Pasteurella multocida toxin: The mitogenic toxin that stimulates signalling cascades to regulate growth and differentiation

International Journal of Medical Microbiology

Volumn 291, Issue 4, 2001, Pages 261-268

  Lax, Alistair J ^a,b   Grigoriadis, Agamemnon E ^a  

^a KING'S COLLEGE LONDON   (United Kingdom)

^b Department of Oral Microbiology   (United Kingdom)

Author keywords

G proteins; Mitogenesis; Osteoblast differentiation; Pasteurella multocida toxin; Rho proteins

Indexed keywords

EID: 0034798767     PISSN: 14384221     EISSN: None     Source Type: Journal    
DOI: 10.1078/1438-4221-00129     Document Type: Article

References (51)

1. Experimental model of atrophic rhinitis in gnotobiotic pigs
2. Increased dosage and amplification of the focal adhesion kinase gene in human cancer cells
3. Advances in the osteoblast lineage
4. Selected glimpses into the activation and function of Src kinase
5. Differential potentiation of mitogen-stimulated phosphoinositide hydrolysis in protein kinase C-depleted Swiss 3T3 cells
6. Phosphoinositide 3-kinase signalling pathways
7. Expression cDNA cloning of a transforming gene encoding the wild-type Gα12 gene product
8. The regulator of G protein signaling family
9. Dermonecrotic toxin production by strains of Pasteurella multocida isolated from man
10. The osteoblast: A sophisticated fibroblast under central surveillance
11. Pasteurella multocida toxin increases endothelial permeability via Rhokinase and myosin light chain phosphatase
12. Effect of Pasteurella multocida toxin on bone resorption in vitro
13. Pasteurella multocida toxin - The characterisation of the toxin and its significance in the diagnosis and prevention of progressive atrophic rhinitis in pigs
14. Pasteurella multocida toxin is a potent inducer of anchorage-independent cell growth
15. Nasal infection with Pasteurella multocida causes proliferation of bladder epithelium in gnotobiotic pigs
16. The genetic transformation of bone biology
17. FAK and paxillin tyrosine phosphorylation, actin stress fiber formation, and focal contact assembly in Swiss 3T3 cells
18. rho-dependent tyrosine phosphorylation of focal adhesion kinase and paxillin in Swiss 3T3 cells
19. Cloning of the toxin gene from Pasteurella multocida and its role in atrophic rhinitis
20. Molecular localization of the Escherichia coli cytotoxic necrotizing factor CNF1 cell-binding and catalytic domains
21. Guanine nucleotide exchange factor GEF115 specifically mediates activation of Rho and serum response factor by the G protein α subunit Gα13
22. Bacterial protein toxins penetrate cells via a four-step mechanism
23. Pasteurella multocida toxin is a mitogen for bone cells in primary culture
24. Pasteurella multocida toxin stimulates bone resorption by osteoclasts via interaction with osteoblasts
25. Pasteurella multocida toxin selectively facilitates phosphatidylinositol 4,5-bisphosphate hydrolysis by bombesin, vasopressin, and endothelin
26. i in ACTH-unresponsive human adrenocortical cancer
27. Purification to homogeneity of protein kinase C from bovine brain - Identity with the phorbol ester receptor
28. The aetiological significance of Bordetella bronchiseptica and Pasteurella multocida in atrophic rhinitis of swine
29. Receptor-mediated binding of Pasteurella multocida dermonecrotic toxin to canine osteosarcoma and monkey kidney (vero) cells
30. Bacterial toxins with intracellular protease activity
31. Pasteurella multocida toxin: Potent mitogen for cultured fibroblasts
32. Pathogenesis of atrophic rhinitis in pigs: A new perspective
33. 11 protein stimulation in rat liver membranes
34. q/11-dependent transactivation of the epidermal growth factor receptor
35. The potent mitogen Pasteurella multocida toxin is highly resistant to proteolysis but becomes susceptible at lysosomal pH
36. Reduced pH causes structural changes in the potent mitogenic toxin of Pasteurella multocida
37. Signal transduction by G-proteins, Rhokinase and protein phosphatase to smooth muscle and non-muscle myosin II
38. 2+ in Swiss 3T3 cells
39. A novel approach to detect toxin-catalyzed ADP-ribosylation in intact cells: Its use to study the action of Pasteurella multocida toxin
40. Pasteurella multocida toxin, a potent mitogen, stimulates protein kinase C-dependent and -independent protein phosphorylation in Swiss 3T3 cells
41. Effects of Pasteurella multocida toxin on osteoblastic cells in vitro
42. Modulation of osteoclast differentiation and function by the new members of the tumor necrosis factor receptor and ligand families
43. Bone resorption by osteoclasts
44. Escherichia coli cytotoxic necrotizing factor and Pasteurella multocida toxin induce FAK autophosphorylation and Src association
45. p125 focal adhesion kinase promotes malignant astrocytoma cell proliferation in vivo
46. Activity of the mitogenic Pasteurella multocida toxin requires an essential C-terminal residue
47. Activation of calcium/calmodulin regulated kinases
48. Localization of the intracellular activity domain of Pasteurella multocida toxin to the N terminus
49. qα-coupled phospholipase C-β1
50. 12 potentiates the eicosanoid pathway and is highly oncogenic in NIH 3T3 cells
51. q-dependent and -independent mechanisms