Mechanism of protein Kinase B activation by insulin/Insulin-like growth Factor-1 revealed by specific inhibitors of phosphoinositide 3-kinase-significance for diabetes and cancer

Pharmacology and Therapeutics

Volumn 82, Issue 2-3, 1999, Pages 409-425

  Galetic , Ivana ^a   Andjelkovic , Mirjana ^a   Meier, Roger ^a   Brodbeck, Daniela ^a   Park, Jongsun ^a   Hemmings, Brian A ^a  

^a FRIEDRICH MIESCHER INSTITUTE FOR BIOMEDICAL RESEARCH   (Switzerland)

Author keywords

Inhibitors; Lipid second messengers; Phosphorylation; PI 3 kinase; PKB

Indexed keywords

2 MORPHOLINO 8 PHENYLCHROMONE; INSULIN; ISOENZYME; PHOSPHATIDYLINOSITOL 3 KINASE; PHOSPHATIDYLINOSITOL 3 KINASE INHIBITOR; PHOSPHATIDYLINOSITOL 3,4 BISPHOSPHATE; PHOSPHATIDYLINOSITOL 3,4,5 TRISPHOSPHATE; PLECKSTRIN; PROTEIN KINASE B; SOMATOMEDIN C; UNCLASSIFIED DRUG; WORTMANNIN;

AMINO TERMINAL SEQUENCE; APOPTOSIS; BREAST CARCINOMA; CANCER; CELL MEMBRANE; CELL TYPE; CONFERENCE PAPER; DIABETES MELLITUS; ENZYME ACTIVATION; ENZYME PHOSPHORYLATION; GLUCOSE METABOLISM; HUMAN; NONHUMAN; OVARY CARCINOMA; PANCREAS CARCINOMA; PRIORITY JOURNAL; PROTEIN DOMAIN; PROTEIN EXPRESSION; PROTEIN PHOSPHORYLATION; SECOND MESSENGER; SIGNAL TRANSDUCTION; TRANSCRIPTION REGULATION;

1-PHOSPHATIDYLINOSITOL 3-KINASE; ANIMALS; CATALYTIC DOMAIN; DIABETES MELLITUS; ENZYME INHIBITORS; HUMANS; INSULIN; INSULIN-LIKE GROWTH FACTOR BINDING PROTEIN 1; NEOPLASMS; PHOSPHATIDYLINOSITOLS; PHOSPHORYLATION; PROTEIN-SERINE-THREONINE KINASES; PROTO-ONCOGENE PROTEINS; PROTO-ONCOGENE PROTEINS C-AKT;

EID: 0033018109     PISSN: 01637258     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0163-7258(98)00071-0     Document Type: Conference Paper

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