Continuous activation of Gαq in osteoblasts results in osteopenia through impaired osteoblast differentiation

Journal of Biological Chemistry

Volumn 282, Issue 49, 2007, Pages 35757-35764

  Ogata, Naoshi ^a,b   Kawaguchi, Hiroshi ^b   Chung, Ung Il ^b   Roth, Sanford I ^a   Segre, Gino V ^a  

^a MASSACHUSETTS GENERAL HOSPITAL   (United States)

^b UNIVERSITY OF TOKYO   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

BIOCHEMISTRY; BONE; GENETIC ENGINEERING; SIGNALING;

BONE FORMATION; BONE VOLUME; SKELETAL HOMEOSTASIS; TRANSGENIC MICE;

OSTEOBLASTS;

2 [1 (3 DIMETHYLAMINOPROPYL) 3 INDOLYL] 3 (3 INDOLYL)MALEIMIDE; PROTEIN KINASE C; PROTEIN KINASE C INHIBITOR;

ANIMAL CELL; ANIMAL EXPERIMENT; ARTICLE; CELL COUNT; CELL DIFFERENTIATION; CELL LINEAGE; CONTROLLED STUDY; MALE; MOUSE; NONHUMAN; OSSIFICATION; OSTEOBLAST; OSTEOCLAST; OSTEOPENIA; PRIORITY JOURNAL; TRABECULAR BONE; TRANSGENE; TRANSGENIC MOUSE;

ANIMALS; BONE AND BONES; BONE DISEASES, METABOLIC; CELL DIFFERENTIATION; ENZYME INHIBITORS; GTP-BINDING PROTEIN ALPHA SUBUNITS, GQ-G11; INDOLES; MALEIMIDES; MICE; MICE, TRANSGENIC; ORGAN SIZE; OSTEOBLASTS; OSTEOGENESIS; PROTEIN KINASE C; SIGNAL TRANSDUCTION;

MUS; MUS MUSCULUS;

EID: 37249084546     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M611902200     Document Type: Article

References (34)

1. Dohlman, H. G., Thorner, J., Caron, M. G., and Lefkowitz, R. J. (1991) Annu. Rev. Biochem. 60, 653-688
2. Spiegel, A. M. (1997) Horm. Res. 47, 89-96
3. Spiegel, A. M., Weinstein, L. S., and Shenker, A. (1992) J. Clin. Investig. 92, 1119-1125
4. Weinstein, L. S., Shenker, A., Gejman, P. V., Merino, M. J., Friedman, E., and Spiegel, A. M. (1991) N. Engl. J. Med. 325, 1688-1695
5. Weinstein, L. S., Yu, S., Warner, D. R., and Liu, J. (2001) Endocr. Rev. 22, 675-705
6. Patten, J. L., Johns, D. R., Valle, D., Eil, C., Gruppuso, P. A., Steele, G., Smallwood, P. M., and Levine, M. A. (1990) N. Engl. J. Med. 322, 1412-1419
7. Sakamoto, A., Chen, M., Nakamura, T., Xie, T., Karsenty, G., and Weinstein, L. S. (2005) J. Biol. Chem. 280, 21369-21375
8. Quarles, L. D., and Siddhanti, S. R. (1996) J. Bone Miner. Res. 11, 1375-1383
9. Wu, D. Q., Lee, C. H., Rhee, S. G., and Simon, M. I. (1992) J. Biol. Chem. 267, 1811-1817
10. Rossert, J., Eberspaecher, H., and Crombrugghe, B. D. (1995) J. Cell Biol. 129, 1421-1432
11. Iida-Klein, A., Guo, J., Xie, L. Y., Juppner, H., Potts, J. T., Kronenberg, H. M., Bringhurst, F. R., Abou-Samra, A. B., and Segre, G. V. (1995) J. Biol. Chem. 270, 8458-8465
12. Calvi, L. M., Sims, N. A., Hunzelman, J. L., Knight, M. C., Giovannetti, A., Saxton, J. M., Kronenberg, H. M., Baron, R., and Schipani, E. (2001) J. Clin. Investig. 107, 277-286
13. Ogata, N., Chikazu, D., Kubota, N., Terauchi, Y., Tobe, K., Azuma, Y., Ohta, T., Kadowaki, T., Nakamura, K., and Kawaguchi, H. (2000) J. Clin. Investig. 105, 935-943
14. Weinstein, L. S. in Principles of Bone Biology (Bilezikian, J., Raisz, L., and Rodan, G., eds), 2nd Ed., pp. 877-888, Academic Press, San Diego
15. Bowler, W. B., Gallagher, J. A., and Bilbe, G. (1998) Front. Biosci. 3, 769-780
16. Swarthout, J. T., Doggett, T. A., Lemker, J. L., and Partridge, N. C. (2001) J. Biol. Chem. 276, 7586-7592
17. Kim, H. J., Kim, J. H., Bae, S. C., Choi, J. Y., Kim, H. J., and Ryoo, H. M. (2003) J. Biol. Chem. 278, 319-326
18. Partridge, N. C., Dickson, C. A., Kopp, K., Teitelbaum, S. L., Crouch, E. C., and Kahn, C. (1989) Mol. Endocrinol. 3, 232-239
19. Swarthout, J. T., D'Alonzo, R. C., Selvamurugan, N., and Partridge, N. C. (2002) Gene (Amst.) 282, 1-17
20. Monier-Faugere, M. C. (1998) in Metabolic Bone Disease (Avioli, L. V., and Krane, S. M., eds) 3rd Ed., pp. 230-240, Academic Press, San Diego
21. Kondo, H., Guo, J., and Bringhurst, F. R. (2002) J. Bone Miner. Res. 17, 1667-1679
22. Liu, W., Toyosawa, S., Furuichi, T., Kanatani, N., Yoshida, C., Liu, Y., Himeno, M., Narai, S., Yamaguchi, A., and Komori, T. (2001) J. Cell Biol. 155, 157-166
23. Offermanns, S., Toombs, C. F., Hu, Y. H., and Simon, M. I. (1997) Nature 389, 183-186
24. Mende, U., Kagen, A., Cohen, A., Aramburu, J., Schoen, F. J., and Neer, E. J. (1998) Proc. Natl. Acad. Sci. U. S. A. 95, 13893-13898
25. Wettschureck, N., Rutten, H., Zywietz, A., Gehring, D., Wilkie, T. M., Chen, J., Chien, K. R., and Offermanns, S. (2001) Nat. Med. 7, 1236-1240
26. Wettschureck, N., Lee, E., Libutti, S. K., Offermanns, S., Robey, P. G., and Spiegel, A. M. (2007) Mol. Endocrinol. 21, 274-280
27. Breur, G. J., VanEnkevort, B. A., Farnum, C. E., and Wilsman, N. J. (1991) J. Orthop. Res. 9, 348-359
28. Breur, G. J., Turgai, J., Vanenkevort, B. A., Farnum, C. E., and Wilsman, N. J. (1994) Anat. Rec. 239, 255-268
29. Kember, N. F. (1978) Cell Tissue Kinet. 11, 477-485
30. Kember, N. F. (1979) J. Theor. Biol. 78, 365-374
31. Corral, D. A., Amlling, M., Priemel, M., Loyer, E., Fuchs, S., Ducy, P., Baron, R., and Karsenty, G. (1998) Proc. Natl. Acad. Sci. U. S. A. 95, 13835-13840
32. Ducy, P., Starbuck, M., Priemel, M., Shen, J., Pinero, G., Geoffroy, V., Amling, M., and Karsenty, G. (1999) Genes Dev. 13, 1025-1036
33. Pantschenko, A. G., Zhang, W., Nahounou, M., McCarthy, M. B., Stover, M. L., Lichtler, A. C., Clark, S. H., and Gronowicz, G. A. (2005) J. Bone Miner. Res. 20, 1414-1429
34. Lanske, B., and Kovacs, C. S. (1998) Recent Prog. Horm. Res. 53, 283-301