Parathyroid hormone activates phosphoinositide 3-kinase-Akt-Bad cascade in osteoblast-like cells

Bone

Volumn 40, Issue 2, 2007, Pages 354-359

  Yamamoto, Takuya ^a,b   Kambe, Fukushi ^a   Cao, Xia ^a   Lu, Xiuli ^a   Ishiguro, Naoki ^b   Seo, Hisao ^a  

^a NAGOYA UNIVERSITY   (Japan)

^b NAGOYA UNIVERSITY SCHOOL OF MEDICINE   (Japan)

Author keywords

Akt; Apoptosis; p85 PI3K; Parathyroid hormone (PTH); PTH 1R

Indexed keywords

2 MORPHOLINO 8 PHENYLCHROMONE; PARATHYROID HORMONE; PARATHYROID HORMONE RECEPTOR 1; PHOSPHATIDYLINOSITOL 3 KINASE; PHOSPHATIDYLINOSITOL 3 KINASE INHIBITOR; PROTEIN BAD; PROTEIN KINASE B; PROTEIN P85; WORTMANNIN;

ANIMAL CELL; ARTICLE; CELL CULTURE; CELL LINE; CELL SURVIVAL; COIMMUNOPRECIPITATION; CONTROLLED STUDY; CULTURE MEDIUM; ENZYME ACTIVATION; ENZYME ACTIVITY; ENZYME INHIBITION; ENZYME PHOSPHORYLATION; HORMONE ACTION; IMMUNOPRECIPITATION; NONHUMAN; OSTEOBLAST; OSTEOBLAST LIKE CELL; PROTEIN PHOSPHORYLATION; PROTEIN PROTEIN INTERACTION; PROTEIN TRANSPORT; RAT; SERUM; SIGNAL TRANSDUCTION; WESTERN BLOTTING;

1-PHOSPHATIDYLINOSITOL 3-KINASE; ANDROSTADIENES; ANIMALS; APOPTOSIS; BCL-ASSOCIATED DEATH PROTEIN; CELL LINE; CELL SURVIVAL; CHROMONES; ENZYME ACTIVATION; HUMANS; MORPHOLINES; OSTEOBLASTS; PARATHYROID HORMONE; PEPTIDE FRAGMENTS; PHOSPHORYLATION; PROTO-ONCOGENE PROTEINS C-AKT; RATS; RECEPTOR, PARATHYROID HORMONE, TYPE 1; SIGNAL TRANSDUCTION;

EID: 33845978384     PISSN: 87563282     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bone.2006.09.002     Document Type: Article

References (23)

1. Dempster D.W., Cosman F., Parisien M., Shen V., and Lindsay R. Anabolic actions of parathyroid hormone on bone. Endocr. Rev. 14 (1993) 690-709
2. Neer R.M., Arnaud C.D., Zanchetta J.R., Prince R., Gaich G.A., Reginster J.Y., et al. Effect of parathyroid hormone (1-34) on fractures and bone mineral density in postmenopausal women with osteoporosis. N. Engl. J. Med. 344 (2001) 1434-1441
3. Jilka R.L., Weinstein R.S., Bellido T., Roberson P., Parfitt A.M., and Manolagas S.C. Increased bone formation by prevention of osteoblast apoptosis with parathyroid hormone. J. Clin. Invest. 104 (1999) 439-446
4. Juppner H., Abou-Samra A.B., Freeman M., Kong X.F., Schipani E., Richards J., et al. A G protein-linked receptor for parathyroid hormone and parathyroid hormone-related peptide. Science 254 (1991) 1024-1026
5. Partridge N.C., Bloch S.R., and Pearman A.T. Signal transduction pathways mediating parathyroid hormone regulation of osteoblastic gene expression. J. Cell. Biochem. 55 (1994) 321-327
6. Lanske B., Karaplis A.C., Lee K., Luz A., Vortkamp A., Pirro A., et al. PTH/PTHrP receptor in early development and Indian hedgehog-regulated bone growth. Science 273 (1996) 663-666
7. Datta S.R., Brunet A., and Greenberg M.E. Cellular survival: a play in three Akts. Genes Dev. 13 (1999) 2905-2927
8. Wymann M.P., and Marone R. Phosphoinositide 3-kinase in disease: timing, location, and scaffolding. Curr Opin Cell Biol 17 (2005) 141-149
9. Woodgett J.R. Recent advances in the protein kinase B signaling pathway. Curr Opin Cell Biol 17 (2005) 150-157
10. Gentili C., Morelli S., and Russo De Boland A. Involvement of PI3-kinase and its association with c-Src in PTH-stimulated rat enterocytes. J. Cell. Biochem. 86 (2002) 773-783
11. Cao X., Kambe F., Moeller L.C., Refetoff S., and Seo H. Thyroid hormone induces rapid activation of Akt/protein kinase B-mammalian target of rapamycin-p70S6K cascade through phosphatidylinositol 3-kinase in human fibroblasts. Mol. Endocrinol. 19 (2005) 102-112
12. Meier R., Alessi D.R., Cron P., Andjelkovic M., and Hemmings B.A. Mitogenic activation, phosphorylation, and nuclear translocation of protein kinase Bbeta. J. Biol. Chem. 272 (1997) 30491-30497
13. Astoul E., Watton S., and Cantrell D. The dynamics of protein kinase B regulation during B cell antigen receptor engagement. J. Cell Biol. 145 (1999) 1511-1520
14. Vazquez F., and Sellers W.R. The PTEN tumor suppressor protein: an antagonist of phosphoinositide 3-kinase signaling. Biochim Biophys Acta 1470 (2000) M21-M35
15. Nielsen-Preiss S.M., Silva S.R., and Gillette J.M. Role of PTEN and Akt in the regulation of growth and apoptosis in human osteoblastic cells. J Cell Biochem 90 (2003) 964-975
16. Bellido T., Ali A.A., Plotkin L.I., Fu Q., Gubrij I., Roberson P.K., et al. Proteasomal degradation of Runx2 shortens parathyroid hormone-induced anti-apoptotic signaling in osteoblasts. A putative explanation for why intermittent administration is needed for bone anabolism. J. Biol. Chem. 278 (2003) 50259-50272
17. Razzouk S., and Shapiro I.M. Detection of apoptotic gene expression in human osteoblast-like cells by cDNA microarrays. J. Bone Miner. Metab. 21 (2003) 261-267
18. Hu Y., Yao J., Liu Z., Liu X., Fu H., and Ye K. Akt phosphorylates acinus and inhibits its proteolytic cleavage, preventing chromatin condensation. EMBO J. 24 (2005) 3543-3554
19. Chen H.L., Demiralp B., Schneider A., Koh A.J., Silve C., Wang C.Y., et al. Parathyroid hormone and parathyroid hormone-related protein exert both pro- and anti-apoptotic effects in mesenchymal cells. J. Biol. Chem. 277 (2002) 19374-19381
20. Linkhart T.A., and Mohan S. Parathyroid hormone stimulates release of insulin-like growth factor-I (IGF-I) and IGF-II from neonatal mouse calvaria in organ culture. Endocrinology 125 (1989) 1484-1491
21. Wu Y., and Kumar R. Parathyroid hormone regulates transforming growth factor beta1 and beta2 synthesis in osteoblasts via divergent signaling pathways. J Bone Miner Res 15 (2000) 879-884
22. Rosen C.J., and Bilezikian J.P. Clinical review 123: anabolic therapy for osteoporosis. J Clin Endocrinol Metab 86 (2001) 957-964
23. Sowa H., Kaji H., Iu M.F., Tsukamoto T., Sugimoto T., and Chihara K. Parathyroid hormone-Smad3 axis exerts anti-apoptotic action and augments anabolic action of transforming growth factor beta in osteoblasts. J. Biol. Chem. 278 (2003) 52240-52252