Severe growth retardation and early lethality in mice lacking the nuclear localization sequence and C-terminus of PTH-related protein

Proceedings of the National Academy of Sciences of the United States of America

Volumn 105, Issue 51, 2008, Pages 20309-20314

  Miao, Dengshun ^a,b   Su, Hanyi ^c   He, Bin ^c   Gao, Jianjun ^b   Xia, Qingwen ^b   Zhu, Min ^a   Gu, Zhen ^a   Goltzman, David ^b   Karaplis, Andrew C ^c  

^a NANJING MEDICAL UNIVERSITY   (China)

^b MCGILL UNIVERSITY HEALTH CENTRE   (Canada)

^c MCGILL UNIVERSITY   (Canada)

Author keywords

Ageing; Nucleus; Osteoporosis; PTHrP senescence

Indexed keywords

BMI1 PROTEIN; CELL SURFACE RECEPTOR; CYCLIN D; CYCLIN DEPENDENT KINASE INHIBITOR 2A; GUANINE NUCLEOTIDE BINDING PROTEIN; P21 ACTIVATED KINASE; PARATHYROID HORMONE RELATED PROTEIN;

AGING; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; APOPTOSIS; ARTICLE; BONE; BONE MARROW CELL; CARBOXY TERMINAL SEQUENCE; CELL PROLIFERATION; CELLULAR DISTRIBUTION; CODON; CONTROLLED STUDY; GENE MUTATION; GENOTYPE; GROWTH RETARDATION; IN VIVO STUDY; LETHALITY; MALNUTRITION; MOUSE; NONHUMAN; NUCLEAR LOCALIZATION SIGNAL; ONCOGENE; OSSIFICATION; OSTEOPOROSIS; PHENOTYPE; PRIORITY JOURNAL; PROTEIN EXPRESSION; SENESCENCE;

ANIMALS; APOPTOSIS; BONE AND BONES; BONE MARROW CELLS; CELL PROLIFERATION; GENE KNOCK-IN TECHNIQUES; GROWTH DISORDERS; MALNUTRITION; MICE; MUTANT PROTEINS; NUCLEAR LOCALIZATION SIGNALS; ONCOGENES; PARATHYROID HORMONE-RELATED PROTEIN; SURVIVAL RATE; TUMOR SUPPRESSOR PROTEINS;

MUS;

EID: 58149481211     PISSN: 00278424     EISSN: 10916490     Source Type: Journal    
DOI: 10.1073/pnas.0805690105     Document Type: Article

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