Cannabinoid receptor type 2 gene is associated with human osteoporosis

Human Molecular Genetics

Volumn 14, Issue 22, 2005, Pages 3389-3396

  Karsak, Meliha ^a   Cohen Solal, Martine ^b   Freudenberg, Jan ^c   Ostertag, Agnes ^b   Morieux, Caroline ^b   Kornak, Uwe ^d   Essig, Julia ^a   Erxlebe, Edda ^a   Bab, Itai ^e   Kubisch, Christian ^f   de Vernejoul, Marie Christine ^b   Zimmer, Andreas ^a  

^a UNIVERSITY OF BONN   (Germany)

^b HÔPITAL LARIBOISIÈRE   (France)

^c UNIVERSITY OF CALIFORNIA   (United States)

^d University Hospital   (Germany)

^e HEBREW UNIVERSITY OF JERUSALEM   (Israel)

^f UNIVERSITY OF COLOGNE   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

CANNABINOID 1 RECEPTOR; CANNABINOID 2 RECEPTOR;

ADULT; AGED; ARTICLE; BONE DENSITY; BONE MASS; CELL ACTIVITY; CHROMOSOME 1P; CONTROLLED STUDY; FEMALE; GENE DELETION; GENE FUNCTION; GENE TARGETING; GENETIC ASSOCIATION; HAPLOTYPE; HUMAN; MAJOR CLINICAL STUDY; OSTEOCLAST; PATHOLOGY; POSTMENOPAUSE OSTEOPOROSIS; PRIORITY JOURNAL; PROTEIN MODIFICATION; SINGLE NUCLEOTIDE POLYMORPHISM;

ANIMALS; BASE SEQUENCE; CASE-CONTROL STUDIES; CHROMOSOMES, HUMAN, PAIR 1; FEMALE; HUMANS; MICE; MIDDLE AGED; MOLECULAR SEQUENCE DATA; OSTEOPOROSIS; POLYMORPHISM, SINGLE NUCLEOTIDE; RECEPTOR, CANNABINOID, CB1; RECEPTOR, CANNABINOID, CB2;

EID: 27944510259     PISSN: 09646906     EISSN: 14602083     Source Type: Journal    
DOI: 10.1093/hmg/ddi370     Document Type: Article

References (20)

1. Foroud, T., Econs, M.J. and Johnston, C.C. (2002) Genetics of osteoporosis. In King, R.A., Rotter, J.I. and Motulsky, A.G. (eds), The Genetic Basis of Common Diseases, 2nd edn. Oxford University Press, Oxford, pp. 510-517.
2. Grant, S.F., Reid, D.M., Blake, G., Herd, R., Fogelman, I. and Ralston, S.H. (1996) Reduced bone density and osteoporosis associated with a polymorphic Sp1 binding site in the collagen type I alpha 1 gene. Nat. Genet., 14, 203-205.
3. Morrison, N.A., Qi, J.C., Tokita, A., Kelly, P.J., Crofts, L., Nguyen, T.V., Sambrook, P.N. and Eisman, J.A. (1994) Prediction of bone density from vitamin D receptor alleles. Nature, 367, 284-287.
4. Gong, Y., Slee, R.B., Fukai, N., Rawadi, G., Roman-Roman, S., Reginato, A.M., Wang, H., Curdy, T., Glorieux, F.H., Lev, D. et al. (2001) LDL receptor-related protein 5 (LRP5) affects bone accrual and eye development. Cell, 107, 513-523.
5. Styrkarsdottir, U., Cazier, J.B., Kong, A., Rolfsson, O., Larsen, H., Bjarnadottir, E., Johannsdottir, V.D., Sigurdardottir, M.S., Bagger, Y., Christiansen, C. et al. (2003) Linkage of osteoporosis to chromosome 20p12 and association to BMP2. PLoS Biol., 1, E69.
6. Devoto, M., Shimoya, K., Caminis, J., Ott, J., Tenenhouse, A., Whyte, M.P., Sereda, L., Hall, S., Considine, E., Williams, C.J. et al. (1998) First-stage autosomal genome screen in extended pedigrees suggests genes predisposing to low bone mineral density on chromosomes 1p, 2p and 4q. Eur. J. Hum. Genet., 6, 151-157.
7. Devoto, M., Specchia, C., Li, H.H., Caminis, J., Tenenhouse, A., Rodriguez, H. and Spotila, L.D. (2001) Variance component linkage analysis indicates a QTL for femoral neck bone mineral density on chromosome 1p36. Hum. Mol. Genet., 10, 2447-2452.
8. Devoto, M., Spotila, L.D., Stabley, D.L., Wharton, G.N., Rydbeck, H., Korkko, J., Kosich, R., Prockop, D., Tenenhouse, A. and Sol-Church, K. (2005) Univariate and bivariate variance component linkage analysis of a whole-genome scan for loci contributing to bone mineral density. Eur. J. Hum. Genet., 13, 781-788.
9. Karsak, M., Ofek, O., Fogel, M., Wright, K., Tam, J., Gabet, Y., Birenboim, R., Attar-Namdar, M., Müller, R., Cohen-Solal, M. et al. (2004) The cannabinoid CB2 receptor: A potential target for the treatment of osteoporosis. J. Bone Miner. Res., 19, S383.
10. Idris, A.I., van't Hof, R.J., Greig, I.R., Ridge, S.A., Baker, D., Ross, R.A. and Ralston, S.H. (2005) Regulation of bone mass, bone loss and osteoclast activity by cannabinoid receptors. Mat. Med., 11, 774-779.
11. Herkenham, M., Lynn, A.B., Little, M.D., Johnson, M.R., Melvin, L.S., de Costa, B.R. and Rice, K.C. (1990) Cannabinoid receptor localization in brain. Proc. Natl Acad. Sci. USA, 87, 1932-1936.
12. Zimmer, A., Zimmer, A.M., Hohmann, A.G., Herkenham, M. and Bonner, T.I. (1999) Increased mortality, hypoactivity, and hypoalgesia in cannabinoid CB1 receptor knockout mice. Proc. Natl Acad. Sci. USA, 96, 5780-5785.
13. Munro, S., Thomas, K.L. and Abu-Shaar, M. (1993) Molecular characterization of a peripheral receptor for cannabinoids. Nature, 365, 61-65.
14. Beamer, W.G., Shultz, K.L., Donahue, L.R., Churchill, G.A., Sen, S., Wergedal, J.R., Baylink, D.J. and Rosen, C.J. (2001) Quantitative trait loci for femoral and lumbar vertebral bone mineral density in C57BL/6J and C3H/HeJ inbred strains of mice. J. Bone Miner. Res., 16, 1195-1206.
15. Klein, R.F., Shea, M., Gunness, M.E., Petz, G.B., Belknap, J.K. and Orwoll, E.S. (2001) Phenotypic characterization of mice bred for high and low peak bone mass. J. Bone Miner. Res., 16, 63-71.
16. Hinds, D.A., Stuve, L.L., Nilsen, G.B., Halperin, E., Eskin, E., Ballinger, D.G., Frazer, K.A. and Cox, D.R. (2005) Whole-genome patterns of common DNA variation in three human populations. Science, 307, 1072-1079.
17. Zhang, K., Qin, Z., Chen, T., Liu, J.S., Waterman, M.S. and Sun, F. (2005) HapBlock: Haplotype block partitioning and tag SNP selection software using a set of dynamic programming algorithms. Bioinformatics, 21, 131-134.
18. Steffens, S., Veillard, N.R., Arnaud, C., Pelli, G., Burger, F., Staub, C., Karsak, M., Zimmer, A., Frossard, J.L. and Mach, F. (2005) Low dose oral cannabinoid therapy reduces progression of atherosclerosis in mice. Nature, 434, 782-786.
19. Jorgensen, L., Joakimsen, O., Rosvold Berntsen, G.K., Heuch, I. and Jacobsen, B.K. (2004) Low bone mineral density is related to echogenic carotid artery plaques: A population-based study. Am. J. Epidemiol., 160, 549-556.
20. Barrett, J.C., Fry, B., Mallet, J. and Daly, M.J. (2005) Haploview: analysis and visualization of LD and haplotype maps. Bioinformatics, 21, 263-265.