The calcium-sensing receptor is involved in Strontium ranelate-induced osteoclast apoptosis new insights into the associated signaling pathways

Journal of Biological Chemistry

Volumn 284, Issue 1, 2009, Pages 575-584

  Hurtel Lemaire, Anne S ^a   Mentaverri, Romuald ^a,d   Caudrillier, Axelle ^a   Cournarie, Fabienne ^b   Wattel, Alice ^a   Kamel, Said ^a   Terwilliger, Ernest F ^c   Brown, Edward M ^d   Brazier, Michel ^a,e  

^a INSERM   (France)

^b INSTITUT DE RECHERCHES INTERNATIONALES SERVIER   (France)

^c BETH ISRAEL DEACONESS MEDICAL CENTER   (United States)

^d BRIGHAM AND WOMEN S HOSPITAL   (United States)

^e UNIVERSITÉ DE PICARDIE JULES VERNE   (France)

Author keywords

[No Author keywords available]

Indexed keywords

APOPTOSIS; BONE CELLS; BONE RESORPTION; MOLECULAR MECHANISMS; PHOSPHOLIPASE C (PLC);

ALKALINE EARTH METALS; ARSENIC; BONE; CALCIUM ALLOYS; CELL DEATH; PIGMENTS; SIGNALING; STRONTIUM; SUGARS;

CALCIUM;

CALCIUM ION; CALCIUM SENSING RECEPTOR; CASPASE; DIACYLGLYCEROL; DIVALENT CATION; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; INOSITOL 1,4,5 TRISPHOSPHATE; PHOSPHOLIPASE C; PROTEIN KINASE C BETA; PROTEIN KINASE C BETA II; STRONTIUM RANELATE; UNCLASSIFIED DRUG;

ANIMAL CELL; APOPTOSIS; ARTICLE; BONE CELL; CHROMOSOME TRANSLOCATION; CONTROLLED STUDY; DOSE RESPONSE; ENZYME ACTIVATION; NONHUMAN; OSTEOCLAST; OSTEOLYSIS; PRIORITY JOURNAL; RABBIT;

ACTIVE TRANSPORT, CELL NUCLEUS; ANIMALS; APOPTOSIS; BONE DENSITY CONSERVATION AGENTS; BONE RESORPTION; CALCIUM; CELL NUCLEUS; CELLS, CULTURED; ENZYME ACTIVATION; NF-KAPPA B; ORGANOMETALLIC COMPOUNDS; OSTEOCLASTS; PROTEIN KINASE C; RABBITS; RECEPTORS, CALCIUM-SENSING; SIGNAL TRANSDUCTION; THIOPHENES; TYPE C PHOSPHOLIPASES;

ORYCTOLAGUS CUNICULUS;

EID: 58649120832     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M801668200     Document Type: Article

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