Differential regulation of RGS-2 by constant and oscillating PTH concentrations

Calcified Tissue International

Volumn 84, Issue 4, 2009, Pages 305-312

  Homme M ^a   Schaefer, F ^a   Mehls, O ^a   Schmitt, C P ^a  

^a Center for Pediatrics and Adolescent Medicine   (Germany)

Author keywords

Gene transcription regulation; Osteoblasts; Parathyroid hormone PTHrP; Peptide hormones

Indexed keywords

COLLAGENASE 3; CYCLIC AMP; CYCLIC AMP DEPENDENT PROTEIN KINASE; MESSENGER RNA; PARATHYROID HORMONE; PARATHYROID HORMONE RECEPTOR; PROTEIN KINASE C; RGS2 PROTEIN; SOMATOMEDIN BINDING PROTEIN 5;

ANIMAL CELL; ARTICLE; BONE METABOLISM; CELL CULTURE; CONCENTRATION (PARAMETERS); CONTROLLED STUDY; DESENSITIZATION; NONHUMAN; OSTEOBLAST; PRIORITY JOURNAL; PULSATILE HORMONE RELEASE; RADIOIMMUNOASSAY; RAT; REAL TIME POLYMERASE CHAIN REACTION; RIBONUCLEASE PROTECTION ASSAY; TRANSCRIPTION REGULATION; WESTERN BLOTTING;

ANIMALS; BONE AND BONES; CELL LINE, TUMOR; CYCLIC AMP-DEPENDENT PROTEIN KINASES; DOSE-RESPONSE RELATIONSHIP, DRUG; DUAL SPECIFICITY PHOSPHATASE 1; DUAL SPECIFICITY PHOSPHATASE 6; GENE EXPRESSION REGULATION; INSULIN-LIKE GROWTH FACTOR BINDING PROTEIN 5; MATRIX METALLOPROTEINASE 13; OSTEOBLASTS; PARATHYROID HORMONE; RATS; RECEPTOR, PARATHYROID HORMONE, TYPE 1; RGS PROTEINS; SIGNAL TRANSDUCTION;

EID: 63949084046     PISSN: 0171967X     EISSN: None     Source Type: Journal    
DOI: 10.1007/s00223-009-9222-1     Document Type: Article

References (31)

1. MH Samuels JD Veldhuis C Cawley RJ Urban M Luther R Bauer G Mundy 1990 Pulsatile secretion of parathyroid hormone in normal young subjects: assessment by deconvolution analysis J Clin Endocrinol Metab 77 399 403
2. CP Schmitt F Schaefer A Bruch JD Veldhuis H Schmitt-Gayk G Stein E Ritz O Mehls 1996 Control of pulsatile and tonic parathyroid hormone secretion by ionized calcium J Endocrinol Metab 81 4236 4243
3. CS Tam JNM Heersche TM Murray JA Parsons 1982 Parathyroid hormone stimulates the bone apposition rate independently of its resorptive action: differential effects of intermittent and continuous administration Endocrinology 110 506 512
4. CP Schmitt S Hessing J Oh L Weber P Ochlich O Mehls 2000 Intermittent administration of parathyroid hormone (1-37) improves growth and bone mineral density in uremic rats Kidney Int 57 1484 1492
5. DW Dempster F Cosman ES Kurland H Zhou J Nieves L Woelfert E Shane K Plavetić R Müller J Bilezikian R Lindsay 2001 Effects of daily treatment with parathyroid hormone on bone microarchitecture and turnover in patiens with osteoporosis: a paired biopsy study J Bone Miner Res 16 1846 1853
6. RM Neer CD Arnaud JR Zanchetta R Prince GA Gaich JY Reginster AB Hodsman EF Eriksen S Ish-Shalom HK Genant O Wang BH Mitlak 2000 Effect of parathyroid hormone (1-34) on fracture and bone mineral density in postmenopausal women with osteoporosis N Engl J Med 344 1434 1441
7. CM Silve GT Hradek AL Jones CD Arnaud 1982 Parathyroid hormone receptor in intact embryonic chicken bone: characterization and cellular localization J Cell Biol 94 379 386
8. AB Abou-Samra H Jüppner T Force MW Freeman XF Kong E Schipani P Urena J Richards JV Bonventre JT Potts HM Kronenberg GV Segre 1992 Expression cloning of a common receptor for parathyroid hormone and parathyroid hormone-related peptide from rat osteoblast-like cells: a single receptor stimulates intracellular accumulation of both cAMP and inositol trisphosphates and increases intracellular free calcium Proc Nat Acad Sci USA 89 2732 2736
9. D Yang R Singh P Divieti J Guo ML Bouxsein FR Bringhurst 2007 Contributions of parathyroid hormone (PTH)/PTH-related peptide receptor signaling pathways to the anabolic effect of PTH on bone Bone 40 1453 1461
10. X Li H Liu L Qin J Tamasi M Bergenstock S Shapses JH Feyen DA Notterman NC Partridge 2007 Determination of dual effects of parathyroid hormone on skeletal gene expression in vivo by microarray and network analysis J Biol Chem 282 33086 33097
11. M Hömme CP Schmitt R Himmele GF Hoffmann O Mehls F Schaefer 2003 Vitamin D and dexamethasone inversely regulate PTH induced regulator of G protein signaling (RGS)-2 expression in osteoblast-like cells Endocrinology 144 2496 2504
12. JK Ko KH Choi IS Kim EK Jung DH Park 2001 Inducible RGS2 is a cross-talk regulator for parathyroid hormone signaling inrat osteoblast-like UMR106 cells Biochem Biophys Res Commun 287 1025 1033
13. RR Miles JP Sluka RF Santerre LV Hale L Bloem G Boguslawski K Thirunavukkarasu JM Hock JE Onyia 2000 Dynamic regulation of RGS2 in bone: potential new insights into parathyroid hormone signaling mechanisms Endocrinology 141 28 36
14. KM Druey 2001 Bridging with GAPs: receptor communication through RGS proteins Sci STKE 104 1 7
15. NC Partridge HW Walling SR Bloch TH Omura PT Chan AT Pearman WY Chou 1996 The regulation and regulatory role of collagenase in bone Crit Rev Eukaryot Gene Expr 6 15 27
16. E Shimizu N Selvamurugan JJ Westendorf NC Partridge 2007 Parathyroid hormone regulates histone deacetylases in osteoblasts Ann NY Acad Sci 1116 349 353
17. JF Ackland KL Knox AA Elskus PC Fallest ES Hiatt NB Schwarz 1994 Use of an in vitro system to study effects of pulsatile hormone administration on the control of the hypothalamic-pituitary-ovarian axis Meth Neurosci 20 466 487
18. M Hömme CP Schmitt O Mehls F Schaefer 2004 Mechanisms of mitogen-activated protein kinase inhibition by parathyroid hormone in osteoblasts J Am Soc Nephrol 15 2844 2850
19. M Muda A Theodosiou N Rodrigues U Boschert M Camps C Gillieron K Davies A Ashworth S Arkinstall 1996 The dual specific phosphatases M3/6 and MKP-3 are highly selective for inactivation of distinct mitogen-activated protein kinases J Biol Chem 271 27205 27208
20. AB Hodsman DC Bauer DW Dempster L Dian DA Hanley ST Harris DL Kendler MR McClung PD Miller WP Olszynski E Orwoll CK Yuen 2005 Parathyroid hormone and teriparatide for the treatment of osteoporosis: a review of the evience and suggested guidelines for its use Endocr Rev 26 688 703
21. RL Jilka 2007 Molecular and cellular mechanisms of the anabolic effect of intermittent PTH Bone 40 1434 1446
22. C Bergwitz AB Abou-Samra RD Hesch H Jüppner 1994 Rapid desensitisation of parathyroid hormone dependent adenylate cyclase in perfused human osteosarcoma cells (SaOS-2) Biochim Biophys Acta 1222 447 456
23. T Ishizuya S Yokose M Hori T Noda T Suda S Yoshiki A Yamaguchi 1997 Parathyroid hormone exerts disparate effects on osteoblastic differentiation depending on exposure time n rat osteoblastic cells J Clin Invest 99 2961 2970
24. JE Onyia LM Helvering L Gelbert T Wei S Hunag P Chen ER Dow A Maran M Zhang S Lotinun X Lin DL Halladay RR Miles NH Kulkarni EM Ambrose YL Ma CA Frolik M Sato HU Bryant RT Turner 2005 Molecular profile of catabolic versus anabolic treatment regiments of parathyroid hormone (PTH) in rat bone: an analysis by DNA microarray J Cell Biochem 95 403 418
25. SP Heximer SP Srinivasa LS Bernstein JL Bernard ME Linder JR Hepler KJ Blumer 1999 G protein selectivity is a determinant of RGS2 function J Biol Chem 274 34253 34259
26. K Horsch H de Wet MM Schuurmans F Allie-Reid AC Cato J Cunningham JM Burrin FS Hough PA Hulley 2007 Mitogen-activated protein kinase phosphatase 1/dual specific phosphatase 1 mediates glucocorticoid inhibition of osteoblast proliferation Mol Endocrinol 21 2929 2940
27. KJ Cowan KB Storey 2003 Mitogen-activated protein kinases: new signaling pathways functioning in cellular responses to environmental stress J Exp Biol 206 1107 1115
28. MS Erclik J Mitchell 2005 Activation of the insluin-like growth factor binding protien-5 promoter by parathyroid hormone in osteosarcoma cells requires activation of an activated protein-2 element J Mol Endocrinol 34 713 722
29. 11α in osteoblastic cells enhances parathyroid hormone activation of phospholipase C and AP-1 regulation of matrix metalloproteinase-13 mRNA J Cell Physiol 204 336 343
30. JM Fleming JA Brnadimarto WS Cohick 2007 The mitogen-activated protein kinase pathway tonically inhibits both basal and IGF-1 stimulated IGF-binding protein-5 production in mammary epithelial cells J Endocrinol 194 349 359
31. DJ Flint M Boutinaud E Tonner CJ Wilde W Hurley PA Accorsi AF Kolb CB Whitelaw J Beattie GJ Allan 2005 Insulin-like growth factor binding proteins initiate cell death and extracellular matrix remodeling in the mammary gland Domest Anim Endocrinol 29 274 282