequential c-fos expression in bone cells in vivo: in situ localization of its receptor and c-fos messenger ribonucleic acids. Endocrinology 134:441-450
14. Onyia JE, Bidwell J, Herring J, Hulman J, Hock JM 1995 In vivo, human parathyroid hormone fragment (hPTH 1-34) transiently stimulates immediate early response gene expression, but not proliferation, in trabecular bone cells of young rats. Bone 17:479-484
15. Pollock JH, Blaha MJ, Lavish SA, Stevenson S, Greenfield EM 1996 In vivo demonstration that parathyroid hormone and parathyroid hormone-related protein stimulate expression by osteoblasts of interleukin-6 and leukemia inhibitory factor. J Bone Miner Res 11:754-759
16. Liang JD, Hock JM, Sandusky GE, Santerre RF, Onyia JE 1999 Immunohistochemical localization of selected early response genes expressed in trabecular bone of young rats given hPTH 1-34. Calcif Tissue Int 65:369-373
17. Miles RR, Sluka JP, Santerre RF, Hale LV, Bloem L, Boguslawski G, Thirunavukkarasu K, Hock JM, Onyia JE 2000 Dynamic regulation of RGS2 in bone: potential new insights into parathyroid hormone signaling mechanism. Endocrinology 141:28-36
18. Miles RR, Sluka JP, Halladay DL, Santerre RF, Hale LV, Bloem L, Thirunavukkarasu K, Galvin RJ, Hock JM, Onyia JE 2000 ADAMTS-1: a cellular disintegrin and metalloprotease with thrombospondin motifs is a target for parathyroid hormone in bone. Endocrinology 141:4533-4542
19. Swarthout JT, D'Alonzo RC, Selvamurugan N, Partridge NC 2002 Parathyroid hormone-dependent signaling pathways regulating genes in bone cells. Gene 282:1-17
20. Speck NA, Terryl S 1995 A new transcription factor family associated with human leukemias. Crit Rev Eukaryot Gene Expr 5:337-364
21. Banerjee C, Hiebert SW, Stein JL, Lian JB, Stein GS 1996 An AML-1 consensus sequence binds an osteoblast-specific complex and transcriptionally activates the osteocalcin gene. Proc Natl Acad Sci USA 93:4968-4973
22. Banerjee C, McCabe LR, Choi J-Y, Hiebert SW, Stein JL, Stein GS, Lian JB 1997 Runt homology domain proteins in osteoblast differentiation: AML3/CBFA1 is a major component of a bone specific complex. J Cell Biochem 66:1-8
23. Ducy P, Karsenty G 1995 Two distinct osteoblast-specific cis-acting elements control expression of a mouse osteocalcin gene. Mol Cell Biol 15:1858-1869
24. Ducy P, Zhang R, Geoffroy V, Ridall AL, Karsenty G 1997 Osf2/Cbfa1: a transcriptional activator of osteoblast differentiation. Cell 89:747-754
25. Komori T, Yagi H, Nomura S, Yamaguchi A, Sasaki K, Deguchi K, Shimizu Y, Bronson RT, Gao YH, Inada M, Sato M, Okamoto R, Kitamura Y, Yoshiki S, Kishimoto T 1997 Targeted disruption of Cbfa1 results in a complete lack of bone formation owing to maturational arrest of osteoblasts. Cell 89:755-764
26. Otto F, Thornell AP, Crompton T, Denzel A, Gilmour KC, Rosewell IR, Stamp GWH, Beddington RSP, Mundlos S, Olsen BR, Selby PB, Owen MJ 1997 Cbfa1, a candidate gene for cleidocranial dysplasia syndrome, is essential for osteoblast differentiation and bone development. Cell 89:765-771
27. Ducy P, Starbuck M, Priemel M, Shen JH, Pinero G, Geoffroy V, Amling M, Karsteny G 1999 A Cbfa1-dependent genetic pathway controls bone formation beyond embryonic development. Genes Dev 13:1025-1036
28. Liu W, Toyosawa S, Furuichi T, Kanatani N, Yoshida C, Liu Y, Himeno M, Narai S, Yamaguchi A, Komori T 2001 Overexpression of Cbfa1 in osteoblasts inhibits osteoblast maturation and causes osteopenia with multiple fractures. J Cell Biol 155:157-166
29. Geoffroy V, Kneissel M, Fournier B, Boyde A, Matthias P 2002 High bone resorption in adult aging transgenic mice overexpressing Cbfa1/Runx2 in cells of the osteoblastic lineage. Mol Cell Biol 22:6222-6233
30. Krishnan V, Ma YL, Moseley JM, Geiser AG, Friant S, Frolik CA 2001 Bone anabolic effects of sonic/Indian hedgehog are mediated by BMP-2/4 dependent pathways in the neonatal rat metatarsal model. Endocrinology 142:940-947
31. Ahlstrom M, Lamberg-Allardt C 1997 Rapid protein kinase A-mediated activation of cyclic AMP-phosphodiesterase by parathyroid hormone in UMR-106 osteoblast-like cells. J Bone Miner Res 12:172-178
32. Fujimori A, Cheng SL, Avioli LV, Civitelli R 1991 Dissociation of second messenger activation by parathyroid hormone fragments in osteosarcoma cells. Endocrinology 128:3032-3039
33. Jouishomme H, Whitfield JF, Gagnon L, Maclean S, Isaacs R, Chakravarthy B, Durkin J, Neugebauer W, Willick G, Rixon RH 1994 Further definition of the protein kinase C activation domain of the parathyroid hormone. J Bone Miner Res 9:943-949
34. Chijiwa T, Mishima A, Hagiwara M, Sano M, Hayashi K, Inoue T, Naito K, Toshioka T, Hidaka H 1990 Inhibition of forskolin-induced neurite outgrowth and protein phosphorylation by a newly synthesized selective inhibitor of cyclic AMP-dependent protein kinase, N-[2-(p-bromocinnamylamino)ethyl]-5-isoquinolinesulfonamide (H-89), of PC12D pheochromocytoma cells. J Biol Chem 265:5267-5272
35. Haaijman A, D'Souza RN, Bronckers ALJ, Goei SW, Burger EH 1997 OP-1 (BMP-7) affects mRNA expression of type I, II, X collagen, and matrix Gla protein in ossifying long bones in vitro. J Bone Miner Res 12:1815-1823
36. Takasu H, Guo J, Bringhurst FR 1999 Dual signaling and ligand selectivity of the human PTH/PTHrP receptor. J Bone Miner Res 14:11-20
37. Takasu H, Gardella TJ, Luck MD, Potts JT, Bringhurst FR 1999 Amino-terminal modifications of human parathyroid hormone (PTH) selectively alter phospholipase C signaling via the type 1 PTH receptor: implications for design of signal-specific PTH ligands. Biochemistry 38:13453-13460
38. Xiao G, Jiang D, Thomas P, Benson MD, Guan K, Karsenty G, Franceschi RT 2000 MAPK pathways activate and phosphorylate the osteoblast-specific transcription factor, Cbfa1. J Biol Chem 275:4453-4459
39. Selvamurugan N, Pulumati MR, Tyson DR, Partridge NC 2000 Parathyroid hormone regulation of the rat collagenase-3 promoter by protein kinase A-dependent transactivation of core binding factor a1. J Biol Chem 275:5037-5042
40. Yu XP, Chandrasekhar S 1997 Parathyroid hormone (PTH 1-34) regulation of rat osteocalcin gene transcription. Endocrinology 138:3085-3092
41. Selvamurugan N, Chou W-Y, Pearman AT, Pulumati MR, Partridge NC 1998 Parathyroid hormone regulates the rat collagenase-3 promoter in osteoblastic cells through the cooperative interaction of the activator protein-1 site and the runt domain binding sequence. J Biol Chem 273:10647-10657
42. Porte D, Tuckerman J, Becker M, Baumann B, Teurich S, Higgins T, Owen MJ, Schorpp-Kistner M, Angel P 1999 Both AP-1 and Cbfa1-like factors are required for the induction of interstitial collagenase by parathyroid hormone. Oncogene 18:667-678
43. Hess J, Porte D, Munz C, Angel P 2001 AP-1 and Cbfa/runt physically interact and regulate parathyroid hormone-dependent MMP13 expression in osteoblasts through a new osteoblast-specific element 2/AP-1 composite element. J Biol Chem 276:20029-20038
44. Thirunavukkarasu K, Mahajan M, McLarren KW, Stifani S, Karsenty G 1998 Two domains unique to osteoblast-specific transcription factor Osf2/CBFA1 contribute to its transactivation function and its inability to heterodimerize with CbfB. Mol Cell Biol 18:4197-4208
45. Tintut Y, Parhami F, Le V, Karsenty G, Demer LL 1999 Inhibition of osteoblast-specific transcription factor Cbfa1 by the cAMP pathway in osteoblastic cells - ubiquitin/proteasome-dependent regulation. J Biol Chem 274:28875-28879
46. Ma YL, Cain RL, Halladay DL, Yang X, Zeng Q, Miles RR, Chandrasekhar S, Martin TJ, Onyia JE 2001 Catabolic effects of continuous human PTH (1-38) in vivo is associated with sustained stimulation of RANKL and inhibition of osteoprotegerin and gene-associated bone formation. Endocrinology 142:4047-4054
47. Xiao GZ, Wang D, Benson MD, Karsenty G, Franceschi RT 1998 Role of the α(2)-integrin in osteoblast-specific gene expression and activation of the osf2 transcription factor. J Biol Chem 273:32988-32994
48. Tsuji K, Ito Y, Noda M 1998 Expression of the PEBP2αA/AML3/CBFA1 gene is regulated by BMP4/7 heterodimer and its overexpression suppresses type I collagen and osteocalcin gene expression in osteoblastic and nonosteoblastic mesenchymal cells. Bone 22:87-92
49. Lee MH, Javed A, Kim HJ, Shin HI, Gutierrez S, Choi JY, Rosen V, Stein JL, vanWijnen AJ, Stein GS, Lian JB, Ryoo HM 1999 Transient upregulation of CBFA1 in response to bone morphogenetic protein-2 and transforming growth factor β 1 in C2C12 myogenic cells coincides with suppression of the myogenic phenotype but is not sufficient for osteoblast differentiation. J Cell Biochem 73:114-125
50. Hanai J, Chen LF, Kanno T, Ohtani-Fujita N, Kim W-Y, Guo W-H, Imamura T, Ishidou Y, Fukuchi M 1999 Interaction and functional cooperation of PEBP2/CBF with Smads. J Biol Chem 274:31577-31582
51. Zhang Y-W, Yasui N, Ito K, Huang G, Fujii M, Hanai J-I, Nogami H, Ochi T, Miyazono K, Ito Y 2000 A RUNX2/PEBP2aA/CBFA1 mutation diplaying impaired transactivation and Smad interaction in cleidocranial dysplasia. Proc Natl Acad Sci USA 97:10549-10554
52. Nishimura R, Hata K, Harris SE, Ikeda F, Yoneda T 2002 Core-binding factor a1 (Cbfa1) induces osteoblastic differentiation of C2C12 cells without interactions with Smad1 and Smad5. Bone 31:303-312
53. Geiser AG, Letterio JL, Kulkarni AB, Karlsson S, Roberts AB, Sporn MB 1993 Transforming growth factor B1 (TGF-B1) controls expression of major histocompatibility genes in the mouse: aberrant histocompatibility antigen expression in the pathogenesis of the TGF-B1 null mouse phenotype. Proc Natl Acad Sci USA 90:9944-9948
54. Krishnan V, Elberg G, Tsai M-J, Tsai SY 1997 Identification of a novel sonic hedgehog response element in the chicken ovalbumin upstream promoter-transcription factor II promoter. Mol Endocrinol 11:1458-1466