Loss of class IA PI3K signaling in muscle leads to impaired muscle growth, insulin response, and hyperlipidemia

Cell Metabolism

Volumn 3, Issue 5, 2006, Pages 355-366

  Luo, Ji ^a   Sobkiw, Cassandra L ^a   Hirshman, Michael F ^b   Logsdon, M Nicole ^a   Li, Timothy Q ^a   Goodyear, Laurie J ^b   Cantley, Lewis C ^a  

^a HARVARD MEDICAL SCHOOL   (United States)

^b JOSLIN DIABETES CENTER   (United States)

Author keywords

SIGNALING

Indexed keywords

FATTY ACID; GLUCOSE; INSULIN; LEPTIN; PHOSPHATIDYLINOSITOL 3 KINASE; PROTEIN P50; PROTEIN P55; PROTEIN P85; PROTEIN SUBUNIT; SOMATOMEDIN C; TRIACYLGLYCEROL; ANTIDIABETIC AGENT;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; BODY FAT; CELL SIZE; CONTROLLED STUDY; DIET RESTRICTION; DISEASE SEVERITY; FATTY ACID BLOOD LEVEL; GLUCOSE BLOOD LEVEL; GLUCOSE INTOLERANCE; HYPERLIPIDEMIA; INSULIN RESISTANCE; METABOLIC PARAMETERS; MOUSE; MUSCLE ATROPHY; MUSCLE CELL; MUSCLE DISEASE; MUSCLE GROWTH; MUSCLE MASS; NON INSULIN DEPENDENT DIABETES MELLITUS; NONHUMAN; OBESITY; PRIORITY JOURNAL; PROTEIN DEFICIENCY; PROTEIN METABOLISM; SIGNAL TRANSDUCTION; SKELETAL MUSCLE; SYMPTOM; TRIACYLGLYCEROL BLOOD LEVEL; ANIMAL; BLOOD; BODY COMPOSITION; C57BL MOUSE; DRUG EFFECT; ENZYMOLOGY; GENETICS; GROWTH, DEVELOPMENT AND AGING; METABOLISM; MOUSE MUTANT; PATHOLOGY;

ANIMALIA;

1-PHOSPHATIDYLINOSITOL 3-KINASE; ANIMALS; BLOOD GLUCOSE; BODY COMPOSITION; DIABETES MELLITUS, TYPE 2; FATTY ACIDS, NONESTERIFIED; GLUCOSE; GLUCOSE INTOLERANCE; HYPERLIPIDEMIAS; HYPOGLYCEMIC AGENTS; INSULIN; INSULIN RESISTANCE; INSULIN-LIKE GROWTH FACTOR I; MICE; MICE, INBRED C57BL; MICE, KNOCKOUT; MUSCLE, SKELETAL; MUSCULAR ATROPHY; SIGNAL TRANSDUCTION; TRIGLYCERIDES;

EID: 33646485943     PISSN: 15504131     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.cmet.2006.04.003     Document Type: Article

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