메뉴 건너뛰기




Volumn 434, Issue 7035, 2005, Pages 843-850

Wnt signalling in stem cells and cancer

Author keywords

[No Author keywords available]

Indexed keywords

CARCINOGENS; CELLS; DERMATOLOGY; DISEASES; GROWTH KINETICS; HEALTH CARE; SIGNALING; TISSUE;

EID: 17244376814     PISSN: 00280836     EISSN: None     Source Type: Journal    
DOI: 10.1038/nature03319     Document Type: Review
Times cited : (3176)

References (90)
  • 1
    • 0023653232 scopus 로고
    • The Drosophila homolog of the mouse mammary oncogene int-1 is identical to the segment polarity gene wingless
    • Rijsewijk, F. et al. The Drosophila homolog of the mouse mammary oncogene int-1 is identical to the segment polarity gene wingless. Cell 50, 649-657 (1987).
    • (1987) Cell , vol.50 , pp. 649-657
    • Rijsewijk, F.1
  • 2
    • 0041695485 scopus 로고    scopus 로고
    • A second canon. Functions and mechanisms of β-catenin-independent Wnt signaling
    • Veeman, M. T., Axelrod, J. D. & Moon, R. T. A second canon. Functions and mechanisms of β-catenin-independent Wnt signaling. Dev. Cell 5, 367-377 (2003).
    • (2003) Dev. Cell , vol.5 , pp. 367-377
    • Veeman, M.T.1    Axelrod, J.D.2    Moon, R.T.3
  • 3
    • 0032941717 scopus 로고    scopus 로고
    • Regulation of LEF-1/TCF transcription factors by Wnt and other signals
    • Eastman, Q. & Grosschedl, R. Regulation of LEF-1/TCF transcription factors by Wnt and other signals. Curr. Opin. Cell Biol. 11, 233-240 (1999).
    • (1999) Curr. Opin. Cell Biol. , vol.11 , pp. 233-240
    • Eastman, Q.1    Grosschedl, R.2
  • 4
    • 0038359353 scopus 로고    scopus 로고
    • Caught up in a Wnt storm: Wnt signaling in cancer
    • Giles, R. H., van Es, J. H. & Clevers, H. Caught up in a Wnt storm: Wnt signaling in cancer. Biochim. Biophys. Acta 1653, 1-24 (2003).
    • (2003) Biochim. Biophys. Acta , vol.1653 , pp. 1-24
    • Giles, R.H.1    Van Es, J.H.2    Clevers, H.3
  • 6
    • 0029940608 scopus 로고    scopus 로고
    • Epithelial cell migration in the intestine
    • Heath, J. P. Epithelial cell migration in the intestine. Cell Biol. Int. 20, 139-146 (1996).
    • (1996) Cell Biol. Int. , vol.20 , pp. 139-146
    • Heath, J.P.1
  • 7
    • 0032578019 scopus 로고    scopus 로고
    • Stem cells in gastrointestinal epithelium: Numbers, characteristics and death
    • Potten, C. S. Stem cells in gastrointestinal epithelium: numbers, characteristics and death. Phil. Trans. R. Soc. Lond. B 353, 821-830 (1998).
    • (1998) Phil. Trans. R. Soc. Lond. B , vol.353 , pp. 821-830
    • Potten, C.S.1
  • 8
    • 0036591968 scopus 로고    scopus 로고
    • Intestinal stem cells protect their genome by selective segregation of template DNA strands
    • Potten, C. S., Owen, G. & Booth, D. Intestinal stem cells protect their genome by selective segregation of template DNA strands. J. Cell Sci. 115, 2381-2388 (2002).
    • (2002) J. Cell Sci. , vol.115 , pp. 2381-2388
    • Potten, C.S.1    Owen, G.2    Booth, D.3
  • 9
    • 0032897996 scopus 로고    scopus 로고
    • Clonal analysis of mouse intestinal epithelial progenitors
    • Bjerknes, M. & Cheng, H. Clonal analysis of mouse intestinal epithelial progenitors. Gastroenterology 116, 7-14 (1999).
    • (1999) Gastroenterology , vol.116 , pp. 7-14
    • Bjerknes, M.1    Cheng, H.2
  • 10
    • 0023780022 scopus 로고
    • Development of the pattern of cell renewal in the crypt-villus unit of chimaeric mouse small intestine
    • Schmidt, G. H., Winton, D. J. & Ponder, B. A. Development of the pattern of cell renewal in the crypt-villus unit of chimaeric mouse small intestine. Development 103, 785-790 (1988).
    • (1988) Development , vol.103 , pp. 785-790
    • Schmidt, G.H.1    Winton, D.J.2    Ponder, B.A.3
  • 11
    • 0034080251 scopus 로고    scopus 로고
    • Gut instincts: Thoughts on intestinal epithelial stem cells
    • Booth, C. & Potten, C. S. Gut instincts: thoughts on intestinal epithelial stem cells. J. Clin. Invest. 105, 1493-1499 (2000).
    • (2000) J. Clin. Invest. , vol.105 , pp. 1493-1499
    • Booth, C.1    Potten, C.S.2
  • 12
    • 0026001002 scopus 로고
    • Use of transgenic mice to infer the biological properties of small intestinal stem cells and to examine the lineage relationships of their descendants
    • Roth, K. A., Hermiston, M. L. & Gordon, J. I. Use of transgenic mice to infer the biological properties of small intestinal stem cells and to examine the lineage relationships of their descendants. Proc. Natl Acad. Sci. USA 88, 9407-9411 (1991).
    • (1991) Proc. Natl Acad. Sci. USA , vol.88 , pp. 9407-9411
    • Roth, K.A.1    Hermiston, M.L.2    Gordon, J.I.3
  • 13
    • 18644376279 scopus 로고    scopus 로고
    • β-catenin and TCF mediate cell positioning in the intestinal epithelium by controlling the expression of EphB/ephrinB
    • Batlle, E. et al. β-catenin and TCF mediate cell positioning in the intestinal epithelium by controlling the expression of EphB/ephrinB. Cell 111, 251-263 (2002).
    • (2002) Cell , vol.111 , pp. 251-263
    • Batlle, E.1
  • 14
    • 0002770481 scopus 로고    scopus 로고
    • Depletion of epithelia stem-cell compartments in the small intestine of mice lacking Tcf-4
    • Korinek, V. et al. Depletion of epithelia stem-cell compartments in the small intestine of mice lacking Tcf-4. Nature Genet. 19, 1-5 (1998).
    • (1998) Nature Genet. , vol.19 , pp. 1-5
    • Korinek, V.1
  • 15
    • 0037829660 scopus 로고    scopus 로고
    • Canonical Wnt signals are essential for homeostasis of the intestinal epithelium
    • Pinto, D., Gregorieff, A., Begthel, H. & Clevers, H. Canonical Wnt signals are essential for homeostasis of the intestinal epithelium. Genes Dev. 17, 1709-1713 (2003).
    • (2003) Genes Dev. , vol.17 , pp. 1709-1713
    • Pinto, D.1    Gregorieff, A.2    Begthel, H.3    Clevers, H.4
  • 16
    • 0346458662 scopus 로고    scopus 로고
    • Essential requirement for Wnt signaling in proliferation of adult small intestine and colon revealed by adenoviral expression of Dickkopf-1
    • Kuhnert, F. et al. Essential requirement for Wnt signaling in proliferation of adult small intestine and colon revealed by adenoviral expression of Dickkopf-1. Proc. Natl Acad. Sci. USA 101, 266-271 (2004).
    • (2004) Proc. Natl Acad. Sci. USA , vol.101 , pp. 266-271
    • Kuhnert, F.1
  • 17
    • 18644373146 scopus 로고    scopus 로고
    • The β-catenin/TCF-4 complex imposes a crypt progenitor phenotype on colorectal cancer cells
    • van de Wetering, M. et al. The β-catenin/TCF-4 complex imposes a crypt progenitor phenotype on colorectal cancer cells. Cell 111, 241-250 (2002).
    • (2002) Cell , vol.111 , pp. 241-250
    • Van De Wetering, M.1
  • 18
    • 0030592517 scopus 로고    scopus 로고
    • Lessons from hereditary colorectal cancer
    • Kinder, K. W. & Vogelstein, B. Lessons from hereditary colorectal cancer. Cell 87, 159-170 (1996).
    • (1996) Cell , vol.87 , pp. 159-170
    • Kinder, K.W.1    Vogelstein, B.2
  • 19
    • 0029664368 scopus 로고    scopus 로고
    • Binding of GSK3β to the APC-β-catenin complex and regulation of complex assembly
    • Rubinfeld, B. et al. Binding of GSK3β to the APC-β-catenin complex and regulation of complex assembly. Science 272, 1023-1026 (1996).
    • (1996) Science , vol.272 , pp. 1023-1026
    • Rubinfeld, B.1
  • 20
    • 0030975671 scopus 로고    scopus 로고
    • Constitutive transcriptional activation by a β-catenin-Tcf complex in APC-/- colon carcinoma
    • Korinek, V. et al. Constitutive transcriptional activation by a β-catenin-Tcf complex in APC-/- colon carcinoma. Science 275, 1784-1787 (1997).
    • (1997) Science , vol.275 , pp. 1784-1787
    • Korinek, V.1
  • 21
    • 0033780630 scopus 로고    scopus 로고
    • Mutations in AXIN2 cause colorectal cancer with defective mismatch repair by activating β-catenin/TCF signalling
    • Liu, W. et al. Mutations in AXIN2 cause colorectal cancer with defective mismatch repair by activating β-catenin/TCF signalling. Nature Genet. 26, 146-147 (2000).
    • (2000) Nature Genet. , vol.26 , pp. 146-147
    • Liu, W.1
  • 22
    • 0030949463 scopus 로고    scopus 로고
    • Activation of β-catenin-Tcf signaling in colon cancer by mutations in β-catenin or APC
    • Morin, P. J. et al. Activation of β-catenin-Tcf signaling in colon cancer by mutations in β-catenin or APC Science 275, 1787-1790 (1997).
    • (1997) Science , vol.275 , pp. 1787-1790
    • Morin, P.J.1
  • 23
    • 0032483439 scopus 로고    scopus 로고
    • Identification of c-MYC as a target of the APC pathway
    • He, T. C. et al. Identification of c-MYC as a target of the APC pathway. Science 281, 1509-1512(1998).
    • (1998) Science , vol.281 , pp. 1509-1512
    • He, T.C.1
  • 24
    • 0033119801 scopus 로고    scopus 로고
    • β-catenin regulates expression of cyclin D1 in colon carcinoma cells
    • Tetsu, O. & McCormick, F. β-catenin regulates expression of cyclin D1 in colon carcinoma cells. Nature 398, 422-426 (1999).
    • (1999) Nature , vol.398 , pp. 422-426
    • Tetsu, O.1    McCormick, F.2
  • 25
    • 2942668475 scopus 로고    scopus 로고
    • Loss of Apc in vivo immediately perturbs Wnt signaling, differentiation, and migration
    • Sansom, O. J. et al. Loss of Apc in vivo immediately perturbs Wnt signaling, differentiation, and migration. Genes Dev. 18, 1385-1390 (2004).
    • (2004) Genes Dev. , vol.18 , pp. 1385-1390
    • Sansom, O.J.1
  • 26
    • 0036537074 scopus 로고    scopus 로고
    • Designer skin: Lineage commitment in postnatal epidermis
    • Niemann, C. & Watt, F. M. Designer skin: lineage commitment in postnatal epidermis. Trends Cell Biol. 12, 185-192 (2002).
    • (2002) Trends Cell Biol. , vol.12 , pp. 185-192
    • Niemann, C.1    Watt, F.M.2
  • 27
    • 0027945654 scopus 로고
    • Development of several organs that require inductive epithelial- mesenchymal interactions is impaired in LEF-1 deficient mice
    • van Genderen, C. et al. Development of several organs that require inductive epithelial-mesenchymal interactions is impaired in LEF-1 deficient mice. Genes Dev. 8, 2691-2703 (1994).
    • (1994) Genes Dev. , vol.8 , pp. 2691-2703
    • Van Genderen, C.1
  • 28
    • 0029167307 scopus 로고
    • Lymphoid enhancer factor 1 directs hair follicle patterning and epithelial cell fate
    • Zhou, P., Byrne, C., Jacobs, J. & Fuchs, E. Lymphoid enhancer factor 1 directs hair follicle patterning and epithelial cell fate. Genes Dev. 9, 700-713 (1995).
    • (1995) Genes Dev. , vol.9 , pp. 700-713
    • Zhou, P.1    Byrne, C.2    Jacobs, J.3    Fuchs, E.4
  • 29
    • 0032567078 scopus 로고    scopus 로고
    • De Novo hair follicle morphogenesis and hair tumors in mice expressing a truncated β-catenin in skin
    • Gat, U., DasGupta, R., Degenstein, L. &; Fuchs, E. De Novo hair follicle morphogenesis and hair tumors in mice expressing a truncated β-catenin in skin. Cell 95, 605-614 (1998).
    • (1998) Cell , vol.95 , pp. 605-614
    • Gat, U.1    DasGupta, R.2    Degenstein, L.3    Fuchs, E.4
  • 30
    • 2342427631 scopus 로고    scopus 로고
    • Transient activation of &-catenin signalling in adult mouse epidermis is sufficient to induce new hair follicles but continuous activation is required to maintain hair follicle tumours
    • Lo Celso, C., Prowse, D. M. & Watt, F. M. Transient activation of &-catenin signalling in adult mouse epidermis is sufficient to induce new hair follicles but continuous activation is required to maintain hair follicle tumours. Development 131, 1787-1799 (2004).
    • (2004) Development , vol.131 , pp. 1787-1799
    • Lo Celso, C.1    Prowse, D.M.2    Watt, F.M.3
  • 31
    • 0035907041 scopus 로고    scopus 로고
    • β-catenin controls hair follicle morphogenesis and stem cell differentiation in the skin
    • Huelsken, J., Vogel, R., Erdmann, B., Cotsarelis, G. & Birchmeier, W. β-Catenin controls hair follicle morphogenesis and stem cell differentiation in the skin. Cell 105, 533-545 (2001).
    • (2001) Cell , vol.105 , pp. 533-545
    • Huelsken, J.1    Vogel, R.2    Erdmann, B.3    Cotsarelis, G.4    Birchmeier, W.5
  • 32
    • 0032718124 scopus 로고    scopus 로고
    • Multiple roles for activated LEF/TCF transcription complexes during hair follicle development and differentiation
    • DasGupta, R. & Fuchs, E. Multiple roles for activated LEF/TCF transcription complexes during hair follicle development and differentiation. Development 126, 4557-4568 (1999).
    • (1999) Development , vol.126 , pp. 4557-4568
    • DasGupta, R.1    Fuchs, E.2
  • 33
    • 0036023356 scopus 로고    scopus 로고
    • Expression of ΔNLef 1 in mouse epidermis results in differentiation of hair follicles into squamous epidermal cysts and formation of skin tumours
    • Niemann, C., Owens, D. M., Hulsken, J., Birchmeier, W. & Watt, F. M. Expression of ΔNLef1 in mouse epidermis results in differentiation of hair follicles into squamous epidermal cysts and formation of skin tumours. Development 129, 95-109 (2002).
    • (2002) Development , vol.129 , pp. 95-109
    • Niemann, C.1    Owens, D.M.2    Hulsken, J.3    Birchmeier, W.4    Watt, F.M.5
  • 34
    • 0242460440 scopus 로고    scopus 로고
    • Manipulation of stem cell proliferation and lineage commitment: Visualisation of label-retaining cells in wholemounts of mouse epidermis
    • Braun, K. M. et al. Manipulation of stem cell proliferation and lineage commitment: visualisation of label-retaining cells in wholemounts of mouse epidermis. Development 130, 5241-5255 (2003).
    • (2003) Development , vol.130 , pp. 5241-5255
    • Braun, K.M.1
  • 35
    • 0035395874 scopus 로고    scopus 로고
    • Tcf3 and Lef1 regulate lineage differentiation of multipotent stem cells in skin
    • Merrill, B. J., Gat, U., DasGupta, R. & Fuchs, E. Tcf3 and Lef1 regulate lineage differentiation of multipotent stem cells in skin. Genes Dev. 15, 1688-1705 (2001).
    • (2001) Genes Dev. , vol.15 , pp. 1688-1705
    • Merrill, B.J.1    Gat, U.2    DasGupta, R.3    Fuchs, E.4
  • 36
    • 0032953231 scopus 로고    scopus 로고
    • A common human skin tumour is caused by activating mutations in β-catenin
    • Chan, E. F., Gat, U., McNiff, J. M. & Fuchs, E. A common human skin tumour is caused by activating mutations in β-catenin. Nature Genet. 21, 410-413 (1999).
    • (1999) Nature Genet. , vol.21 , pp. 410-413
    • Chan, E.F.1    Gat, U.2    McNiff, J.M.3    Fuchs, E.4
  • 37
    • 84956427297 scopus 로고
    • A direct measurement of the radiation sensitivity of normal mouse bone marrow cells
    • Till, J. & McCulloch, E. A direct measurement of the radiation sensitivity of normal mouse bone marrow cells. Radiat. Res. 14, 213-222 (1961).
    • (1961) Radiat. Res. , vol.14 , pp. 213-222
    • Till, J.1    McCulloch, E.2
  • 38
    • 0000062301 scopus 로고
    • Cytological demonstration of the clonal nature of spleen colonies derived from transplanted mouse marrow cells
    • Becker, A. J., McCulloch, E. A. & Till, J. E. Cytological demonstration of the clonal nature of spleen colonies derived from transplanted mouse marrow cells. Nature 197, 452-454 (1963).
    • (1963) Nature , vol.197 , pp. 452-454
    • Becker, A.J.1    McCulloch, E.A.2    Till, J.E.3
  • 39
    • 0034712022 scopus 로고    scopus 로고
    • Translating stem and progenitor cell biology to the clinic: Barriers and opportunities
    • Weissman, I. L. Translating stem and progenitor cell biology to the clinic: barriers and opportunities. Science 287, 1442-1446 (2000).
    • (2000) Science , vol.287 , pp. 1442-1446
    • Weissman, I.L.1
  • 40
    • 0035902140 scopus 로고    scopus 로고
    • The Hedgehog and Wnt signalling pathways in cancer
    • Taipale, J. & Beachy, P. A. The Hedgehog and Wnt signalling pathways in cancer. Nature 411, 349-354 (2001).
    • (2001) Nature , vol.411 , pp. 349-354
    • Taipale, J.1    Beachy, P.A.2
  • 41
  • 42
    • 0033694305 scopus 로고    scopus 로고
    • Pluripotent, cytokine-dependent, hematopoietic stem cells are immortalized by constitutive Notchl signaling
    • Varnum-Finney, B. et al. Pluripotent, cytokine-dependent, hematopoietic stem cells are immortalized by constitutive Notchl signaling. Nature Med. 6, 1278-1281 (2000).
    • (2000) Nature Med. , vol.6 , pp. 1278-1281
    • Varnum-Finney, B.1
  • 43
    • 0035257660 scopus 로고    scopus 로고
    • Sonic hedgehog induces the proliferation of primitive human hematopoietic cells via BMP regulation
    • Bhardwaj, G. et al. Sonic hedgehog induces the proliferation of primitive human hematopoietic cells via BMP regulation. Nature Immunol. 2, 172-180 (2001).
    • (2001) Nature Immunol. , vol.2 , pp. 172-180
    • Bhardwaj, G.1
  • 45
    • 0037737728 scopus 로고    scopus 로고
    • A role for Wnt signalling in self-renewal of haematopoietic stem cells
    • Reya, T. et al. A role for Wnt signalling in self-renewal of haematopoietic stem cells. Nature 423, 409-414 (2003).
    • (2003) Nature , vol.423 , pp. 409-414
    • Reya, T.1
  • 46
    • 0030989287 scopus 로고    scopus 로고
    • A role for the Wnt gene family in hematopoiesis: Expansion of multilineage progenitor cells
    • Austin, T. W., Solar, G. P., Ziegler, F. C., Liem, L. & Matthews, W. A role for the Wnt gene family in hematopoiesis: expansion of multilineage progenitor cells. Blood 89, 3624-3635 (1997).
    • (1997) Blood , vol.89 , pp. 3624-3635
    • Austin, T.W.1    Solar, G.P.2    Ziegler, F.C.3    Liem, L.4    Matthews, W.5
  • 47
    • 0037737726 scopus 로고    scopus 로고
    • Wnt proteins are lipid-modified and can act as stem cell growth factors
    • Willert, K. et al. Wnt proteins are lipid-modified and can act as stem cell growth factors. Nature 423, 448-452 (2003).
    • (2003) Nature , vol.423 , pp. 448-452
    • Willert, K.1
  • 48
    • 0032212190 scopus 로고    scopus 로고
    • Role of members of the Wnt gene family in human hematopoiesis
    • Van Den Berg, D. J., Sharma, A. K., Bruno, E. & Hoffman, R. Role of members of the Wnt gene family in human hematopoiesis. Blood 92, 3189-3202 (1998).
    • (1998) Blood , vol.92 , pp. 3189-3202
    • Van Den Berg, D.J.1    Sharma, A.K.2    Bruno, E.3    Hoffman, R.4
  • 49
    • 0037452998 scopus 로고    scopus 로고
    • Wnt-5A augments repopulating capacity and primitive hematopoietic development of human blood stem cells in vivo
    • Murdoch, B. et al Wnt-5A augments repopulating capacity and primitive hematopoietic development of human blood stem cells in vivo. Proc. Natl Acad. Sci. USA 100, 3422-3427 (2003).
    • (2003) Proc. Natl Acad. Sci. USA , vol.100 , pp. 3422-3427
    • Murdoch, B.1
  • 50
    • 1642499734 scopus 로고    scopus 로고
    • β-catenin is dispensable for hematopoiesis and lymphopoiesis
    • Cobas, M et al. β-Catenin is dispensable for hematopoiesis and lymphopoiesis. J. Exp. Med. 199, 221-229 (2004).
    • (2004) J. Exp. Med. , vol.199 , pp. 221-229
    • Cobas, M.1
  • 52
    • 0033711624 scopus 로고    scopus 로고
    • Wnt signaling regulates B lymphocyte proliferation through a LEF-1 dependent mechanism
    • Reya, T. et al. Wnt signaling regulates B lymphocyte proliferation through a LEF-1 dependent mechanism. Immunity 13, 15-24 (2000).
    • (2000) Immunity , vol.13 , pp. 15-24
    • Reya, T.1
  • 53
    • 15244345063 scopus 로고    scopus 로고
    • Frizzled 9 knockout mice have abnormal B cell development
    • ahead of print publication, 30 November (doi:10.1182/blood-2004-06-2334
    • Ranheim, E., Kwan, H., Reya, T., Weissman, I. L. & Francke, U. Frizzled 9 knockout mice have abnormal B cell development. Blood ahead of print publication, 30 November 2004 (doi:10.1182/blood-2004-06-2334).
    • (2004) Blood
    • Ranheim, E.1    Kwan, H.2    Reya, T.3    Weissman, I.L.4    Francke, U.5
  • 54
    • 0036236572 scopus 로고    scopus 로고
    • WNT signaling and lymphocyte development
    • van de Wetering, M., de Lau, W. & Clevers, H. WNT signaling and lymphocyte development. Cell 109(suppl.), S13-S19 (2002).
    • (2002) Cell , vol.109 , Issue.SUPPL.
    • Van De Wetering, M.1    De Lau, W.2    Clevers, H.3
  • 55
    • 0022345716 scopus 로고
    • The complement of desmosomal plaque proteins in different cell types
    • Cowin, R, Kapprell, H. P. & Franke, W. W. The complement of desmosomal plaque proteins in different cell types. J. Cell Biol. 101, 1442-1454 (1985).
    • (1985) J. Cell Biol. , vol.101 , pp. 1442-1454
    • Cowin, R.1    Kapprell, H.P.2    Franke, W.W.3
  • 56
    • 11144355530 scopus 로고    scopus 로고
    • γ-catenin contributes to leukemogenesis induced by AML-associated translocation products by increasing the self-renewal of very primitive progenitor cells
    • Zheng, X. et al. γ-catenin contributes to leukemogenesis induced by AML-associated translocation products by increasing the self-renewal of very primitive progenitor cells. Blood 103, 3535-3543 (2004).
    • (2004) Blood , vol.103 , pp. 3535-3543
    • Zheng, X.1
  • 57
    • 0242268524 scopus 로고    scopus 로고
    • Osteoblastic cells regulate the haematopoietic stem cell niche
    • Calvi, L. M. et al. Osteoblastic cells regulate the haematopoietic stem cell niche. Nature 425, 841-846 (2003).
    • (2003) Nature , vol.425 , pp. 841-846
    • Calvi, L.M.1
  • 58
    • 0242363225 scopus 로고    scopus 로고
    • Identification of the haematopoietic stem cell niche and control of the niche size
    • Zhang, J. et al. Identification of the haematopoietic stem cell niche and control of the niche size. Nature 425, 836-841 (2003).
    • (2003) Nature , vol.425 , pp. 836-841
    • Zhang, J.1
  • 59
    • 0036791040 scopus 로고    scopus 로고
    • A molecular profile of a hematopoietic stem cell niche
    • Hackney, J. A. et al. A molecular profile of a hematopoietic stem cell niche. Proc. Natl Acad. Sci. USA 99, 13061-13066 (2002).
    • (2002) Proc. Natl Acad. Sci. USA , vol.99 , pp. 13061-13066
    • Hackney, J.A.1
  • 60
    • 3943088431 scopus 로고    scopus 로고
    • Granulocyte/macrophage progenitors in chronic myelogenous leukemia are candidate leukemia stem cells that activate the β-catenin pathway
    • Jamieson, C. H. et al. Granulocyte/macrophage progenitors in chronic myelogenous leukemia are candidate leukemia stem cells that activate the β-catenin pathway. N. Engl J. Med. 351, 657-667 [2004).
    • (2004) N. Engl J. Med. , vol.351 , pp. 657-667
    • Jamieson, C.H.1
  • 61
    • 12144287598 scopus 로고    scopus 로고
    • Translocation products in acute myeloid leukemia activate the Wnt signaling pathway in hematopoietic cells
    • Muller-Tidow, C. et al. Translocation products in acute myeloid leukemia activate the Wnt signaling pathway in hematopoietic cells. Mol. Cell. Biol. 24, 2890-2904 (2004).
    • (2004) Mol. Cell. Biol. , vol.24 , pp. 2890-2904
    • Muller-Tidow, C.1
  • 62
    • 0033613097 scopus 로고    scopus 로고
    • Oncogenic homeodomain transcription factor E2A-Pbx1 activates a novel WKT gene in pre-B acute lymphoblastoid leukemia
    • McWhirter, J. R. et al. Oncogenic homeodomain transcription factor E2A-Pbx1 activates a novel WKT gene in pre-B acute lymphoblastoid leukemia. Proc. Natl Acad. Sci. USA 96, 11464-11469 (1999).
    • (1999) Proc. Natl Acad. Sci. USA , vol.96 , pp. 11464-11469
    • McWhirter, J.R.1
  • 63
    • 11144355390 scopus 로고    scopus 로고
    • Illegitimate WNT signaling promotes proliferation of multiple myeloma cells
    • Derksen, P. W. et al. illegitimate WNT signaling promotes proliferation of multiple myeloma cells. Proc. Natl Acad. Sci. USA 101, 6122-6127 (2004).
    • (2004) Proc. Natl Acad. Sci. USA , vol.101 , pp. 6122-6127
    • Derksen, P.W.1
  • 64
    • 0242669237 scopus 로고    scopus 로고
    • Hedgehog signalling within airway epithelial progenitors and in small-cell lung cancer
    • Watkins, D. N. et al. Hedgehog signalling within airway epithelial progenitors and in small-cell lung cancer. Nature 422, 313-317 (2003).
    • (2003) Nature , vol.422 , pp. 313-317
    • Watkins, D.N.1
  • 65
    • 0345356929 scopus 로고    scopus 로고
    • Wnt 5a inhibits B cell proliferation and functions as a tumor suppressor in hematopoietic tissue
    • Liang, H. et al. Wnt5a inhibits B cell proliferation and functions as a tumor suppressor in hematopoietic tissue. Cancer Cell 4, 349-360 (2003).
    • (2003) Cancer Cell , vol.4 , pp. 349-360
    • Liang, H.1
  • 66
    • 2342444945 scopus 로고    scopus 로고
    • Wnt activates the Tak1/Nemo-like kinase pathway
    • Smit, L. et al. Wnt activates the Tak1/Nemo-like kinase pathway. J. Biol Chem. 279, 17232-17240 (2004).
    • (2004) J. Biol Chem. , vol.279 , pp. 17232-17240
    • Smit, L.1
  • 67
    • 0037135177 scopus 로고    scopus 로고
    • Regulation of cerebral cortical size by control of cell cycle exit in neural precursors
    • Chenn, A. & Walsh, C. A. Regulation of cerebral cortical size by control of cell cycle exit in neural precursors. Science 297, 365-369 (2002).
    • (2002) Science , vol.297 , pp. 365-369
    • Chenn, A.1    Walsh, C.A.2
  • 68
    • 0038517899 scopus 로고    scopus 로고
    • β-catenin signals regulate cell growth and the balance between progenitor cell expansion and differentiation in the nervous system
    • Zechner, D. et al. β-catenin signals regulate cell growth and the balance between progenitor cell expansion and differentiation in the nervous system. Dev. Biol. 258, 406-418 (2003).
    • (2003) Dev. Biol. , vol.258 , pp. 406-418
    • Zechner, D.1
  • 69
    • 0032030894 scopus 로고    scopus 로고
    • Sporadic medulloblastomas contain oncogenic β-catenin mutations
    • Zurawel, R. H., Chiappa, S. A., Allen, C. & Raffel, C. Sporadic medulloblastomas contain oncogenic β-catenin mutations. Cancer Res. 58, 896-899 (1998).
    • (1998) Cancer Res. , vol.58 , pp. 896-899
    • Zurawel, R.H.1    Chiappa, S.A.2    Allen, C.3    Raffel, C.4
  • 70
    • 0035477364 scopus 로고    scopus 로고
    • Deletions of AXIN1, a component of the WNT/wingless pathway, in sporadic medulloblastomas
    • Dahmen, R. P. et al. Deletions of AXIN1, a component of the WNT/wingless pathway, in sporadic medulloblastomas. Cancer Res. 61, 7039-7043 (2001).
    • (2001) Cancer Res. , vol.61 , pp. 7039-7043
    • Dahmen, R.P.1
  • 71
    • 0037473082 scopus 로고    scopus 로고
    • AXIN1 mutations but not deletions in cerebellar medulloblastomas
    • Baeza, N., Masuoka, J., Kleihues, P. & Ohgaki, H. AXIN1 mutations but not deletions in cerebellar medulloblastomas. Oncogene 22, 632-636 (2003).
    • (2003) Oncogene , vol.22 , pp. 632-636
    • Baeza, N.1    Masuoka, J.2    Kleihues, P.3    Ohgaki, H.4
  • 72
    • 1642570244 scopus 로고    scopus 로고
    • The transforming activity of Wnt effectors correlates with their ability to induce the accumulation of mammary progenitor cells
    • Liu, B. Y., McDermott, S. P., Khwaja, S. S. & Alexander, C. M. The transforming activity of Wnt effectors correlates with their ability to induce the accumulation of mammary progenitor cells. Proc. Natl Acad. Sci. USA 101, 4158-4163 (2004).
    • (2004) Proc. Natl Acad. Sci. USA , vol.101 , pp. 4158-4163
    • Liu, B.Y.1    McDermott, S.P.2    Khwaja, S.S.3    Alexander, C.M.4
  • 73
    • 9144269759 scopus 로고    scopus 로고
    • Evidence that transgenes encoding components of the Wnt signaling pathway preferentially induce mammary cancers from progenitor cells
    • Li, Y. et al. Evidence that transgenes encoding components of the Wnt signaling pathway preferentially induce mammary cancers from progenitor cells. Proc. Natl Acad. Sci. USA 100, 15853-15858 (2003).
    • (2003) Proc. Natl Acad. Sci. USA , vol.100 , pp. 15853-15858
    • Li, Y.1
  • 74
    • 1242267927 scopus 로고    scopus 로고
    • Maintenance of pluripotency in human and mouse embryonic stem cells through activation of Wnt signaling by a pharmacological GSK-3-specific inhibitor
    • Sato, N., Meijer, L., Skaltsounis, L., Greengard, P. & Brivanlou, A. H. Maintenance of pluripotency in human and mouse embryonic stem cells through activation of Wnt signaling by a pharmacological GSK-3-specific inhibitor. Nature Med. 10, 55-63 (2004).
    • (2004) Nature Med. , vol.10 , pp. 55-63
    • Sato, N.1    Meijer, L.2    Skaltsounis, L.3    Greengard, P.4    Brivanlou, A.H.5
  • 75
    • 18744398990 scopus 로고    scopus 로고
    • Apc modulates embryonic stem-cell differentiation by controlling the dosage of β-catenin signaling
    • Kielman, M. F. et al. Apc modulates embryonic stem-cell differentiation by controlling the dosage of β-catenin signaling. Nature Genet. 32, 594-605 (2002).
    • (2002) Nature Genet. , vol.32 , pp. 594-605
    • Kielman, M.F.1
  • 76
    • 20144370145 scopus 로고    scopus 로고
    • Integration of Notch and Wnt signaling in hematopoietic stem cell maintenance
    • Duncan, A. W. et al. Integration of Notch and Wnt signaling in hematopoietic stem cell maintenance. Nature Immunol. 6(3), 314-322 (2005).
    • (2005) Nature Immunol. , vol.6 , Issue.3 , pp. 314-322
    • Duncan, A.W.1
  • 77
    • 8644219672 scopus 로고    scopus 로고
    • LEF1-mediated regulation of Delta-like1 links Wnt and Notch signaling in somitogenesis
    • Galceran, J., Sustmann, C., Hsu, S. C., Folberth, S. & Grosschedl, R. LEF1-mediated regulation of Delta-like1 links Wnt and Notch signaling in somitogenesis. Genes Dev. 18, 2718-2723 (2004).
    • (2004) Genes Dev. , vol.18 , pp. 2718-2723
    • Galceran, J.1    Sustmann, C.2    Hsu, S.C.3    Folberth, S.4    Grosschedl, R.5
  • 78
    • 6944224156 scopus 로고    scopus 로고
    • BMP signaling inhibits intestinal stem cell self-renewal through suppression of Wnt-β-catenin signalling
    • He, X. C. et al BMP signaling inhibits intestinal stem cell self-renewal through suppression of Wnt-β-catenin signalling. Nature Genet. 36, 1117-1121 (2004).
    • (2004) Nature Genet. , vol.36 , pp. 1117-1121
    • He, X.C.1
  • 79
    • 0038383629 scopus 로고    scopus 로고
    • Wnt regulation of progenitor maturation in the cortex depends on Shh or fibroblast growth factor 2
    • Viti, J., Gulacsi, A. & Lillien, L. Wnt regulation of progenitor maturation in the cortex depends on Shh or fibroblast growth factor 2. J. Neurosci. 23, 5919-5927 (2003).
    • (2003) J. Neurosci. , vol.23 , pp. 5919-5927
    • Viti, J.1    Gulacsi, A.2    Lillien, L.3
  • 80
    • 1142298447 scopus 로고    scopus 로고
    • Instructive role of Wnt/β-catenin in sensory fate specification in neural crest stem cells
    • Lee, H. Y. et al. Instructive role of Wnt/β-catenin in sensory fate specification in neural crest stem cells. Science 303, 1020-1023 (2004).
    • (2004) Science , vol.303 , pp. 1020-1023
    • Lee, H.Y.1
  • 81
    • 0347359163 scopus 로고    scopus 로고
    • Wnt proteins promote neuronal differentiation in neural stem cell culture
    • Muroyama, Y., Kondoh, H. & Takada, S. Wnt proteins promote neuronal differentiation in neural stem cell culture. Biochem. Biophys. Res. Commun. 313, 915-921 (2004).
    • (2004) Biochem. Biophys. Res. Commun. , vol.313 , pp. 915-921
    • Muroyama, Y.1    Kondoh, H.2    Takada, S.3
  • 82
    • 0034672241 scopus 로고    scopus 로고
    • WNT signaling modulates the diversification of hematopoietic cells
    • Brandon, C, Eisenberg, L. M. & Eisenberg, C. A. WNT signaling modulates the diversification of hematopoietic cells. Blood 96, 4132-4141 (2000).
    • (2000) Blood , vol.96 , pp. 4132-4141
    • Brandon, C.1    Eisenberg, L.M.2    Eisenberg, C.A.3
  • 83
    • 0032972372 scopus 로고    scopus 로고
    • β-catenin signalling modulates proliferative potential of human epidermal keratinocytes independently of intercellular adhesion
    • Zhu, A. J. & Watt, F. M. β-catenin signalling modulates proliferative potential of human epidermal keratinocytes independently of intercellular adhesion. Development 126, 2285-2298 (1999).
    • (1999) Development , vol.126 , pp. 2285-2298
    • Zhu, A.J.1    Watt, F.M.2
  • 84
    • 0028985161 scopus 로고
    • An HMG-box-containing T-cell factor required for thymocyte differentiation
    • Verbeek, S. et al. An HMG-box-containing T-cell factor required for thymocyte differentiation. Nature 374, 70-74 (1995).
    • (1995) Nature , vol.374 , pp. 70-74
    • Verbeek, S.1
  • 85
    • 0031883962 scopus 로고    scopus 로고
    • Redundant regulation of T cell differentiation and TCRα gene expression by the transcription factors LEF-1 and TCF-1
    • Okamura, R. M., Sigvardsson, M., Verbeek, S., Clevers, H. & Grosschedl, R. Redundant regulation of T cell differentiation and TCRα gene expression by the transcription factors LEF-1 and TCF-1. Immunity 8, 11-20 (1998).
    • (1998) Immunity , vol.8 , pp. 11-20
    • Okamura, R.M.1    Sigvardsson, M.2    Verbeek, S.3    Clevers, H.4    Grosschedl, R.5
  • 87
    • 0035842902 scopus 로고    scopus 로고
    • Impaired mammary gland and lymphoid development caused by inducible expression of Axin in transgenic mice
    • Hsu, W., Shakya, R. & Costantini, F. impaired mammary gland and lymphoid development caused by inducible expression of Axin in transgenic mice. J. Cell Biol. 155, 1055-1064 (2001).
    • (2001) J. Cell Biol. , vol.155 , pp. 1055-1064
    • Hsu, W.1    Shakya, R.2    Costantini, F.3
  • 88
    • 0035879356 scopus 로고    scopus 로고
    • Wnt signaling regulates hemopoiesis through stromal cells
    • Yamane, T. et al. Wnt signaling regulates hemopoiesis through stromal cells. J. Immunol. 167, 765-772 (2001).
    • (2001) J. Immunol. , vol.167 , pp. 765-772
    • Yamane, T.1
  • 89
    • 8444220513 scopus 로고    scopus 로고
    • Signaling pathways in intestinal development and cancer
    • Sancho, E., Batlle, E. & Clevers, H. Signaling pathways in intestinal development and cancer. Annu. Rev. Cell Dev. Biol. 20, 695-723 (2004).
    • (2004) Annu. Rev. Cell Dev. Biol. , vol.20 , pp. 695-723
    • Sancho, E.1    Batlle, E.2    Clevers, H.3
  • 90
    • 1842531283 scopus 로고    scopus 로고
    • Revisiting the bulge
    • Turksen, K. Revisiting the bulge. Dev Cell 6, 454-456 (2004).
    • (2004) Dev. Cell , vol.6 , pp. 454-456
    • Turksen, K.1


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.