Role of activator protein 1 transcriptional activity in the regulation of gene expression by transforming growth factor β1 and bone morphogenetic protein 2 in ROS 17/2.8 osteoblast-like cells

Journal of Bone and Mineral Research

Volumn 15, Issue 12, 2000, Pages 2352-2361

  Palcy, Sandrine ^a   Bolivar, Isabel ^a   Goltzman, David ^a  

^a ROYAL VICTORIA HOSPITAL   (Canada)

Author keywords

c fos; Jun B; Parathyroid hormone parathyroid hormone related peptide receptor; Protein kinase; Type I collagen

Indexed keywords

BONE MORPHOGENETIC PROTEIN 2; CHELERYTHRINE; GENISTEIN; MESSENGER RNA; PARATHYROID HORMONE; PARATHYROID HORMONE RELATED PROTEIN; PROTEIN KINASE C; PROTEIN TYROSINE KINASE; PROTEIN TYROSINE KINASE INHIBITOR; STRESS ACTIVATED PROTEIN KINASE; TRANSCRIPTION FACTOR AP 1; TRANSFORMING GROWTH FACTOR BETA1;

ANIMAL CELL; ARTICLE; CONTROLLED STUDY; DNA BINDING; ENZYME ACTIVITY; GENE EXPRESSION REGULATION; GENETIC TRANSCRIPTION; MITOGENICITY; NONHUMAN; ONCOGENE C FOS; OSTEOBLAST; PROTO ONCOGENE; RAT; SIGNAL TRANSDUCTION;

ANIMALS; BLOTTING, NORTHERN; BONE MORPHOGENETIC PROTEINS; COLLAGEN; IMMUNOBLOTTING; OSTEOBLASTS; PARATHYROID HORMONE-RELATED PROTEIN; PRECIPITIN TESTS; PROTEIN BIOSYNTHESIS; PROTEIN KINASE C; PROTEIN-TYROSINE KINASES; PROTEINS; PROTO-ONCOGENE PROTEINS C-FOS; PROTO-ONCOGENE PROTEINS C-JUN; RATS; RNA, MESSENGER; SIGNAL TRANSDUCTION; TRANSCRIPTION FACTOR AP-1; TRANSCRIPTION, GENETIC; TRANSFECTION; TRANSFORMING GROWTH FACTOR BETA; UP-REGULATION;

EID: 0033680723     PISSN: 08840431     EISSN: None     Source Type: Journal    
DOI: 10.1359/jbmr.2000.15.12.2352     Document Type: Article

References (50)

1. Transforming growth factor-β gene family members and bone
2. Transcriptional regulation of osteocalcin production by transforming growth factor-β in rat osteoblast-like cells
3. Transcriptional regulation of osteopontin production in rat osteosarcoma cells by type β transforming growth factor
4. Type-β transforming growth factor inhibits proliferation and expression of alkaline phosphatase in murine osteoblast-like cells
5. Type-β transforming growth factor (TGFβ) regulation of alkaline phosphatase expression and other phenotype-related mRNAs in osteoblastic rat osteosarcoma cells
6. 1 regulates steady-state PTH/PTHrP receptor mRNA levels and PTHrP binding in ROS 17/28 osteosarcoma cells
7. Bone morphogenetic protein-2 stimulates alkaline phosphatase activity and collagen synthesis in cultured osteoblastic cells, MC3T3
8. Recombinant human bone morphogenetic protein-2 stimulates osteoblastic maturation and inhibits myogenic differentiation in vitro
9. TGFβ signalling, receptors, transducers and mad proteins
10. TGF-β signalling through the smad pathway
11. Tumor suppressor Smad4 is a transforming growth factor β-inducible DNA binding protein
12. Evidence for involvement of phosphatidylcholine-phospholipase C and protein kinase C in transforming growth factor-β signalling
13. 1 on gene expression
14. Evidence for a role of Rho-like GTPases and stress-activated protein kinase/c-jun N-terminal kinase (SAPK/JNK) in transforming growth factor β-mediated signalling
15. Transforming growth factor-β1 induces activation of Ras, Raf-1, MEK and MAPK in rat hepatic stellate cells
16. Involvement of extracellular signal-regulated kinase 2 and stress-activated protein kinase/jun N-terminal kinase activation by transforming growth factor β in the negative growth control of breast cancer cells
17. Transcription factor AP-1 regulation by mitogen-activated protein kinase signal transduction pathways
18. A transcriptional partner for MAD proteins in TGF-β signalling
19. Smad3 and Smad4 cooperate with c-Jun/c-Fos to mediate TGF-beta-induced transcription
20. Identification of regulatory sequences in the type 1 plasminogen activator inhibitor gene responsive to transforming growth factor β
21. An AP-1 binding sequence is essential for regulation of the human α2(I) collagen (COL1A2) promoter activity by transforming growth factor-β
22. Differential effects of transforming growth factor-β on the expression of collagenase-1 and collagenase-3 in human fibroblasts
23. Regulation of clusterin gene expression by transforming growth factor β
24. Transforming growth factor-β stimulates interleukin-11 transcription via complex activating protein-1-dependent pathways
25. Three activator protein-1-binding sites bound by the Fra-2JunD complex cooperate for the regulation of murine laminin α3A (lama3A) promoter activity by transforming growth factor-β
26. Early gene responses associated with transforming growth factor-β1 growth inhibition and autoinduction in MCF-7 breast adenocarcinoma cells
27. Early gene responses to transforming growth factor-β in cells lacking growth-suppressive RB function
28. Cell-specific induction of distinct oncogenes of the Jun family is responsible for differential regulation of collagenase gene expression by transforming growth factor-β in fibroblasts and keratinocytes
29. TGF-β regulation of nuclear proto-oncogenes and TGF-β gene expression in normal human osteoblast-like cells
30. Bone morphogenetic proteins (BMP-2 and BMP-3) induce the late phase expression of the protooncogene c-fos in murine osteoblastic MC 3TC-E1 cells
31. Transforming growth factor-β1 responsiveness of the rat osteocalcin gene is mediated by an activator protein-1 binding site
32. Transcriptional regulation by transforming growth factor β of the expression of retinoic acid and retinoid X receptor genes in osteoblastic cells is mediated through AP-1
33. TGF-β induces expression of monocyte chemoattractant JE/monocyte chemoattractant protein 1 via transcriptional factor AP-1 induced by protein kinase in osteoblastic cells
34. Parathyroid hormone-responsive clonal cell lines from rat osteosarcoma
35. A gene activated by growth factors is related to the oncogene v-jun
36. Induction of protooncogene c-jun by serum growth factors
37. Analysis of FBJ-MuSV provirus and c-fos (mouse) gene reveals that viral and cellular fos gene products have different carboxy termini
38. Construction of DNA sequences complementary to rat α1 and α2 collagen mRNA and their use in studying the regulation of type I collagen synthesis by 1, 25-dihydroxyvitamin D
39. Expression cloning of a common receptor for parathyroid hormone and parathyroid hormone-related peptide from rat osteoblast-like cells, a single receptor stimulates intracellular accumulation of both cAMP and inositol triphosphates and increases intracellular free calcium
40. Isolation and characterization of rat and human glyceraldehyde-3-phosphate dehydrogenase cDNAs, genomic complexity and molecular evolution of the gene
41. A naturally occurring truncated form of FosB that inhibits Fos/Jun transcriptional activity
42. Protein kinase signalling pathways involved in the up-regulation of the rat aα1(1) collagen gene by transforming growth factor β1 and bone morphogenetic protein 2 in osteoblastic cells
43. An AP-1-like motif in the first intron of human proα1(I) collagen gene is a critical determinant of its transcriptional activity
44. Selective expression of fos-and jun-related genes during osteoblast proliferation and differentiation
45. Coordinate occupancy of AP-1 sites in the vitamin D-responsive and CCAAT box elements by Fos-Jun in the osteocalcin gene, model for phenotype suppression of transcription
46. JunB is involved in the inhibition of myogenic differentiation by bone morphogenetic protein-2
47. The role of Jun, Fos and the AP-1 complex in cell-proliferation and transformation
48. The role of MAP kinase in TPA-mediated cell cycle arrest of human breast cancer cells
49. The regulation of AP-1 activity by mitogen-activated protein kinases
50. Transforming growth factor-beta1 stimulates protein kinase A in mesangial cells