Phosphoinositide 3-kinase signaling in the vertebrate retina

Journal of Lipid Research

Volumn 51, Issue 1, 2010, Pages 4-22

  Rajala, Raju V S ^a  

^a UNIVERSITY OF OKLAHOMA COLLEGE OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CHECKPOINT KINASE RAD3; DIACYLGLYCEROL KINASE; G PROTEIN COUPLED RECEPTOR; GLYCOGEN SYNTHASE KINASE 3; GUANOSINE TRIPHOSPHATASE; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; INSULIN RECEPTOR SUBSTRATE 1; PHOSPHATIDYLINOSITIDE; PHOSPHATIDYLINOSITOL 3 KINASE; PHOSPHATIDYLINOSITOL 3,4,5 TRISPHOSPHATE 3 PHOSPHATASE; PHOSPHATIDYLINOSITOL KINASE; PHOSPHOLIPASE C; PLATELET DERIVED GROWTH FACTOR; PROTEIN CDC42; PROTEIN KINASE B; PROTEIN P50; PROTEIN P85; PROTEIN SH2; PROTEIN TYROSINE PHOSPHATASE 1B; RETINA S ANTIGEN; S6 KINASE; SOMATOMEDIN RECEPTOR; TARGET OF RAPAMYCIN KINASE; TRANSDUCIN;

CATALYSIS; CYTOSKELETON; DOWNSTREAM PROCESSING; ENZYME ACTIVATION; ENZYME METABOLISM; ENZYME PHOSPHORYLATION; ENZYME REGULATION; LIPOGENESIS; NEUROPROTECTION; NONHUMAN; PHENOTYPE; PHOTORECEPTOR; PHOTOSTIMULATION; PRIORITY JOURNAL; PROTEIN BINDING; PROTEIN FUNCTION; PROTEIN MOTIF; PROTEIN PHOSPHORYLATION; PROTEIN TRANSPORT; RETINA; RETINA ROD OUTER SEGMENT; REVIEW; SECOND MESSENGER; SIGNAL TRANSDUCTION; VERTEBRATE;

1-PHOSPHATIDYLINOSITOL 3-KINASE; ANIMALS; DIABETIC RETINOPATHY; HUMANS; PHOSPHATIDYLINOSITOLS; PHOSPHORYLATION; PROTEIN SUBUNITS; PROTEIN TYROSINE PHOSPHATASES; RETINA; RETINAL CONE PHOTORECEPTOR CELLS; SIGNAL TRANSDUCTION;

EID: 73149103927     PISSN: 00222275     EISSN: 15397262     Source Type: Journal    
DOI: 10.1194/jlr.R000232     Document Type: Review

References (291)

1. Hokin, M. R., and L. E. Hokin. 1953. Enzyme secretion and the incorporation of P32 into phospholipides of pancreas slices. J. Biol. Chem. 203: 967-977.
2. Hokin, L. E., and M. R. Hokin. 1955. Effects of acetylcholine on the turnover of phosphoryl units in individual phospholipids of pancreas slices and brain cortex slices. Biochim. Biophys. Acta. 18: 102-110.
3. Streb, H., R. F. Irvine, M. J. Berridge, and I. Schulz. 1983. Release of Ca2+ from a nonmitochondrial intracellular store in pancreatic acinar cells by inositol-1,4,5-trisphosphate. Nature. 306: 67-69.
4. Nishizuka, Y. 1986. Studies and perspectives of protein kinase C. Science. 233: 305-312.
5. Rhee, S. G. 1991. Inositol phospholipids-specific phospholipase C: interaction of the gamma 1 isoform with tyrosine kinase. Trends Biochem. Sci. 16: 297-301.
6. Rhee, S. G., and K. D. Choi. 1992. Regulation of inositol phospholipid-specific phospholipase C isozymes. J. Biol. Chem. 267: 12393-12396.
7. Berridge, M. J. 1993.Inositol trisphosphate and calcium signalling. Nature. 361: 315-325.
8. Auger, K. R., C. L. Carpenter, L. C. Cantley, and L. Varticovski. 1989. Phosphatidylinositol 3-kinase and its novel product, phosphatidylinositol 3-phosphate, are present in Saccharomyces cerevisiae. J. Biol. Chem. 264: 20181-20184.
9. Vanhaesebroeck, B., and M. D. Waterfield. 1999. Signaling by distinct classes of phosphoinositide 3-kinases. Exp. Cell Res. 253: 239-254.
10. Datta, S. R., A. Brunet, and M. E. Greenberg. 1999. Cellular survival: a play in three Akts. Genes Dev. 13: 2905-2927.
11. Rameh, L. E., and L. C. Cantley. 1999. The role of phosphoinositide 3-kinase lipid products in cell function. J. Biol. Chem. 274: 8347-8350.
12. Ghalayini, A. J., and R. E. Anderson. 1995. Light adaptation of bovine retinas in situ stimulates phosphatidylinositol synthesis in rod outer segments in vitro. Curr. Eye Res. 14: 1025-1029.
13. Huang, Z., A. Ghalayini, X. X. Guo, K. M. Alvarez, and R. E. Anderson. 2000. Light-mediated activation of diacylglycerol kinase in rat and bovine rod outer segments. J. Neurochem. 75: 355-362.
14. Guo, X., A. J. Ghalayini, H. Chen, and R. E. Anderson. 1997. Phosphatidylinositol 3-kinase in bovine photoreceptor rod outer segments. Invest. Ophthalmol. Vis. Sci. 38: 1873-1882.
15. Guo, X. X., Z. Huang, M. W. Bell, H. Chen, and R. E. Anderson. 2000. Tyrosine phosphorylation is involved in phosphatidylinositol 3-kinase activation in bovine rod outer segments. Mol. Vis. 6: 216-221.
16. Martin, T. F. 1998. Phosphoinositide lipids as signaling molecules: common themes for signal transduction, cytoskeletal regulation, and membrane trafficking. Annu. Rev. Cell Dev. Biol. 14: 231-264.
17. Grado, C. and C. E. Ballou. 1960. Myo-inositol phosphates from beef brain phosphoinostide. J. Biol. Chem. 235: C23-C24.
18. Whitman, M., C. P. Downes, M. Keeler, T. Keller, and L. Cantley. 1988. Type I phosphatidylinositol kinase makes a novel inositol phospholipid, phosphatidylinositol-3-phosphate. Nature. 332: 644-646.
19. Vanhaesebroeck, B., S. J. Leevers, G. Panayotou, and M. D. Waterfield. 1997. Phosphoinositide 3-kinases: a conserved family of signal transducers. Trends Biochem. Sci. 22: 267-272.
20. Brogiolo, W., H. Stocker, T. Ikeya, F. Rintelen, R. Fernandez, and E. Hafen. 2001. An evolutionarily conserved function of the Drosophila insulin receptor and insulin-like peptides in growth control. Curr. Biol. 11: 213-221.
21. Goberdhan, D. C., N. Paricio, E. C. Goodman, M. Mlodzik, and C. Wilson. 1999. Drosophila tumor suppressor PTEN controls cell size and number by antagonizing the Chico/PI3-kinase signaling pathway. Genes Dev. 13: 3244-3258.
22. Verdu, J., M. A. Buratovich, E. L. Wilder, and M. J. Birnbaum. 1999. Cell-autonomous regulation of cell and organ growth in Drosophila by Akt/ PKB. Nat. Cell Biol. 1: 500-506.
23. Lin, K., J. B. Dorman, A. Rodan, and C. Kenyon. 1997. daf-16: an HNF-3/ forkhead family member that can function to double the life-span of Caenorhabditis elegans. Science. 278: 1319-1322.
24. Ogg, S., and G. Ruvkun. 1998. The C. elegans PTEN homolog, DAF-18, acts in the insulin receptor-like metabolic signaling pathway. Mol. Cell. 2: 887-893.
25. Kuruvilla, F. G., and S. L. Schreiber. 1999. The PIK-related kinases intercept conventional signaling pathways. Chem. Biol. 6: R129-R136.
26. Engelman, J. A., J. Luo, and L. C. Cantley. 2006. The evolution of phosphatidylinositol 3-kinases as regulators of growth and metabolism. Nat. Rev. Genet. 7: 606-619.
27. Hawkins, P. T., K. E. Anderson, K. Davidson, and L. R. Stephens. 2006. Signalling through Class I PI3Ks in mammalian cells. Biochem. Soc. Trans. 34: 647-662.
28. Stephens, L., A. Smrcka, F. T. Cooke, T. R. Jackson, P. C. Sternweis, and P. T. Hawkins. 1994. A novel phosphoinositide 3 kinase activity in myeloid-derived cells is activated by G protein beta gamma subunits. Cell. 77: 83-93.
29. Fruman, D. A., R. E. Meyers, and L. C. Cantley. 1998. Phosphoinositide kinases. Annu. Rev. Biochem. 67: 481-507.
30. Maffucci, T., A. Brancaccio, E. Piccolo, R. C. Stein, and M. Falasca. 2003. Insulin induces phosphatidylinositol-3-phosphate formation through TC10 activation. EMBO J. 22: 4178-4189.
31. Lindmo, K., and H. Stenmark. 2006. Regulation of membrane traffic by phosphoinositide 3-kinases. J. Cell Sci. 119: 605-614.
32. Carpenter, C. L., B. C. Duckworth, K. R. Auger, B. Cohen, B. S. Schaffhausen, and L. C. Cantley. 1990. Purification and characterization of phosphoinositide 3-kinase from rat liver. J. Biol. Chem. 265: 19704-19711.
33. Zhao, L., and P. K. Vogt. 2008. Class I PI3K in oncogenic cellular transformation. Oncogene. 27: 5486-5496.
34. Hirsch, E., G. Lembo, G. Montrucchio, C. Rommel, C. Costa, and L. Barberis. 2006. Signaling through PI3Kgamma: a common platform for leukocyte, platelet and cardiovascular stress sensing. Thromb. Haemost. 95: 29-35.
35. Hirsch, E., C. Costa, and E. Ciraolo. 2007. Phosphoinositide 3-kinases as a common platform for multi-hormone signaling. J. Endocrinol. 194: 243-256.
36. Geering, B., P. R. Cutillas, G. Nock, S. I. Gharbi, and B. Vanhaesebroeck. 2007. Class IA phosphoinositide 3-kinases are obligate p85-p110 heterodimers. Proc. Natl. Acad. Sci. USA. 104: 7809-7814.
37. Antonetti, D. A., P. Algenstaedt, and C. R. Kahn. 1996. Insulin receptor substrate 1 binds two novel splice variants of the regulatory subunit of phosphatidylinositol 3-kinase in muscle and brain. Mol. Cell. Biol. 16: 2195-2203.
38. Inukai, K., M. Anai, E. Van Breda, T. Hosaka, H. Katagiri, M. Funaki, Y. Fukushima, T. Ogihara, Y. Yazaki, Kikuchi, Y. Oka, and T. Asano. 1996. A novel 55-kDa regulatory subunit for phosphatidylinositol 3-kinase structurally similar to p55PIK Is generated by alternative splicing of the p85alpha gene. J. Biol. Chem. 271: 5317-5320.
39. Pons, S., T. Asano, E. Glasheen, M. Miralpeix, Y. Zhang, T. L. Fisher, M. G. Myers, Jr., X. J. Sun, and M. F. White. 1995. The structure and function of p55PIK reveal a new regulatory subunit for phosphatidylinositol 3-kinase. Mol. Cell. Biol. 15: 4453-4465.
40. Hiles, I. D., M. Otsu, S. Volinia, M. J. Fry, I. Gout, R. Dhand, G. Panayotou, F. Ruiz-Larrea, A. Thompson, and N. F. Totty. 1992. Phosphatidylinositol 3-kinase: structure and expression of the 110 kd catalytic subunit. Cell. 70: 419-429.
41. Murga, C., S. Fukuhara, and J. S. Gutkind. 2000. A novel role for phosphatidylinositol 3-kinase beta in signaling from G protein-coupled receptors to Akt. J. Biol. Chem. 275: 12069-12073.
42. Stephens, L. R., A. Eguinoa, H. Erdjument-Bromage, M. Lui, F. Cooke, J. Coadwell, A. S. Smrcka, M. Thelen, K. Cadwallader, P. Tempst, et al. 1997. The G beta gamma sensitivity of a PI3K is dependent upon a tightly associated adaptor, p101. Cell. 89: 105-114.
43. Suire, S., J. Coadwell, G. J. Ferguson, K. Davidson, P. Hawkins, and L. Stephens. 2005. p84, a new Gbetagamma-activated regulatory subunit of the type IB phosphoinositide 3-kinase p110gamma. Curr. Biol. 15: 566-570.
44. Voigt, P., C. Brock, B. Nurnberg, and M. Schaefer. 2005. Assigning functional domains within the p101 regulatory subunit of phosphoinositide 3-kinase gamma. J. Biol. Chem. 280: 5121-5127.
45. Clement, S., U. Krause, F. Desmedt, J. F. Tanti, J. Behrends, X. Pesesse, T. Sasaki, J. Penninger, M. Doherty, W. Malaisse, et al. 2001. The lipid phosphatase SHIP2 controls insulin sensitivity. Nature. 409: 92-97.
46. Maehama, T., and J. E. Dixon. 1999. PTEN: a tumour suppressor that functions as a phospholipid phosphatase. Trends Cell Biol. 9: 125-128.
47. Maehama, T., and J. E. Dixon. 1998. The tumor suppressor, PTEN/MMAC1, dephosphorylates the lipid second messenger, phosphatidylinositol 3,4,5-trisphosphate. J. Biol. Chem. 273: 13375-13378.
48. Dilly, A. K., and R. V. Rajala. 2008. Insulin growth factor 1 receptor/ PI3K/AKT survival pathway in outer segment membranes of rod photoreceptors. Invest. Ophthalmol. Vis. Sci. 49: 4765-4773.
49. Rajala, A., R. E. Anderson, J. X. Ma, J. Lem, M. R. Al Ubaidi, and R. V. Rajala. 2007. G-protein-coupled receptor rhodopsin regulates the phosphorylation of retinal insulin receptor. J. Biol. Chem. 282: 9865-9873.
50. Rajala, R. V., M. E. McClellan, J. D. Ash, and R. E. Anderson. 2002. In vivo regulation of phosphoinositide 3-kinase in retina through light-induced tyrosine phosphorylation of the insulin receptor beta-subunit. J. Biol. Chem. 277: 43319-43326.
51. Rajala, R. V., and R. E. Anderson. 2001. Interaction of the insulin receptor beta-subunit with phosphatidylinositol 3-kinase in bovine ROS. Invest. Ophthalmol. Vis. Sci. 42: 3110-3117.
52. Reiter, C. E., L. Sandirasegarane, E. B. Wolpert, M. Klinger, I. A. Simpson, A. J. Barber, D. A. Antonetti, M. Kester, and T. W. Gardner. 2003. Characterization of insulin signaling in rat retina in vivo and ex vivo. Am. J. Physiol. Endocrinol. Metab. 285: E763-E774.
53. Parish, C. A., A. V. Smrcka, and R. R. Rando. 1995. Functional significance of beta gamma-subunit carboxymethylation for the activation of phospholipase C and phosphoinositide 3-kinase. Biochemistry. 34: 7722-7727.
54. Chuang, J. Z., Y. Zhao, and C. H. Sung. 2007. SARA-regulated vesicular targeting underlies formation of the light-sensing organelle in mammalian rods. Cell. 130: 535-547.
55. Hu, P., A. Mondino, E. Y. Skolnik, and J. Schlessinger. 1993. Cloning of a novel, ubiquitously expressed human phosphatidylinositol 3-kinase and identification of its binding site on p85. Mol. Cell. Biol. 13: 7677-7688.
56. Klippel, A., J. A. Escobedo, W. J. Fantl, and L. T. Williams. 1992. The C-terminal SH2 domain of p85 accounts for the high affinity and specificity of the binding of phosphatidylinositol 3-kinase to phosphorylated platelet-derived growth factor beta receptor. Mol. Cell. Biol. 12: 1451-1459.
57. White, M. F., and C. R. Kahn. 1994. The insulin signaling system. J. Biol. Chem. 269: 1-4.
58. DeFronzo, R. A., R. C. Bonadonna, and E. Ferrannini. 1992. Pathogenesis of NIDDM. A balanced overview. Diabetes Care. 15: 318-368.
59. Van Horn, D. J., M. G. Myers, Jr., and J. M. Backer. 1994. Direct activation of the phosphatidylinositol 3′-kinase by the insulin receptor. J. Biol. Chem. 269: 29-32.
60. Backer, J. M., M. G. Myers, Jr., S. E. Shoelson, D. J. Chin, X. J. Sun, M. Miralpeix, P. Hu, B. Margolis, E. Y. Skolnik, and J. Schlessinger. 1992. Phosphatidylinositol 3′-kinase is activated by association with IRS-1 during insulin stimulation. EMBO J. 11: 3469-3479.
61. Li, G., A. Rajala, A. F. Wiechmann, R. E. Anderson, and R. V. Rajala. 2008. Activation and membrane binding of retinal protein kinase Balpha/ Akt1 is regulated through light-dependent generation of phosphoinositides. J. Neurochem. 107: 1382-1397.
62. Biswas, S. K., Y. Zhao, A. Nagalingam, T. W. Gardner, and L. Sandirasegarane. 2008. PDGF- and insulin/IGF-1-specific distinct modes of class IA PI 3-kinase activation in normal rat retinas and RGC-5 retinal ganglion cells. Invest. Ophthalmol. Vis. Sci. 49: 3687-3698.
63. Hollborn, M., A. Bringmann, F. Faude, P. Wiedemann, and L. Kohen. 2006. Signaling pathways involved in PDGF-evoked cellular responses in human RPE cells. Biochem. Biophys. Res. Commun. 344: 912-919.
64. Hollborn, M., K. Jahn, G. A. Limb, L. Kohen, P. Wiedemann, and A. Bringmann. 2004. Characterization of the basic fibroblast growth factor-evoked proliferation of the human Muller cell line, MIO-M1. Graefes Arch. Clin. Exp. Ophthalmol. 242: 414-422.
65. Nakazawa, T., M. Tamai, and N. Mori. 2002. Brain-derived neurotrophic factor prevents axotomized retinal ganglion cell death through MAPK and PI3K signaling pathways. Invest. Ophthalmol. Vis. Sci. 43: 3319-3326.
66. Kretz, A., C. J. Happold, J. K. Marticke, and S. Isenmann. 2005. Erythropoietin promotes regeneration of adult CNS neurons via Jak2/Stat3 and PI3K/AKT pathway activation. Mol. Cell. Neurosci. 29: 569-579.
67. Ikeda, K., T. Tatsuno, H. Noguchi, and C. Nakayama. 2004. Ciliary neurotrophic factor protects rat retina cells in vitro and in vivo via PI3 kinase. Curr. Eye Res. 29: 349-355.
68. Rajala, R. V., M. E. McClellan, M. D. Chan, L. Tsiokas, and R. E. Anderson. 2004. Interaction of the retinal insulin receptor beta-subunit with the P85 subunit of phosphoinositide 3-kinase. Biochemistry. 43: 5637-5650.
69. Yi, X., M. Schubert, N. S. Peachey, K. Suzuma, D. J. Burks, J. A. Kushner, I. Suzuma, C. Cahill, C. L. Flint, M. A. Dow, et al. 2005. Insulin receptor substrate 2 is essential for maturation and survival of photoreceptor cells. J. Neurosci. 25: 1240-1248.
70. Andjelkovic, M., D. R. Alessi, R. Meier, A. Fernandez, N. J. Lamb, M. Frech, P. Cron, P. Cohen, J. M. Lucocq, and B. A. Hemmings. 1997. Role of translocation in the activation and function of protein kinase B. J. Biol. Chem. 272: 31515-31524.
71. Meier, R., D. R. Alessi, P. Cron, M. Andjelkovic, and B. A. Hemmings. 1997. Mitogenic activation, phosphorylation, and nuclear translocation of protein kinase Bbeta. J. Biol. Chem. 272: 30491-30497.
72. Wijkander, J., L. S. Holst, T. Rahn, S. Resjo, I. Castan, V. Manganiello, P. Belfrage, and E. Degerman. 1997. Regulation of protein kinase B in rat adipocytes by insulin, vanadate, and peroxovanadate. J. Biol. Chem. 272: 21520-21526.
73. Zhang, X., and T. A. Vik. 1997. Growth factor stimulation of hematopoietic cells leads to membrane translocation of AKT1 protein kinase. Leuk. Res. 21: 849-856.
74. Sable, C. L., N. Filippa, C. Filloux, B. A. Hemmings, and E. Van Obberghen. 1998. Involvement of the pleckstrin homology domain in the insulin-stimulated activation of protein kinase B. J. Biol. Chem. 273: 29600-29606.
75. Currie, R. A., K. S. Walker, A. Gray, M. Deak, A. Casamayor, C. P. Downes, P. Cohen, D. R. Alessi, and J. Lucocq. 1999. Role of phosphatidylinositol 3,4,5-trisphosphate in regulating the activity and localization of 3-phosphoinositide-dependent protein kinase-1. Biochem. J. 337: 575-583.
76. Manning, B. D., and L. C. Cantley. 2007. AKT/PKB signaling: navigating downstream. Cell. 129: 1261-1274.
77. Fayard, E., L. A. Tintignac, A. Baudry, and B. A. Hemmings. 2005. Protein kinase B/Akt at a glance. J. Cell Sci. 118: 5675-5678.
78. Alessi, D. R., M. T. Kozlowski, Q. P. Weng, N. Morrice, and J. Avruch. 1998. 3-Phosphoinositide-dependent protein kinase 1 (PDK1) phosphorylates and activates the p70 S6 kinase in vivo and in vitro. Curr. Biol. 8: 69-81.
79. Hresko, R. C., and M. Mueckler. 2005. mTOR.RICTOR is the Ser473 kinase for Akt/protein kinase B in 3T3-L1 adipocytes. J. Biol. Chem. 280: 40406-40416.
80. Carvalho, E., B. Eliasson, C. Wesslau, and U. Smith. 2000. Impaired phosphorylation and insulin-stimulated translocation to the plasma membrane of protein kinase B/Akt in adipocytes from Type II diabetic subjects. Diabetologia. 43: 1107-1115.
81. Bijur, G. N., and R. S. Jope. 2003. Rapid accumulation of Akt in mitochondria following phosphatidylinositol 3-kinase activation. J. Neurochem. 87: 1427-1435.
82. Testa, J. R., and A. Bellacosa. 1997. Membrane translocation and activation of the Akt kinase in growth factor-stimulated hematopoietic cells. Leuk. Res. 21: 1027-1031.
83. Borgatti, P., A. M. Martelli, A. Bellacosa, R. Casto, L. Massari, S. Capitani, and L. M. Neri. 2000. Translocation of Akt/PKB to the nucleus of osteoblast-like MC3T3-E1 cells exposed to proliferative growth factors. FEBS Lett. 477: 27-32.
84. New, D. C., K. Wu, A. W. Kwok, and Y. H. Wong. 2007. G protein-coupled receptor-induced Akt activity in cellular proliferation and apoptosis. FEBS J. 274: 6025-6036.
85. Parcellier, A., L. A. Tintignac, E. Zhuravleva, and B. A. Hemmings. 2008. PKB and the mitochondria: AKTing on apoptosis. Cell. Signal. 20: 21-30.
86. Franke, T. F., D. R. Kaplan, and L. C. Cantley. 1997. PI3K: downstream AKTion blocks apoptosis. Cell. 88: 435-437.
87. Proud, C. G. 2006. Regulation of protein synthesis by insulin. Biochem. Soc. Trans. 34: 213-216.
88. Banerjee, P., M. F. Ahmad, J. R. Grove, C. Kozlosky, D. J. Price, and J. Avruch. 1990. Molecular structure of a major insulin/mitogen-activated 70-kDa S6 protein kinase. Proc. Natl. Acad. Sci. USA. 87: 8550-8554.
89. Kozma, S. C., S. Ferrari, P. Bassand, M. Siegmann, N. Totty, and G. Thomas. 1990. Cloning of the mitogen-activated S6 kinase from rat liver reveals an enzyme of the second messenger subfamily. Proc. Natl. Acad. Sci. USA. 87: 7365-7369.
90. Grove, J. R., P. Banerjee, A. Balasubramanyam, P. J. Coffer, D. J. Price, J. Avruch, and J. R. Woodgett. 1991. Cloning and expression of two human p70 S6 kinase polypeptides differing only at their amino termini. Mol. Cell. Biol. 11: 5541-5550.
91. Reinhard, C., G. Thomas, and S. C. Kozma. 1992. A single gene encodes two isoforms of the p70 S6 kinase: activation upon mitogenic stimulation. Proc. Natl. Acad. Sci. USA. 89: 4052-4056.
92. Reinhard, C., A. Fernandez, N. J. Lamb, and G. Thomas. 1994. Nuclear localization of p85s6k: functional requirement for entry into S phase. EMBO J. 13: 1557-1565.
93. Pullen, N., P. B. Dennis, M. Andjelkovic, A. Dufner, S. C. Kozma, B. A. Hemmings, and G. Thomas. 1998. Phosphorylation and activation of p70s6k by PDK1. Science. 279: 707-710.
94. Dennis, P. B., N. Pullen, S. C. Kozma, and G. Thomas. 1996. The principal rapamycin-sensitive p70(s6k) phosphorylation sites, T-229 and T-389, are differentially regulated by rapamycin-insensitive kinase kinases. Mol. Cell. Biol. 16: 6242-6251.
95. Dufner, A., M. Andjelkovic, B. M. Burgering, B. A. Hemmings, and G. Thomas. 1999. Protein kinase B localization and activation differentially affect S6 kinase 1 activity and eukaryotic translation initiation factor 4E-binding protein 1 phosphorylation. Mol. Cell. Biol. 19: 4525-4534.
96. Alessi, D. R., M. Andjelkovic, B. Caudwell, P. Cron, N. Morrice, P. Cohen, and B. A. Hemmings. 1996. Mechanism of activation of protein kinase B by insulin and IGF-1. EMBO J. 15: 6541-6551.
97. Alessi, D. R., and C. P. Downes. 1998. The role of PI 3-kinase in insulin action. Biochim. Biophys. Acta. 1436: 151-164.
98. Aoki, M., O. Batista, A. Bellacosa, P. Tsichlis, and P. K. Vogt. 1998. The akt kinase: molecular determinants of oncogenicity. Proc. Natl. Acad. Sci. USA. 95: 14950-14955.
99. Akimoto, K., M. Nakaya, T. Yamanaka, J. Tanaka, S. Matsuda, Q. P. Weng, J. Avruch, and S. Ohno. 1998. Atypical protein kinase Clambda binds and regulates p70 S6 kinase. Biochem. J. 335: 417-424.
100. Romanelli, A., K. A. Martin, A. Toker, and J. Blenis. 1999. p70 S6 kinase is regulated by protein kinase Czeta and participates in a phosphoinositide 3-kinase-regulated signalling complex. Mol. Cell. Biol. 19: 2921-2928.
101. Sigal, N. H., C. S. Lin, and J. J. Siekierka. 1991. Inhibition of human T-cell activation by FK 506, rapamycin, and cyclosporine A. Transplant. Proc. 23: 1-5.
102. Chung, J., C. J. Kuo, G. R. Crabtree, and J. Blenis. 1992. Rapamycin-FKBP specifically blocks growth-dependent activation of and signaling by the 70 kd S6 protein kinases. Cell. 69: 1227-1236.
103. Kuo, C. J., J. Chung, D. F. Fiorentino, W. M. Flanagan, J. Blenis, and G. R. Crabtree. 1992. Rapamycin selectively inhibits interleukin-2 activation of p70 S6 kinase. Nature. 358: 70-73.
104. Price, D. J., J. R. Grove, V. Calvo, J. Avruch, and B. E. Bierer. 1992. Rapamycin-induced inhibition of the 70-kilodalton S6 protein kinase. Science. 257: 973-977.
105. Brown, E. J., P. A. Beal, C. T. Keith, J. Chen, T. B. Shin, and S. L. Schreiber. 1995. Control of p70 s6 kinase by kinase activity of FRAP in vivo. Nature. 377: 441-446.
106. Burnett, P. E., R. K. Barrow, N. A. Cohen, S. H. Snyder, and D. M. Sabatini. 1998. RAFT1 phosphorylation of the translational regulators p70 S6 kinase and 4E-BP1. Proc. Natl. Acad. Sci. USA. 95: 1432-1437.
107. Holcik, M., N. Sonenberg, and R. G. Korneluk. 2000. Internal ribosome initiation of translation and the control of cell death. Trends Genet. 16: 469-473.
108. Rehen, S. K., D. D. Neves, L. Fragel-Madeira, L. R. Britto, and R. Linden. 1999. Selective sensitivity of early postmitotic retinal cells to apoptosis induced by inhibition of protein synthesis. Eur. J. Neurosci. 11: 4349-4356.
109. Punzo, C., K. Kornacker, and C. L. Cepko. 2009. Stimulation of the insulin/mTOR pathway delays cone death in a mouse model of retinitis pigmentosa. Nat. Neurosci. 12: 44-52.
110. Ahmad, F., J. L. Azevedo, R. Cortright, G. L. Dohm, and B. J. Goldstein. 1997. Alterations in skeletal muscle protein-tyrosine phosphatase activity and expression in insulin-resistant human obesity and diabetes. J. Clin. Invest. 100: 449-458.
111. Ahmad, F., R. V. Considine, T. L. Bauer, J. P. Ohannesian, C. C. Marco, and B. J. Goldstein. 1997. Improved sensitivity to insulin in obese subjects following weight loss is accompanied by reduced protein-tyrosine phosphatases in adipose tissue. Metabolism. 46: 1140-1145.
112. Ahmad, F., R. V. Considine, and B. J. Goldstein. 1995. Increased abundance of the receptor-type protein-tyrosine phosphatase LAR accounts for the elevated insulin receptor dephosphorylating activity in adipose tissue of obese human subjects. J. Clin. Invest. 95: 2806-2812.
113. Ahmad, F., and B. J. Goldstein. 1995. Increased abundance of specific skeletal muscle protein-tyrosine phosphatases in a genetic model of insulin-resistant obesity an diabetes mellitus. Metabolism. 44: 1175-1184.
114. Bleyle, L. A., Y. Peng, C. Ellis, and R. A. Mooney. 1999. Dissociation of PTPase levels from their modulation of insulin receptor signal transduction. Cell. Signal. 11: 719-725.
115. Hashimoto, N., E. P. Feener, W. R. Zhang, and B. J. Goldstein. 1992. Insulin receptor protein-tyrosine phosphatases. Leukocyte common antigen-related phosphatase rapidly deactivates the insulin receptor kinase by preferential dephosphorylation of the receptor regulatory domain. J. Biol. Chem. 267: 13811-13814.
116. Kenner, K. A., D. E. Hill, J. M. Olefsky, and J. Kusari. 1993. Regulation of protein tyrosine phosphatases by insulin and insulin-like growth factor I. J. Biol. Chem. 268: 25455-25462.
117. Kenner, K. A., E. Anyanwu, J. M. Olefsky, and J. Kusari. 1996. Protein-tyrosine phosphatase 1B is a negative regulator of insulin- and insulin-like growth factor-I-stimulated signaling. J. Biol. Chem. 271: 19810-19816.
118. Kuhne, M. R., T. Pawson, G. E. Lienhard, and G. S. Feng. 1993. The insulin receptor substrate 1 associates with the SH2-containing phosphotyrosine phosphatase Syp. J. Biol. Chem. 268: 11479-11481.
119. Maegawa, H., M. Hasegawa, S. Sugai, T. Obata, S. Ugi, K. Morino, K. Egawa, T. Fujita, T. Sakamoto, Y. Nishio, et al. 1999. Expression of a dominant negative SHP-2 in transgenic mice induces insulin resistance. J. Biol. Chem. 274: 30236-30243.
120. Myers, M. G., Jr., R. Mendez, P. Shi, J. H. Pierce, R. Rhoads, and M. F. White. 1998. The COOH-terminal tyrosine phosphorylation sites on IRS-1 bind SHP-2 and negatively regulate insulin signaling. J. Biol. Chem. 273: 26908-26914.
121. Seely, B. L., P. A. Staubs, D. R. Reichart, P. Berhanu, K. L. Milarski, A. R. Saltiel, J. Kusari, and J. M. Olefsky. 1996. Protein tyrosine phosphatase 1B interacts with the activated insulin receptor. Diabetes. 45: 1379-1385.
122. Byon, J. C., A. B. Kusari, and J. Kusari. 1998. Protein-tyrosine phosphatase-1B acts as a negative regulator of insulin signal transduction. Mol. Cell. Biochem. 182: 101-108.
123. Goldstein, B. J., F. Ahmad, W. Ding, P. M. Li, and W. R. Zhang. 1998. Regulation of the insulin signalling pathway by cellular protein-tyrosine phosphatases. Mol. Cell. Biochem. 182: 91-99.
124. Frangioni, J. V., P. H. Beahm, V. Shifrin, C. A. Jost, and B. G. Neel. 1992. The nontransmembrane tyrosine phosphatase PTP-1B localizes to the endoplasmic reticulum via its 35 amino acid C-terminal sequence. Cell. 68: 545-560.
125. Woodford-Thomas, T. A., J. D. Rhodes, and J. E. Dixon. 1992. Expression of a protein tyrosine phosphatase in normal and v-src-transformed mouse 3T3 fibroblasts. J. Cell Biol. 117: 401-414.
126. Simoncic, P. D., C. J. McGlade, and M. L. Tremblay. 2006. PTP1B and TC-PTP: novel roles in immune-cell signaling. Can. J. Physiol. Pharmacol. 84: 667-675.
127. Tonks, N. K. 2003. PTP1B: from the sidelines to the front lines! FEBS Lett. 546: 140-148.
128. Byon, J. C., K. A. Kenner, A. B. Kusari, and J. Kusari. 1997. Regulation of growth factor-induced signaling by protein-tyrosine-phosphatases. Proc. Soc. Exp. Biol. Med. 216: 1-20.
129. Ahmad, F., P. M. Li, J. Meyerovitch, and B. J. Goldstein. 1995. Osmotic loading of neutralizing antibodies demonstrates a role for protein-tyrosine phosphatase 1B in negative regulation of the insulin action pathway. J. Biol. Chem. 270: 20503-20508.
130. Klaman, L. D., O. Boss, O. D. Peroni, J. K. Kim, J. L. Martino, J. M. Zabolotny, N. Moghal, M. Lubkin, Y. B. Kim, A. H. Sharpe, et al. 2000. Increased energy expenditure, decreased adiposity, and tissue-specific insulin sensitivity in protein-tyrosine phosphatase 1B-deficient mice. Mol. Cell. Biol. 20: 5479-5489.
131. Elchebly, M., P. Payette, E. Michaliszyn, W. Cromlish, S. Collins, A. L. Loy, D. Normandin, A. Cheng, J. Himms-Hagen, C. C. Chan, et al. 1999. Increased insulin sensitivity and obesity resistance in mice lacking the protein tyrosine phosphatase-1B gene. Science. 283: 1544-1548.
132. Reiter, C. E., X. Wu, L. Sandirasegarane, M. Nakamura, K. A. Gilbert, R. S. Singh, P. E. Fort, D. A. Antonetti, and T. W. Gardner. 2006. Diabetes reduces basal retinal insulin receptor signaling: reversal with systemic and local insulin. Diabetes. 55: 1148-1156.
133. Rajala, R. V., B. Wiskur, M. Tanito, M. Callegan, and A. Rajala. 2009. Diabetes reduces autophosphorylation of retinal insulin receptor and increases protein-tyrosine phosphatase-1B activity. Invest. Ophthalmol. Vis. Sci. 50: 1033-1040.
134. Ravichandran, L. V., H. Chen, Y. Li, and M. J. Quon. 2001. Phosphorylation of PTP1B at Ser(50) by Akt impairs its ability to dephosphorylate the insulin receptor. Mol. Endocrinol. 15: 1768-1780.
135. Li, G., R. E. Anderson, H. Tomita, R. Adler, X. Liu, D. J. Zack, and R. V. Rajala. 2007. Nonredundant role of Akt2 for neuroprotection of rod photoreceptor cells from light-induced cell death. J. Neurosci. 27: 203-211.
136. Galetic, I., M. Andjelkovic, R. Meier, D. Brodbeck, J. Park, and B. A. Hemmings. 1999. Mechanism of protein kinase B activation by insulin/ insulin-like growth factor-1 revealed by specific inhibitors of phosphoinositide 3-kinase-significance for diabetes and cancer. Pharmacol. Ther. 82: 409-425.
137. Tremblay, F., C. Lavigne, H. Jacques, and A. Marette. 2001. Defective insulin-induced GLUT4 translocation in skeletal muscle of high fat-fed rats is associated with alterations in both Akt/protein kinase B and atypical protein kinase C (zeta/lambda) activities. Diabetes. 50: 1901-1910.
138. Hernandez, R., T. Teruel, and M. Lorenzo. 2001. Akt mediates insulin induction of glucose uptake and up-regulation of GLUT4 gene expression in brown adipocytes. FEBS Lett. 494: 225-231.
139. Vosseller, K., L. Wells, M. D. Lane, and G. W. Hart. 2002. Elevated nucleocytoplasmic glycosylation by O-GlcNAc results in insulin resistance associated with defects in Akt activation in 3T3-L1 adipocytes. Proc. Natl. Acad. Sci. USA. 99: 5313-5318.
140. Jiang, B. H., J. Z. Zheng, M. Aoki, and P. K. Vogt. 2000. Phosphatidylinositol 3-kinase signaling mediates angiogenesis and expression of vascular endothelial growth factor in endothelial cells. Proc. Natl. Acad. Sci. USA. 97: 1749-1753.
141. Gousseva, N., K. Kugathasan, C. N. Chesterman, and L. M. Khachigian. 2001. Early growth response factor-1 mediates insulin-inducible vascular endothelial cell proliferation and regrowth after injury. J. Cell. Biochem. 81: 523-534.
142. Lal, B. K., S. Varma, P. J. Pappas, R. W. Hobson, and W. N. Duran. 2001. VEGF increases permeability of the endothelial cell monolayer by activation of PKB/akt, endothelial nitric-oxide synthase, and MAP kinase pathways. Microvasc. Res. 62: 252-262.
143. Shioi, T., J. R. McMullen, P. M. Kang, P. S. Douglas, T. Obata, T. F. Franke, L. C. Cantley, and S. Izumo. 2002. Akt/protein kinase B promotes organ growth in transgenic mice. Mol. Cell. Biol. 22: 2799-2809.
144. Luo, J., C. L. Sobkiw, M. F. Hirshman, M. N. Logsdon, T. Q. Li, L. J. Goodyear, and L. C. Cantley. 2006. Loss of class IA PI3K signaling in muscle leads to impaired muscle growth, insulin response, and hyperlipidemia. Cell Metab. 3: 355-366.
145. Reiter, C. E., and T. W. Gardner. 2003. Functions of insulin and insulin receptor signaling in retina: possible implications for diabetic retinopathy. Prog. Retin. Eye Res. 22: 545-562.
146. Rajala, R. V., A. Rajala, R. S. Brush, N. P. Rotstein, and L. E. Politi. 2009. Insulin receptor signaling regulates actin cytoskeletal organization in developing photoreceptors. J. Neurochem. 110: 1648-1660.
147. Takenawa, T., and T. Itoh. 2001. Phosphoinositides, key molecules for regulation of actin cytoskeletal organization and membrane traffic from the plasma membrane. Biochim. Biophys. Acta. 1533: 190-206.
148. Rajala, A., M. Tanito, Y. Z. Le, C. R. Kahn, and R. V. Rajala. 2008. Loss of neuroprotective survival signal in mice lacking insulin receptor gene in rod photoreceptor cells. J. Biol. Chem. 283: 19781-19792.
149. Conway, B. R., A. P. Maxwell, D. A. Savage, C. C. Patterson, P. P. Doran, M. Murphy, H. R. Brady, and D. G. Fogarty. 2004. Association between variation in the actin-binding gene caldesmon and diabetic nephropathy in type 1 diabetes. Diabetes. 53: 1162-1165.
150. McLean, W. G. 1997. The role of axonal cytoskeleton in diabetic neuropathy. Neurochem. Res. 22: 951-956.
151. McLean, W. G., R. E. Roberts, and F. H. Mullins. 1995. Post-translational modifications of microtubule- and growth-associated proteins in nerve regeneration and neuropathy. Biochem. Soc. Trans. 23: 76-80.
152. Olson, T. M., V. V. Michels, S. N. Thibodeau, Y. S. Tai, and M. T. Keating. 1998. Actin mutations in dilated cardiomyopathy, a heritable form of heart failure. Science. 280: 750-752.
153. Fein, F. S., A. Malhotra, B. Miller-Green, J. Scheuer, and E. H. Sonnenblick. 1984. Diabetic cardiomyopathy in rats: mechanical and biochemical response to different insulin doses. Am. J. Physiol. 247: H817-H823.
154. Zherebitskaya, E., E. Akude, D. R. Smith, and P. Fernyhough. 2009. Development of selective axonopathy in adult sensory neurons isolated from diabetic rats: role of glucose-induced oxidative stress. Diabetes. 58: 1356-1364.
155. Tosaki, T., H. Kamiya, Y. Yasuda, K. Naruse, K. Kato, M. Kozakae, N. Nakamura, T. Shibata, Y. Hamada, E. Nakashima, et al. 2008. Reduced NGF secretion by Schwann cells under the high glucose condition decreases neurite outgrowth of DRG neurons. Exp. Neurol. 213: 381-387.
156. Rajala, R. V., and M. D. Chan. 2005. Identification of a NPXY motif in growth factor receptor-bound protein 14 (Grb14) and its interaction with the phosphotyrosine-binding (PTB) domain of IRS-1. Biochemistry. 44: 7929-7935.
157. Rajala, R. V., M. D. Chan, and A. Rajala. 2005. Lipid-protein interactions of growth factor receptor-bound protein 14 in insulin receptor signaling. Biochemistry. 44: 15461-15471.
158. Jones, N., Z. Master, J. Jones, D. Bouchard, Y. Gunji, H. Sasaki, R. Daly, K. Alitalo, and D. J. Dumont. 1999. Identification of Tek/Tie2 binding partners. Binding to a multifunctional docking site mediates cell survival and migration. J. Biol. Chem. 274: 30896-30905.
159. Daly, R. J., G. M. Sanderson, P. W. Janes, and R. L. Sutherland. 1996. Cloning and characterization of GRB14, a novel member of the GRB7 gene family. J. Biol. Chem. 271: 12502-12510.
160. Reilly, J. F., G. Mickey, and P. A. Maher. 2000. Association of fibroblast growth factor receptor 1 with the adaptor protein Grb14. Characterization of a new receptor binding partner. J. Biol. Chem. 275: 7771-7778.
161. Kasus-Jacobi, A., D. Perdereau, C. Auzan, E. Clauser, E. Van Obberghen, F. Mauvais-Jarvis, J. Girard, and A. F. Burnol. 1998. Identification of the rat adapter Grb14 as an inhibitor of insulin actions. J. Biol. Chem. 273: 26026-26035.
162. Rajala, A., R. J. Daly, M. Tanito, D. T. Allen, L. J. Holt, E. Lobanova, V. Y. Arshavsky, and R. V. Rajala. 2009. Growth factor receptor-bound protein 14 undergoes light-dependent intracellular translocation in rod photoreceptors: functional role on retinal insulin receptor activation. Biochemistry. 48: 5563-5572.
163. Luttrell, L. M., T. van Biesen, B. E. Hawes, W. J. Koch, K. M. Krueger, K. Touhara, and R. J. Lefkowitz. 1997. G-protein-coupled receptors and their regulation: activation of the MAP kinase signaling pathway by G-protein-coupled receptors. Adv. Second Messenger Phosphoprotein Res. 31: 263-277.
164. Luttrell, L. M., Y. Daaka, and R. J. Lefkowitz. 1999. Regulation of tyrosine kinase cascades by G-protein-coupled receptors. Curr. Opin. Cell Biol. 11: 177-183.
165. Lev, S., J. Hernandez, R. Martinez, A. Chen, G. Plowman, and J. Schlessinger. 1999. Identification of a novel family of targets of PYK2 related to Drosophila retinal degeneration B (rdgB) protein. Mol. Cell. Biol. 19: 2278-2288.
166. Halet, G. 2005. Imaging phosphoinositide dynamics using GFP-tagged protein domains. Biol. Cell. 97: 501-518.
167. Lorenzo, O., S. Urbe, and M. J. Clague. 2005. Analysis of phosphoinositide binding domain properties within the myotubularin-related protein MTMR3. J. Cell Sci. 118: 2005-2012.
168. Dormann, D., G. Weijer, S. Dowler, and C. J. Weijer. 2004. In vivo analysis of 3-phosphoinositide dynamics during Dictyostelium phagocytosis and chemotaxis. J. Cell Sci. 117: 6497-6509.
169. Pattni, K., M. Jepson, H. Stenmark, and G. Banting. 2001. A PtdIns(3)P-specific probe cycles on and off host cell membranes during Salmonella invasion of mammalian cells. Curr. Biol. 11: 1636-1642.
170. Rusten, T. E., and H. Stenmark. 2006. Analyzing phosphoinositides and their interacting proteins. Nat. Methods. 3: 251-258.
171. Basinger, S., R. Hoffman, and M. Matthes. 1976. Photoreceptor shedding is initiated by light in the frog retina. Science. 194: 1074-1076.
172. Hollyfield, J. G., and M. E. Rayborn. 1979. Photoreceptor outer segment development: light and dark regulate the rate of membrane addition and loss. Invest. Ophthalmol. Vis. Sci. 18: 117-132.
173. Fain, G. L., H. R. Matthews, M. C. Cornwall, and Y. Koutalos. 2001. Adaptation in vertebrate photoreceptors. Physiol. Rev. 81: 117-151.
174. D'Mello, S. R., K. Borodezt, and S. P. Soltoff. 1997. Insulin-like growth factor and potassium depolarization maintain neuronal survival by distinct pathways: possible involvement of PI 3-kinase in IGF-1 signaling. J. Neurosci. 17: 1548-1560.
175. Spear, N., A. G. Estevez, L. Barbeito, J. S. Beckman, and G. V. Johnson. 1997. Nerve growth factor protects PC12 cells against peroxynitrite-induced apoptosis via a mechanism dependent on phosphatidylinositol 3-kinase. J. Neurochem. 69: 53-59.
176. Noell, W. K., and R. Albrecht. 1971. Irreversible effects on visible light on the retina: role of vitamin A. Science. 172: 76-79.
177. Noell, W. K. 1980. Possible mechanisms of photoreceptor damage by light in mammalian eyes. Vision Res. 20: 1163-1171.
178. Wang, W., A. Fridman, W. Blackledge, S. Connelly, I. A. Wilson, R. B. Pilz, and G. R. Boss. 2009. The phosphatidylinositol 3-kinase/akt cassette regulates purine nucleotide synthesis. J. Biol. Chem. 284: 3521-3528.
179. Suzuki, H., Y. Terauchi, M. Fujiwara, S. Aizawa, Y. Yazaki, T. Kadowaki, and S. Koyasu. 1999. Xid-like immunodeficiency in mice with disruption of the p85alpha subunit of phosphoinositide 3-kinase. Science. 283: 390-392.
180. Terauchi, Y., Y. Tsuji, S. Satoh, H. Minoura, K. Murakami, A. Okuno, K. Inukai, T. Asano, Y. Kaburagi, K. Ueki, et al. 1999. Increased insulin sensitivity and hypoglycaemia in mice lacking the p85 alpha subunit of phosphoinositide 3-kinase. Nat. Genet. 21: 230-235.
181. Fruman, D. A., S. B. Snapper, C. M. Yballe, L. Davidson, J. Y. Yu, F. W. Alt, and L. C. Cantley. 1999. Impaired B cell development and proliferation in absence of phosphoinositide 3-kinase p85alpha. Science. 283: 393-397.
182. Chen, D., F. Mauvais-Jarvis, M. Bluher, S. J. Fisher, A. Jozsi, L. J. Goodyear, K. Ueki, and C. R. Kahn. 2004. p50alpha/p55alpha phosphoinositide 3-kinase knockout mice exhibit enhanced insulin sensitivity. Mol. Cell. Biol. 24: 320-329.
183. Ueki, K., C. M. Yballe, S. M. Brachmann, D. Vicent, J. M. Watt, C. R. Kahn, and L. C. Cantley. 2002. Increased insulin sensitivity in mice lacking p85beta subunit of phosphoinositide 3-kinase. Proc. Natl. Acad. Sci. USA. 99: 419-424.
184. Ueki, K., D. A. Fruman, C. M. Yballe, M. Fasshauer, J. Klein, T. Asano, L. C. Cantley, and C. R. Kahn. 2003. Positive and negative roles of p85 alpha and p85 beta regulatory subunits of phosphoinositide 3-kinase in insulin signaling. J. Biol. Chem. 278: 48453-48466.
185. Ueki, K., D. A. Fruman, S. M. Brachmann, Y. H. Tseng, L. C. Cantley, and C. R. Kahn. 2002. Molecular balance between the regulatory and catalytic subunits of phosphoinositide 3-kinase regulates cell signaling and survival. Mol. Cell. Biol. 22: 965-977.
186. Inoue, G., B. Cheatham, R. Emkey, and C. R. Kahn. 1998. Dynamics of insulin signaling in 3T3-L1 adipocytes. Differential compartmentalization and trafficking of insulin receptor substrate (IRS)-1 and IRS-2. J. Biol. Chem. 273: 11548-11555.
187. Luo, J., S. J. Field, J. Y. Lee, J. A. Engelman, and L. C. Cantley. 2005. The p85 regulatory subunit of phosphoinositide 3-kinase down-regulates IRS-1 signaling via the formation of a sequestration complex. J. Cell Biol. 170: 455-464.
188. Cinar, B., N. K. Mukhopadhyay, G. Meng, and M. R. Freeman. 2007. Phosphoinositide 3-kinase-independent non-genomic signals transit from the androgen receptor to Akt1 in membrane raft microdomains. J. Biol. Chem. 282: 29584-29593.
189. Arcaro, A., M. Aubert, M. E. Espinosa del Hierro, U. K. Khanzada, S. Angelidou, T. D. Tetley, A. G. Bittermann, M. C. Frame, and M. J. Seckl. 2007. Critical role for lipid raft-associated Src kinases in activation of PI3K-Akt signalling. Cell. Signal. 19: 1081-1092.
190. Peres, C., A. Yart, B. Perret, J. P. Salles, and P. Raynal. 2003. Modulation of phosphoinositide 3-kinase activation by cholesterol level suggests a novel positive role for lipid rafts in lysophosphatidic acid signalling. FEBS Lett. 534: 164-168.
191. Rajala, R. V., M. H. Elliott, M. E. McClellan, and R. E. Anderson. 2006. Localization of the insulin receptor and phosphoinositide 3-kinase in detergent-resistant membrane rafts of rod photoreceptor outer segments. Adv. Exp. Med. Biol. 572: 491-497.
192. Mauvais-Jarvis, F., K. Ueki, D. A. Fruman, M. F. Hirshman, K. Sakamoto, L. J. Goodyear, M. Iannacone, D. Accili, L. C. Cantley, and C. R. Kahn. 2002. Reduced expression of the murine p85alpha subunit of phosphoinositide 3-kinase improves insulin signaling and ameliorates diabetes. J. Clin. Invest. 109: 141-149.
193. Luo, J., J. R. McMullen, C. L. Sobkiw, L. Zhang, A. L. Dorfman, M. C. Sherwood, M. N. Logsdon, J. W. Horner, R. A. DePinho, S. Izumo, et al. 2005. Class IA phosphoinositide 3-kinase regulates heart size and physiological cardiac hypertrophy. Mol. Cell. Biol. 25: 9491-9502.
194. Taniguchi, C. M., J. O. Aleman, K. Ueki, J. Luo, T. Asano, H. Kaneto, G. Stephanopoulos, L. C. Cantley, and C. R. Kahn. 2007. The p85alpha regulatory subunit of phosphoinositide 3-kinase potentiates c-Jun N-terminal kinase-mediated insulin resistance. Mol. Cell. Biol. 27: 2830-2840.
195. Rajala, R. V., M. E. McClellan, J. D. Ash, and R. E. Anderson. 2003. Regulation of retinal phosphoinositide 3-kinase activity in p85alpha-subunit knockout mice. Adv. Exp. Med. Biol. 533: 369-376.
196. Brachmann, S. M., K. Ueki, J. A. Engelman, R. C. Kahn, and L. C. Cantley. 2005. Phosphoinositide 3-kinase catalytic subunit deletion and regulatory subunit deletion have opposite effects on insulin sensitivity in mice. Mol. Cell. Biol. 25: 1596-1607.
197. Foukas, L. C., M. Claret, W. Pearce, K. Okkenhaug, S. Meek, E. Peskett, S. Sancho, A. J. Smith, D. J. Withers, and B. Vanhaesebroeck. 2006. Critical role for the p110alpha phosphoinositide-3-OH kinase in growth and metabolic regulation. Nature. 441: 366-370.
198. Knight, Z. A., B. Gonzalez, M. E. Feldman, E. R. Zunder, D. D. Goldenberg, O. Williams, R. Loewith, D. Stokoe, A. Balla, B. Toth, et al. 2006. A pharmacological map of the PI3-K family defines a role for p110alpha in insulin signaling. Cell. 125: 733-747.
199. Schlessinger, J. 2000. Cell signaling by receptor tyrosine kinases. Cell. 103: 211-225.
200. Touhara, K., J. Inglese, J. A. Pitcher, G. Shaw, and R. J. Lefkowitz. 1994. Binding of G protein beta gamma-subunits to pleckstrin homology domains. J. Biol. Chem. 269: 10217-10220.
201. Rodriguez, M. M., D. Ron, K. Touhara, C. H. Chen, and D. Mochly-Rosen. 1999. RACK1, a protein kinase C anchoring protein, coordinates the binding of activated protein kinase C and select pleckstrin homology domains in vitro. Biochemistry. 38: 13787-13794.
202. Krappa, R., A. Nguyen, P. Burrola, D. Deretic, and G. Lemke. 1999. Evectins: vesicular proteins that carry a pleckstrin homology domain and localize to post-Golgi membranes. Proc. Natl. Acad. Sci. USA. 96: 4633-4638.
203. Xu, S., Y. Wang, H. Zhao, L. Zhang, W. Xiong, K. W. Yau, H. Hiel, E. Glowatzki, D. K. Ryugo, and D. Valle. 2004. PHR1, a PH domain-containing protein expressed in primary sensory neurons. Mol. Cell. Biol. 24: 9137-9151.
204. Xu, S., R. Ladak, D. A. Swanson, A. Soltyk, H. Sun, L. Ploder, D. Vidgen, A. M. Duncan, E. Garami, D. Valle, et al. 1999. PHR1 encodes an abundant, pleckstrin homology domain-containing integral membrane protein in the photoreceptor outer segments. J. Biol. Chem. 274: 35676-35685.
205. Brognard, J., E. Sierecki, T. Gao, and A. C. Newton. 2007. PHLPP and a second isoform, PHLPP2, differentially attenuate the amplitude of Akt signaling by regulating distinct Akt isoforms. Mol. Cell. 25: 917-931.
206. Anderson, R. E., M. B. Maude, P. A. Kelleher, T. M. Maida, and S. F. Basinger. 1980. Metabolism of phosphatidylcholine in the frog retina. Biochim. Biophys. Acta. 620: 212-226.
207. Anderson, R. E., P. A. Kelleher, and M. B. Maude. 1980. Metabolism of phosphatidylethanolamine in the frog retina. Biochim. Biophys. Acta. 620: 227-235.
208. Anderson, R. E., M. B. Maude, P. A. Kelleher, M. E. Rayborn, and J. G. Hollyfield. 1983. Phosphoinositide metabolism in the retina: localization to horizontal cells and regulation by light and divalent cations. J. Neurochem. 41: 764-771.
209. Anderson, R. E., and J. G. Hollyfield. 1984. Inositol incorporation into phosphoinositides in retinal horizontal cells of Xenopus laevis: enhancement by acetylcholine, inhibition by glycine. J. Cell Biol. 99: 686-691.
210. Anderson, R. E., M. B. Maude, G. A. Pu, and J. G. Hollyfield. 1985. Effect of light on the metabolism of lipids in the rat retina. J. Neurochem. 44: 773-778.
211. Jung, H. H., C. E. Reme, and J. Pfeilschifter. 1993. Light evoked inositol trisphosphate release in the rat retina in vitro. Curr. Eye Res. 12: 727-732.
212. Schmidt, S. Y. 1983. Phosphatidylinositol synthesis and phosphorylation are enhanced by light in rat retinas. J. Biol. Chem. 258: 6863-6868.
213. Schmidt, S. Y. 1983. Light enhances the turnover of phosphatidylinositol in rat retinas. J. Neurochem. 40: 1630-1638.
214. Schmidt, S. Y. 1983. Light- and cytidine-dependent phosphatidylinositol synthesis in photoreceptor cells of the rat. J. Cell Biol. 97: 832-837.
215. Choe, H. G., A. J. Ghalayini, and R. E. Anderson. 1990. Phosphoinositide metabolism in frog rod outer segments. Exp. Eye Res. 51: 167-176.
216. Ghalayini, A. J., X. X. Guo, C. A. Koutz, and R. E. Anderson. 1998. Light stimulates tyrosine phosphorylation of rat rod outer segments in vivo. Exp. Eye Res. 66: 817-821.
217. Brown, J. E., C. Blazynski, and A. I. Cohen. 1987. Light induces a rapid and transient increase in inositol-trisphosphate in toad rod outer segments. Biochem. Biophys. Res. Commun. 146: 1392-1396.
218. Brown, J. E., L. J. Rubin, A. J. Ghalayini, A. P. Tarver, R. F. Irvine, M. J. Berridge, and R. E. Anderson. 1984. myo-Inositol polyphosphate may be a messenger for visual excitation in Limulus photoreceptors. Nature. 311: 160-163.
219. Das, N. D., T. Yoshioka, D. Samuelson, and H. Shichi. 1986. Immunocytochemical localization of phosphatidylinositol-4,5-bisphosphate in dark- and light-adapted rat retinas. Cell Struct. Funct. 11: 53-63.
220. Das, N. D., T. Yoshioka, D. Samuelson, R. J. Cohen, and H. Shichi. 1987. Immunochemical evidence for the light-regulated modulation of phosphatidylinositol-4,5-bisphosphate in rat photoreceptor cells. Cell Struct. Funct. 12: 471-481.
221. Ferreira, P. A., R. D. Shortridge, and W. L. Pak. 1993. Distinctive subtypes of bovine phospholipase C that have preferential expression in the retina and high homology to the norpA gene product of Drosophila. Proc. Natl. Acad. Sci. USA. 90: 6042-6046.
222. Gehm, B. D., and D. G. Mc Connell. 1990. Phosphoinositide synthesis in bovine rod outer segments. Biochemistry. 29: 5442-5446.
223. Gehm, B. D., R. M. Pinke, S. Laquerre, J. G. Chafouleas, D. A. Schultz, D. J. Pepperl, and D. G. McConnell. 1991. Activation of bovine rod outer segment phosphatidylinositol-4,5-bisphosphate phospholipase C by calmodulin antagonists does not depend on calmodulin. Biochemistry. 30: 11302-11306.
224. Hayashi, F., and T. Amakawa. 1985. Light-mediated breakdown of phosphatidylinositol-4,5-bisphosphate in isolated rod outer segments of frog photoreceptor. Biochem. Biophys. Res. Commun. 128: 954-959.
225. Jelsema, C. L. 1989. Regulation of phospholipase A2 and phospholipase C in rod outer segments of bovine retina involves a common GTP-binding protein but different mechanisms of action. Ann. N. Y. Acad. Sci. 559: 158-177.
226. Millar, F. A., S. C. Fisher, C. A. Muir, E. Edwards, and J. N. Hawthorne. 1988. Polyphosphoinositide hydrolysis in response to light stimulation of rat and chick retina and retinal rod outer segments. Biochim. Biophys. Acta. 970: 205-211.
227. Peng, Y. W., S. G. Rhee, W. P. Yu, Y. K. Ho, T. Schoen, G. J. Chader, and K. W. Yau. 1997. Identification of components of a phosphoinositide signaling pathway in retinal rod outer segments. Proc. Natl. Acad. Sci. USA. 94: 1995-2000.
228. Huang, Z., X. X. Guo, S. X. Chen, K. M. Alvarez, M. W. Bell, and R. E. Anderson. 2001. Regulation of type II phosphatidylinositol phosphate kinase by tyrosine phosphorylation in bovine rod outer segments. Biochemistry. 40: 4550-4559.
229. Ghalayini, A., and R. E. Anderson. 1984. Phosphatidylinositol 4,5-bisphosphate: light-mediated breakdown in the vertebrate retina. Biochem. Biophys. Res. Commun. 124: 503-506.
230. Kapoor, C. L., P. J. O'Brien, and G. J. Chader. 1987. Phorbol ester- and light-induced endogenous phosphorylation of rat rod outer-segment proteins. Exp. Eye Res. 45: 545-556.
231. Kapoor, C. L., and G. J. Chader. 1984. Endogenous phosphorylation of retinal photoreceptor outer segment proteins by calcium phospholipid-dependent protein kinase. Biochem. Biophys. Res. Commun. 122: 1397-1403.
232. Kelleher, D. J., and G. L. Johnson. 1985. Purification of protein kinase C from bovine rod outer segments. J. Cyclic Nucleotide Protein Phosphor. Res. 10: 579-591.
233. Kelleher, D. J., and G. L. Johnson. 1986. Phosphorylation of rhodopsin by protein kinase C in vitro. J. Biol. Chem. 261: 4749-4757.
234. Newton, A. C., and D. S. Williams. 1993. Rhodopsin is the major in situ substrate of protein kinase C in rod outer segments of photoreceptors. J. Biol. Chem. 268: 18181-18186.
235. Greene, N. M., D. S. Williams, and A. C. Newton. 1997. Identification of protein kinase C phosphorylation sites on bovine rhodopsin. J. Biol. Chem. 272: 10341-10344.
236. Greene, N. M., D. S. Williams, and A. C. Newton. 1995. Kinetics and localization of the phosphorylation of rhodopsin by protein kinase C. J. Biol. Chem. 270: 6710-6717.
237. Williams, D. S., X. Liu, C. L. Schlamp, B. Ondek, S. Jaken, and A. C. Newton. 1997. Characterization of protein kinase C in photoreceptor outer segments. J. Neurochem. 69: 1693-1702.
238. Udovichenko, I. P., J. Cunnick, K. Gonzalez, A. Yakhnin, and D. J. Takemoto. 1996. Protein kinase C in rod outer segments: effects of phosphorylation of the phosphodiesterase inhibitory subunit. Biochem. J. 317: 291-295.
239. Udovichenko, I. P., J. Cunnick, K. Gonzalez, and D. J. Takemoto. 1994. Functional effect of phosphorylation of the photoreceptor phosphodiesterase inhibitory subunit by protein kinase C. J. Biol. Chem. 269: 9850-9856.
240. Womack, K. B., S. E. Gordon, F. He, T. G. Wensel, C. C. Lu, and D. W. Hilgemann. 2000. Do phosphatidylinositides modulate vertebrate phototransduction? J. Neurosci. 20: 2792-2799.
241. He, F., M. Mao, and T. G. Wensel. 2004. Enhancement of phototransduction g protein-effector interactions by phosphoinositides. J. Biol. Chem. 279: 8986-8990.
242. Chuang, J. Z., Y. Zhao, and C. H. Sung. 2007. SARA-regulated vesicular targeting underlies formation of the light-sensing organelle in mammalian rods. Cell. 130: 535-547.
243. Lee, S. J., H. Xu, L. W. Kang, L. M. Amzel, and C. Montell. 2003. Light adaptation through phosphoinositide-regulated translocation of Drosophila visual arrestin. Neuron. 39: 121-132.
244. Tanaka, M., H. Konishi, K. Touhara, F. Sakane, M. Hirata, Y. Ono, and U. Kikkawa. 1999. Identification of myosin II as a binding protein to the PH domain of protein kinase B. Biochem. Biophys. Res. Commun. 255: 169-174.
245. Weil, D., S. Blanchard, J. Kaplan, P. Guilford, F. Gibson, J. Walsh, P. Mburu, A. Varela, J. Levilliers, and M. D. Weston. 1995. Defective myosin VIIA gene responsible for Usher syndrome type 1B. Nature. 374: 60-61.
246. Barber, A. J., M. Nakamura, E. B. Wolpert, C. E. Reiter, G. M. Seigel, D. A. Antonetti, and T. W. Gardner. 2001. Insulin rescues retinal neurons from apoptosis by a phosphatidylinositol 3-kinase/Akt-mediated mechanism that reduces the activation of caspase-3. J. Biol. Chem. 276: 32814-32821.
247. Yu, X., R. V. Rajala, J. F. McGinnis, F. Li, R. E. Anderson, X. Yan, S. Li, R. V. Elias, R. R. Knapp, X. Zhou, et al. 2004. Involvement of insulin/phosphoinositide 3-kinase/Akt signal pathway in 17 beta-estradiol-mediated neuroprotection. J. Biol. Chem. 279: 13086-13094.
248. Park, K. K., K. Liu, Y. Hu, P. D. Smith, C. Wang, B. Cai, B. Xu, L. Connolly, I. Kramvis, M. Sahin, et al. 2008. Promoting axon regeneration in the adult CNS by modulation of the PTEN/mTOR pathway. Science. 322: 963-966.
249. Stitt, A. W., S. J. Hughes, P. Canning, O. Lynch, O. Cox, N. Frizzell, S. R. Thorpe, T. G. Cotter, T. M. Curtis, and T. A. Gardiner. 2004. Substrates modified by advanced glycation end-products cause dysfunction and death in retinal pericytes by reducing survival signals mediated by platelet-derived growth factor. Diabetologia. 47: 1735-1746.
250. Gomez-Vicente, V., F. Doonan, M. Donovan, and T. G. Cotter. 2006. Induction of BIM(EL) following growth factor withdrawal is a key event in caspase-dependent apoptosis of 661W photoreceptor cells. Eur. J. Neurosci. 24: 981-990.
251. Pinal, N., D. C. Goberdhan, L. Collinson, Y. Fujita, I. M. Cox, C. Wilson, and F. Pichaud. 2006. Regulated and polarized PtdIns(3,4,5)P3 accumulation is essential for apical membrane morphogenesis in photoreceptor epithelial cells. Curr. Biol. 16: 140-149.
252. Jomary, C., J. Cullen, and S. E. Jones. 2006. Inactivation of the Akt survival pathway during photoreceptor apoptosis in the retinal degeneration mouse. Invest. Ophthalmol. Vis. Sci. 47: 1620-1629.
253. Kim, J. W., K. H. Kang, P. Burrola, T. W. Mak, and G. Lemke. 2008. Retinal degeneration triggered by inactivation of PTEN in the retinal pigment epithelium. Genes Dev. 22: 3147-3157.
254. Cai, J., K. C. Nelson, M. Wu, P. Sternberg, Jr., and D. P. Jones. 2000. Oxidative damage and protection of the RPE. Prog. Retin. Eye Res. 19: 205-221.
255. Bailey, T. A., N. Kanuga, I. A. Romero, J. Greenwood, P. J. Luthert, and M. E. Cheetham. 2004. Oxidative stress affects the junctional integrity of retinal pigment epithelial cells. Invest. Ophthalmol. Vis. Sci. 45: 675-684.
256. Wenzel, A., C. Grimm, M. Samardzija, and C. E. Reme. 2005. Molecular mechanisms of light-induced photoreceptor apoptosis and neuroprotection for retinal degeneration. Prog. Retin. Eye Res. 24: 275-306.
257. Lee, S. R., K. S. Yang, J. Kwon, C. Lee, W. Jeong, and S. G. Rhee. 2002. Reversible inactivation of the tumor suppressor PTEN by H2O2. J. Biol. Chem. 277: 20336-20342.
258. Leslie, N. R., D. Bennett, Y. E. Lindsay, H. Stewart, A. Gray, and C. P. Downes. 2003. Redox regulation of PI 3-kinase signalling via inactivation of PTEN. EMBO J. 22: 5501-5510.
259. Yang, P., J. J. Peairs, R. Tano, and G. J. Jaffe. 2006. Oxidant-mediated Akt activation in human RPE cells. Invest. Ophthalmol. Vis. Sci. 47: 4598-4606.
260. Barbieri, S. S., L. Ruggiero, E. Tremoli, and B. B. Weksler. 2008. Suppressing PTEN activity by tobacco smoke plus interleukin-1beta modulates dissociation of VE-cadherin/beta-catenin complexes in endothelium. Arterioscler. Thromb. Vasc. Biol. 28: 732-738.
261. Wang, K., and A. Spector. 2000. Alpha-crystallin prevents irreversible protein denaturation and acts cooperatively with other heat-shock proteins to renature the stabilized partially denatured protein in an ATP-dependent manner. Eur. J. Biochem. 267: 4705-4712.
262. Defoe, D. M., and R. D. Grindstaff. 2004. Epidermal growth factor stimulation of RPE cell survival: contribution of phosphatidylinositol 3-kinase and mitogen-activated protein kinase pathways. Exp. Eye Res. 79: 51-59.
263. Cai, J., K. C. Nelson, M. Wu, P. Sternberg, Jr., and D. P. Jones. 2000. Oxidative damage and protection of the RPE. Prog.Retin.Eye Res. 19: 205-221.
264. Lavie, Y., J. Dybowski, and B. W. Agranoff. 1997. Wortmannin blocks goldfish retinal phosphatidylinositol 3-kinase and neurite outgrowth. Neurochem. Res. 22: 373-378.
265. Pimentel, B., L. Rodriguez-Borlado, C. Hernandez, and A. C. Carrera. 2002. A role for phosphoinositide 3-kinase in the control of cell division and survival during retinal development. Dev. Biol. 247: 295-306.
266. Nakazawa, T., M. Shimura, H. Tomita, H. Akiyama, Y. Yoshioka, H. Kudou, and M. Tamai. 2003. Intrinsic activation of PI3K/Akt signaling pathway and its neuroprotective effect against retinal injury. Curr. Eye Res. 26: 55-63.
267. Huang, Y., L. P. Cen, J. M. Luo, N. Wang, M. Z. Zhang, N. van Rooijen, C. P. Pang, and Q. Cui. 2008. Differential roles of phosphatidylinositol 3-kinase/akt pathway in retinal ganglion cell survival in rats with or without acute ocular hypertension. Neuroscience. 153: 214-225.
268. Huang, Y., Z. Li, N. Wang, N. van Rooijen, and Q. Cui. 2008. Roles of PI3K and JAK pathways in viability of retinal ganglion cells after acute elevation of intraocular pressure in rats with different autoimmune backgrounds. BMC Neurosci. 9: 78.
269. Chen, J., L. Wang, Y. Chen, P. Sternberg, and J. Cai. 2009. Phosphatidylinositol 3 kinase pathway and 4-hydroxy-2-nonenal-induced oxidative injury in the RPE. Invest. Ophthalmol. Vis. Sci. 50: 936-942.
270. Geraldes, P., K. Yagi, Y. Ohshiro, Z. He, Y. Maeno, J. Yamamoto-Hiraoka, C. Rask-Madsen, S. W. Chung, M. A. Perrella, and G. L. King. 2008. Selective regulation of heme oxygenase-1 expression and function by insulin through IRS1/phosphoinositide 3-kinase/Akt-2 pathway. J. Biol. Chem. 283: 34327-34336.
271. Wolf, A. M., A. I. Lyuksyutova, A. G. Fenstermaker, B. Shafer, C. G. Lo, and Y. Zou. 2008. Phosphatidylinositol-3-kinase-atypical protein kinase C signaling is required for Wnt attraction and anterior-posterior axon guidance. J. Neurosci. 28: 3456-3467.
272. Ko, M. L., K. Jian, L. Shi, and G. Y. Ko. 2009. Phosphatidylinositol 3 kinase-Akt signaling serves as a circadian output in the retina. J. Neurochem. 108: 1607-1620.
273. Blakesley, V. A., A. Scrimgeour, D. Esposito, and D. Le Roith. 1996. Signaling via the insulin-like growth factor-I receptor: does it differ from insulin receptor signaling? Cytokine Growth Factor Rev. 7: 153-159.
274. Saltiel, A. R., and C. R. Kahn. 2001. Insulin signalling and the regulation of glucose and lipid metabolism. Nature. 414: 799-806.
275. Kondo, T., D. Vicent, K. Suzuma, M. Yanagisawa, G. L. King, M. Holzenberger, and C. R. Kahn. 2003. Knockout of insulin and IGF-1 receptors on vascular endothelial cells protects against retinal neovascularization. J. Clin. Invest. 111: 1835-1842.
276. Johnson, L. E., T. van Veen, and P. A. Ekstrom. 2005. Differential Akt activation in the photoreceptors of normal and rd1 mice. Cell Tissue Res. 320: 213-222.
277. Rajala, R. V., I. Ivanovic, and A. K. Dilly. 2009. Retinal insulin receptor signaling in hyperosmotic stress. Vitam. Horm. 80: 583-612.
278. Schmitz, F., and D. Drenckhahn. 1993. Li(+)-induced structural changes of synaptic ribbons are related to the phosphoinositide metabolism in photoreceptor synapses. Brain Res. 604: 142-148.
279. LaVail, M. M. 1976. Rod outer segment disk shedding in rat retina: relationship to cyclic lighting. Science. 194: 1071-1074.
280. Papermaster, D. S., C. A. Converse, and J. Siuss. 1975. Membrane biosynthesis in the frog retina: opsin transport in the photoreceptor cell. Biochemistry. 14: 1343-1352.
281. McGinnis, J. F., J. P. Whelan, and L. A. Donoso. 1992. Transient, cyclic changes in mouse visual cell gene products during the light-dark cycle. J. Neurosci. Res. 31: 584-590.
282. Calvert, P. D., K. J. Strissel, W. E. Schiesser, E. N. Pugh, Jr., and V. Y. Arshavsky. 2006. Light-driven translocation of signaling proteins in vertebrate photoreceptors. Trends Cell Biol. 16: 560-568.
283. Steenhard, B. M., and J. C. Besharse. 2000. Phase shifting the retinal circadian clock: xPer2 mRNA induction by light and dopamine. J. Neurosci. 20: 8572-8577.
284. Li, F., W. Cao, and R. E. Anderson. 2001. Protection of photoreceptor cells in adult rats from light-induced degeneration by adaptation to bright cyclic light. Exp. Eye Res. 73: 569-577.
285. Penn, J. S., and R. E. Anderson. 1987. Effect of light history on rod outer-segment membrane composition in the rat. Exp. Eye Res. 44: 767-778.
286. Inoue, H., T. Yoshioka, and Y. Hotta. 1989. Diacylglycerol kinase defect in a Drosophila retinal degeneration mutant rdgA. J. Biol. Chem. 264: 5996-6000.
287. Kim, S., R. R. McKay, K. Miller, and R. D. Shortridge. 1995. Multiple subtypes of phospholipase C are encoded by the norpA gene of Drosophila melanogaster. J. Biol. Chem. 270: 14376-14382.
288. McKay, R. R., D. M. Chen, K. Miller, S. Kim, W. S. Stark, and R. D. Shortridge. 1995. Phospholipase C rescues visual defect in norpA mutant of Drosophila melanogaster. J. Biol. Chem. 270: 13271-13276.
289. Attree, O., I. M. Olivos, I. Okabe, L. C. Bailey, D. L. Nelson, R. A. Lewis, R. R. McInnes, and R. L. Nussbaum. 1992. The Lowe's oculocerebrorenal syndrome gene encodes a protein highly homologous to inositol polyphosphate-5-phosphatase. Nature. 358: 239-242.
290. Majerus, P. W., M. V. Kisseleva, and F. A. Norris. 1999. The role of phosphatases in inositol signaling reactions. J. Biol. Chem. 274: 10669-10672.
291. Kohn, L., K. Kadzhaev, M. S. Burstedt, S. Haraldsson, B. Hallberg, O. Sandgren, and I. Golovleva. 2007. Mutation in the PYK2-binding domain of PITPNM3 causes autosomal dominant cone dystrophy (CORD5) in two Swedish families. Eur. J. Hum. Genet. 15: 664-671.