Chondrocyte-specific knockout of the G protein Gsα leads to epiphyseal and growth plate abnormalities and ectopic chondrocyte formation

Journal of Bone and Mineral Research

Volumn 20, Issue 4, 2005, Pages 663-671

  Sakamoto, Akio ^a   Chen, Min ^a   Kobayashi, Tatsuya ^b   Kronenberg, Henry M ^b   Weinstein, Lee S ^a  

^a NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES   (United States)

^b MASSACHUSETTS GENERAL HOSPITAL   (United States)

Author keywords

Animal models (rodent); Growth plate; Hedgehog; Pseudohypoparathyroidism; PTH PTH related peptide

Indexed keywords

ADENYLATE CYCLASE; COLLAGEN TYPE 2; COLLAGEN TYPE 2A1; CRE RECOMBINASE; CYCLIC AMP; CYCLIC AMP DEPENDENT PROTEIN KINASE; G PROTEIN COUPLED RECEPTOR; GUANINE NUCLEOTIDE BINDING PROTEIN ALPHA SUBUNIT; PARATHYROID HORMONE; PARATHYROID HORMONE RECEPTOR; PARATHYROID HORMONE RELATED PROTEIN; PARATHYROID HORMONE RELATED PROTEIN RECEPTOR; SONIC HEDGEHOG PROTEIN; UNCLASSIFIED DRUG;

ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; ARTICULAR CARTILAGE; CARTILAGE CELL; CELL DIFFERENTIATION; CELL PROLIFERATION; CHONDROGENESIS; CHONDROPATHY; ECTOPIC TISSUE; EMBRYO; EPIPHYSIS DISEASE; GENE; GENE DISRUPTION; GENE EXPRESSION; GROWTH PLATE; GSALPHA GENE; HETEROZYGOTE; HISTOPATHOLOGY; HYPERPARATHYROIDISM; IN SITU HYBRIDIZATION; KNOCKOUT MOUSE; LOXP SITE; METAPHYSIS; MORTALITY; MOUSE; NEWBORN; NONHUMAN; NUCLEOTIDE SEQUENCE; PERIARTICULAR CARTILAGE; PHENOTYPE; PROMOTER REGION; PROTEIN DEFICIENCY; PROTEIN EXPRESSION; PSEUDOHYPERPARATHYROIDISM; RECEPTOR BINDING; REGULATORY MECHANISM; SIGNAL TRANSDUCTION; TIBIA; TRANSGENIC MOUSE;

ANIMALS; BONE AND BONES; CELL DIFFERENTIATION; CHONDROCYTES; GENES, LETHAL; GROWTH PLATE; GTP-BINDING PROTEIN ALPHA SUBUNITS, GS; HEDGEHOG PROTEINS; MICE; MICE, KNOCKOUT; PARATHYROID HORMONE-RELATED PROTEIN; PHENOTYPE; TRANS-ACTIVATORS;

EID: 15344349695     PISSN: 08840431     EISSN: None     Source Type: Journal    
DOI: 10.1359/JBMR.041210     Document Type: Article

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