Calcitonin-induced changes in the cytoskeleton are mediated by a signal pathway associated with protein kinase A in osteoclasts

Endocrinology

Volumn 137, Issue 11, 1996, Pages 4685-4690

  Suzuki, Hiroaki ^a   Nakamura, Ichiro ^b   Takahashi, Naoyuki ^b   Ikuhara, Toshihiko ^a   Matsuzaki, Kenichiro ^b   Isogai, Yukihiro ^a   Hori, Masayuki ^a   Suda, Tatsuo ^b  

^a ASAHI CHEMICAL INDUSTRY CO   (Japan)

^b SHOWA UNIVERSITY   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

BUCLADESINE; CALCITONIN; CALCITONIN RECEPTOR; CYCLIC AMP DEPENDENT PROTEIN KINASE; ELCATONIN; F ACTIN; FORSKOLIN; PHORBOL 13 ACETATE 12 MYRISTATE; PHORBOL DIBUTYRATE; PROTEIN KINASE C; PROTEIN KINASE INHIBITOR;

ANIMAL CELL; ARTICLE; CONTROLLED STUDY; CYTOSKELETON; DOSE RESPONSE; ENZYME ACTIVATION; ENZYME ACTIVITY; ENZYME LINKED IMMUNOSORBENT ASSAY; MALE; MOUSE; NEWBORN; NONHUMAN; OSTEOCLAST; OSTEOLYSIS; PRIORITY JOURNAL;

EID: 0029825378     PISSN: 00137227     EISSN: None     Source Type: Journal    
DOI: 10.1210/endo.137.11.8895334     Document Type: Article

References (31)

1. Nicholson GC, Moseley JM, Sexton PM, Mendelsohn FAO, Martin TJ 1986 Abundant calcitonin receptors in isolated rat osteoclasts. J Clin Invest 78:355-360
2. Suda T, Takahashi N, Martin TJ 1992 Modulation of osteoclast differentiation. Endocr Rev 13:66-80
3. Lin HY, Harris TL, Flannery MS, Azuffo A, Kaji EH, Gorn A, Kolakowski LF Jr., Lodish HF, Goldring SR 1991 Expression cloning of an adenylate cyclase-coupled calcitonin receptor. Science 254:1022-1024
4. Nicholson GC, Linsey SA, Moseley JM, Martin TJ 1986 Actions of calcitonin, parathyroid hormone and prostaglandin E2 on cyclic AMP formation in chicken and rat osteoclasts. J Cell Biochem 31:229-241
5. Nicholson GC, Moseley JM, Yates AJP, Martin TJ 1987 Control of cyclic adenosine 3′,5′-monophosphate production in osteoclasts: calcitonin and homologous desensitization of adenylate cyclase. Endocrinology 120:1902-1908
6. Malgaroli A, Meldolesi J, Zallone AZ, Teti A 1989 Control of cytosolic free calcium in rat and chicken osteoclasts: the role of extracellular calcium and calcitonin. J Biol Chem 264:14342-14347
7. Zaidi M, Datta HK, Patchell A, Moonga BS, MacIntyre I 1989 Calcium-activated intracellular calcium elevation: a novel mechanism of osteoclast regulation. Biochem Biophys Res Commun 163:1461-1465
8. Zaidi M, Datta HK, Moonga BS, MacIntyre I 1990 Evidence that the action of calcitonin on rat osteoclasts is mediated by two G proteins acting via separate post-receptor pathways. J Endocrinol 126:473-481
9. Moonga BS, Alam AS, Bevis PJ, Avaldi F, Soncini R, Huang CL, Zaidi M 1992 Regulation of cytosolic free calcium in isolated rat osteoclasts by calcitonin. J Endocrinol 132:241-249
10. Chabre O, Conklin BR, Lin HY, Lodish HF, Wilson E, Ives HE, Catanzariti L, Hemmings BA, Bourne HR 1992 A recombinant calcitonin receptor independently stimulates 3′,5′-cyclic adenosine monophosphate and Ca2+/inositol phosphate signaling pathways. Mol Endocrinol 6:551-556
11. Kaji H, Sugimoto T, Miyauchi A, Fukase M, Tezuka K, Hakeda Y, Kumegawa M, Chihara K 1994 Calcitonin inhibits osteopontin mRNA expression in isolated rabbit osteoclasts. Endocrinology 135:484-487
12. Nicholson GC, Yumita S, Moseley JM, Yates AJP, Martin TJ 1988 Forskolin augments the effects of calcitonin on cytoplasmic spreading of isolated rat osteoclast and plasma calcium levels in the rats. J Bone Miner Res 3:181-184
13. Su Y, Chakraborty M, Nathanson MH, Baron R 1992 Differential effects of the 3′,5′-cyclic adenosine monophosphate and protein kinase C pathways on the response of isolated rat osteoclasts to calcitonin. Endocrinology 131:1497-1502
14. Tanaka S, Takahashi N, Udagawa N, Murakami H, Nakamura I, Kurokawa T, Suda T 1995 Possible involvement of focal adhesion kinase, p125FAK, in osteoclastic bone resorption. J Cell Biochem 58:424-435
15. Zhang D, Udagawa N, Nakamura I, Murakami H, Saito S, Yamasaki K, Shibasaki Y, Morii N, Narumiya S, Takahashi N, Suda T 1995 The small GTP-binding protein, rho, is involved in bone resorption by regulating cytoskeletal organization in osteoclasts. J Cell Sci 108:2285-2292
16. Nakamura I, Takahashi N, Sasaki T, Tanaka S, Udagawa N, Murakami H, Kimura K, Kabuyama Y, Kurokawa T, Suda T, Fukui Y 1995 Wortmannin, a specific inhibitor of phosphatidylinositol-3 kinase, blocks osteoclastic bone resorption. FEBS Lett 361:79-84
17. Turksen K, Kanehisa J, Opas M, Heersche JNM, Aubin JE 1988 Adhesion patterns and cytoskeleton of rabbit osteoclasts on bone slices and glass. J Bone Miner Res 4:389-400
18. Teti A, Marchisio PC, Zambonin-Zallon A 1991 Clear zone in osteoclast function: role of podosomes in regulation of bone-resorbing activity. Am J Physiol 261:C1-C7
19. Lakkakorpi PT, Väänänen HK 1996 Cytoskeletal changes in osteoclasts during the resorption cycle. Microsc Res Tech 33:171-181
20. 1.7)-eel calcitonin: contribution of the disulfide bond to the hormonal activity. Experientia 32:1104-1106
21. Cheng HC, Kemp BE, Pearson RB, Smith AJ, Misconi L, Patten SMV, Walsh DA 1986 A protein synthetic peptide inhibitor of the cAMP-dependent protein kinase. J Biol Chem 3:989-992
22. Takahashi N, Akatsu T, Udagawa N, Sasaki T, Yamaguchi A, Moseley JM, Martin TJ, Suda T 1988 Osteoblastic cells are involved in osteoclast formation. Endocrinology 123:2600-2602
23. Akatsu T, Tamura T, Takahashi N, Udagawa N, Tanaka S, Sasaki T, Yamaguchi A, Nagata N, Suda T 1992 Preparation and characterization of a mouse osteoclast-like multinucleated cell population. J Bone Miner Res 7:1297-1306
24. Murakami H, Takahashi N, Sasaki T, Udagawa N, Tanaka S, Nakamura I, Zhang D, Barbier A, Suda T 1995 A possible mechanism of the specific action of bisphosphonates on osteoclasts: tiludronate preferentially affects polarized osteoclasts having ruffled borders. Bone 17:137-144
25. Tamura T, Takahashi N, Akatsu T, Sasaki T, Udagawa N, Tanaka S, Suda T 1993 A new resorption assay with mouse osteoclast-like multinucleated cells formed in vitro. J Bone Miner Res 8:953-960
26. Fujimori A, Chen S, Avioli LV, Civitelli R 1992 Structure-function relationship of parathyroid hormone: activation of phospholipase-C protein kinase-A and -C in osteosarcoma cells. Endocrinology 130:29-36
27. Toomik R, Ekman P, Eller M, Jarv J, Zaitsev D, Myasoedov N, Rangnarsson U, Engstrom L 1993 Protein kinase assay using tritiated peptide substrates and ferric adsorbent paper for phosphopeptide binding. Anal Biochem 209:348-353
28. Beavo JA, Bechtel PJ, Krebs EG 1974 Preparation of homogeneous cyclic AMP-dependent protein kinase(s) and its subunits from rabbit skeletal muscle. Methods Enzymol 38:299-315
29. Takaishi K, Kikuchi A, Kuroda S, Kotani K, Sasaki T, Takai Y 1993 Involvement of rho p21 and its inhibitory GDP/GTP exchange protein (rho GDI) in cell motility. Mol Cell Biol 13:72-79
30. 37). Biochem Biophys Res Commun 179:134-139
31. Wada S, Udagawa N, Nagata N, Martin TJ, Findlay DM 1996 Physiological levels of calcitonin regulate the mouse osteoclast calciitonin receptor by protein kinase A-mediated mechanism. Endocrinology 137:312-320