cAMP-PKA signaling pathway regulates bone resorption mediated by processing of cathepsin K in cultured mouse osteoclasts

International Immunopharmacology

Volumn 6, Issue 6, 2006, Pages 947-956

  Park, Young Guk ^a   Kim, Young Hun ^a,b   Kang, Sung Koo ^b   Kim, Cheorl Ho ^b  

^a Kyung Hee University   (South Korea)

^b Sungkyunkwan University   (South Korea)

Author keywords

cAMP antagonist; Cathepsin; Osteoblast; Oteoclast; Protein kinase A inhibitor

Indexed keywords

ADENYLATE CYCLASE ACTIVATOR; CALPHOSTIN C; CATHEPSIN K; CYCLIC AMP DEPENDENT PROTEIN KINASE; CYCLIC AMP DEPENDENT PROTEIN KINASE INHIBITOR; FORSKOLIN; KT 5720; MANNOSE 6 PHOSPHATE; N [2 (4 BROMOCINNAMYLAMINO)ETHYL] 5 ISOQUINOLINESULFONAMIDE; PROTEIN KINASE C; PROTEIN KINASE C INHIBITOR; RP CYCLIC AMP; UNCLASSIFIED DRUG; WORTMANNIN;

ANIMAL CELL; ANIMAL TISSUE; ARTICLE; BONE CELL; CELL CULTURE; CELL MATURATION; CONCENTRATION RESPONSE; CONTROLLED STUDY; DRUG POTENCY; MOUSE; MOUSE STRAIN; NONHUMAN; NUCLEOTIDE SEQUENCE; OSTEOCLAST; OSTEOLYSIS; PRIORITY JOURNAL; SIGNAL TRANSDUCTION;

ANIMALS; ANTIBODIES; BONE RESORPTION; CARBAZOLES; CATHEPSINS; CELLS, CULTURED; CHLOROQUINE; CYCLIC AMP; CYCLIC AMP-DEPENDENT PROTEIN KINASES; FORSKOLIN; INDOLES; ISOQUINOLINES; LYSOSOMES; MANNOSE; MICE; MONENSIN; NAPHTHALENES; OSTEOCLASTS; PROTEIN KINASE INHIBITORS; PROTEIN PROCESSING, POST-TRANSLATIONAL; PYRROLES; RECEPTOR, IGF TYPE 2; SIGNAL TRANSDUCTION; SULFONAMIDES;

EID: 33646110737     PISSN: 15675769     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.intimp.2006.01.005     Document Type: Article

References (41)

1. Moon S.K., Kang B.S., Lee Y.C., Lee T.K., and Kim C.H. Interleukin-1β and tumor necrosis factor-α induce collagenolysis and bone resorption by regulation of matrix metalloproteinase-2 in mouse calvarial bone cells. Immunopharm Immunotoxicol 25 3 (2003) 347-364
2. Vaes G. Cellular biology and biochemical mechanism of bone resorption. Clin Orthop 231 (1988) 239-271
3. Park Y.G., Kang S.K., Kim W.J., Lee Y.C., and Kim C.H. Effects of TGF-β, TNF-α, IL-β and IL-6 alone or in combination, and tyrosine kinase inhibitor on cyclooxygenase expression, prostaglandin E(2) production and bone resorption in mouse calvarial bone cells. Int J Biochem Cell Biol 36 11 (2004) 2270-2280
4. Buttle D.J., and Saklatvala J. Lysosomal cysteine endopeptidases mediate interleukin 1-stimulated cartilage proteoglycan degradation. Biochem J 287 (1992) 657-661
5. Chapman H.A., Riese R.J., and Shi G.O. Emerging roles for cysteine proteases in human biology. Annu Rev Phys 59 (1997) 63-88
6. Delaisse J.M., Eeckout Y., and Vaes G. In vivo and in vitro evidence for the involvement of cysteine proteinases in bone resorption. Biochem Biophys Res Commun 125 (1984) 441-447
7. Afonso S., Romagnano L., and Babiarz B. The expression and function of cystatin C and cathepsin B and cathepsin L during mouse embryo implantation and placentation. Development 124 (1997) 3415-3425
8. Iwata Y., Mort J.S., Tateishi H., and Lee E.R. Macrophage cathepsin L, a factor in the erosion of subchondral bone in rheumatoid arthritis. Arthritis Rheum 40 (1997) 499-509
9. Yagel S., Warner A.H., Nellans H.N., Lala P.K., Waghorne C., and Denhardt D.T. Suppression by cathepsin L inhibitors of the invasion of the amnion membranes by murine cancer cells. Cancer Res 49 (1989) 3553-3557
10. Chambers A.F., Colella R., Denhardt D.T., and Wilson S.M. Increased expression of cathepsins L and B and decreased activity of their inhibitors in metastatic, ras-transformed NIH 3T3 cells. Mol Carcin 5 (1992) 238-245
11. Esser R.E., Angelo R.A., Murphey M.D., Watts L.M., Thornburg L.P., Palmer J.T., et al. Cysteine proteinase inhibitors decrease articular cartilage and bone destruction in chronic inflammatory arthritis. Arthritis Rheum 37 (1994) 236-247
12. Lenarcic B., Gabrijelcic D., Rozman B., Drobnic-Kosorok M., and Turk V. Human cathepsin B and cysteine proteinase inhibitors (CPIs) in inflammatory and metabolic joint diseases. Biol Chem Hoppe-Seyler 369 (1988) 257-261
13. Bromme D., Okamoto K., Wang B.B., and Biroc S. Human cathepsin O2, a matrix protein-degrading cysteine protease expressed in osteoclasts. J Biol Chem 271 (1996) 2126-2132
14. Tezuka K., Tezuka Y., Maejima M., Sato T., Nemoto K., Kamioka H., et al. Molecular cloning of a possible cysteine proteinase predominantly expressed in osteoclasts. J Biol Chem 269 (1994) 1106-1109
15. Li Y.P., Alexander M., Wucherpfennig A.L., Yelick P., Chen W., and Stashenko P. Cloning and complete coding sequence of a novel human cathepsin expressed in giant cells of osteoclastomas. J Bone Miner Res 10 (1995) 1197-1202
16. Gelb B.D., Moissoglu K., Zhang J., Martgnetti J.A., Bromme D., and Desnick R.J. Cathepsin K: isolation and characterization of the murine cDNA and genomic sequence, the homologue of the human pycnodysostosis gene. Biochem Molec Med 59 (1996) 200-206
17. Rantakokko J., Aro H.T., Savontaus M., and Vuorio E. Mouse cathepsin KL cDNA cloning and predominant expression of the gene in osteoclasts, and in some hypertrophying chondrocytes during mouse development. FEBS Lett 393 (1996) 307-313
18. Li Y.P., and Chen W. Characterization of mouse cathepsin K gene, the gene promoter, and the gene expression. J Bone Miner Res 14 (1999) 487-499
19. Drake F.H., Dodds R.A., James I.E., Connor J.R., DeBouck C., Richardson S., et al. Cathepsin K, but not B, L or S is abundantly expressed in human osteoclasts. J Biol Chem 271 (1996) 12511-12516
20. Inaoka T., Bilbe G., Ishibashi O., Tezuka K., Kumegawa M., and Kokubo T. Molecular cloning of human cDNA for cathepsin K. Novel cysteine proteinase predominantly expressed in bone. Biochem Biophys Res Commun 206 (1995) 89-96
21. Tezuka K.Y., Tezuka A., Maejima T., Sato K., Nemoto H., Kamioka Y., et al. Molecular cloning of a possible cysteine proteinase predominantly expressed in osteoclasts. J Biol Chem 269 (1994) 1100-1109
22. Garnero P., Borel O., Byrjalsen I., Ferreras M., Drake F.H., McQueney M.S., et al. The collagenolytic activity of cathepsin K is unique among mammalian proteinases. J Biol Chem 273 (1998) 32347-32352
23. Kafienah W.D., Bromme D.J., Buttle L.J., Croucher C., and Holander A.P. Human cathepsin K cleaves native type I and II collagens at the N-terminal end of the triple complex. Biochem J 331 (1998) 727-732
24. Rieman D.J., Mcclung H.A., Dodds R.A., Hwang S.M., Lark M.W., Holmes S., et al. Biosynthesis and processing of cathepsin k in cultured human osteoblasts. Bone 28 (2001) 282-289
25. Clohisy J.C., Connolly T.J., Bergman K.D., Quinn C.O., and Patridge N.C. Prostanoid-induced expression of matrix metalloproteinase-1 messenger ribonucleic acid in rat osteosarcoma cells. Endocrinology 135 (1994) 1447-1453
26. Akatsu T., Takahashi N., Udagawa N., Imamura K., Yamaguchi A., Sato K., et al. Role of prostaglandins in interleukin-1 induced bone resorption in mice in vitro. J Bone Miner Res 6 (1991) 183-190
27. Jeong J.C., Kang S.K., Youn C.H., Jeong C.W., Kim H.M., Lee Y.C., et al. Inhibition of Drynariae Rhizoma extracts on bone resorption mediated by processing of cathepsin K in cultured mouse osteoclasts. Int Immunopharmacol 3 (2003) 1563-1697
28. Kim Y.J., Kim K.S., Chang J.E., Lee Y.C., Ko J.H., Chung T.W., et al. Analysis of 5′-flanking and promoter region of Human N-acetylglucosaminyltransferase gene. Gene 170 (1996) 281-283
29. Evans D.B., Bunning R.A.D., and Russell R.G.G. The effects of recombinant human interleukin-1β on cellular proliferation and the production of prostaglandin E2, plasminogen activator, osteocalcin and alkaline phosphatase by osteoblast-like cells derived from human bone. Biochem Biophys Res Commun 166 (1990) 208-216
30. Hong H.T., Kim H.J., Kim D.W., Lee Y.C., Par Y.G., Kim H.M., et al. Inhibotory effect of a Korean traditional medicine, Honghwain-Jahage (water extracts of Carthamus tinctorius L. seed and Homminis placenta) on interleukin-1-mediated bone resorption. J Ethnopharm 79 (2002) 143-148
31. James I.E., Dodds R.A., Lee-Rykaczewski E., Eichman C.F., Connor J.R., Hart T.K., et al. Purification and characterization of fully functional osteoclast precursors. J Bone Miner Res 11 (1996) 1608-1618
32. James I.E., Lark M.W., Zembryki D., Lee-Rykaczewski W., Hwang S.M., Tomaszek T.A., et al. Development and characterization of a human in vitro resorption assay: demonstration of utility using novel antiresorptive agents. J Bone Miner Res 14 (1999) 1562-1569
33. Laemmli U.K. Cleavage of structural proteins during the assembly of the head of bacteriophage T4. Nature 227 (1950) 680-685
34. Lowry O.H., Rosenbrough N.J., Farr A.L., and Randall R.J. Protein measurement with the Folin phenol reagent. J Biol Chem 193 (1951) 265-275
35. Nakamura I., Sasaki T., Tanaka S., Takahashi N., Jimi E., Kurokawa T., et al. PI3 kinase is involved in ruffled border formation in osteoclasts. J Cell Physiol 172 (1997) 230-239
36. Nakamura I., Takahashi N., Sasaki T., Tanaka S., Udagawa N., Murakami H., et al. Wortmannin, a specific inhibitor of phosphatidylinositol-3 kinase, blocks osteoclastic bone resorption. Fed Eur Bone Soc Lett 361 (1995) 79-84
37. Nakajima Y., and Pfeffer S.R. Phosphoinositol 3-kinase is not required for recycling of mannose-6-phosphate receptors from late endosomes to the trans-Golgi network. Mol Cell Biol 8 (1997) 677-682
38. Lakkakorpi P.T., Wesolowski G., Zimolo Z., Rodan G.A., and Rodan S.B. Phosphatidylinositol 3-kinase association with the osteoclast cytoskeleton, and its involvement in osteoclast attachment and spreading. Exp Cell Res 237 (1997) 296-306
39. McCarthy T.L., Thomas M.J., Centrella M., and Rotwein P. Regulation of insulin-like growth factor I transcription by cyclic adenosine 3′,5′-monophosphate (cAMP) in fetal rat bone cells through an element within exon 1: protein kinase A-dependent control without a consensus AMP response element. Endocrinology 136 (1995) 3901-3908
40. Millet I., McCarthy T.L., and Vignery A. Regulation of interleukin-6 production by prostaglandin E2 in fetal rat osteoblasts: role of protein kinase A signaling pathway. J Bone Miner Res 13 (1998) 1092-1100
41. Hidaka H., and Kobayashi R. Pharmacology of protein kinase inhibitors. Annu Rev Pharmacol Toxicol 32 (1992) 377-397