Inhibition of WNT signaling by G protein-coupled receptor (GPCR) kinase 2 (GRK2)

Molecular Endocrinology

Volumn 23, Issue 9, 2009, Pages 1455-1465

  Wang, Liming ^a   Gesty Palmer, Diane ^a   Fields, Timothy A ^b   Spurney, Robert F ^a,c  

^a DUKE UNIVERSITY MEDICAL CENTER   (United States)

^b UNIVERSITY OF KANSAS SCHOOL OF MEDICINE   (United States)

^c NONE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

APC PROTEIN; BETA CATENIN; G PROTEIN COUPLED RECEPTOR KINASE 2; RGS PROTEIN; SMALL INTERFERING RNA; WNT PROTEIN; WNT3A PROTEIN;

AMINO TERMINAL SEQUENCE; ANIMAL CELL; ARTICLE; BONE MASS; CALVARIA; CONTROLLED STUDY; EMBRYO; ENZYME ACTIVITY; ENZYME REGULATION; GENE OVEREXPRESSION; HUMAN; HUMAN CELL; IMMUNOPRECIPITATION; INHIBITION KINETICS; MOUSE; NONHUMAN; OSSIFICATION; OSTEOBLAST; PRIORITY JOURNAL; PROTEIN DEPLETION; PROTEIN DOMAIN; PROTEIN PHOSPHORYLATION; PROTEIN PROTEIN INTERACTION; PROTEIN STABILITY; REPORTER GENE; RNA INTERFERENCE; SIGNAL TRANSDUCTION;

ANIMALS; BETA CATENIN; BONE AND BONES; CELL NUCLEUS; CULTURE MEDIA, CONDITIONED; G-PROTEIN-COUPLED RECEPTOR KINASE 2; GENE EXPRESSION REGULATION, ENZYMOLOGIC; HUMANS; MICE; MODELS, BIOLOGICAL; PROTEIN INTERACTION MAPPING; PROTEIN STRUCTURE, TERTIARY; RNA, SMALL INTERFERING; SIGNAL TRANSDUCTION; WNT PROTEINS;

EID: 69449105718     PISSN: 08888809     EISSN: None     Source Type: Journal    
DOI: 10.1210/me.2009-0084     Document Type: Article

References (54)

1. Eastell R 1998 Treatment of postmenopausal osteoporosis. N Engl J Med 338:736-746
2. Rodan GA, Martin TJ 2000 Therapeutic approaches to bone diseases. Science 289:1508-1514
3. Quarles LD, Siddhanti SR 1996 Guanine nucleotide binding-protein coupled signaling pathway regulation of osteoblast-mediated bone formation. J Bone Miner Res 11:1375-1383
4. Malbon CC, Wang H, Moon RT 2001 Wnt signaling and heterotrimeric G-proteins: strange bedfellows or a classic romance? Biochem Biophys Res Commun 287:589-593
5. Miller JR 2001 The Wnts. Genome Biol 3:S3001-S3015
6. Novak A, Dedhar S 1999 Signaling through β-catenin and Lef/Tcf. Cell Mol Life Sci 56:523-537
7. Eastman Q, Grosschedl R 1999 Regulation of LEF-1/TCF transcription factors by Wnts and other signals. Curr Opin Cell Biol 11:233-240 (Pubitemid 29164039)
8. Zeng X, Tamai K, Doble B, Li S, Huang H, Habas R, Okamura H, Woodgett J, He X 2005 A dual-kinase mechanism for Wnt co-receptor phosphorylation and activation. Nature 438:873-877 (Pubitemid 41753071)
9. Huelsken J, Behrens J 2002 The Wnt signaling pathway. J Cell Sci 115:3977-3978
10. Boyden LM, Mao J, Belsky J, Mitzner L, Farhi A, Mitnick MA, Wu D, Insogna K, Lifton RP 2002 High bone density due to a mutation in LDL-receptor-related protein 5. N Engl J Med 346:1513-1521 (Pubitemid 34755690)
11. Gong Y, Slee RB, Fukai N, Rawadi G, Roman-Roman S, Reginato AM, Wang H, Cundy T, Glorieux FH, Lev D, Zacharin M, Oexle K, Marcelino J, Suwairi W, Heeger S, Sabatakos G, Apte S, Adkins WN, Allgrove J, Arslan-Kirchner M, Batch JA, Beighton P, Black GC, Boles RG, Boon LM, et al. 2001 Osteoporosis-Pseudoglioma Syndrome Collaborative Group LDL receptor-related protein 5 (LRP5) affects bone accrual and eye development. Cell 107:513-523
12. Ferguson SS, Barak LS, Zhang J, Caron MG 1996 G-protein-coupled receptor regulation: role of G-protein-coupled receptor kinases and arrestins. Can J Physiol Pharmacol 74:1095-1110 (Pubitemid 27047505)
13. Kohout TA, Lefkowitz RJ 2003 Regulation of G protein-coupled receptor kinases and arrestins during receptor desensitization. Mol Pharmacol 63:9-18 (Pubitemid 36043803)
14. Lefkowitz RJ 1993 G-protein-coupled receptor kinases. Cell 74:409-412
15. Premont RT, Inglese J, Lefkowitz RJ 1995 Protein kinases that phosphorylate activated G protein-coupled receptors. FASEB J 9:175-182
16. Ahumada A, Slusarski DC, Liu X, Moon RT, Malbon CC, Wang HY 2002 Signaling of rat frizzled-2 through phosphodiesterase and cyclic GMP. Science 298:2006-2010 (Pubitemid 35425259)
17. Liu X, Liu T, Slusarski DC, Yang-Snyder J, Malbon CC, Moon RT, Wang H 1999 Activation of a frizzled-2/β-adrenergic receptor chimera promotes Wnt signaling and differentiation of mouse F9 teratocarcinoma cells via Gαo and Gαt. Proc Natl Acad Sci USA 96:14383-14388 (Pubitemid 30000659)
18. Liu T, DeCostanzo AJ, Liu X, Wang Hy, Hallagan S, Moon RT, Malbon CC 2001 G protein signaling from activated rat frizzled-1 to the β-catenin-Lef-Tcf pathway. Science 292:1718-1722 (Pubitemid 32506245)
19. Slusarski DC, Yang-Snyder J, Busa WB, Moon RT 1997 Modulation of embryonic intracellular Ca2+ signaling by Wnt-5A. Dev Biol 182:114-120 (Pubitemid 27107320)
20. Chen W, ten Berge D, Brown J, Ahn S, Hu LA, Miller WE, Caron MG, Barak LS, Nusse R, Lefkowitz RJ 2003 Dishevelled 2 recruits β-arrestin 2 to mediate Wnt5A-stimulated endocytosis of frizzled 4. Science 301:1391-1394
21. Wang HY, Malbon CC 2003 Wnt signaling, Ca2+, and cyclic GMP: visualizing frizzled functions. Science 300:1529-1530
22. Wu C, Zeng Q, Blumer KJ, Muslin AJ 2000 RGS proteins inhibit Xwnt-8 signaling in Xenopus embryonic development. Development 127:2773-2784
23. Fagotto F, Jho E, Zeng L, Kurth T, Joos T, Kaufmann C, Costantini F 1999 Domains of axin involved in protein-protein interactions, Wnt pathway inhibition, and intracellular localization. J Cell Biol 145:741-756 (Pubitemid 29240852)
24. Song DH, Sussman DJ, Seldin DC 2000 Endogenous protein kinase CK2 participates in Wnt signaling in mammary epithelial cells. J Biol Chem 275:23790-23797
25. Sterne-Marr R, Tesmer JJ, Day PW, Stacquantanio RP, Cilente JE, O'Connor KE, Pronin AN, Benovic JL, Wedegaertner PB 2003 G protein-coupled receptor kinase 2/Gαq/11 interaction. J Biol Chem 278:6050-6058
26. Koch WJ, Inglese J, Stone WC, Lefkowitz RJ 1993 The binding site for βγ-subunits of β-adrenergic receptor kinase. J Biol Chem 268:8256-8260
27. Flannery PJ, Spurney RF 2001 Domains of the parathyroid hormone (PTH) receptor required for regulation by G protein-coupled receptor kinases. Biochem Pharmacol 62:1047-1058
28. Moon RT, Bowerman B, Boutros M, Perrimon N 2002 The promise and perils of Wnt signaling through β-catenin. Science 296:1644-1646 (Pubitemid 34579151)
29. Giles RH, van Es JH, Clevers H 2003 Caught up in a Wnt storm: Wnt signaling in cancer. Biochim Biophys Acta 1653:1-24 (Pubitemid 36627817)
30. Reya T, Duncan AW, Ailles L, Domen J, Scherer DC, Willert K, Hintz L, Nusse R, Weissman IL 2003 A role for Wnt signaling in self-renewal of haematopoietic stem cells. Nature 423:409-414 (Pubitemid 36626987)
31. Kato M, Patel MS, Levasseur R, Lobov I, Chang BH, Glass II DA, Hartmann C, Li L, Hwang TH, Brayton CF, Lang RA, Karsenty G, Chan L 2002 Cbfa 1-independent decrease in osteoblast proliferation, osteopenia, and persistent embryonic eye vascularization in mice deficient in Lrp5, a Wnt coreceptor. J Cell Biol 157:303-314 (Pubitemid 34839826)
32. Johnson ML, Gong G, Kimberling W, Reckŕ SM, Kimmel DB, Recker RB 1997 Linkage of a gene causing high bone mass to human chromosome 11 (11q12-13). Am J Hum Genet 60:1326-1332 (Pubitemid 27258064)
33. Wang L, Lui S, Quarles LD, Spurney RF 2005 Targeted overexpression of G protein coupled receptor kinase 2 in osteoblasts promotes bone loss. Am J Physiol 288:E826-E834 (Pubitemid 40397221)
34. Spurney RF, Flannery PJ, Garner SC, Athirakul K, Liu S, Guilak F, Quarles LD 2002 Anabolic effects of a G protein-coupled receptor kinase inhibitor expressed in osteoblasts. J Clin Invest 109:1361-1371 (Pubitemid 34546901)
35. 2 promotes colon cancer cell growth through a Gs-axin-β-catenin signaling axis. Science 310:1504-1510
36. Wang L, Quarles LD, Spurney RF 2004 Unmasking the osteoinductive effects of a G protein-coupled receptor kinase inhibitor by treatment with PTH(1-34). J Bone Miner Res 19:1661-1670 (Pubitemid 41094329)
37. Bodine PV, Zhao W, Kharode YP, Bex FJ, Lambert AJ, Goad MB, Gaur T, Stein GS, Lian JB, Komm BS 2004 The Wnt antagonist secreted frizzled-related protein-1 is a negative regulator of trabecular bone formation in adult mice. Mol Endocrinol 18:1222-1237 (Pubitemid 38591287)
38. Hall RA, Spurney RF, Premont RT, Rahman N, Blitzer JT, Pitcher JA, Lefkowitz RJ 1999 G-protein-coupled receptor kinase 6A binds to and phosphorylates the Na+/H+ exchanger regulatory factor (NHERF) via a PDZ domain-mediated interaction. J Biol Chem 274:24328-24334 (Pubitemid 29390371)
39. Pitcher JA, Hall RA, Daaka Y, Zhang J, Ferguson SS, Hester S, Miller S, Caron MG, Lefkowitz RJ, Barak LS 1998 The G protein-coupled receptor kinase 2 is a microtubule-associated protein kinase that phosphorylates tubulin. J Biol Chem 273:12316-12324 (Pubitemid 28240600)
40. Freeman JL, Pitcher JA, Li X, Bennett V, Lefkowitz RJ 2000 α-Actinin is a potent regulator of G protein-coupled receptor kinase activity and substrate specificity in vitro. FEBS Lett 473:280-284 (Pubitemid 30249140)
41. Freeman JL, Gonzalo P, Pitcher JA, Claing A, Lavergne JP, Reboud JP, Lefkowitz RJ 2002 β2-adrenergic receptor stimulated, G protein- coupled receptor kinase 2 mediated, phosphorylation of ribosomal protein P2. Biochemistry 41:12850-12857 (Pubitemid 35192514)
42. Pronin AN, Morris AJ, Surguchov A, Benovic JL 2000 Synucleins are a novel class of substrates for G protein-coupled receptor kinases. J Biol Chem 275:26515-26522 (Pubitemid 30676709)
43. Yanfeng WA, Tan C, Fagan RJ, Klein PS 2006 Phosphorylation of frizzled-3. J Biol Chem 281:11603-11609
44. van Gijn ME, Daemen MJ, Smits JF, Blakesteijn WM 2002 The Wnt-frizzled cascade in a cardiovascular disease. Cardiovasc Res 55:16-24
45. Yu QM, Cheng ZJ, Gan XQ, Bao GB, Li L, Pei G 1999 The amino terminus with a conserved glutamic acid of G protein-coupled receptor kinases is indispensable for their ability to phosphorylate photoactivated rhodopsin. J Neurochem 73:1222-1227 (Pubitemid 29395482)
46. Becker-Hapak M, McAllister SS, Dowdy SF 2001 TAT-mediated protein transduction into mammalian cells. Methods 24:247-256 (Pubitemid 32846431)
47. Freedman NJ, Liggett SB, Drachman DE, Pei G, Caron MG, Lefkowitz RJ 1995 Phosphorylation and desensitization of the human β-adrenergic receptor Involvement of G protein-coupled receptor kinases and cAMP-dependent protein kinase. J Biol Chem 270:17953-17961
48. Miller JR, Moon RT 1997 Analysis of the signaling activities of localization mutants of β-catenin during axis specification in Xenopus. J Cell Biol 139:229-243
49. Willert K, Brown JD, Danenberg E, Duncan AW, Weissman IL, Reya T, Yates 3rd JR, Nusse R 2003 Wnt proteins are lipid-modified and can act as stem cell growth factors. Nature 423:448-452
50. Andrews NC, Faller DV 1991 A rapid micropreparation technique for extraction of DNA-binding proteins from limiting number of mammalian cells. Nuclei Acids Res 19:2499-2505
51. Laemmli UK 1970 Cleavage of structural proteins during the assembly of the head of bacteriophage T4. Nature 227:680-685
52. Kim J, Ahn S, Ren XR, Whalen EJ, Reiter E, Wei H, Lefkowitz RJ 2005 Functional antagonism of different G protein-coupled receptor kinases for β-arrestin-mediated angiotensin II receptor signaling. Proc Natl Acad Sci USA 102:1442-1447 (Pubitemid 40209189)
53. Spurney RF 1998 Role of C-terminal serines in desensitization and phosphorylation of the mouse thromboxane receptor. J Biol Chem 273:28496-28503 (Pubitemid 28496156)
54. Pi M, Garner SC, Flannery P, Spurney RF, Quarles LD 2000 Sensing extracellular cations in CasR-deficient osteoblasts: Evidence for a novel cation-sensing mechanism. J Biol Chem 275:3256-3263 (Pubitemid 30083026)