Normal parathyroid hormone responsiveness of bone-derived cells from a patient with pseudohypoparathyroidism

Journal of Bone and Mineral Research

Volumn 11, Issue 1, 1996, Pages 8-14

  Ish Shalom, Sophia ^a,f   Rao, Letitia G ^b,c   Levine, Michael A ^d   Fraser, Donald ^c   Kooh, Sang W ^c   Josse, Robert G ^b   Mcbroom, Robert ^b,e   Wong, Min Min ^b   Murray, Timothy M ^b  

^a TECHNION ISRAEL INSTITUTE OF TECHNOLOGY   (Israel)

^b ST MICHAEL'S HOSPITAL   (Canada)

^c UNIVERSITY OF TORONTO   (Canada)

^d JOHNS HOPKINS UNIVERSITY SCHOOL OF MEDICINE   (United States)

^e TORONTO REHABILITATION INSTITUTE   (Canada)

^f RAMBAM MEDICAL CENTER   (Israel)

Author keywords

[No Author keywords available]

Indexed keywords

ADENYLATE CYCLASE; ALKALINE PHOSPHATASE; CHOLERA TOXIN; CYCLIC AMP; FORSKOLIN; OSTEOCALCIN; PARATHYROID HORMONE;

ADULT; ALBRIGHT SYNDROME; ARTICLE; BONE CELL; CALCIUM CELL LEVEL; CASE REPORT; HORMONE RESPONSE; HUMAN; MALE; PATHOGENESIS; PSEUDOHYPOPARATHYROIDISM;

EID: 0030042981     PISSN: 08840431     EISSN: None     Source Type: Journal    
DOI: 10.1002/jbmr.5650110103     Document Type: Article

References (41)

1. Albright F, Burnett CH, Smith PH 1942 Pseudohypoparathyroidism: An example of "Seabright bantam syndrome." Endocrinology 30:922-932.
2. Werder EA, Fischer JA, Illig R, Kind HP, Bernasconi S, Fanconi A, Prader H 1978 Pseudohypoparathyroidism and idiopathic hypoparathyroidism: Relationship between serum calcium and parathyroid hormone levels and urinary cyclic adenosine 3′.5′-monophosphate response to parathyroid extract. J Clin Endocrinol Metab 46:872-879.
3. Nusinowitz ML, Frame B, Kolb FO 1976 The spectrum of hypoparathyroid states: A classification based on physiologic principles. Medicine (Baltimore) 55:105-119.
4. Allen EH, Millard FJC Nassim JR 1968 Hypo-hyperparathyroidism. Arch Dis Child 43:295-301.
5. Frame B, Hanson CA, Fross HM, Block M, Arnstein AR 1972 Renal resistance to parathyroid hormone with osteitis fibrosa: "Pseudohypohyperpara-thyroidism." Am J Med 52:311-321.
6. Kidd GS, Schaaf M, Adler RA, Lassman MN, Wray HL 1980 Skeletal responsiveness in pseudohypoparathyroidism: A spectrum of clinical disease. Am J Med 68:772-781.
7. Kolb FO. Steinbach HL 1962 Pseudohypoparathyroidism with secondary hyperparathyroidism and osteitis fibrosa. J Clin Endocrinol Metabol 22:59-70.
8. Nagant de Deuxchaisnes C, Krane SM 1978 Hypoparathyroidism. In: Avioli CV, Krane SM (eds.) Metabolic Bone Disease, Vol. 2. Academic Press, New York, pp. 218-445.
9. Singleton EB, Teng CT 1962 Pseudohypoparathyroidism with bone changes simulating hyperparathyroidism: Report of a case. Radiology 38:388-393.
10. Breslau NA, Moses AM, Pak CY 1983 Evidence for bone remodeling but lack of calcium mobilization response to parathyroid hormone in pseudohypoparathyroidism. J Clin Endocrinol Metab 57:638-644.
11. Cohen RD, Vince FP 1969 Pseudohypoparathyroidism with raised plasma alkaline phosphatase. Arch Dis Child 44:96-101.
12. Kruse K, Kracht U, Wolfhart K, Kruse U 1989 Biochemical markers of bone turnover, intact serum parathyroid hormone and renal calcium secretion in patients with pseudohypoparathyroidism and hypoparathyroidism before and during vitamin D treatment. Eur J Pediatr 148:535-539.
13. Levine MA, Downs RW, Singer MJ, Marx SJ, Aurbach GD, Spiegel AM 1980 Deficient activity of guanine nucleotide regulatory protein in erythrocytes from patients with pseudohypoparathyroidism. Biochem Biophys Res Commun 94:1319-1324.
14. Farfel Z, Brickman AS, Kaslow HR, Brothers VM, Bourne HR 1980 Defect of receptor cyclase coupling protein in pseudohypoparathyroidism. New Engl J Med 303:237-242.
15. Levine MA, Downs RW Jr, Moses AM, Breslau NA, Marx SJ, Lasker RD, Rirroli RE, Aurbach GD, Spiegel AM 1983 Resistance to multiple hormones in patients with pseudohypoparathyroidism and deficient guanine nucleotide regulatory protein. Am J Med 74:545-546.
16. Levine MA, Eil C, Downs RW Jr, Spiegel AM 1983 Deficient guanine nucleotide regulatory unit activity in cultured fibroblast membranes from patients with pseudohypoparathyroidism type I. J Clin Invest 72:316-324.
17. Murray TM, Keutmann HT 1973 The immunochemical specificity of antisera to bovine parathyroid hormone: An approach to region-specific immunoassay. J Endocrinol 56:493-501.
18. 3 in human plasma by high-performance liquid chromatography. Clin Chem 24:287-298.
19. Goverde BC, Veenkamp FJ 1972 Routine assay of total urinary hydroxyproline based on resin-catalysed hydrolysis. Clin Chim Acta 41:29-40.
20. Beresford JN, Gallagher JA, Gowan M, McGuire MKB, Poser J 1983 Human bone cells in culture: A novel system for the investigation of bone cell metabolism. Clin Sci 64:38-39.
21. Wong MM, Rao LG, Ly H, Hamilton L, Tong J, Sturtridge W, McBroom R, Aubin JE, Murray TM 1990 Long-term effects of physiologic concentrations of dexamethasone on human bone-derived cells. J Bone Miner Res 5:803-813.
22. Shimizu H, Daley JW, Creveling CR 1969 A radioisotopic method for measuring the formation of adenosine 3′.5′-cyclic monophosphate in incubated slices of brain. J Neurochem 16:1609-1619.
23. Salomon Y 1979 Adenylate cyclase assay. Adv Cyclic Nucleotide Res 10:35-55.
24. Price PA, Nichimoto SK 1980 Radioimmunoassay for the vitamin K-dependent protein of bone and its discovery in plasma. Proc Natl Acad Sci USA 77:2234-2238.
25. Lowry OH 1955 Micromethods for the assay of enzymes. II. Specific procedures: Alkaline phosphatase. Meth Enzymol 4:371-372.
26. Auf mkolk B, Hauschka PV, Schwartz ER 1985 Characterization of human bone cells in culture. Calcif Tissue Int 37:228-235.
27. Mizunashi K, Furukawa Y, Euy Sohn H, Miura R, Yumita S, Yoshinaga K 1990 Heterogeneity of pseudohypoparathyroidism type I from the aspect of urinary excretion of calcium and serum levels of parathyroid hormone. Calcif Tissue Int 46:227-232.
28. Abou-Samra AB, Yuppner H, Force T, Freeman MW. Kong XH, Schipani E, Urena P, Richards J, Bonventre JM, Potts JT Jr 1992 Expression cloning of a common receptor for parathyroid hormone and parathyroid hormone-related peptide from rat osteoblast-like cells: A single receptor stimulates intracellular accumulation of both cAMP and inositol triphosphate and increases intracellular free calcium. Proc Natl Acad Sci USA 89:2732-2736.
29. Murray TM, Rao LG, Wong MM, Waddell JP, McBroom R, Tam CS, Rosen A, Levine MA 1993 Pseudohypoparathyroidism with osteitis fibrosa cystica: Direct demonstration of skeletal responsiveness to parathyroid hormone in cells cultured from bone. J Bone Miner Res 8:83-91.
30. Patten JL, Johns DR, Valle D, Eu C, Gruppuso PA, Steele G, Smallwood PM, Levine MA 1990 Mutation in the gene encoding the stimulatory G protein of adenylate cyclase in Albright's hereditary osteodystrophy. New Engl J Med 322:1412-1419.
31. Levine MA, Jap TWS, Mauseth RS, Downs RW, Spiegel AM 1986 Activity of the stimulatory guanine nucleotide-binding protein is reduced in erythrocytes from patients with pseudohypoparathyroidism and pseudopseudohypoparathyroidism: Biochemical, endocrine, and genetic analysis of Albright's hereditary osteodystrophy in six kindreds. J Clin Endocrinol Metab 62:497-502.
32. Levine MA, Eil C, Downs RW Jr, Spiegel AM 1983 Deficient guanine nucleotide regulatory unit activity in cultured fibroblast membranes from patients with pseudohypoparathyroidism type I: A case of impaired synthesis of 3′,5′-cyclic AMP by intact and broken cells. J Clin Invest 72:316-324.
33. Downs RW Jr, Levine MA, Drezner MK, Burch WM Jr, Spiegel AM 1983 Deficient adenylate cyclase regulatory protein in renal membranes from a patient with pseudohypoparathyroidism. J Clin Invest 71:231-235.
34. s alpha-subunit gene in Albright's hereditary osteodystrophy detected by denaturing gradient gel electrophoresis. Proc Natl Acad Sci USA 87:8287-8290.
35. Motulsky HJ, Hughes RJ, Brickman AS, Farfel Z, Bourne HR, Insel PA 1982 Platelets of pseudohypoparathyroid patients: Evidence that distinct receptor-cyclase coupling proteins mediate stimulation and inhibition of adenylate cyclase. Proc Natl Acad Sci USA 79:4193-4197.
36. Farfel Z, Bourne HR 1980 Deficient activity of receptor-cyclase coupling protein in platelets of patients with pseudohypoparathyroidism J Clin Endocrinol Metabol 51:1202-1204.
37. Bourne HR, Kaslow HR, Brickman AS, Farfel Z 1981 Fibroblast defect in pseudohypoparathyroidism type I: Reduced activity of receptor-cyclase coupling protein. J Clin Endocrinol Metabol 53:636-640.
38. Farfel Z, Abood ME, Brickman AS, Bourne HR 1982 Deficient activity of receptor-cyclase coupling protein in transformed lymphoblasts of patients with pseudohypoparathyroidism, type I. J Clin Endocrinol Metabol 55:113-117.
39. Tang WJ, Gilman AG 1992 Adenylyl cyclases. Cell 70:869-872.
40. Gao BN, Gilman AG 1991 Cloning and expression of a widely distributed (type IV) adenylyl cyclase. Proc Natl Acad Sci USA 88:10178-10182.
41. Tang WJ, Gilman AG 1991 Type-specific regulation of adenylyl cyclase by G protein beta-gamma subunits. Science 254: 1500-1503.