Improved sensitivity to insulin in obese subjects following weight loss is accompanied by reduced protein-tyrosine phosphatases in adipose tissue

Metabolism: Clinical and Experimental

Volumn 46, Issue 10, 1997, Pages 1140-1145

  Ahmad, Faiyaz ^b   Considine, Robert V ^b   Bauer, Thomas L ^b   Ohannesian, Joanna P ^b   Marco, Cheryl C ^b   Goldstein, Barry J ^a  

^a THOMAS JEFFERSON UNIVERSITY   (United States)

^b NONE

Author keywords

[No Author keywords available]

Indexed keywords

INSULIN; PROTEIN TYROSINE PHOSPHATASE;

ADIPOSE TISSUE; ARTICLE; BODY MASS; CLINICAL ARTICLE; CONTROLLED STUDY; FEMALE; HUMAN; HUMAN CELL; HUMAN TISSUE; INSULIN RESISTANCE; INSULIN SENSITIVITY; MALE; OBESITY; PATHOGENESIS; PRIORITY JOURNAL; WEIGHT REDUCTION;

EID: 0030821972     PISSN: 00260495     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0026-0495(97)90206-7     Document Type: Article

References (49)

1. Kuczmarski RJ, Flegal KM, Campbell SM, et al: Increasing prevalence of overweight among US adults. The National Health and Nutrition Examination Surveys, 1960 to 1991. JAMA 272:205-211, 1994
2. Rabinowitz D: Some endocrine and metabolic aspects of obesity. Annu Rev Med 21:241-258, 1970
3. Kolterman OG, Insel J, Saekow M, et al: Mechanisms of insulin resistance in human obesity: Evidence for receptor and postreceptor defects. J Clin Invest 65:1272-1284, 1980
4. Caro JF, Dohm LG, Pories WJ, et al: Cellular alterations in liver, skeletal muscle, and adipose tissue responsible for insulin resistance in obesity and type II diabetes. Diabetes Metab Rev 5:665-689, 1989
5. White MF, Kahn CR: The insulin signalling system. J Biol Chem 269:1-4, 1994
6. Goldstein BJ: Protein-tyrosine phosphatases and the regulation of insulin action, in LeRoith D, Olefsky JM, Taylor SI (eds): Diabetes Mellitus: A Fundamental and Clinical Text. Philadelphia, PA, Lippincott, 1996, pp 174-186
7. Ahmad F, Considine RV, Goldstein BJ: Increased abundance of the receptor-type protein-tyrosine phosphatase LAR accounts for the elevated insulin receptor dephosphorylating activity in adipose tissue of obese human subjects. J Clin Invest 95:2806-2812, 1995
8. Ahmad F, Li PM, Meyerovitch J, et al: Osmotic loading of neutralizing antibodies defines a role for protein-tyrosine phosphatase IB in negative regulation of the insulin action pathway. J Biol Chem 270:20503-20508, 1995
9. Kulas DT, Zhang WR, Goldstein BJ, et al: Insulin receptor signalling is augmented by antisense inhibition of the protein-tyrosine phosphatase LAR. J Biol Chem 270:2435-2438, 1995
10. Li PM, Zhang WR, Goldstein BJ: Suppression of insulin receptor activation by overexpression of the protein-tyrosine phosphatase LAR in hepatoma cells. Cell Signal 8:467-473, 1996
11. Zhang WR, Li PM, Oswald MA, et al: Modulation of insulin signal transduction by eutopic overexpression of the receptor-type protein-tyrosine phosphatase LAR. Mol Endocrinol 10:575-584, 1996
12. Considine RV, Sinha MK, Heiman ML, et al: Serum immunore-active-leptin concentrations in normal-weight and obese humans. N Engl J Med 334:292-295, 1996
13. Kolaczynski JW, Morales LM, Moore JH Jr, et al: A new technique for biopsy of human abdominal fat under local anaesthesia with lidocaine. Int J Obes Relat Metab Disord 18:161-166, 1994
14. Bradford MM: A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding. Anal Biochem 72:248-254, 1976
15. Pike LJ, Kuenzel EA, Casnellie JE, et al: A comparison of the insulin- and epidermal growth factor-stimulated protein kinases from human placenta. J Biol Chem 259:9913-9921, 1984
16. Tonks NK, Diltz CD, Fischer EH: Purification of proteintyrosine phosphatases from human placenta. Methods Enzymol 201:427-442, 1991
17. Laemmli EK: Cleavage of structural proteins during the assembly of the head of bacteriophage T4. Nature 227:680-685, 1970
18. Towbin H, Staehelin T, Gordon J: Electrophoretic transfer of proteins from polyacrylamide gels to nitrocellulose sheets: Procedure and some applications. Proc Natl Acad Sci USA 76:4350-4354, 1979
19. Hashimoto N, Zhang WR, Goldstein BJ: Insulin receptor and epidermal growth factor receptor dephosphorylation by three major rat liver protein-tyrosine phosphatases expressed in a recombinant bacterial system. Biochem J 284:569-576, 1992
20. Harlow E, Lane D: Antibodies: A Laboratory Manual. Cold Spring Harbor, NY, Cold Spring Harbor Laboratory, 1988
21. Ahmad F, Goldstein BJ: Purification, identification and subcellular distribution of three predominant protein-tyrosine phosphatase enzymes in skeletal muscle tissue. Biochim Biophys Acta 1248:57-69, 1995
22. Ahmad F, Goldstein BJ: Alterations in specific protein-tyrosine phosphatases accompany the insulin resistance of streptozotocin-diabetes. Am J Physiol 268:E932-E940, 1995
23. Campbell PJ, Gerich JE: Impact of obesity on insulin action in volunteers with normal glucose tolerance: Demonstration of a threshold for the adverse effect of obesity. J Clin Endocrinol Metab 70:1114-1118, 1990
24. Boden G: Effects of age and body fat on insulin resistance in healthy men. Diabetes Care 16:728-733, 1993
25. Caro JF: Insulin resistance in obese and nonobese man. J Clin Endocrinol Metab 73:691-695, 1991
26. Olefsky JM: Insulin binding to adipocytes and circulating monocytes from obese patients. J Clin Invest 57:1165-1172, 1976
27. Ciaraldi TP, Molina JM, Olefsky JM: Insulin action kinetics in adipocytes from obese and noninsulin-dependent diabetes mellitus subjects: Identification of multiple cellular defects in glucose transport. J Clin Endocrinol Metab 72:876-882, 1991
28. Freidenberg GR, Henry RR, Klein HH, et al: Decreased kinase activity of insulin receptors from adipocytes of non-insulin-dependent diabetic subjects. J Clin Invest 79:240-250, 1987
29. Sinha MK, Pories WI, Flickinger EG, et al: Insulin-receptor kinase activity of adipose tissue from morbidly obese humans with and without NIDDM. Diabetes 36:620-625, 1987
30. Moller NPH, Moller KB, Lammers R, et al: Selective down-regulation of the insulin receptor signal by protein-tyrosine phosphatases alpha and epsilon. J Biol Chem 270:23126-23131, 1995
31. Kusari J, Kenner KA, Suh KI, et al: Skeletal muscle protein tyrosine phosphatase activity and tyrosine phosphatase IB protein content are associated with insulin action and resistance. J Clin Invest 93:1156-1162, 1994
32. Meyerovitch J, Rothenberg PL, Shechter Y, et al: Vanadate normalizes hyperglycemia in two mouse models of non-insulin dependent diabetes mellitus. J Clin Invest 87:1286-1294, 1991
33. Posner BI, Faure R, Burgess JW, et al: Peroxovanadium compounds - A new class of potent phosphotyrosine phosphatase inhibitors which are insulin mimetics. J Biol Chem 269:4596-4604, 1994
34. Shisheva A, Ikonomov O, Shechter Y: The protein tyrosine phosphatase inhibitor, pervanadate, is a powerful antidiabetic agent in streptozotocin-treated diabetic rats. Endocrinology 134:507-510, 1994
35. Brichard SM, Henquin JC: The role of vanadium in the management of diabetes. Trends Pharmacol Sci 16:265-270, 1995
36. Cohen N, Halberstam M, Shlimovich P, et al: Oral vanadyl sulfate improves hepatic and peripheral insulin sensitivity in patients with non-insulin-dependent diabetes mellitus. J Clin Invest 95:2501-2509, 1995
37. Goldfine AB, Simonson DC, Folli F, et al: Metabolic effects of sodium metavanadate in humans with insulin-dependent and noninsulin-dependent diabetes mellitus: In vivo and in vitro studies. J Clin Endocrinol Metab 80:3311-3320, 1995
38. Freidenberg GR, Reichart D, Olefsky JM, et al: Reversibility of defective adipocyte insulin receptor kinase activity in non-insulin-dependent diabetes mellitus. Effect of weight loss. J Clin Invest 82:1398-1406, 1988
39. Friedman JE, Dohm GL, Leggettfrazier N, et al: Restoration of insulin responsiveness in skeletal muscle of morbidly obese patients after weight loss - Effect on muscle glucose transport and glucose transporter GLUT4. J Clin Invest 89:701-705, 1992
40. Perriello G, Misericordia P, Volpi E, et al: Contribution of obesity to insulin resistance in noninsulin-dependent diabetes mellitus. J Clin Endocrinol Metab 80:2464-2469, 1995
41. Goldstein BJ: Regulation of insulin receptor signalling by protein-tyrosine dephosphorylation. Receptor 3:1-15, 1993
42. Mooney RA, Anderson DL: Phosphorylation of the insulin receptor in permeabilized adipocytes is coupled to a rapid dephosphorylation reaction. J Biol Chem 264:6850-6857, 1989
43. Bernier M, Liotta AS, Kole HK, et al: Dynamic regulation of intact and C-terminal truncated insulin receptor phosphorylation in permeabilized cells. Biochemistry 33:4343-4351, 1994
44. Hashimoto N, Feener EP, Zhang WR, et al: Insulin receptor protein-tyrosine phosphatases - Leukocyte common antigen-related phosphatase rapidly deactivates the insulin receptor kinase by preferential dephosphorylation of the receptor regulatory domain. J Biol Chem 267:13811-13814, 1992
45. Charbonneau H, Tonks NK, Kumar S, et al: Human placenta protein-tyrosine-phosphatase: Amino acid sequence and relationship to a family of receptor-like proteins. Proc Natl Acad Sci USA 86:5252-5256, 1989
46. Cicirelli MF, Tonks NK, Diltz CD, et al: Microinjection of a protein-tyrosine-phosphatase inhibits insulin action in Xenopus oocytes. Proc Natl Acad Sci USA 87:5514-5518, 1990
47. Tonks NK, Cicirelli MF, Diltz CD, et al: Effect of microinjection of a low-Mr human placenta protein tyrosine phosphatase on induction of meiotic cell division in Xenopus oocytes. Mol Cell Biol 10:458-463, 1990
48. Lammers R, Bossenmaier B, Cool DE, et al: Differential activities of protein tyrosine phosphatases in intact cells. J Biol Chem 268:22456-22462, 1993
49. Kenner KA, Anyanwu E, Olefsky JM, et al: Protein-tyrosine phosphatase IB is a negative regulator of insulin- and insulin-like growth factor-1 stimulated signaling. J Biol Chem 271:19810-19816, 1996