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Volumn 6, Issue 9, 2005, Pages 689-701

G proteins in development

Author keywords

[No Author keywords available]

Indexed keywords

GUANINE NUCLEOTIDE BINDING PROTEIN; GUANINE NUCLEOTIDE BINDING PROTEIN ALPHA SUBUNIT; GUANINE NUCLEOTIDE BINDING PROTEIN BETA SUBUNIT; GUANINE NUCLEOTIDE BINDING PROTEIN GAMMA SUBUNIT; HETEROTRIMERIC GUANINE NUCLEOTIDE BINDING PROTEIN; MITOGEN ACTIVATED PROTEIN KINASE; MITOGEN ACTIVATED PROTEIN KINASE 1; RGS PROTEIN; RHODOPSIN; STRESS ACTIVATED PROTEIN KINASE; G PROTEIN COUPLED RECEPTOR; PROTEIN SUBUNIT;

EID: 27744445165     PISSN: 14710072     EISSN: 14710080     Source Type: Journal    
DOI: 10.1038/nrm1716     Document Type: Review
Times cited : (134)

References (114)
  • 1
    • 0032875356 scopus 로고    scopus 로고
    • Physiological regulation of G protein-linked signalling
    • Morris, A. J. & Malbon, C. C. Physiological regulation of G protein-linked signalling. Physiol. Rev. 79, 1373-1430 (1999).
    • (1999) Physiol. Rev. , vol.79 , pp. 1373-1430
    • Morris, A.J.1    Malbon, C.C.2
  • 3
    • 0028957913 scopus 로고
    • Mechanisms of protein prenylation and role in G protein function
    • Casey, P. J. Mechanisms of protein prenylation and role in G protein function. Biochem. Soc. Trans. 23, 161-166 (1995).
    • (1995) Biochem. Soc. Trans. , vol.23 , pp. 161-166
    • Casey, P.J.1
  • 4
    • 0037188868 scopus 로고    scopus 로고
    • Signal transduction. MAP kinase signalling specificity
    • Weston, C. R., Lambright, D. G. & Davis, R. J. Signal transduction. MAP kinase signalling specificity. Science 296, 2345-2347 (2002).
    • (2002) Science , vol.296 , pp. 2345-2347
    • Weston, C.R.1    Lambright, D.G.2    Davis, R.J.3
  • 5
    • 0032514679 scopus 로고    scopus 로고
    • A DNA damage and stress inducible G protein-coupled receptor blocks cells in G2/M
    • Weng, Z. et al. A DNA damage and stress inducible G protein-coupled receptor blocks cells in G2/M. Proc. Natl Acad. Sci. USA 95, 12334-12339 (1998).
    • (1998) Proc. Natl. Acad. Sci. USA , vol.95 , pp. 12334-12339
    • Weng, Z.1
  • 6
    • 0025127424 scopus 로고
    • Two G protein oncogenes in human endocrine tumours
    • Lyons, J. et al. Two G protein oncogenes in human endocrine tumours. Science 249, 655-659 (1990).
    • (1990) Science , vol.249 , pp. 655-659
    • Lyons, J.1
  • 7
    • 0031157691 scopus 로고    scopus 로고
    • Inborn errors of signal transduction: Mutations in G proteins and G protein-coupled receptors as a cause of disease
    • Spiegel, A. M. Inborn errors of signal transduction: mutations in G proteins and G protein-coupled receptors as a cause of disease. J. Inherit. Metab. Dis. 20, 113-121 (1997).
    • (1997) J. Inherit. Metab. Dis. , vol.20 , pp. 113-121
    • Spiegel, A.M.1
  • 8
    • 0031060659 scopus 로고    scopus 로고
    • Heterotrimeric G-proteins and development
    • Malbon, C. C. Heterotrimeric G-proteins and development. Biochem. Pharmacol. 53, 1-4 (1997).
    • (1997) Biochem. Pharmacol. , vol.53 , pp. 1-4
    • Malbon, C.C.1
  • 9
    • 0032582489 scopus 로고    scopus 로고
    • Extended life-span and stress resistance in the Drosophila mutant methuselah
    • Lin, Y. J., Seroude, L. & Benzer, S. Extended life-span and stress resistance in the Drosophila mutant methuselah. Science 282, 943-946 (1998). Identification of the product of the methuselah gene in D. melanogaster as a GPCR that controls the lifespan of the organism.
    • (1998) Science , vol.282 , pp. 943-946
    • Lin, Y.J.1    Seroude, L.2    Benzer, S.3
  • 10
    • 0024146560 scopus 로고
    • cAMP receptor and G-protein interactions control development in Dictyostelium
    • Pupillo, M. et al. cAMP receptor and G-protein interactions control development in Dictyostelium. Cold Spring Harb. Symp. Quant. Biol. 53, 657-665 (1988).
    • (1988) Cold Spring Harb. Symp. Quant. Biol. , vol.53 , pp. 657-665
    • Pupillo, M.1
  • 12
    • 0026068650 scopus 로고
    • The Drosophila gastrulation gene concertina encodes a Gα- Like protein
    • Parks, S. & Wieschaus, E. The Drosophila gastrulation gene concertina encodes a Gα- like protein. Cell 64, 447-458 (1991).
    • (1991) Cell , vol.64 , pp. 447-458
    • Parks, S.1    Wieschaus, E.2
  • 13
    • 0026612087 scopus 로고
    • sprotein α-subunit sequence accelerate differentiation of fibroblasts to adipocytes
    • sprotein α-subunit sequence accelerate differentiation of fibroblasts to adipocytes. Nature 358, 334-337 (1992).
    • (1992) Nature , vol.358 , pp. 334-337
    • Wang, H.Y.1    Watkins, D.C.2    Malbon, C.C.3
  • 14
    • 0027249144 scopus 로고
    • i2-specific antisense RNA in vivo inhibits neonatal growth
    • i2-specific antisense RNA in vivo inhibits neonatal growth. Science 260, 991-995 (1993).
    • (1993) Science , vol.260 , pp. 991-995
    • Moxham, C.M.1    Hod, Y.2    Malbon, C.C.3
  • 15
    • 0034018370 scopus 로고    scopus 로고
    • Paternal versus maternal transmission of a stimulatory G-protein α subunit knockout produces opposite effects on energy metabolism
    • Yu, S. et al. Paternal versus maternal transmission of a stimulatory G-protein α subunit knockout produces opposite effects on energy metabolism. J. Clin. Invest. 105, 615-623 (2000).
    • (2000) J. Clin. Invest. , vol.105 , pp. 615-623
    • Yu, S.1
  • 16
    • 0346687569 scopus 로고    scopus 로고
    • Mouse models to study G-protein-mediated signalling
    • Wettschureck, N., Moers, A. & Offermanns, S. Mouse models to study G-protein-mediated signalling. Pharmacol. Ther. 101, 75-89 (2004).
    • (2004) Pharmacol. Ther. , vol.101 , pp. 75-89
    • Wettschureck, N.1    Moers, A.2    Offermanns, S.3
  • 17
    • 0033813712 scopus 로고    scopus 로고
    • G protein defects in signal transduction
    • Spiegel, A. M. G protein defects in signal transduction. Horm. Res. 53, 17-22 (2000).
    • (2000) Horm. Res. , vol.53 , pp. 17-22
    • Spiegel, A.M.1
  • 18
    • 0035368394 scopus 로고    scopus 로고
    • G protein signalling from activated rat frizzled-1 to the β-catenin-Lef-Tcf pathway
    • Liu, T. et al. G protein signalling from activated rat frizzled-1 to the β-catenin-Lef-Tcf pathway. Science 292, 1718-1722 (2001). First publication to show the obligate role for heterotrimeric G proteins in the Wnt-β-catenin pathway of development.
    • (2001) Science , vol.292 , pp. 1718-1722
    • Liu, T.1
  • 19
    • 0031456672 scopus 로고    scopus 로고
    • Interaction of Wnt and a Frizzled homologue triggers G-protein-linked phosphatidylinositol signalling
    • 2+ release triggered by Xwnt5a and the rat Fz2.
    • (1997) Nature , vol.390 , pp. 410-413
    • Slusarski, D.C.1    Corces, V.G.2    Moon, R.T.3
  • 20
    • 1942486375 scopus 로고    scopus 로고
    • sα is required for the growth and function of neuromuscular synapses in Drosophila
    • sα is required for the growth and function of neuromuscular synapses in Drosophila. Dev. Biol. 268, 295-311 (2004).
    • (2004) Dev. Biol. , vol.268 , pp. 295-311
    • Wolfgang, W.J.1
  • 24
    • 0033279835 scopus 로고    scopus 로고
    • Integration of signalling networks that regulate Dictyostelium differentiation
    • Aubry, L. & Firtel, R. Integration of signalling networks that regulate Dictyostelium differentiation. Annu. Rev. Cell Dev. Biol. 15, 469-517 (1999).
    • (1999) Annu. Rev. Cell Dev. Biol. , vol.15 , pp. 469-517
    • Aubry, L.1    Firtel, R.2
  • 25
    • 0034611690 scopus 로고    scopus 로고
    • A protein complex containing Inscuteable and the Gα-binding protein Pins orients asymmetric cell divisions in Drosophila
    • Schaefer, M., Shevchenko, A., Shevchenko, A. & Knoblich, J. A. A protein complex containing Inscuteable and the Gα-binding protein Pins orients asymmetric cell divisions in Drosophila. Curr. Biol. 10, 353-362 (2000). Important report that shows the essential role of heterotrimeric G proteins in regulating the proper orientation of asymmetric cell division during the development of D. melanogaster.
    • (2000) Curr. Biol. , vol.10 , pp. 353-362
    • Schaefer, M.1    Shevchenko, A.2    Shevchenko, A.3    Knoblich, J.A.4
  • 26
    • 1442274678 scopus 로고    scopus 로고
    • Regulatory contribution of heterotrimeric G-proteins to oocyte maturation in the sea urchin
    • Voronina, E. & Wessel, G. M. Regulatory contribution of heterotrimeric G-proteins to oocyte maturation in the sea urchin. Mech. Dev. 121, 247-259 (2004).
    • (2004) Mech. Dev. , vol.121 , pp. 247-259
    • Voronina, E.1    Wessel, G.M.2
  • 28
    • 2242453282 scopus 로고    scopus 로고
    • Signalling of rat Frizzled-2 through phosphodiesterase and cyclic GMP
    • Ahumada, A. et al. Signalling of rat Frizzled-2 through phosphodiesterase and cyclic GMP. Science 298, 2006-2010 (2002).
    • (2002) Science , vol.298 , pp. 2006-2010
    • Ahumada, A.1
  • 30
    • 0029061801 scopus 로고
    • i2-deficient mice
    • i2-deficient mice. Nature Genet. 10, 143-150 (1995).
    • (1995) Nature Genet. , vol.10 , pp. 143-150
    • Rudolph, U.1
  • 32
    • 0024284962 scopus 로고
    • Roles of G protein subunits in transmembrane signalling
    • Neer, E. J. & Clapham, D. E. Roles of G protein subunits in transmembrane signalling. Nature 333, 129-134 (1988).
    • (1988) Nature , vol.333 , pp. 129-134
    • Neer, E.J.1    Clapham, D.E.2
  • 33
    • 0033620488 scopus 로고    scopus 로고
    • o is required for the formation of heart epithelium in Drosophila
    • o is required for the formation of heart epithelium in Drosophila. J. Cell Biol. 145, 1063-1076 (1999).
    • (1999) J. Cell Biol. , vol.145 , pp. 1063-1076
    • Fremion, F.1
  • 35
    • 0029081954 scopus 로고
    • Pertussis toxin specifically inhibits growth cone guidance by a mechanism independent of direct G protein inactivation
    • Kindt, R. M. & Lander, A. D. Pertussis toxin specifically inhibits growth cone guidance by a mechanism independent of direct G protein inactivation. Neuron 15, 79-88 (1995).
    • (1995) Neuron , vol.15 , pp. 79-88
    • Kindt, R.M.1    Lander, A.D.2
  • 36
    • 0028208687 scopus 로고
    • Developmental expression of G proteins in a migratory population of embryonic neurons
    • Morgan, A. M., Lagrange, M. T. & Copenhaver, P. F. Developmental expression of G proteins in a migratory population of embryonic neurons. Development 120, 729-742 (1994).
    • (1994) Development , vol.120 , pp. 729-742
    • Morgan, A.M.1    Lagrange, M.T.2    Copenhaver, P.F.3
  • 38
    • 0028075023 scopus 로고
    • o) with mitosis
    • o) with mitosis. Lab. Invest. 71, 175-181 (1994). Early report indicating that heterotrimeric G proteins have an essential role in cellular mitosis.
    • (1994) Lab. Invest. , vol.71 , pp. 175-181
    • Wu, H.C.1    Lin, C.T.2
  • 39
    • 4344648897 scopus 로고    scopus 로고
    • Dare to be different: Asymmetric cell division in Drosophila, C. elegans and vertebrates
    • Betschinger, J. & Knoblich, J. A. Dare to be different: asymmetric cell division in Drosophila, C. elegans and vertebrates. Curr. Biol. 14, R674-R685 (2004).
    • (2004) Curr. Biol. , vol.14
    • Betschinger, J.1    Knoblich, J.A.2
  • 40
    • 0038414642 scopus 로고    scopus 로고
    • Heterotrimeric G-proteins associate with microtubules during differentiation in PC12 pheochromocytoma cells
    • Sarma, T., Voyno-Yasenetskaya, T., Hope, T. J. & Rasenick, M. M. Heterotrimeric G-proteins associate with microtubules during differentiation in PC12 pheochromocytoma cells. FASEB J. 17, 848-859 (2003).
    • (2003) FASEB J. , vol.17 , pp. 848-859
    • Sarma, T.1    Voyno-Yasenetskaya, T.2    Hope, T.J.3    Rasenick, M.M.4
  • 41
    • 0030068938 scopus 로고    scopus 로고
    • A large family of putative transmembrane receptors homologous to the product of the Drosophila tissue polarity gene frizzled
    • Wang, Y. et al. A large family of putative transmembrane receptors homologous to the product of the Drosophila tissue polarity gene frizzled. J. Biol. Chem. 271, 4468-4476 (1996).
    • (1996) J. Biol. Chem. , vol.271 , pp. 4468-4476
    • Wang, Y.1
  • 42
    • 1642499389 scopus 로고    scopus 로고
    • Wnt-frizzled signalling to G-protein-coupled effectors
    • Wang, H. Y. & Malbon, C. C. Wnt-frizzled signalling to G-protein-coupled effectors. Cell. Mol. Life Sci. 61, 69-75 (2004).
    • (2004) Cell. Mol. Life Sci. , vol.61 , pp. 69-75
    • Wang, H.Y.1    Malbon, C.C.2
  • 44
    • 0000003605 scopus 로고
    • Isolation of the α subunits of GTP-binding regulatory proteins by affinity chromatography with immobilized βγ subunits
    • Pang, I. H. & Sternweis, P. C. Isolation of the α subunits of GTP-binding regulatory proteins by affinity chromatography with immobilized βγ subunits. Proc. Natl Acad. Sci. USA 86, 7814-7818 (1989).
    • (1989) Proc. Natl. Acad. Sci. USA , vol.86 , pp. 7814-7818
    • Pang, I.H.1    Sternweis, P.C.2
  • 47
    • 0032480009 scopus 로고    scopus 로고
    • 11-mutant mice
    • 11-mutant mice. EMBO J. 17, 4304-4312 (1998).
    • (1998) EMBO J. , vol.17 , pp. 4304-4312
    • Offermanns, S.1
  • 51
    • 0035952734 scopus 로고    scopus 로고
    • In vivo functions of heterotrimeric G-proteins: Studies in Gα-deficient mice
    • Offermanns, S. In vivo functions of heterotrimeric G-proteins: studies in Gα-deficient mice. Oncogene 20, 1635-1642 (2001).
    • (2001) Oncogene , vol.20 , pp. 1635-1642
    • Offermanns, S.1
  • 52
    • 0347706226 scopus 로고    scopus 로고
    • Embryonic handedness choice in C. elegans involves the Gα protein GPA-16
    • Bergmann, D. C. et al. Embryonic handedness choice in C. elegans involves the Gα protein GPA-16. Development 130, 5731-5740 (2003). Provocative demonstration that the 'handedness' of the C. elegans embryo requires the activity of a heterotrimeric G protein, GPA-16.
    • (2003) Development , vol.130 , pp. 5731-5740
    • Bergmann, D.C.1
  • 54
    • 0036242676 scopus 로고    scopus 로고
    • zα deficient mice: Enzyme levels in the autonomic nervous system, neuronal survival and effect of genetic background
    • zα deficient mice: enzyme levels in the autonomic nervous system, neuronal survival and effect of genetic background. Int. J. Dev. Neurosci. 20, 39-46 (2002).
    • (2002) Int. J. Dev. Neurosci. , vol.20 , pp. 39-46
    • Powell, K.L.1    Matthaei, K.I.2    Heydon, K.3    Hendry, I.A.4
  • 56
    • 0037044577 scopus 로고    scopus 로고
    • z attenuates Rap1-mediated differentiation of PC12 cells
    • z attenuates Rap1-mediated differentiation of PC12 cells. J. Biol. Chem. 277, 43417-43424 (2002).
    • (2002) J. Biol. Chem. , vol.277 , pp. 43417-43424
    • Meng, J.1    Casey, P.J.2
  • 57
    • 9444245314 scopus 로고    scopus 로고
    • z inhibits serum response factor-dependent transcription by inhibiting Rho signalling
    • z inhibits serum response factor-dependent transcription by inhibiting Rho signalling. Mol. Pharmacol. 66, 1508-1516 (2004).
    • (2004) Mol. Pharmacol. , vol.66 , pp. 1508-1516
    • Dutt, P.1    Jaffe, A.B.2    Merdek, K.D.3    Hall, A.4    Toksoz, D.5
  • 58
    • 0030612486 scopus 로고    scopus 로고
    • 13 mediate differentiation of P19 mouse embryonal carcinoma cells in response to retinoic acid
    • 13 mediate differentiation of P19 mouse embryonal carcinoma cells in response to retinoic acid. J. Biol. Chem. 272, 24461-24467 (1997).
    • (1997) J. Biol. Chem. , vol.272 , pp. 24461-24467
    • Jho, E.H.1    Malbon, C.C.2
  • 59
    • 11144238908 scopus 로고    scopus 로고
    • 13 signals via p115RhoGEF cascades regulating JNK1 and primitive endoderm formation
    • 13 signals via p115RhoGEF cascades regulating JNK1 and primitive endoderm formation. J. Biol. Chem. 279, 54896-54904 (2004).
    • (2004) J. Biol. Chem. , vol.279 , pp. 54896-54904
    • Lee, Y.N.1    Malbon, C.C.2    Wang, H.Y.3
  • 60
    • 0030870193 scopus 로고    scopus 로고
    • 13 and obligate for differentiation of P19 embryonal carcinoma cells by retinoic acid
    • 13 and obligate for differentiation of P19 embryonal carcinoma cells by retinoic acid. J. Biol. Chem. 272, 24468-24474 (1997).
    • (1997) J. Biol. Chem. , vol.272 , pp. 24468-24474
    • Jho, E.H.1    Davis, R.J.2    Malbon, C.C.3
  • 62
    • 0344304446 scopus 로고    scopus 로고
    • 12-Rho guanine nucleotide exchange factor pathway in Caenorhabditis elegans
    • 12-Rho guanine nucleotide exchange factor pathway in Caenorhabditis elegans. Proc. Natl Acad. Sci. USA 100, 14748-14753 (2003).
    • (2003) Proc. Natl. Acad. Sci. USA , vol.100 , pp. 14748-14753
    • Yau, D.M.1
  • 64
    • 0347623882 scopus 로고    scopus 로고
    • 12 family of heterotrimeric G proteins and Rho GTPase mediate Sonic hedgehog signalling
    • 12 family mediate the signalling of the Sonic hedgehog-Smoothened pathway.
    • (2004) Genes Cells , vol.9 , pp. 49-58
    • Kasai, K.1
  • 65
    • 0027495684 scopus 로고
    • New roles for G-protein βγ-dimers in transmembrane signalling
    • Clapham, D. E. & Neer, E. J. New roles for G-protein βγ-dimers in transmembrane signalling. Nature 365, 403-406 (1993).
    • (1993) Nature , vol.365 , pp. 403-406
    • Clapham, D.E.1    Neer, E.J.2
  • 66
    • 0030598875 scopus 로고    scopus 로고
    • G proteins are required for spatial orientation of early cell cleavages in C. elegans embryos
    • Zwaal, R. R. et al. G proteins are required for spatial orientation of early cell cleavages in C. elegans embryos. Cell 86, 619-629 (1996).
    • (1996) Cell , vol.86 , pp. 619-629
    • Zwaal, R.R.1
  • 67
    • 0035913905 scopus 로고    scopus 로고
    • Heterotrimeric G proteins direct two modes of asymmetric cell division in the Drosophila nervous system
    • Schaefer, M., Petronczki, M., Dorner, D., Forte, M. & Knoblich, J. A. Heterotrimeric G proteins direct two modes of asymmetric cell division in the Drosophila nervous system. Cell 107, 183-194 (2001).
    • (2001) Cell , vol.107 , pp. 183-194
    • Schaefer, M.1    Petronczki, M.2    Dorner, D.3    Forte, M.4    Knoblich, J.A.5
  • 68
    • 0041977037 scopus 로고    scopus 로고
    • 13F subunits of the heterotrimeric G protein complex in the mediation of Drosophila neuroblast asymmetric divisions
    • 13F subunits of the heterotrimeric G protein complex in the mediation of Drosophila neuroblast asymmetric divisions. J. Cell Biol. 162, 623-633 (2003).
    • (2003) J. Cell Biol. , vol.162 , pp. 623-633
    • Yu, F.1    Cai, Y.2    Kaushik, R.3    Yang, X.4    Chia, W.5
  • 69
    • 0037850976 scopus 로고    scopus 로고
    • Heterotrimeric G proteins regulate daughter cell size asymmetry in Drosophila neuroblast divisions
    • Fuse, N., Hisata, K., Katzen, A. L. & Matsuzaki, F. Heterotrimeric G proteins regulate daughter cell size asymmetry in Drosophila neuroblast divisions. Curr. Biol. 13, 947-954 (2003).
    • (2003) Curr. Biol. , vol.13 , pp. 947-954
    • Fuse, N.1    Hisata, K.2    Katzen, A.L.3    Matsuzaki, F.4
  • 70
    • 1442334318 scopus 로고    scopus 로고
    • Differential functions of G protein and Baz-aPKC signalling pathways in Drosophila neuroblast asymmetric division
    • Izumi, Y., Ohta, N., Itoh-Furuya, A., Fuse, N. & Matsuzaki, F. Differential functions of G protein and Baz-aPKC signalling pathways in Drosophila neuroblast asymmetric division. J. Cell Biol. 164, 729-738 (2004).
    • (2004) J. Cell Biol. , vol.164 , pp. 729-738
    • Izumi, Y.1    Ohta, N.2    Itoh-Furuya, A.3    Fuse, N.4    Matsuzaki, F.5
  • 71
    • 0034745355 scopus 로고    scopus 로고
    • Distinct roles for Gα and Gβγ in regulating spindle position and orientation in Caenorhabditis elegans embryos
    • Gotta, M. & Ahringer, J. Distinct roles for Gα and Gβγ in regulating spindle position and orientation in Caenorhabditis elegans embryos. Nature Cell Biol. 3, 297-300 (2001).
    • (2001) Nature Cell Biol. , vol.3 , pp. 297-300
    • Gotta, M.1    Ahringer, J.2
  • 72
    • 4344684893 scopus 로고    scopus 로고
    • Mice with deficiency of G protein γ3 are lean and have seizures
    • Schwindinger, W. F. et al. Mice with deficiency of G protein γ3 are lean and have seizures. Mol. Cell Biol. 24, 7758-7768 (2004).
    • (2004) Mol. Cell Biol. , vol.24 , pp. 7758-7768
    • Schwindinger, W.F.1
  • 73
    • 0037458639 scopus 로고    scopus 로고
    • olf level and cAMP production
    • olf level and cAMP production. J. Biol. Chem. 278, 6575-6579 (2003).
    • (2003) J. Biol. Chem. , vol.278 , pp. 6575-6579
    • Schwindinger, W.F.1
  • 74
    • 0030610854 scopus 로고    scopus 로고
    • q overexpression induces cardiac contractile failure in mice
    • q overexpression induces cardiac contractile failure in mice. Proc. Natl Acad. Sci. USA 94, 8121-8126 (1997).
    • (1997) Proc. Natl. Acad. Sci. USA , vol.94 , pp. 8121-8126
    • D'Angelo, D.D.1
  • 75
    • 0035964862 scopus 로고    scopus 로고
    • Wnt signalling and heterotrimeric G-proteins: Strange bedfellows or a classic romance?
    • Malbon, C. C., Wang, H. & Moon, R. T. Wnt signalling and heterotrimeric G-proteins: strange bedfellows or a classic romance? Biochem. Biophys. Res. Commun. 287, 589-593 (2001).
    • (2001) Biochem. Biophys. Res. Commun. , vol.287 , pp. 589-593
    • Malbon, C.C.1    Wang, H.2    Moon, R.T.3
  • 76
    • 0038581580 scopus 로고    scopus 로고
    • 2+, and cyclic GMP: Visualizing Frizzled functions
    • 2+, and cyclic GMP: visualizing Frizzled functions. Science 300, 1529-1530 (2003).
    • (2003) Science , vol.300 , pp. 1529-1530
    • Wang, H.Y.1    Malbon, C.C.2
  • 77
    • 0036641444 scopus 로고    scopus 로고
    • Wnt signalling - 20 Years and counting
    • Cadigan, K. M. Wnt signalling - 20 years and counting. Trends Genet. 18, 340-342 (2002).
    • (2002) Trends Genet. , vol.18 , pp. 340-342
    • Cadigan, K.M.1
  • 78
    • 0036860191 scopus 로고    scopus 로고
    • Longevity determination genes in Drosophila melanogaster
    • Aigaki, T., Seong, K. H. & Matsuo, T. Longevity determination genes in Drosophila melanogaster. Mech Ageing Dev. 123, 1531-1541 (2002).
    • (2002) Mech. Ageing Dev. , vol.123 , pp. 1531-1541
    • Aigaki, T.1    Seong, K.H.2    Matsuo, T.3
  • 79
    • 2942738996 scopus 로고    scopus 로고
    • The Hedgehog response network: Sensors, switches, and routers
    • Lum, L. & Beachy, P. A. The Hedgehog response network: sensors, switches, and routers. Science 304, 1755-1759 (2004).
    • (2004) Science , vol.304 , pp. 1755-1759
    • Lum, L.1    Beachy, P.A.2
  • 80
    • 2942748080 scopus 로고    scopus 로고
    • The endogenous ligand Stunted of the GPCR Methuselah extends lifespan in Drosophila
    • Cvejic, S., Zhu, Z., Felice, S. J., Berman, Y. & Huang, X. Y. The endogenous ligand Stunted of the GPCR Methuselah extends lifespan in Drosophila. Nature Cell Biol. 6, 540-546 (2004).
    • (2004) Nature Cell Biol. , vol.6 , pp. 540-546
    • Cvejic, S.1    Zhu, Z.2    Felice, S.J.3    Berman, Y.4    Huang, X.Y.5
  • 82
    • 11144256194 scopus 로고    scopus 로고
    • Activity-dependent internalization of smoothened mediated by β-arrestin 2 and GRK2
    • Chen, W. et al. Activity-dependent internalization of smoothened mediated by β-arrestin 2 and GRK2. Science 306, 2257-2260 (2004).
    • (2004) Science , vol.306 , pp. 2257-2260
    • Chen, W.1
  • 83
    • 0036725845 scopus 로고    scopus 로고
    • Nerve growth cone guidance mediated by G protein-coupled receptors
    • Xiang, Y. et al. Nerve growth cone guidance mediated by G protein-coupled receptors. Nature Neurosci. 5, 843-848 (2002).
    • (2002) Nature Neurosci. , vol.5 , pp. 843-848
    • Xiang, Y.1
  • 84
    • 12144286654 scopus 로고    scopus 로고
    • G protein-coupled receptor-dependent development of human frontal cortex
    • Piao, X. et al. G protein-coupled receptor-dependent development of human frontal cortex. Science 303, 2033-2036 (2004).
    • (2004) Science , vol.303 , pp. 2033-2036
    • Piao, X.1
  • 85
    • 0037444047 scopus 로고    scopus 로고
    • 11 proteins mediate endothelin-1 signalling in neural crest-derived pharyngeal arch mesenchyme
    • 11 proteins mediate endothelin-1 signalling in neural crest-derived pharyngeal arch mesenchyme. Dev. Biol. 255, 230-237 (2003).
    • (2003) Dev. Biol. , vol.255 , pp. 230-237
    • Ivey, K.1
  • 86
    • 0041410000 scopus 로고    scopus 로고
    • The C. elegans G-protein-coupled receptor SRA-13 inhibits RAS/MAPK signalling during olfaction and vulval development
    • Battu, G., Hoier, E. F. & Hajnal, A. The C. elegans G-protein-coupled receptor SRA-13 inhibits RAS/MAPK signalling during olfaction and vulval development. Development 130, 2567-2577 (2003).
    • (2003) Development , vol.130 , pp. 2567-2577
    • Battu, G.1    Hoier, E.F.2    Hajnal, A.3
  • 87
    • 2442708165 scopus 로고    scopus 로고
    • Frizzleds: New members of the superfamily of G-protein-coupled receptors
    • Malbon, C. C. Frizzleds: new members of the superfamily of G-protein-coupled receptors. Front. Biosci. 9, 1048-1058 (2004).
    • (2004) Front. Biosci. , vol.9 , pp. 1048-1058
    • Malbon, C.C.1
  • 88
    • 0036733358 scopus 로고    scopus 로고
    • Cellular regulation of RGS proteins: Modulators and integrators of G protein signalling
    • Hollinger, S. & Hepler, J. R. Cellular regulation of RGS proteins: modulators and integrators of G protein signalling. Pharmacol. Rev. 54, 527-559 (2002).
    • (2002) Pharmacol. Rev. , vol.54 , pp. 527-559
    • Hollinger, S.1    Hepler, J.R.2
  • 89
    • 0032915461 scopus 로고    scopus 로고
    • Ioco encodes an RGS protein required for Drosophila glial differentiation
    • Granderath, S. et al. Ioco encodes an RGS protein required for Drosophila glial differentiation. Development 126, 1781-1791 (1999).
    • (1999) Development , vol.126 , pp. 1781-1791
    • Granderath, S.1
  • 90
    • 0033930669 scopus 로고    scopus 로고
    • RGS proteins inhibit Xwnt-8 signalling in Xenopus embryonic development
    • Wu, C., Zeng, Q., Blumer, K. J. & Muslin, A. J. RGS proteins inhibit Xwnt-8 signalling in Xenopus embryonic development. Development 127, 2773-2784 (2000). First demonstration that regulators of G-protein signalling proteins function in Wnt signalling and embryonic development in the X. laevis model.
    • (2000) Development , vol.127 , pp. 2773-2784
    • Wu, C.1    Zeng, Q.2    Blumer, K.J.3    Muslin, A.J.4
  • 91
    • 0344442671 scopus 로고    scopus 로고
    • Dynamic expression of RGS4 in the developing nervous system and regulation by the neural type-specific transcription factor Phox2b
    • Grillet, N., Dubreuil, V., Dufour, H. D. & Brunet, J. F. Dynamic expression of RGS4 in the developing nervous system and regulation by the neural type-specific transcription factor Phox2b. J. Neurosci. 23, 10613-10621 (2003).
    • (2003) J. Neurosci. , vol.23 , pp. 10613-10621
    • Grillet, N.1    Dubreuil, V.2    Dufour, H.D.3    Brunet, J.F.4
  • 92
    • 0347135657 scopus 로고    scopus 로고
    • Morpholino-based gene knockdown screen of novel genes with developmental function in Ciona intestinalis
    • Yamada, L. et al. Morpholino-based gene knockdown screen of novel genes with developmental function in Ciona intestinalis. Development 130, 6485-6495 (2003).
    • (2003) Development , vol.130 , pp. 6485-6495
    • Yamada, L.1
  • 93
    • 0037694090 scopus 로고    scopus 로고
    • A regulator of G protein signalling-containing kinase is important for chemotaxis and multicellular development in Dictyostelium
    • Sun, B. & Firtel, R. A. A regulator of G protein signalling- containing kinase is important for chemotaxis and multicellular development in Dictyostelium. Mol. Biol. Cell 14, 1727-1743 (2003).
    • (2003) Mol. Biol. Cell , vol.14 , pp. 1727-1743
    • Sun, B.1    Firtel, R.A.2
  • 94
    • 3042523825 scopus 로고    scopus 로고
    • AGS proteins, GPR motifs and the signals processed by heterotrimeric G proteins
    • Lanier, S. M. AGS proteins, GPR motifs and the signals processed by heterotrimeric G proteins. Biol. Cell 96, 369-372 (2004).
    • (2004) Biol. Cell , vol.96 , pp. 369-372
    • Lanier, S.M.1
  • 95
    • 0038106690 scopus 로고    scopus 로고
    • Accessory proteins for G protein-signalling systems: Activators of G protein signalling and other nonreceptor proteins influencing the activation state of G proteins
    • Blumer, J. B. & Lanier, S. M. Accessory proteins for G protein-signalling systems: activators of G protein signalling and other nonreceptor proteins influencing the activation state of G proteins. Recept. Channels 9, 195-204 (2003).
    • (2003) Recept. Channels , vol.9 , pp. 195-204
    • Blumer, J.B.1    Lanier, S.M.2
  • 96
    • 0034681261 scopus 로고    scopus 로고
    • Analysis of partner of inscuteable, a novel player of Drosophila asymmetric divisions, reveals two distinct steps in inscuteable apical localization
    • Yu, F., Morin, X., Cai, Y., Yang, X. & Chia, W. Analysis of partner of inscuteable, a novel player of Drosophila asymmetric divisions, reveals two distinct steps in inscuteable apical localization. Cell 100, 399-409 (2000).
    • (2000) Cell , vol.100 , pp. 399-409
    • Yu, F.1    Morin, X.2    Cai, Y.3    Yang, X.4    Chia, W.5
  • 97
    • 0037665297 scopus 로고    scopus 로고
    • Asymmetrically distributed C. elegans homologues of AGS3/PINS control spindle position in the early embryo
    • Gotta, M., Dong, Y., Peterson, Y. K., Lanier, S. M. & Ahringer, J. Asymmetrically distributed C. elegans homologues of AGS3/PINS control spindle position in the early embryo. Curr. Biol. 13, 1029-1037 (2003).
    • (2003) Curr. Biol. , vol.13 , pp. 1029-1037
    • Gotta, M.1    Dong, Y.2    Peterson, Y.K.3    Lanier, S.M.4    Ahringer, J.5
  • 98
    • 8344271193 scopus 로고    scopus 로고
    • Mammalian Pins is a conformational switch that links NuMA to heterotrimeric G proteins
    • Du, Q. & Macara, I. G. Mammalian Pins is a conformational switch that links NuMA to heterotrimeric G proteins. Cell 119, 503-516 (2004).
    • (2004) Cell , vol.119 , pp. 503-516
    • Du, Q.1    Macara, I.G.2
  • 99
    • 10044253425 scopus 로고    scopus 로고
    • AKAP signalling complexes: Focal points in space and time
    • Wong, W. & Scott, J. D. AKAP signalling complexes: focal points in space and time. Nature Rev. Mol. Cell Biol. 5, 959-970 (2004).
    • (2004) Nature Rev. Mol. Cell Biol. , vol.5 , pp. 959-970
    • Wong, W.1    Scott, J.D.2
  • 100
    • 1842866233 scopus 로고    scopus 로고
    • AKAPs (A-kinase anchoring proteins) and molecules that compose their G-protein-coupled receptor signalling complexes
    • Malbon, C. C., Tao, J. & Wang, H. Y. AKAPs (A-kinase anchoring proteins) and molecules that compose their G-protein-coupled receptor signalling complexes. Biochem. J. 379, 1-9 (2004).
    • (2004) Biochem. J. , vol.379 , pp. 1-9
    • Malbon, C.C.1    Tao, J.2    Wang, H.Y.3
  • 101
    • 0346993722 scopus 로고    scopus 로고
    • Protein kinase a regulates AKAP250 (gravin) scaffold binding to the β2-adrenergic receptor
    • Tao, J., Wang, H. Y. & Malbon, C. C. Protein kinase A regulates AKAP250 (gravin) scaffold binding to the β2-adrenergic receptor. EMBO J. 22, 6419-6429 (2003).
    • (2003) EMBO J. , vol.22 , pp. 6419-6429
    • Tao, J.1    Wang, H.Y.2    Malbon, C.C.3
  • 102
    • 8744235277 scopus 로고    scopus 로고
    • AKAP (A-kinase anchoring protein) domains: Beads of structure-function on the necklace of G-protein signalling
    • Malbon, C. C., Tao, J., Shumay, E. & Wang, H. Y. AKAP (A-kinase anchoring protein) domains: beads of structure-function on the necklace of G-protein signalling. Biochem. Soc. Trans. 32, 861-864 (2004).
    • (2004) Biochem. Soc. Trans. , vol.32 , pp. 861-864
    • Malbon, C.C.1    Tao, J.2    Shumay, E.3    Wang, H.Y.4
  • 104
    • 0037162285 scopus 로고    scopus 로고
    • Gα-mediated inhibition of developmental signal response
    • Brzostowski, J. A., Johnson, C. & Kimmel, A. R. Gα-mediated inhibition of developmental signal response. Curr. Biol. 12, 1199-1208 (2002).
    • (2002) Curr. Biol. , vol.12 , pp. 1199-1208
    • Brzostowski, J.A.1    Johnson, C.2    Kimmel, A.R.3
  • 105
    • 6944256893 scopus 로고    scopus 로고
    • Control of embryonic spindle positioning and Gα activity by C. elegans RIC-8
    • Couwenbergs, C., Spilker, A. C. & Gotta, M. Control of embryonic spindle positioning and Gα activity by C. elegans RIC-8. Curr. Biol. 14, 1871-1876 (2004).
    • (2004) Curr. Biol. , vol.14 , pp. 1871-1876
    • Couwenbergs, C.1    Spilker, A.C.2    Gotta, M.3
  • 106
    • 5444259457 scopus 로고    scopus 로고
    • RGS-7 completes a receptor-independent heterotrimeric G protein cycle to asymmetrically regulate mitotic spindle positioning in C. elegans
    • Hess, H. A., Roper, J. C., Grill, S. W. & Koelle, M. R. RGS-7 completes a receptor-independent heterotrimeric G protein cycle to asymmetrically regulate mitotic spindle positioning in C. elegans. Cell 119, 209-218 (2004).
    • (2004) Cell , vol.119 , pp. 209-218
    • Hess, H.A.1    Roper, J.C.2    Grill, S.W.3    Koelle, M.R.4
  • 107
    • 7744244752 scopus 로고    scopus 로고
    • RGS14 is a mitotic spindle protein essential from the first division of the mammalian zygote
    • Martin-McCaffrey, L. et al. RGS14 is a mitotic spindle protein essential from the first division of the mammalian zygote. Dev. Cell 7, 763-769 (2004).
    • (2004) Dev. Cell , vol.7 , pp. 763-769
    • Martin-McCaffrey, L.1
  • 108
    • 5444260164 scopus 로고    scopus 로고
    • RIC-8 is required for GPR-1/2-dependent Gα function during asymmetric division of C. elegans embryos
    • Afshar, K. et al. RIC-8 is required for GPR-1/2-dependent Gα function during asymmetric division of C. elegans embryos. Cell 119, 219-230 (2004).
    • (2004) Cell , vol.119 , pp. 219-230
    • Afshar, K.1
  • 113
    • 0034604548 scopus 로고    scopus 로고
    • MEKK4 mediates differentiation in response to retinoic acid via activation of c-Jun N-terminal kinase in rat embryonal carcinoma P19 cells
    • Kanungo, J., Potapova, I., Malbon, C. C. & Wang, H. MEKK4 mediates differentiation in response to retinoic acid via activation of c-Jun N-terminal kinase in rat embryonal carcinoma P19 cells. J. Biol. Chem. 275, 24032-24039 (2000).
    • (2000) J. Biol. Chem. , vol.275 , pp. 24032-24039
    • Kanungo, J.1    Potapova, I.2    Malbon, C.C.3    Wang, H.4
  • 114
    • 0343293801 scopus 로고    scopus 로고
    • 2+/calmodulin-dependent protein kinase II is stimulated by Wnt and Frizzled homologues and promotes ventral cell fates in Xenopus
    • 2+/calmodulin-dependent protein kinase II is stimulated by Wnt and Frizzled homologues and promotes ventral cell fates in Xenopus. J. Biol. Chem. 275, 12701-12711 (2000).
    • (2000) J. Biol. Chem. , vol.275 , pp. 12701-12711
    • Kuhl, M.1    Sheldahl, L.C.2    Malbon, C.C.3    Moon, R.T.4


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