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Volumn 423, Issue 6937, 2003, Pages 337-342

Osteoclast differentiation and activation

Author keywords

[No Author keywords available]

Indexed keywords

BONE; DISEASES; ENZYMES;

EID: 0037673945     PISSN: 00280836     EISSN: None     Source Type: Journal    
DOI: 10.1038/nature01658     Document Type: Review
Times cited : (5450)

References (77)
  • 1
    • 0033828271 scopus 로고    scopus 로고
    • Regulation of the differentiation and function of osteoclasts
    • Chambers, T. J. Regulation of the differentiation and function of osteoclasts. J. Pathol. 192, 4-13 (2000).
    • (2000) J. Pathol. , vol.192 , pp. 4-13
    • Chambers, T.J.1
  • 2
    • 0034284970 scopus 로고    scopus 로고
    • Bone resorption by osteoclasts
    • Teitlelbaum, S. L. Bone resorption by osteoclasts. Science 289, 1504-1508 (2000).
    • (2000) Science , vol.289 , pp. 1504-1508
    • Teitlelbaum, S.L.1
  • 3
    • 0034284550 scopus 로고    scopus 로고
    • Therapeutic approaches to bone diseases
    • Rodan, G. A. & Martin, T. J. Therapeutic approaches to bone diseases. Science 289, 1508-1514 (2000).
    • (2000) Science , vol.289 , pp. 1508-1514
    • Rodan, G.A.1    Martin, T.J.2
  • 4
    • 0035206443 scopus 로고    scopus 로고
    • Minireview: The OPG/RANKL/RANK system
    • Khosla, S. Minireview: the OPG/RANKL/RANK system. Endocrinology 142, 5050-5055 (2001).
    • (2001) Endocrinology , vol.142 , pp. 5050-5055
    • Khosla, S.1
  • 5
    • 0023928381 scopus 로고
    • Osteoclast-like cell formation and its regulation by osteotropic hormones in mouse bone marrow cultures
    • Takahashi, N. et al. Osteoclast-like cell formation and its regulation by osteotropic hormones in mouse bone marrow cultures. Endocrinology 122, 1373-1382 (1988).
    • (1988) Endocrinology , vol.122 , pp. 1373-1382
    • Takahashi, N.1
  • 6
    • 0032584208 scopus 로고    scopus 로고
    • Osteoclast differentiation factor is a ligand for osteoprotegerin/ osteoclastogenesis-inhibitory factor and is identical to TRANCE/RANKL
    • Yasuda, H. et al. Osteoclast differentiation factor is a ligand for osteoprotegerin/osteoclastogenesis-inhibitory factor and is identical to TRANCE/RANKL. Proc. Natl Acad. Sci. USA 95, 3597-3602 (1998).
    • (1998) Proc. Natl. Acad. Sci. USA , vol.95 , pp. 3597-3602
    • Yasuda, H.1
  • 7
    • 0032540319 scopus 로고    scopus 로고
    • Osteoprotegerin ligand is a cytokine that regulates osteoclast differentiation and activation
    • Lacey, D. L. et al. Osteoprotegerin ligand is a cytokine that regulates osteoclast differentiation and activation. Cell 93, 165-176 (1998).
    • (1998) Cell , vol.93 , pp. 165-176
    • Lacey, D.L.1
  • 8
    • 0032545355 scopus 로고    scopus 로고
    • RANK is the essential signaling receptor for osteoclast differentiation factor in osteoclastogenesis
    • Nakagawa, N. et al. RANK is the essential signaling receptor for osteoclast differentiation factor in osteoclastogenesis. Biochem. Biophys. Res. Commun. 253, 395-400 (1998).
    • (1998) Biochem. Biophys. Res. Commun. , vol.253 , pp. 395-400
    • Nakagawa, N.1
  • 9
    • 13044316551 scopus 로고    scopus 로고
    • Tumor necrosis factor receptor family member RANK mediates osteoclast differentiation and activation induced by osteoprotegerin ligand
    • Hsu, H. et al. Tumor necrosis factor receptor family member RANK mediates osteoclast differentiation and activation induced by osteoprotegerin ligand. Proc. Natl Acad. Sci. USA 96, 3540-3545 (1999).
    • (1999) Proc. Natl. Acad. Sci. USA , vol.96 , pp. 3540-3545
    • Hsu, H.1
  • 10
    • 0033519221 scopus 로고    scopus 로고
    • The ligand for osteoprotegerin (OPGL) directly activates mature osteoclasts
    • Burgess, T. L. et al. The ligand for osteoprotegerin (OPGL) directly activates mature osteoclasts. J. Cell Biol. 145, 527-538 (1999).
    • (1999) J. Cell Biol. , vol.145 , pp. 527-538
    • Burgess, T.L.1
  • 11
    • 0032748995 scopus 로고    scopus 로고
    • Atp61-deficient mice exhibit severe osteopetrosis due to loss of osteoclast-mediated extracellular acidification
    • Li, Y. P., Chen, W., Liang, Y., Li, E. & Stashenko, P. Atp61-deficient mice exhibit severe osteopetrosis due to loss of osteoclast-mediated extracellular acidification. Nature Genet. 23, 447-151 (1999).
    • (1999) Nature Genet. , vol.23 , pp. 447-1151
    • Li, Y.P.1    Chen, W.2    Liang, Y.3    Li, E.4    Stashenko, P.5
  • 12
    • 85047685623 scopus 로고    scopus 로고
    • TNFα potently activates osteoclasts, through a direct action independent of and strongly synergistic with RANKL
    • Fuller, K., Murphy, C., Kirstein, B., Fox, S.W. & Chambers, T. J. TNFα potently activates osteoclasts, through a direct action independent of and strongly synergistic with RANKL. Endocrinology 143, 1108-1118 (2002).
    • (2002) Endocrinology , vol.143 , pp. 1108-1118
    • Fuller, K.1    Murphy, C.2    Kirstein, B.3    Fox, S.W.4    Chambers, T.J.5
  • 14
    • 0033168518 scopus 로고    scopus 로고
    • Osteoclast differentiation factor acts as a multifunctional regulator in murine osteoclast differentiation and function
    • Jimi, E. et al. Osteoclast differentiation factor acts as a multifunctional regulator in murine osteoclast differentiation and function. J. Immunol. 163, 434-442 (1999).
    • (1999) J. Immunol. , vol.163 , pp. 434-442
    • Jimi, E.1
  • 15
    • 0033888977 scopus 로고    scopus 로고
    • Osteoprotegerin ligand modulates murine osteoclast survival in vitro and in vivo
    • Lacey, D. L. et al. Osteoprotegerin ligand modulates murine osteoclast survival in vitro and in vivo. Am. J. Pathol. 157, 435-448 (2000).
    • (2000) Am. J. Pathol. , vol.157 , pp. 435-448
    • Lacey, D.L.1
  • 16
    • 0024429248 scopus 로고
    • Osteoclast biology: Lessons from mammalian mutations
    • Marks, S. C. Jr Osteoclast biology: lessons from mammalian mutations. Am. J. Med. Genet. 34, 43-53 (1989).
    • (1989) Am. J. Med. Genet. , vol.34 , pp. 43-53
    • Marks Jr., S.C.1
  • 17
    • 0035478997 scopus 로고    scopus 로고
    • Mouse models of abnormal skeletal development and homeostasis
    • McLean, W. & Olsen, B. R. Mouse models of abnormal skeletal development and homeostasis. Trends Genet. 17, S38-S43 (2001).
    • (2001) Trends Genet. , vol.17
    • McLean, W.1    Olsen, B.R.2
  • 18
    • 0037195141 scopus 로고    scopus 로고
    • The osteopetrotic mutation toothless (tl) is a loss-of-function frameshift mutation in the rat Csf1 gene: Evidence of a crucial role for CSF-1 in osteoclastogenesis and endochondral ossification
    • Van Wesenbeeck, L. et al. The osteopetrotic mutation toothless (tl) is a loss-of-function frameshift mutation in the rat Csf1 gene: evidence of a crucial role for CSF-1 in osteoclastogenesis and endochondral ossification. Proc. Natl Acad. Sci. USA 99, 14303-14308 (2002).
    • (2002) Proc. Natl. Acad. Sci. USA , vol.99 , pp. 14303-14308
    • Van Wesenbeeck, L.1
  • 19
    • 0036732410 scopus 로고    scopus 로고
    • SHIP-deficient mice are severely osteoporotic due to increased numbers of hyperresorptive osteoclasts
    • Takeshita, S. et al. SHIP-deficient mice are severely osteoporotic due to increased numbers of hyperresorptive osteoclasts. Nature Med. 9, 943-949 (2002).
    • (2002) Nature Med. , vol.9 , pp. 943-949
    • Takeshita, S.1
  • 20
    • 0032079445 scopus 로고    scopus 로고
    • Osteoprotegerin-deficient mice develop early onset osteoporosis and arterial calcification
    • Bucay, N. et al. Osteoprotegerin-deficient mice develop early onset osteoporosis and arterial calcification. Genes Dev. 12, 1260-1268 (1998).
    • (1998) Genes Dev. , vol.12 , pp. 1260-1268
    • Bucay, N.1
  • 21
    • 0035479838 scopus 로고    scopus 로고
    • Genetic control of skeletal development
    • Wagner, E. F. & Karsenty, G. Genetic control of skeletal development. Curr. Opin. Genet. Dev. 5, 527-532 (2001).
    • (2001) Curr. Opin. Genet. Dev. , vol.5 , pp. 527-532
    • Wagner, E.F.1    Karsenty, G.2
  • 22
    • 0031005576 scopus 로고    scopus 로고
    • Osteoprotegerin: A novel secreted protein involved in the regulation of bone density
    • Simonet, W. S. et al. Osteoprotegerin: a novel secreted protein involved in the regulation of bone density. Cell 89, 309-319 (1997).
    • (1997) Cell , vol.89 , pp. 309-319
    • Simonet, W.S.1
  • 23
    • 0009660825 scopus 로고    scopus 로고
    • Identity of osteoclastogenesis inhibitory factor (OCIF) and osteoprotegerin (OPG): A mechanism by which OPG/OCIF inhibits osteoclastogenesis in vitro
    • Yasuda, H. et al. Identity of osteoclastogenesis inhibitory factor (OCIF) and osteoprotegerin (OPG): a mechanism by which OPG/OCIF inhibits osteoclastogenesis in vitro. Endocrinology 139, 1329-1337 (1998).
    • (1998) Endocrinology , vol.139 , pp. 1329-1337
    • Yasuda, H.1
  • 25
    • 14444272043 scopus 로고    scopus 로고
    • TRANCE is a novel ligand of the tumor necrosis factor receptor family that activates c-jun N-terminal kinase in T cells
    • Wong, B. R. et al. TRANCE is a novel ligand of the tumor necrosis factor receptor family that activates c-jun N-terminal kinase in T cells. J. Biol. Chem. 272, 25190 (1997).
    • (1997) J. Biol. Chem. , vol.272 , pp. 25190
    • Wong, B.R.1
  • 26
    • 0030714605 scopus 로고    scopus 로고
    • A homologue of the TNF receptor and its ligand enhance T-cell growth and dendritic-cell function
    • Anderson, D. M. et al. A homologue of the TNF receptor and its ligand enhance T-cell growth and dendritic-cell function. Nature 390, 175-179 (1997).
    • (1997) Nature , vol.390 , pp. 175-179
    • Anderson, D.M.1
  • 27
    • 12944262423 scopus 로고    scopus 로고
    • RANK is the intrinsic hematopoietic cell surface receptor that controls osteoclastogenesis and regulation of bone mass and calcium metabolism
    • Li, J. et al. RANK is the intrinsic hematopoietic cell surface receptor that controls osteoclastogenesis and regulation of bone mass and calcium metabolism. Proc. Natl Acad. Sci. USA 97, 1566-1571 (2000).
    • (2000) Proc. Natl. Acad. Sci. USA , vol.97 , pp. 1566-1571
    • Li, J.1
  • 28
    • 0033568341 scopus 로고    scopus 로고
    • RANK is essential for osteoclast and lymph node development
    • Dougall, W. C. et al. RANK is essential for osteoclast and lymph node development. Genes Dev. 13, 2412-2424 (1999).
    • (1999) Genes Dev. , vol.13 , pp. 2412-2424
    • Dougall, W.C.1
  • 29
    • 0033611467 scopus 로고    scopus 로고
    • OPGL is a key regulator of osteoclastogenesis, lymphocyte development and lymphnode organogenesis
    • Kong, Y. Y. et al. OPGL is a key regulator of osteoclastogenesis, lymphocyte development and lymphnode organogenesis. Nature 397, 315-323 (1999).
    • (1999) Nature , vol.397 , pp. 315-323
    • Kong, Y.Y.1
  • 30
    • 0033984313 scopus 로고    scopus 로고
    • The roles of osteoprotegerin and osteoprotegerin ligand in the paracrine regulation of bone resorption
    • Hofbauer, L. C. et al. The roles of osteoprotegerin and osteoprotegerin ligand in the paracrine regulation of bone resorption. J. Bone Miner. Res. 15, 2-12 (2000).
    • (2000) J. Bone Miner. Res. , vol.15 , pp. 2-12
    • Hofbauer, L.C.1
  • 31
    • 0036218666 scopus 로고    scopus 로고
    • RANK-L and RANK: T cells, bone loss, and mammalian evolution
    • Theill, L. E., Boyle, W. J. & Penninger, J. M. RANK-L and RANK: T cells, bone loss, and mammalian evolution. Annu. Rev. Immunol. 20, 795-823 (2002).
    • (2002) Annu. Rev. Immunol. , vol.20 , pp. 795-823
    • Theill, L.E.1    Boyle, W.J.2    Penninger, J.M.3
  • 32
    • 17744388339 scopus 로고    scopus 로고
    • Osteoprotegerin produced by osteoblasts is an important regulator in osteoclast development and function
    • Udagawa, N. et al. Osteoprotegerin produced by osteoblasts is an important regulator in osteoclast development and function. Endocrinology 141, 3478-3484 (2000).
    • (2000) Endocrinology , vol.141 , pp. 3478-3484
    • Udagawa, N.1
  • 33
    • 0036120427 scopus 로고    scopus 로고
    • RANK ligand and osteoprotegerin: Paracrine regulators of bone metabolism and vascular function
    • Schoppet, M., Preissner, K. T. & Hofbauer, L. C. RANK ligand and osteoprotegerin: paracrine regulators of bone metabolism and vascular function. Arterioscler. Thromb. Vasc. Biol. 22, 549-553 (2002).
    • (2002) Arterioscler. Thromb. Vasc. Biol. , vol.22 , pp. 549-553
    • Schoppet, M.1    Preissner, K.T.2    Hofbauer, L.C.3
  • 34
    • 0032493737 scopus 로고    scopus 로고
    • Characterization of the intracellular domain of receptor activator of NF-κB (RANK). Interaction with tumor necrosis factor receptor-associated factors and activation of NF-κB and c-Jun N-terminal kinase
    • Darnay, B. G., Haridas, V., Ni, J., Moore, P. A. & Aggarwal, B. B. Characterization of the intracellular domain of receptor activator of NF-κB (RANK). Interaction with tumor necrosis factor receptor-associated factors and activation of NF-κB and c-Jun N-terminal kinase. J. Biol Chem. 273, 20551-20555 (1998).
    • (1998) J. Biol. Chem. , vol.273 , pp. 20551-20555
    • Darnay, B.G.1    Haridas, V.2    Ni, J.3    Moore, P.A.4    Aggarwal, B.B.5
  • 35
    • 0032545465 scopus 로고    scopus 로고
    • The involvement of multiple tumor necrosis factor receptor (TNFR)-associated factors in the signaling mechanisms of receptor activator of NF-κB, a member of the TNFR superfamily
    • Galibert, L., Tometsko, M. E., Anderson, D. M., Cosman, D. & Dougall, W. C. The involvement of multiple tumor necrosis factor receptor (TNFR)-associated factors in the signaling mechanisms of receptor activator of NF-κB, a member of the TNFR superfamily. J. Biol. Chem. 273, 34120-34127 (1998).
    • (1998) J. Biol. Chem. , vol.273 , pp. 34120-34127
    • Galibert, L.1    Tometsko, M.E.2    Anderson, D.M.3    Cosman, D.4    Dougall, W.C.5
  • 36
    • 0033561039 scopus 로고    scopus 로고
    • TRAF6 deficiency results in osteopetrosis and defective interleukin-1, CD40, and LPS signaling
    • Lomaga, M. A. et al. TRAF6 deficiency results in osteopetrosis and defective interleukin-1, CD40, and LPS signaling. Genes Dev. 13, 1015-1024 (1999).
    • (1999) Genes Dev. , vol.13 , pp. 1015-1024
    • Lomaga, M.A.1
  • 37
    • 0035868884 scopus 로고    scopus 로고
    • Segregation of TRAF6-mediated signaling pathways clarifies its role in osteoclastogenesis
    • Kobayashi, N. et al. Segregation of TRAF6-mediated signaling pathways clarifies its role in osteoclastogenesis. EMBO J. 20, 1271-1280 (2001).
    • (2001) EMBO J. , vol.20 , pp. 1271-1280
    • Kobayashi, N.1
  • 38
    • 0037113931 scopus 로고    scopus 로고
    • A RANK/TRAF6-dependent signal transduction pathway is essential for osteoclast cytoskeletal organization and resorptive function
    • Armstrong, A. P. et al. A RANK/TRAF6-dependent signal transduction pathway is essential for osteoclast cytoskeletal organization and resorptive function. J. Biol. Chem. 277, 44347-44356 (2002).
    • (2002) J. Biol. Chem. , vol.277 , pp. 44347-44356
    • Armstrong, A.P.1
  • 39
    • 18444390259 scopus 로고    scopus 로고
    • Distinct molecular mechanism for initiating TRAF6 signalling
    • Ye, H. et al. Distinct molecular mechanism for initiating TRAF6 signalling. Nature 418, 443-447 (2002).
    • (2002) Nature , vol.418 , pp. 443-447
    • Ye, H.1
  • 40
    • 15444357762 scopus 로고    scopus 로고
    • Requirement for NF-κB in osteoclast and B-cell development
    • Franzoso, G. et al. Requirement for NF-κB in osteoclast and B-cell development. Genes Dev. 11, 3482-3496 (1997).
    • (1997) Genes Dev. , vol.11 , pp. 3482-3496
    • Franzoso, G.1
  • 41
    • 0036085510 scopus 로고    scopus 로고
    • NF-κB p50 and p52 expression is not required for RANK-expressing osteoclast progenitor formation but is essential for RANK- and cytokine-mediated osteoclastogenesis
    • Xing, L. et al. NF-κB p50 and p52 expression is not required for RANK-expressing osteoclast progenitor formation but is essential for RANK- and cytokine-mediated osteoclastogenesis. J. Bone Miner. Res. 17, 1200-1210 (2002).
    • (2002) J. Bone Miner. Res. , vol.17 , pp. 1200-1210
    • Xing, L.1
  • 42
    • 0028173214 scopus 로고
    • c-Fos: A key regulator of osteoclast-macrophage lineage determination and bone remodeling
    • Grigoriadis, A. E. et al. c-Fos: a key regulator of osteoclast-macrophage lineage determination and bone remodeling. Science 266, 443-448 (1994).
    • (1994) Science , vol.266 , pp. 443-448
    • Grigoriadis, A.E.1
  • 43
    • 0036546501 scopus 로고    scopus 로고
    • NF-κB in cancer: From an innocent bystander to major culprit
    • Karin, M., Cao, Y., Greten, F. R. & Li, Z.-W. NF-κB in cancer: from an innocent bystander to major culprit. Nature Rev. Cancer 2, 301-310 (2002).
    • (2002) Nature Rev. Cancer , vol.2 , pp. 301-310
    • Karin, M.1    Cao, Y.2    Greten, F.R.3    Li, Z.-W.4
  • 44
    • 0037113034 scopus 로고    scopus 로고
    • JNK1 modulates osteoclastogenesis through both c-Jun phosphorylation- dependent and -independent mechanisms
    • David, J. P., Sabapathy, K., Hoffmann, O., Idarraga, M. H. & Wagner, E. F. JNK1 modulates osteoclastogenesis through both c-Jun phosphorylation- dependent and -independent mechanisms. J. Cell Sci. 115, 4317-4325 (2002).
    • (2002) J. Cell Sci. , vol.115 , pp. 4317-4325
    • David, J.P.1    Sabapathy, K.2    Hoffmann, O.3    Idarraga, M.H.4    Wagner, E.F.5
  • 45
    • 0036023042 scopus 로고    scopus 로고
    • TAK1-dependent activation of AP-1 and c-Jun N-terminal kinase by receptor activator of NF-κB
    • Lee, S. W., Han, S. I., Kim, H. H. & Lee, Z. H. TAK1-dependent activation of AP-1 and c-Jun N-terminal kinase by receptor activator of NF-κB. J. Biochem. Mol. Biol. 35, 371-376 (2002).
    • (2002) J. Biochem. Mol. Biol. , vol.35 , pp. 371-376
    • Lee, S.W.1    Han, S.I.2    Kim, H.H.3    Lee, Z.H.4
  • 46
    • 0036150184 scopus 로고    scopus 로고
    • Receptor activator of NF-κB ligand (RANKL) activates TAK1 mitogen-activated protein kinase kinase kinase through a signaling complex containing RANK, TAB2, and TRAF6
    • Mizukami, J. et al. Receptor activator of NF-κB ligand (RANKL) activates TAK1 mitogen-activated protein kinase kinase kinase through a signaling complex containing RANK, TAB2, and TRAF6. Mol. Cell. Biol. 22, 992-1000 (2002).
    • (2002) Mol. Cell. Biol. , vol.22 , pp. 992-1000
    • Mizukami, J.1
  • 47
    • 0036006406 scopus 로고    scopus 로고
    • Possible involvement of IκB kinase 2 and MKK7 in osteoclastogenesis induced by receptor activator of nuclear factor κB ligand
    • Oda, H., Nakamura, K. & Tanaka, S. Possible involvement of IκB kinase 2 and MKK7 in osteoclastogenesis induced by receptor activator of nuclear factor κB ligand. J. Bone Miner. Res. 17, 612-621 (2002).
    • (2002) J. Bone Miner. Res. , vol.17 , pp. 612-621
    • Oda, H.1    Nakamura, K.2    Tanaka, S.3
  • 48
    • 0036321005 scopus 로고    scopus 로고
    • p38 MAPK-mediated signals are required for inducing osteoclast differentiation but not for osteoclast function
    • Li, X. et al. p38 MAPK-mediated signals are required for inducing osteoclast differentiation but not for osteoclast function. Endocrinology 143, 3105-3113 (2002).
    • (2002) Endocrinology , vol.143 , pp. 3105-3113
    • Li, X.1
  • 49
    • 0034613188 scopus 로고    scopus 로고
    • Involvement of p38 mitogen-activated protein kinase signaling pathway in osteoclastogenesis mediated by receptor activator of NF-κB ligand (RANKL)
    • Matsumoto, M., Sudo, T., Saito, T., Osada, H. & Tsujimoto, M. Involvement of p38 mitogen-activated protein kinase signaling pathway in osteoclastogenesis mediated by receptor activator of NF-κB ligand (RANKL). J. Biol. Chem. 275, 31155-31161 (2000).
    • (2000) J. Biol. Chem. , vol.275 , pp. 31155-31161
    • Matsumoto, M.1    Sudo, T.2    Saito, T.3    Osada, H.4    Tsujimoto, M.5
  • 50
    • 0037192784 scopus 로고    scopus 로고
    • Microphthalmia transcription factor is a target of the p38 MAPK pathway in response to receptor activator of NF-κB ligand signaling
    • Mansky, K. C., Sankar, U., Han, J. & Ostrowski, M. C. Microphthalmia transcription factor is a target of the p38 MAPK pathway in response to receptor activator of NF-κB ligand signaling. J. Biol. Chem. 277, 11077-11083 (2002).
    • (2002) J. Biol. Chem. , vol.277 , pp. 11077-11083
    • Mansky, K.C.1    Sankar, U.2    Han, J.3    Ostrowski, M.C.4
  • 51
    • 0037155165 scopus 로고    scopus 로고
    • Interleukin-4 reversibly inhibits osteoclastogenesis via inhibition of NF-κB and mitogen-activated protein kinase signaling
    • Wei, S., Wang, M. W., Teitelbaum, S. L. & Ross, F. P. Interleukin-4 reversibly inhibits osteoclastogenesis via inhibition of NF-κB and mitogen-activated protein kinase signaling. J. Biol. Chem. 277, 6622-6630 (2002).
    • (2002) J. Biol. Chem. , vol.277 , pp. 6622-6630
    • Wei, S.1    Wang, M.W.2    Teitelbaum, S.L.3    Ross, F.P.4
  • 52
    • 0346525140 scopus 로고    scopus 로고
    • U0126 and PD98059, specific inhibitors of MEK, accelerate differentiation of RAW264.7 cells into osteoclast-like cells
    • Hotokezaka, H. et al. U0126 and PD98059, specific inhibitors of MEK, accelerate differentiation of RAW264.7 cells into osteoclast-like cells. J. Biol. Chem. 277, 47366-47372 (2002).
    • (2002) J. Biol. Chem. , vol.277 , pp. 47366-47372
    • Hotokezaka, H.1
  • 53
    • 0033393957 scopus 로고    scopus 로고
    • TRANCE, a TNF family member, activates Akt/PKB through a signaling complex involving TRAF6 and c-Src
    • Wong, B. R. et al. TRANCE, a TNF family member, activates Akt/PKB through a signaling complex involving TRAF6 and c-Src. Mol. Cell 4, 1041-1049 (1999).
    • (1999) Mol. Cell , vol.4 , pp. 1041-1049
    • Wong, B.R.1
  • 54
    • 0041663764 scopus 로고    scopus 로고
    • The immunosuppressant rapamycin, alone or with transforming growth factor-β, enhances osteoclast differentiation of RAW264.7 monocyte-macrophage cells in the presence of RANK-ligand
    • Shui, C., Riggs, B. L. & Khosla, S. The immunosuppressant rapamycin, alone or with transforming growth factor-β, enhances osteoclast differentiation of RAW264.7 monocyte-macrophage cells in the presence of RANK-ligand. Calcif. Tissue Int. 71, 437-446 (2002).
    • (2002) Calcif. Tissue Int. , vol.71 , pp. 437-446
    • Shui, C.1    Riggs, B.L.2    Khosla, S.3
  • 55
    • 0037077303 scopus 로고    scopus 로고
    • Transcriptional program of mouse osteoclast differentiation governed by the macrophage colony-stimulating factor and the ligand for the receptor activator of NFκB
    • Cappellen, D. et al. Transcriptional program of mouse osteoclast differentiation governed by the macrophage colony-stimulating factor and the ligand for the receptor activator of NFκB. J. Biol. Chem. 277, 21971-21982 (2002).
    • (2002) J. Biol. Chem. , vol.277 , pp. 21971-21982
    • Cappellen, D.1
  • 56
    • 0037174944 scopus 로고    scopus 로고
    • Large scale gene expression analysis of osteoclastogenesis in vitro and elucidation of NFAT2 as a key regulator
    • Ishida, N. et al. Large scale gene expression analysis of osteoclastogenesis in vitro and elucidation of NFAT2 as a key regulator. J. Biol. Chem. 277, 41147-41156 (2002).
    • (2002) J. Biol. Chem. , vol.277 , pp. 41147-41156
    • Ishida, N.1
  • 57
    • 18744366041 scopus 로고    scopus 로고
    • Induction and activation of the transcription factor NFATc1 (NFAT2) integrate RANKL signaling in terminal differentiation of osteoclasts
    • Takayanagi, H. et al. Induction and activation of the transcription factor NFATc01 (NFAT2) integrate RANKL signaling in terminal differentiation of osteoclasts. Dev. Cell 3, 889-901 (2002).
    • (2002) Dev. Cell , vol.3 , pp. 889-901
    • Takayanagi, H.1
  • 58
    • 0036233577 scopus 로고    scopus 로고
    • c-myc is required for osteoclast differentiation
    • Battaglino, R. et al. c-myc is required for osteoclast differentiation. J. Bone Miner. Res. 17, 763-773 (2002).
    • (2002) J. Bone Miner. Res. , vol.17 , pp. 763-773
    • Battaglino, R.1
  • 59
    • 0037158723 scopus 로고    scopus 로고
    • A block at the toll gate
    • Mak, T. W. & Yeh, W. C. A block at the toll gate. Nature 418, 835-836 (2002).
    • (2002) Nature , vol.418 , pp. 835-836
    • Mak, T.W.1    Yeh, W.C.2
  • 60
    • 0033398996 scopus 로고    scopus 로고
    • Commitment and differentiation of osteoclast precursor cells by the sequential expression of c-Fms and receptor activator of nuclear factor κB (RANK) receptors
    • Arai, F. et al. Commitment and differentiation of osteoclast precursor cells by the sequential expression of c-Fms and receptor activator of nuclear factor κB (RANK) receptors. J. Exp. Med. 190, 1741-1754 (1999).
    • (1999) J. Exp. Med. , vol.190 , pp. 1741-1754
    • Arai, F.1
  • 61
    • 0034835405 scopus 로고    scopus 로고
    • Regulation of osteoclastogenesis and RANK expression by TGF-β1
    • Yan, T., Riggs, B. L., Boyle, W. J. & Khosla, S. Regulation of osteoclastogenesis and RANK expression by TGF-β1. J. Cell. Biochem. 83, 320-325 (2001).
    • (2001) J. Cell. Biochem. , vol.83 , pp. 320-325
    • Yan, T.1    Riggs, B.L.2    Boyle, W.J.3    Khosla, S.4
  • 62
    • 0034878897 scopus 로고    scopus 로고
    • Catabolic effects of continuous human PTH (1-38) in vivo is associated with sustained stimulation of RANKL and inhibition of osteoprotegerin and gene-associated bone formation
    • Ma, Y. L. et al. Catabolic effects of continuous human PTH (1-38) in vivo is associated with sustained stimulation of RANKL and inhibition of osteoprotegerin and gene-associated bone formation. Endocrinology 142, 4047-4054 (2001).
    • (2001) Endocrinology , vol.142 , pp. 4047-4054
    • Ma, Y.L.1
  • 63
    • 0037129205 scopus 로고    scopus 로고
    • RANKL maintains bone homeostasis through c-Fos-dependent induction of interferon-β
    • Takayanagi, H. et al. RANKL maintains bone homeostasis through c-Fos-dependent induction of interferon-β. Nature 416, 744-749 (2002).
    • (2002) Nature , vol.416 , pp. 744-749
    • Takayanagi, H.1
  • 64
    • 0037008742 scopus 로고    scopus 로고
    • Regulation of receptor activator of NF-κB ligand-induced osteoclastogenesis by endogenous interferon-β (INF-β) and suppressors of cytokine signaling (SOCS). The possible counteracting role of SOCSs in IFN-β-inhibited osteoclast formation
    • Hayashi, T., Kaneda, T., Toyama, Y., Kumegawa, M. & Hakeda, Y. Regulation of receptor activator of NF-κB ligand-induced osteoclastogenesis by endogenous interferon-β (INF-β) and suppressors of cytokine signaling (SOCS). The possible counteracting role of SOCSs in IFN-β-inhibited osteoclast formation. J. Biol. Chem. 277, 27880-27886 (2002).
    • (2002) J. Biol. Chem. , vol.277 , pp. 27880-27886
    • Hayashi, T.1    Kaneda, T.2    Toyama, Y.3    Kumegawa, M.4    Hakeda, Y.5
  • 65
    • 0034735773 scopus 로고    scopus 로고
    • T-cell-mediated regulation of osteoclastogenesis by signalling cross-talk between RANKL and IFN-γ
    • Takayanagi, H. et al. T-cell-mediated regulation of osteoclastogenesis by signalling cross-talk between RANKL and IFN-γ. Nature 408, 600-605 (2000).
    • (2000) Nature , vol.408 , pp. 600-605
    • Takayanagi, H.1
  • 66
    • 0033581952 scopus 로고    scopus 로고
    • Activated T cells regulate bone loss and joint destruction in adjuvant arthritis through osteoprotegerin ligand
    • Kong, Y. Y. et al. Activated T cells regulate bone loss and joint destruction in adjuvant arthritis through osteoprotegerin ligand. Nature 402, 304-309 (1999).
    • (1999) Nature , vol.402 , pp. 304-309
    • Kong, Y.Y.1
  • 67
    • 0037606007 scopus 로고    scopus 로고
    • Stimulation of osteoprotegerin production is responsible for osteosclerosis in mice overexpressing TPO
    • in the press
    • Chagraoui, H. et al. Stimulation of osteoprotegerin production is responsible for osteosclerosis in mice overexpressing TPO. Blood (in the press).
    • Blood
    • Chagraoui, H.1
  • 68
    • 0033987358 scopus 로고    scopus 로고
    • Mutations in TNFRSF11A, affecting the signal peptide of RANK, cause familial expansile osteolysis
    • Hughes, A. E. et al. Mutations in TNFRSF11A, affecting the signal peptide of RANK, cause familial expansile osteolysis. Nature Genet. 24, 45-48 (2000).
    • (2000) Nature Genet. , vol.24 , pp. 45-48
    • Hughes, A.E.1
  • 69
    • 0036133351 scopus 로고    scopus 로고
    • Expansile skeletal hyperphosphatasia is caused by a 15-base pair tandem duplication in TNFRSF11A encoding RANK and is allelic to familial expansile osteolysis
    • Whyte, M. P. & Hughes, A. E. Expansile skeletal hyperphosphatasia is caused by a 15-base pair tandem duplication in TNFRSF11A encoding RANK and is allelic to familial expansile osteolysis. J. Bone Miner. Res. 17, 26-29 (2002).
    • (2002) J. Bone Miner. Res. , vol.17 , pp. 26-29
    • Whyte, M.P.1    Hughes, A.E.2
  • 70
    • 0037130183 scopus 로고    scopus 로고
    • Osteoprotegerin deficiency and juvenile Paget's disease
    • Whyte, M. P. et al. Osteoprotegerin deficiency and juvenile Paget's disease. N. Engl. J. Med. 347, 175-184 (2002).
    • (2002) N. Engl. J. Med. , vol.347 , pp. 175-184
    • Whyte, M.P.1
  • 71
    • 18544371504 scopus 로고    scopus 로고
    • A mutation in the gene TNFRSF11B encoding osteoprotegerin causes an idiopathic hyperphosphatasia phenotype
    • Cundy, T. et al. A mutation in the gene TNFRSF11B encoding osteoprotegerin causes an idiopathic hyperphosphatasia phenotype. Hum. Mol. Genet. 11, 2119-2127 (2002).
    • (2002) Hum. Mol. Genet. , vol.11 , pp. 2119-2127
    • Cundy, T.1
  • 72
    • 0035991255 scopus 로고    scopus 로고
    • Polymorphisms in the osteoprotegerin gene are associated with osteoporotic fractures
    • Langdahl, B. L., Carstens, M., Stenkjaer, L. & Eriksen, E. F. Polymorphisms in the osteoprotegerin gene are associated with osteoporotic fractures. J. Bone Miner. Res. 17, 1245-1255 (2002).
    • (2002) J. Bone Miner. Res. , vol.17 , pp. 1245-1255
    • Langdahl, B.L.1    Carstens, M.2    Stenkjaer, L.3    Eriksen, E.F.4
  • 73
    • 0035139584 scopus 로고    scopus 로고
    • The effect of a single dose of osteoprotegerin in postmenopausal women
    • Bekker, P. J. et al. The effect of a single dose of osteoprotegerin in postmenopausal women. J. Bone Miner. Res. 16, 348-360 (2001).
    • (2001) J. Bone Miner. Res. , vol.16 , pp. 348-360
    • Bekker, P.J.1
  • 74
    • 0346837985 scopus 로고    scopus 로고
    • A Phase I study of AMGN-0007, a recombinant osteoprotegerin construct, in patients with multiple myeloma or breast carcinoma related bone metastases
    • Body, J. J. et al. A Phase I study of AMGN-0007, a recombinant osteoprotegerin construct, in patients with multiple myeloma or breast carcinoma related bone metastases. Cancer97(Suppl.), 887-892 (2003).
    • (2003) Cancer , vol.97 , Issue.SUPPL. , pp. 887-892
    • Body, J.J.1
  • 75
    • 0037398261 scopus 로고    scopus 로고
    • Role of RANK ligand in mediating the increased bone resorption in early postmenopausal women
    • Eghbali-Fatourechi, G. et al. Role of RANK ligand in mediating the increased bone resorption in early postmenopausal women. J. Clin. Invest. 111, 1221-1230 (2003).
    • (2003) J. Clin. Invest. , vol.111 , pp. 1221-1230
    • Eghbali-Fatourechi, G.1
  • 76
    • 0037204816 scopus 로고    scopus 로고
    • Inhibitory action of bisphosphonates on bone resorption does not involve the regulation of RANKL and OPG expression
    • Kim, Y. H., Kim, G. S. & Jeong-Hwa, B. Inhibitory action of bisphosphonates on bone resorption does not involve the regulation of RANKL and OPG expression. Exp. Mol. Med. 34, 145-151 (2002).
    • (2002) Exp. Mol. Med. , vol.34 , pp. 145-151
    • Kim, Y.H.1    Kim, G.S.2    Jeong-Hwa, B.3
  • 77
    • 18444379071 scopus 로고    scopus 로고
    • Transgenic mice overexpressing soluble osteoclast differentiation factor (sODF) exhibit severe osteoporosis
    • Mizuno, A. et al. Transgenic mice overexpressing soluble osteoclast differentiation factor (sODF) exhibit severe osteoporosis. J. Bone Miner. Metab. 20, 337-344 (2002).
    • (2002) J. Bone Miner. Metab. , vol.20 , pp. 337-344
    • Mizuno, A.1


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