Specificity of RGS10A as a key component in the RANKL signaling mechanism for osteoclast differentiation

Journal of Cell Science

Volumn 120, Issue 19, 2007, Pages 3362-3371

  Yang, Shuying ^a,b   Chen, Wei ^a,b   Stashenko, Philip ^a,b   Li, Yi Ping ^a,b  

^a FORSYTH INSTITUTE   (United States)

^b HARVARD SCHOOL OF DENTAL MEDICINE   (United States)

Author keywords

Ca2+ i oscillations; Differential screening; Osteoclast differentiation; RANKL signaling pathway; RGS10 RNA interference

Indexed keywords

CALCIUM ION; COMPLEMENTARY DNA; OSTEOCLAST DIFFERENTIATION FACTOR; RGS PROTEIN; RGS10A PROTEIN; RGS10B PROTEIN; RGS12 PROTEIN; SMALL INTERFERING RNA; TRANSCRIPTION FACTOR NFAT; UNCLASSIFIED DRUG;

ANIMAL CELL; APOPTOSIS; ARTICLE; BONE MARROW CELL; CALCIUM SIGNALING; CELL DIFFERENTIATION; CELL LINE; CONTROLLED STUDY; DNA LIBRARY; GENE EXPRESSION; GENE SILENCING; GENETIC SCREENING; HUMAN; HUMAN CELL; INHIBITION KINETICS; MOUSE; NONHUMAN; NUCLEOTIDE SEQUENCE; OSTEOCLAST; OSTEOCLASTOMA; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN TARGETING; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; RNA INTERFERENCE; SIGNAL TRANSDUCTION; STEM CELL;

ANIMALS; BONE MARROW CELLS; CELL DIFFERENTIATION; CELLS, CULTURED; GENE LIBRARY; HUMANS; MACROPHAGE COLONY-STIMULATING FACTOR; MICE; NFATC TRANSCRIPTION FACTORS; OSTEOCLASTS; PROTEIN ISOFORMS; RANK LIGAND; RGS PROTEINS; RNA INTERFERENCE; SIGNAL TRANSDUCTION; TISSUE DISTRIBUTION;

EID: 35648929280     PISSN: 00219533     EISSN: None     Source Type: Journal    
DOI: 10.1242/jcs.008300     Document Type: Article

References (41)

1. Alliston, T. and Derynck, R. (2002). Medicine: interfering with bone remodelling. Nature 416, 686-687.
2. Boyle, W. J., Simonet, W. S. and Lacey, D. L. (2003). Osteoclast differentiation and activation 1. Nature 423, 337-342.
3. Chambers, T. J., Fuller, K., Darby, J. A., Pringle, J. A. and Horton, M. A. (1986). Monoclonal antibodies against osteoclasts inhibit bone resorption in vitro. Bone Miner. 1, 127-135.
4. Chen, W. and Li, Y. P. (1998). Generation of mouse osteoclastogenic cell lines immortalized with SV40 large T antigen. J. Bone Miner. Res. 13, 1112-1123.
5. Crabtree, G. R. and Olson, E. N. (2002). NFAT signaling: choreographing the social lives of cells. Cell 109, S67-S79.
6. 2+/calmodulin 1. EMBO J. 24, 2688-2699.
7. El Hajj Dibb, I., Gallet, M., Mentaverri, R., Sevenet, N., Brazier, M. and Kamel, S. (2006). Imatinib mesylate (Gleevec) enhances mature osteoclast apoptosis and suppresses osteoclast bone resorbing activity. Eur. J. Pharmacol. 551, 27-33.
8. Erickson-Viitanen, S. and DeGrado, W. F. (1987). Recognition and characterization of calmodulin-binding sequences in pcptides and proteins 1. Meth. Enzymol. 139, 455-478.
9. Faccio, R., Takeshita, S., Zallone, A., Ross, F. P. and Teitelhaum, S. L. (2003). c-Fms and the alphavbeta3 integrin collaborate during osteoclast differentiation 2. J. Clin. Invest. 111, 749-758.
10. Faccio, R., Teitelbaum, S. L., Fujikawa, K., Chappel, J., Zallone, A., Tybulewicz, V. L., Ross, F. P. and Swat, W. (2005). Vav3 regulates osteoclast function and bone mass 4. Nat. Med. 11, 284-290.
11. Flanagan, A. M., Nui, B., Tinkler, S. M., Horton, M. A., Williams, D. M. and Chambers, T. J. (1988). The multinucleate cells in giant cell granulomas of the jaw are osteoclasts. Cancer 62, 1139-1145.
12. Franzoso, G., Carlson, L., Xing, L., Poljak, L., Shores, E. W., Brown, K. D., Leonardi, A., Tran, T., Boyce, B. F. and Siebenlist, U. (1997). Requirement for NF-kappaB in osteoclast and B-cell development. Genes Dev. 11, 3482-3496.
13. Grigoriadis, A. E., Wang, Z. Q., Cecchini, M. G, Hofstetter, W., Felix, R., Fleisch, H. A. and Wagner, E. F. (1994). c-Fos: a key regulator of osteoclast-macrophage lineage determination and bone remodeling. Science 266, 443-448.
14. + channel. Proc. Natl. Acad. Sci. USA 99, 4325-4330.
15. 2+/ calmodulin competitively bind to the regulators of G-protein-signalling (RGS) domain of RGS4 and reciprocally regulate its action 35. Biochem. J. 385, 65-73.
16. Kameda, T., Miyazawa, K., Mori, Y., Yuasa, T., Shiokawa, M., Nakamaru, Y., Mano, H., Hakeda, Y., Kameda, A. and Kumegawa, M. (1996). Vitamin K2 inhibits osteoclastic bone resorption by inducing osteoclast apoptosis. Biochem. Biophys. Res. Commun. 220, 515-519.
17. Kehrl, J. H. (1998). Heterotrimeric G protein signaling: roles in immune function and fine-tuning by RGS proteins. Immunity 8, 1-10.
18. Kelly, K. A., Tanaka, S., Baron, R. and Gimble, J. M. (1998). Murine bone marrow stromally derived BMS2 adipocytes support differentiation and function of osteoclast-like cells in vitro. Endocrinology 139, 2092-2101.
19. Koga, T., Inui, M., Inoue, K., Kim, S., Suematsu, A., Kobayashi, E., Iwata, T., Ohnishi, H., Matozaki, T., Kodama, T. et al. (2004). Costimulatory signals mediated by the ITAM motif cooperate with RANKL for bone homeostasis. Nature 428, 758-763.
20. Lee, S. J., Xu, H., Kang, L. W., Amzel, L. M. and Montell, C. (2003). Light adaptation through phosphoinositide-regulated translocation of Drosophila visual arrestin 6. Neuron 39, 121-132.
21. Li, Y. P., Alexander, M., Wucherpfennig, A. L., Yelick, P., Chen, W. and Stashenko, P. (1995). Cloning and complete coding sequence of a novel human cathepsin expressed in giant cells of osteoclastomas. J. Bone Miner. Res. 10, 1197-1202.
22. Li, Y. P., Chen, W., Liang, Y., Li, E. and Stashenko, F. (1999). Atp6i-deficient mice exhibit severe osteopetrosis due to loss of osteoclast-mediated extracellular acidification. Nat. Genet. 23, 447-451.
23. Liu, J., Farmer, J. D., Jr, Lane, W. S., Friedman, J., Weissman, I. and Schreiber, S. L. (1991). Calcincurin is a common target of cyclophilin-cyclosporin A and FKBP-FK506 complexes 3. Cell 66, 807-815.
24. Maffucci, T. and Falasca, M. (2007). Phosphoinositide 3-kinase-dependent regulation of phospholipase Cgamma. Biochem. Soc. Trans. 35, 229-230.
25. Matson, K., Owens, J. M., Tonko, M., Elliott, C., Chambers, T. J. and Wagner, E. F. (2000). Fosll is a transcriptional target of c-Fos during osteoclast differentiation. Nat. Genet. 24, 184-187.
26. Mentaverri, R., Yano, S., Chattopadhyay, N., Petit, L., Kifor, O., Kamel, S., Terwilliger, E. F., Brazier, M. and Brown, E. M. (2006). The calcium sensing receptor is directly involved in both osteoclast differentiation and apoptosis. FASEB J. 20, 2562-2564.
27. Mocsai, A., Humphrey, M. B., Van Ziffle, J. A., Hu, Y., Burghardt, A., Spusta, S. C., Majumdar, S., Lanier, L. L., Lowell, C. A. and Nakamura, M. C. (2004). The immunomodulatory adapter proteins DAP12 and Fc receptor gamma-chain (FcRgamma) regulate development of functional osteoclasts through the Syk tyrosine kinase. Proc. Natl. Acad. Sci. USA 101, 6159-6163.
28. Naito, A., Azuma, S., Tanaka, S., Miyazaki, T., Takaki, S., Takatsu, K., Nakao, K., Nakamura, K., Katsuki, M., Yamamoto, T. et al. (1999). Severe osteopetrosis, defective interleukin-1 signalling and lymph node organogenesis in TRAF6-deficient mice. Genes Cells 4, 353-362.
29. Seales, E. C., Micoli, K. J. and McDonald, J. M. (2006). Calmodulin is a critical regulator of osteoclastic differentiation, function, and survival. J. Cell. Biochem. 97, 45-55.
30. Sinnarajah, S., Dessauer, C. W., Srikumar, D., Chen, J., Yuen, J., Yilma, S., Dennis, J. C., Morrison, E. E., Vodyanoy, V. and Kehrl, J. H. (2001). RGS2 regulates signal transduction in olfactory neurons by attenuating activation of adenylyl cyclase III. Nature 409, 1051-1055.
31. Sun, L., Peng, Y., Zaidi, N., Zhu, L. L., Iqbal, J., Yamoah, K, Wang, X., Liu, P., Abe, E., Moonga, B. S. et al. (2006). Evidence that calcineurin is required for the genesis of bone resorbing osteoclasts 1. Am. J. Physiol. Renal Physiol. 292, F285-F291.
32. Takayanagi, H., Kim, S., Koga, T., Nishina, H., Isshiki, M., Yoshida, H., Saiura, A., Isobe, M., Yokochi, T., Inoue, J. et al. (2002). Induction and activation of the transcription factor NFATc1 (NFAT2) integrate RANKL signaling in terminal differentiation of osteoclasts. Dev. Cell 3, 889-901.
33. 2+ signals and immunosuppression. Nature 383, 837-840.
34. Tseng, P. H., Lin, H. P., Hu, H., Wang, C., Zhu, M. X. and Chen, C. S. (2004). The canonical transient receptor potential 6 channel as aputative phosphatidylinositol 3,4,5-trisphosphate-sensitive calcium entry system 1. Biochemistry 43, 11701-11708.
35. Wagner, E. F. and Karsenty, G. (2001). Genetic control of skeletal development. Curr Opin. Genet. Dev. 11, 527-532.
36. Wang, X., Huang, G., Luo, X., Penninger, J. M. and Muallem, S. (2004). Role of regulator of G protein signaling 2 (RGS2) in Ca(2+) oscillations and adaptation of Ca(2+) signaling to reduce excitability of RGS2-/- cells. J. Biol. Chem. 279, 41642-41649.
37. Wu, X., McKenna, M. A., Feng, X., Nagy, T. R. and McDonald, J. M. (2003). Osteoclast apoptosis: the role of Fas in vivo and in vitro. Endocrinology 144, 5545-5555.
38. Yang, S. and Li, Y. P. (2007). RGS12 is essential for RANKL-evoked signaling for terminal differentiation of osteoclasts in vitro 1. J. Bone Miner. Res. 22, 45-54.
39. Yang, S., Wei, D., Wang, D., Phimphilai, M., Krebsbach, P. H. and Franceschi, R. T. (2003). In vitro and in vivo synergistic interactions between the Runx2/Cbfal transcription factor and bone morphogenetic protein-2 in stimulating osteoblast differentiation. J. Bone Miner. Res. 18, 705-715.
40. Yu, J. Y., DeRuiter, S. L. and Turner, D. L. (2002). RNA interference by expression of short-interfering RNAs and hairpin RNAs in mammalian cells. Proc. Natl. Acad. Sci. USA 99, 6047-6052.
41. Zhou, J., Moroi, K., Nishiyama, M., Usui, H., Seki, N., Ishida, J., Fukamizu, A. and Kimura, S. (2001). Characterization of RGS5 in regulation of G protein-coupled receptor signaling 2. Life Sci. 68, 1457-1469.