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Volumn 144, Issue 12, 2003, Pages 5511-5520

Parathyroid Hormone-Related Peptide Interacts with Bone Morphogenetic Protein 2 to Increase Osteoblastogenesis and Decrease Adipogenesis in Pluripotent C3H10T1/2 Mesenchymal Cells

Author keywords

[No Author keywords available]

Indexed keywords

ADIPOCYTE SPECIFIC PROTEIN AP2; ALKALINE PHOSPHATASE; BONE MORPHOGENETIC PROTEIN 2; BONE MORPHOGENETIC PROTEIN RECEPTOR; CHELERYTHRINE; COLLAGEN TYPE 1; HORMONE RECEPTOR; OSTEOCALCIN; PARATHYROID HORMONE RELATED PROTEIN; PARATHYROID HORMONE RELATED PROTEIN RECEPTOR; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR GAMMA; PHORBOL ESTER DERIVATIVE; PROTEIN; PROTEIN KINASE C ACTIVATOR; PROTEIN KINASE C INHIBITOR; SMAD PROTEIN; UNCLASSIFIED DRUG;

EID: 0345688670     PISSN: 00137227     EISSN: None     Source Type: Journal    
DOI: 10.1210/en.2003-0273     Document Type: Article
Times cited : (68)

References (46)
  • 1
    • 0023787477 scopus 로고
    • Differentiation of muscle, fat, cartilage, and bone from progenitor cells present in a bone-derived clonal cell population: Effect of dexamethasone
    • Grigoriadis AE, Heersche JN, Aubin JE 1988 Differentiation of muscle, fat, cartilage, and bone from progenitor cells present in a bone-derived clonal cell population: effect of dexamethasone. J Cell Biol 106:2139-2151
    • (1988) J Cell Biol , vol.106 , pp. 2139-2151
    • Grigoriadis, A.E.1    Heersche, J.N.2    Aubin, J.E.3
  • 2
    • 0015137446 scopus 로고
    • Osteoporosis and the replacement of cell populations of the marrow by adipose tissue. A quantitative study of 84 iliac bone biopsies
    • Meunier P, Aaron J, Edouard C, Vignon G 1971 Osteoporosis and the replacement of cell populations of the marrow by adipose tissue. A quantitative study of 84 iliac bone biopsies. Clin Orthop Related Res 80:147-154
    • (1971) Clin Orthop Related Res , vol.80 , pp. 147-154
    • Meunier, P.1    Aaron, J.2    Edouard, C.3    Vignon, G.4
  • 3
    • 0029961204 scopus 로고    scopus 로고
    • The function of adipocytes in the bone marrow stroma: An update
    • Gimble JM, Robinson CE, Wu X, Kelly KA 1996 The function of adipocytes in the bone marrow stroma: an update. Bone 19:421-428
    • (1996) Bone , vol.19 , pp. 421-428
    • Gimble, J.M.1    Robinson, C.E.2    Wu, X.3    Kelly, K.A.4
  • 4
    • 0033926146 scopus 로고    scopus 로고
    • Is there a therapeutic opportunity to either prevent or treat osteopenic disorders by inhibiting marrow adipogenesis?
    • Nuttall ME, Gimble JM 2000 Is there a therapeutic opportunity to either prevent or treat osteopenic disorders by inhibiting marrow adipogenesis? Bone 27:177-184
    • (2000) Bone , vol.27 , pp. 177-184
    • Nuttall, M.E.1    Gimble, J.M.2
  • 5
    • 0027721063 scopus 로고
    • Expression of human bone morphogenetic proteins-2 or -4 in murine mesenchymal progenitor C3H10T1/2 cells induces differentiation into distinct mesenchymal cell lineages
    • Ahrens M, Ankenbauer T, Schroder D, Hollnagel A, Mayer H, Gross G 1993 Expression of human bone morphogenetic proteins-2 or -4 in murine mesenchymal progenitor C3H10T1/2 cells induces differentiation into distinct mesenchymal cell lineages. DNA Cell Biol 12:871-880
    • (1993) DNA Cell Biol , vol.12 , pp. 871-880
    • Ahrens, M.1    Ankenbauer, T.2    Schroder, D.3    Hollnagel, A.4    Mayer, H.5    Gross, G.6
  • 6
    • 0034016101 scopus 로고    scopus 로고
    • Positive and negative regulation of TGF-β signaling
    • Miyazono K 2000 Positive and negative regulation of TGF-β signaling. J Cell Sci 113:1101-1109
    • (2000) J Cell Sci , vol.113 , pp. 1101-1109
    • Miyazono, K.1
  • 7
    • 0030113479 scopus 로고    scopus 로고
    • PTH: A future role in the management of osteoporosis?
    • Reeve J 1996 PTH: a future role in the management of osteoporosis [Editorial]? J Bone Miner Res 11:440-445
    • (1996) J Bone Miner Res , vol.11 , pp. 440-445
    • Reeve, J.1
  • 8
    • 0028286662 scopus 로고
    • Direct involvement of cAMP-dependent protein kinase in the regulation of alkaline phosphatase activity by parathyroid hormone (PTH) and PTH-related peptide in osteoblastic UMR-106 cells
    • Kano J, Sugimoto T, Fukase M, Chihara K 1994 Direct involvement of cAMP-dependent protein kinase in the regulation of alkaline phosphatase activity by parathyroid hormone (PTH) and PTH-related peptide in osteoblastic UMR-106 cells. Biochem Biophys Res Commun 199:271-276
    • (1994) Biochem Biophys Res Commun , vol.199 , pp. 271-276
    • Kano, J.1    Sugimoto, T.2    Fukase, M.3    Chihara, K.4
  • 9
    • 0035943682 scopus 로고    scopus 로고
    • Parathyroid hormone-related peptide stimulates osteogenic cell proliferation through protein kinase C activation of the Ras/mitogen-activated protein kinase signaling pathway
    • Miao D, Tong XK, Chan GK, Panda D, McPherson PS, Goltzman D 2001 Parathyroid hormone-related peptide stimulates osteogenic cell proliferation through protein kinase C activation of the Ras/mitogen-activated protein kinase signaling pathway. J Biol Chem 276:32204-32213
    • (2001) J Biol Chem , vol.276 , pp. 32204-32213
    • Miao, D.1    Tong, X.K.2    Chan, G.K.3    Panda, D.4    McPherson, P.S.5    Goltzman, D.6
  • 10
    • 0034836846 scopus 로고    scopus 로고
    • Induction of osteoblast differentiation indexes by PTHrP in MG-63 cells involves multiple signaling pathways
    • Carpio L, Gladu J, Goltzman D, Rabbani SA 2001 Induction of osteoblast differentiation indexes by PTHrP in MG-63 cells involves multiple signaling pathways. Am J Physiol 281:E489-E499
    • (2001) Am J Physiol , vol.281
    • Carpio, L.1    Gladu, J.2    Goltzman, D.3    Rabbani, S.A.4
  • 12
    • 0034681454 scopus 로고    scopus 로고
    • Parathyroid hormone regulation of the rat collagenase-3 promoter by protein kinase A-dependent transactivation of core binding factor α1
    • Selvamurugan N, Pulumati MR, Tyson DR, Partridge NC 2000 Parathyroid hormone regulation of the rat collagenase-3 promoter by protein kinase A-dependent transactivation of core binding factor α1. J Biol Chem 275:5037-5042
    • (2000) J Biol Chem , vol.275 , pp. 5037-5042
    • Selvamurugan, N.1    Pulumati, M.R.2    Tyson, D.R.3    Partridge, N.C.4
  • 13
    • 0034748575 scopus 로고    scopus 로고
    • PTHrP inhibits adipocyte differentiation by down-regulating PPARγ activity via a MAPK-dependent pathway
    • Chan GK, Deckelbaum RA, Bolivar I, Goltzman D, Karaplis AC 2001 PTHrP inhibits adipocyte differentiation by down-regulating PPARγ activity via a MAPK-dependent pathway. Endocrinology 142:4900-4909
    • (2001) Endocrinology , vol.142 , pp. 4900-4909
    • Chan, G.K.1    Deckelbaum, R.A.2    Bolivar, I.3    Goltzman, D.4    Karaplis, A.C.5
  • 15
    • 0018581647 scopus 로고
    • Multiple new phenotypes induced in 10T1/2 and 3T3 cells treated with 5-azacytidine
    • Taylor SM, Jones PA 1979 Multiple new phenotypes induced in 10T1/2 and 3T3 cells treated with 5-azacytidine. Cell 17:771-779
    • (1979) Cell , vol.17 , pp. 771-779
    • Taylor, S.M.1    Jones, P.A.2
  • 16
    • 0027185702 scopus 로고
    • Bone morphogenetic protein-2 causes commitment and differentiation in C3H10T1/2 and 3T3 cells
    • Wang EA, Israel DI, Kelly S, Luxenberg DP 1993 Bone morphogenetic protein-2 causes commitment and differentiation in C3H10T1/2 and 3T3 cells. Growth Factors 9:57-71
    • (1993) Growth Factors , vol.9 , pp. 57-71
    • Wang, E.A.1    Israel, D.I.2    Kelly, S.3    Luxenberg, D.P.4
  • 18
    • 0031725472 scopus 로고    scopus 로고
    • Inhibition of protein kinase C translocation from cytosol to membrane by chelerythrine
    • Chao MD, Chen IS, Cheng JT 1998 Inhibition of protein kinase C translocation from cytosol to membrane by chelerythrine. Planta Med 64:662-663
    • (1998) Planta Med , vol.64 , pp. 662-663
    • Chao, M.D.1    Chen, I.S.2    Cheng, J.T.3
  • 19
    • 0028150744 scopus 로고
    • Molecular cloning of rat bone morphogenetic protein (BMP) type IA receptor and its expression during ectopic bone formation induced by BMP
    • Takeda K, Oida S, Ichijo H, Iimura T, Maruoka Y, Amagasa T, Sasaki S 1994 Molecular cloning of rat bone morphogenetic protein (BMP) type IA receptor and its expression during ectopic bone formation induced by BMP. Biochem Biophys Res Commun 204:203-209
    • (1994) Biochem Biophys Res Commun , vol.204 , pp. 203-209
    • Takeda, K.1    Oida, S.2    Ichijo, H.3    Iimura, T.4    Maruoka, Y.5    Amagasa, T.6    Sasaki, S.7
  • 20
    • 0034093738 scopus 로고    scopus 로고
    • Smad6 is a Smad1/5-induced smad inhibitor. Characterization of bone morphogenetic protein-responsive element in the mouse Smad6 promoter
    • Ishida W, Hamamoto T, Kusanagi K, Yagi K, Kawabata M, Takehara K, Sampath TK, Kato M, Miyazono K 2000 Smad6 is a Smad1/5-induced smad inhibitor. Characterization of bone morphogenetic protein-responsive element in the mouse Smad6 promoter. J Biol Chem 275:6075-6079
    • (2000) J Biol Chem , vol.275 , pp. 6075-6079
    • Ishida, W.1    Hamamoto, T.2    Kusanagi, K.3    Yagi, K.4    Kawabata, M.5    Takehara, K.6    Sampath, T.K.7    Kato, M.8    Miyazono, K.9
  • 21
    • 0021731952 scopus 로고
    • Construction of DNA sequences complementary to rat α1 and α2 collagen mRNA and their use in studying the regulation of type I collagen synthesis by 1,25-dihydroxyvitamin D
    • Genovese C, Rowe D, Kream B 1984 Construction of DNA sequences complementary to rat α1 and α2 collagen mRNA and their use in studying the regulation of type I collagen synthesis by 1,25-dihydroxyvitamin D. Biochemistry 23:6210-6216
    • (1984) Biochemistry , vol.23 , pp. 6210-6216
    • Genovese, C.1    Rowe, D.2    Kream, B.3
  • 23
    • 0017759258 scopus 로고
    • Serial passaging and differentiation of myogenic cells isolated from dystrophic mouse muscle
    • Yaffe D, Saxel O 1977 Serial passaging and differentiation of myogenic cells isolated from dystrophic mouse muscle. Nature 270:725-727
    • (1977) Nature , vol.270 , pp. 725-727
    • Yaffe, D.1    Saxel, O.2
  • 24
    • 0015752438 scopus 로고
    • Establishment and characterization of a cloned line of C3H mouse embryo cells sensitive to postcon-fluence inhibition of division
    • Reznikoff CA, Brankow DW, Heidelberger C 1973 Establishment and characterization of a cloned line of C3H mouse embryo cells sensitive to postcon-fluence inhibition of division. Cancer Res 33:3231-3238
    • (1973) Cancer Res , vol.33 , pp. 3231-3238
    • Reznikoff, C.A.1    Brankow, D.W.2    Heidelberger, C.3
  • 25
    • 0032514135 scopus 로고    scopus 로고
    • Differential roles for bone morphogenetic protein (BMP) receptor type IB and IA in differentiation and specification of mesenchymal precursor cells to osteoblast and adipocyte lineages
    • Chen D, Ji X, Harris MA, Feng JQ, Karsenty G, Celeste AJ, Rosen V, Mundy GR, Harris SE 1998 Differential roles for bone morphogenetic protein (BMP) receptor type IB and IA in differentiation and specification of mesenchymal precursor cells to osteoblast and adipocyte lineages. J Cell Biol 142:295-305
    • (1998) J Cell Biol , vol.142 , pp. 295-305
    • Chen, D.1    Ji, X.2    Harris, M.A.3    Feng, J.Q.4    Karsenty, G.5    Celeste, A.J.6    Rosen, V.7    Mundy, G.R.8    Harris, S.E.9
  • 26
    • 0032879350 scopus 로고    scopus 로고
    • Differentiation of human marrow stromal precursor cells: Bone morphogenetic protein-2 increases OSF2/CBFA1, enhances osteoblast commitment, and inhibits late adipocyte maturation
    • Gori F, Thomas T, Hicok KC, Spelsberg TC, Riggs BL 1999 Differentiation of human marrow stromal precursor cells: bone morphogenetic protein-2 increases OSF2/CBFA1, enhances osteoblast commitment, and inhibits late adipocyte maturation. J Bone Miner Res 14:1522-1535
    • (1999) J Bone Miner Res , vol.14 , pp. 1522-1535
    • Gori, F.1    Thomas, T.2    Hicok, K.C.3    Spelsberg, T.C.4    Riggs, B.L.5
  • 27
    • 0034011315 scopus 로고    scopus 로고
    • Patterns of gene expression associated with BMP-2-induced osteoblast and adipocyte differentiation of mesenchymal progenitor cell 3T3-F442A
    • Ji X, Chen D, Xu C, Harris SE, Mundy GR, Yoneda T 2000 Patterns of gene expression associated with BMP-2-induced osteoblast and adipocyte differentiation of mesenchymal progenitor cell 3T3-F442A. J Bone Miner Metab 18:132-139
    • (2000) J Bone Miner Metab , vol.18 , pp. 132-139
    • Ji, X.1    Chen, D.2    Xu, C.3    Harris, S.E.4    Mundy, G.R.5    Yoneda, T.6
  • 28
    • 0033995295 scopus 로고    scopus 로고
    • Osteogenesis coordinated in C3H10TV1/2 cells by adipogenesis-dependent BMP-2 expression system
    • Mie M, Ohgushi H, Yanagida Y, Haruyama T, Kobatake E, Aizawa M 2000 Osteogenesis coordinated in C3H10TV1/2 cells by adipogenesis-dependent BMP-2 expression system. Tissue Engin 6:9-18
    • (2000) Tissue Engin , vol.6 , pp. 9-18
    • Mie, M.1    Ohgushi, H.2    Yanagida, Y.3    Haruyama, T.4    Kobatake, E.5    Aizawa, M.6
  • 30
    • 0036256989 scopus 로고    scopus 로고
    • Effects of cortisol and bone morphogenetic protein-2 on stromal cell differentiation: Correlation with CCAAT-enhancer binding protein expression
    • Pereira RC, Delany AM, Canalis E 2002 Effects of cortisol and bone morphogenetic protein-2 on stromal cell differentiation: correlation with CCAAT-enhancer binding protein expression. Bone 30:685-691
    • (2002) Bone , vol.30 , pp. 685-691
    • Pereira, R.C.1    Delany, A.M.2    Canalis, E.3
  • 31
    • 0036090574 scopus 로고    scopus 로고
    • Estrogen promotes early osteoblast differentiation and inhibits adipocyte differentiation in mouse bone marrow stromal cell lines that express estrogen receptor (ER) α or β
    • Okazaki R, Inoue D, Shibata M, Saika M, Kido S, Ooka H, Tomiyama H, Sakamoto Y, Matsumoto T 2002 Estrogen promotes early osteoblast differentiation and inhibits adipocyte differentiation in mouse bone marrow stromal cell lines that express estrogen receptor (ER) α or β. Endocrinology 143:2349-2356
    • (2002) Endocrinology , vol.143 , pp. 2349-2356
    • Okazaki, R.1    Inoue, D.2    Shibata, M.3    Saika, M.4    Kido, S.5    Ooka, H.6    Tomiyama, H.7    Sakamoto, Y.8    Matsumoto, T.9
  • 32
    • 0030831889 scopus 로고    scopus 로고
    • Parathyroid hormone enhances early and suppresses late stages of osteogenic and chondrogenic development in a BMP-dependent mesenchymal differentiation system (CSH10T1/2)
    • Hollnagel A, Ahrens M, Gross G 1997 Parathyroid hormone enhances early and suppresses late stages of osteogenic and chondrogenic development in a BMP-dependent mesenchymal differentiation system (CSH10T1/2). J Bone Miner Res 12:1993-2004
    • (1997) J Bone Miner Res , vol.12 , pp. 1993-2004
    • Hollnagel, A.1    Ahrens, M.2    Gross, G.3
  • 35
    • 0030678549 scopus 로고    scopus 로고
    • Osf2/Cbfa1: A transcriptional activator of osteoblast differentiation
    • Ducy P, Zhang R, Geoffroy V, Ridall AL, Karsenty G 1997 Osf2/Cbfa1: a transcriptional activator of osteoblast differentiation. Cell 89:747-754
    • (1997) Cell , vol.89 , pp. 747-754
    • Ducy, P.1    Zhang, R.2    Geoffroy, V.3    Ridall, A.L.4    Karsenty, G.5
  • 37
    • 0034905168 scopus 로고    scopus 로고
    • Characterization of the up-stream mouse Cbfa1/Runx2 promoter
    • Xiao ZS, Liu SG, Hinson TK, Quarles LD 2001 Characterization of the up-stream mouse Cbfa1/Runx2 promoter. J Cell Biochem 82:647-659
    • (2001) J Cell Biochem , vol.82 , pp. 647-659
    • Xiao, Z.S.1    Liu, S.G.2    Hinson, T.K.3    Quarles, L.D.4
  • 40
    • 0033960316 scopus 로고    scopus 로고
    • The type I BMP receptor BMPRIB is required for chondrogenesis in the mouse limb
    • Yi SE, Daluiski A, Pederson R, Rosen V, Lyons KM 2000 The type I BMP receptor BMPRIB is required for chondrogenesis in the mouse limb. Development 127:621-630
    • (2000) Development , vol.127 , pp. 621-630
    • Yi, S.E.1    Daluiski, A.2    Pederson, R.3    Rosen, V.4    Lyons, K.M.5
  • 41
  • 42
    • 0033819740 scopus 로고    scopus 로고
    • The bone morphogenetic protein 2 signaling mediator Smad1 participates predominantly in osteogenic and not in chondrogenic differentiation in mesenchymal progenitors C3H10T1/2
    • Ju W, Hoffmann A, Verschueren K, Tylzanowski P, Kaps C, Gross G, Huylebroeck D 2000 The bone morphogenetic protein 2 signaling mediator Smad1 participates predominantly in osteogenic and not in chondrogenic differentiation in mesenchymal progenitors C3H10T1/2. J Bone Miner Res 15:1889-1899
    • (2000) J Bone Miner Res , vol.15 , pp. 1889-1899
    • Ju, W.1    Hoffmann, A.2    Verschueren, K.3    Tylzanowski, P.4    Kaps, C.5    Gross, G.6    Huylebroeck, D.7
  • 43
    • 0031939744 scopus 로고    scopus 로고
    • Smad5 and DPC4 are key molecules in mediating BMP-2-induced osteoblastic differentiation of the pluripotent mesenchymal precursor cell line C2C12
    • Nishimura R, Kato Y, Chen D, Harris SE, Mundy GR, Yoneda T 1998 Smad5 and DPC4 are key molecules in mediating BMP-2-induced osteoblastic differentiation of the pluripotent mesenchymal precursor cell line C2C12. J Biol Chem 273:1872-1879
    • (1998) J Biol Chem , vol.273 , pp. 1872-1879
    • Nishimura, R.1    Kato, Y.2    Chen, D.3    Harris, S.E.4    Mundy, G.R.5    Yoneda, T.6
  • 44
    • 0033861095 scopus 로고    scopus 로고
    • BMP-2 and sonic hedgehog have contrary effects on adipocyte-like differentiation of C3H10T1/2 cells
    • Zehentner BK, Leser U, Burtscher H 2000 BMP-2 and sonic hedgehog have contrary effects on adipocyte-like differentiation of C3H10T1/2 cells. DNA Cell Biol 19:275-281
    • (2000) DNA Cell Biol , vol.19 , pp. 275-281
    • Zehentner, B.K.1    Leser, U.2    Burtscher, H.3
  • 46
    • 0035106438 scopus 로고    scopus 로고
    • Bone anabolic effects of sonic/Indian hedgehog are mediated by bmp-2/4-dependent pathways in the neonatal rat metatarsal model
    • Krishnan V, Ma Y, Moseley J, Geiser A, Friant S, Frolik C 2001 Bone anabolic effects of sonic/Indian hedgehog are mediated by bmp-2/4-dependent pathways in the neonatal rat metatarsal model. Endocrinology 142:940-947
    • (2001) Endocrinology , vol.142 , pp. 940-947
    • Krishnan, V.1    Ma, Y.2    Moseley, J.3    Geiser, A.4    Friant, S.5    Frolik, C.6


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