Adaptation in vertebrate photoreceptors

Physiological Reviews

Volumn 81, Issue 1, 2001, Pages 117-151

  Fain, G L ^a   Matthews, H R ^a   Cornwall, M C ^a   Koutalos, Y ^a  

^a UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CALCIUM; CYCLIC NUCLEOTIDE; GUANYLATE CYCLASE; PHOSPHODIESTERASE; RHODOPSIN; TRANSDUCIN;

CALCIUM CELL LEVEL; DESENSITIZATION; LIGHT ADAPTATION; NONHUMAN; PHOTORECEPTOR; PIGMENTATION; PRIORITY JOURNAL; RETINA CONE; RETINA ROD; REVIEW; SECOND MESSENGER; SIGNAL TRANSDUCTION; VERTEBRATE; VISUAL ADAPTATION;

EID: 0035138836     PISSN: 00319333     EISSN: None     Source Type: Journal    
DOI: 10.1152/physrev.2001.81.1.117     Document Type: Review

References (298)

1. A GTPase-accelerating factor for transducin, distinct from its effector cGMP phosphodiesterase, in rod outer segment membranes
2. 31P nuclear magnetic resonance
3. On the role of transducin GTPase in the quenching of a phosphodiesterase cascade of vision
4. Regulation of deactivation of photoreceptor G protein by its target enzyme and cGMP
5. Regeneration of rhodopsin in frog rod outer segments
6. Characterization of bovine rod outer segment G-protein
7. Dark-adaptation: A new hypothesis
8. Dark and light adaptation: Psychophysics
9. Light adaptation in toad rods: Requirement for an internal messenger which is not calcium
10. 2+-calmodulin binding sites
11. How photons start vision
12. Changes in time scale and sensitivity in turtle photoreceptors
13. Responses of retinal rods to single photons
14. Two components of electrical dark noise in toad retinal rod outer segments
15. Cyclic nucleotide phosphodiesterases: Functional implications of multiple isoforms
16. In vivo isomerization of all-trans- to 11-cis-retinoids in the eye occurs at the alcohol oxidation state
17. G proteins in signal transduction
18. The rod increment threshold during dark adaptation in normal and rod monochromat
19. Rod and cone photoreceptor cells express distinct genes for cGMP-gated channels
20. GTPases: A family of molecular switches and clocks
21. Phosphorylation of frog photoreceptor membranes induced by light
22. Biochemical steps in visual transduction: Roles for nucleotides and calcium ions
23. Biochemical correlates of adaptation processes in isolated frog photoreceptor membranes
24. Mechanisms of opsin activation
25. Onset of feedback reactions underlying vertebrate rod photoreceptor light adaptation
26. Measurement of the scotopic pigment in the living human eye
27. Extrusion of calcium from rod outer segments is driven by both sodium and potassium gradients
28. 2+-dependent interaction of recoverin with rhodopsin kinase
29. RGS-r, a retinal specific RGS protein, binds an intermediate conformation of transducin and enhances recycling
30. Mechanisms of rhodopsin inactivation in vivo as revealed by a COOH-terminal truncation mutant
31. Mechanism of activation and inactivation of opsin: Role of Glu113 and Lys296
32. Constitutive activation of opsin: Influence of charge at position 134 and size at position 296
33. Bleached pigment activates transduction in isolated rods of the salamander retina
34. Spatial localization of bleaching adaptation in isolated vertebrate rod photoreceptors
35. Cellular mechanisms that underlie bleaching and background adaptation
36. Electrophysiological methods for measurements of activation of phototransduction by bleached visual pigment in salamander photoreceptors
37. Bleached pigment activates transduction in salamander cones
38. Membrane current responses of skate photoreceptors
39. Persistence of opsin desensitization
40. cGMP binding sites on photoreceptor phosphodiesterase: Role in feedback regulation of visual transduction
41. High expression levels in cones of RGS9, the predominant GTPase accelerating protein of rods
42. Visual adaptation in relation to brief conditioning stimuli
43. Retinoids and the visual process
44. Inhibition of rhodopsin regeneration by cyclohexyl derivatives
45. The localization of guanylyl cyclase-activating proteins in the mammalian retina
46. The chromophore binding space of opsin
47. Inositol-1,4,5-trisphosphate receptors in the vertebrate retina
48. cGMP phosphodiesterase of retinal rods is regulated by two inhibitory subunits
49. The mechanisms of vertebrate light adaptation: Speeded recovery versus slowed activation
50. 2+-induced "activator- to-inhibitor" transition
51. The human photoreceptor membrane guanylyl cyclase, RetGC, is present in outer segments and is regulated by calcium and a soluble activator
52. Recoverin: A calcium sensitive activator of retinal rod guanylate cyclase
53. Dark and light adaptation in pigmented and white rat as measured by electroretinogram threshold
54. Kinetics of long-lived rhodopsin photoproducts in the frog retina as a function of the amount bleached
55. Excitation and adaptation in the vertebrate rod photoreceptor
56. Dark-adaptation processes in the rhodopsin rods of the frog's retina
57. Neural and photochemical mechanisms of visual adaptation in the rat
58. Adaptation in skate photoreceptors
59. Complex formation between metarhodopsin II and GTP-binding protein in bovine photoreceptor membranes leads to a shift of the photoproduct equilibrium
60. The effect of recombinant recoverin on the photoresponse of truncated rod photoreceptors
61. Deactivation of visual transduction without guanosine triphosphate hydrolysis by G protein
62. Sensitivity of toad rods: Dependence on wave-length and background illumination
63. Light and dark adaptation in vertebrate photoreceptors
64. Cytoplasmic calcium as the messenger for light adaptation in salamander rods
65. Light-evoked calcium release in vertebrate photoreceptors
66. Dark adaptation in vertebrate photoreceptors
67. Calcium content and light-induced release from photoreceptors: Measurements with laser micro-mass analysis
68. Calcium in dark-adapted toad rods: Evidence for pooling and cyclic guanosine-3′-5′-monophosphate-dependent release
69. Light-induced calcium release and re-uptake in toad rods
70. Photoactivated conformational changes in rhodopsin: A time-resolved spin label study
71. From mice to men: The cyclic GMP phosphodiesterase gene in vision and disease
72. Requirement of rigid-body motion of transmembrane helices for light activation of rhodopsin
73. Induction by cyclic GMP of cationic conductance in plasma membrane of retinal rod outer segment
74. Cyclic nucleotide-gated ion channels: An extended family with diverse functions
75. Solubilization of membranebound rod phosphodiesterase by the rod phosphodiesterase recombinant delta subunit
76. Interplay of phosphorylation and desphosphorylation in vision: Protein phosphatases of bovine rod outer segments
77. Rhodopsin phosphorylation and retinal outer segment cyclic nucleotide phosphodiesterase: Lack of a causal relationship
78. Cyclic nucleotide-gated channels and calcium: An intimate relation
79. Functional characterization of a guanylyl cyclase-activating protein from vertebrate rods. Cloning, heterologous expression, and localization
80. Activation of phosphodiesterase in frog rod outer segment by an intermediate of rhodopsin photolysis I
81. Photolyzed rhodopsin catalyzes the exchange of GTP for bound GDP in retinal rod outer segments
82. Guanylyl cyclase receptors
83. Purification and physiological evaluation of a guanylate cyclase activating protein from retinal rods
84. Protein phosphatases modulate the apparent agonist affinity of the light-regulated ion channel in retinal rods
85. Diacylglycerol analogs inhibit the rod cGMP-gated channel by a phosphorylation-independent mechanism
86. Modulation of the cGMP-gated ion channel in frog rods by calmodulin and an endogenous inhibitory factor
87. Intracellular recordings of rod responses during dark-adaptation
88. Longitudinal spread of second messenger signals in isolated rod outer segments of lizards
89. The calcium feedback signal in the phototransduction cascade of vertebrate rods
90. 2+ dependence of dark- and light-adapted flash responses in rod photoreceptors
91. The effect of recoverin-like calcium-binding proteins on the photoresponse of retinal rods
92. Functional and structural complexity of signal transduction via G-protein-coupled receptors
93. Calcium modulation of ligand affinity in the cyclic GMP-gated ion channels of cone photoreceptors
94. Divalent cation selectivity is a function of gating in native and recombinant cyclic nucleotide-gated ion channels from retinal photoreceptors
95. Molecular characterization of a novel short-chain dehydrogenase/reductase that reduces all-trans-retinal
96. Heterotrimeric G proteins
97. Future directions for rhodopsin structure and function studies
98. Regulation of visual transduction
99. Modulation of rod, but not cone, cGMPgated photoreceptor channels by calcium-calmodulin
100. RGS9, a GTPase accelerator for phototransduction
101. The influence of light adaptation on subsequent dark adaptation of the eye
102. Longitudinal spread of adaptation in the rods of the frog's retina
103. The ionic selectivity and calcium dependence of the light-sensitive pathway in toad rods
104. Measurement of sodium-calcium exchange in salamander rods
105. Control of light-sensitive current in salamander rods
106. The role of arrestin and retinoids in the regeneration pathway of rhodopsin
107. Modulation of the cGMP-gated channel of rod photoreceptor cells by calmodulin
108. Interaction of calmodulin with the cyclic GMP-gated channel of rod photoreceptor cells. Modulation of activity, affinity purification, and localization
109. The action of light on rhodopsin
110. Effects of Ca and recoverin on rod photoreceptor function in intact retinas
111. Rhodopsin phosphorylation and its role in photoreceptor function
112. Opsin/all-trans-retinal complex activates transducin by different mechanisms than photolyzed rhodopsin
113. Phospholipase C β4 is involved in modulating the visual response in mice
114. Noncovalent occupancy of the retinal-binding pocket of opsin diminishes bleaching adaptation of retinal cones
115. Light adaptation and the rising phase of the flash photocurrent of salamander retinal rods
116. Membrane current noise in dark-adapted and light-adapted isolated retinal rods of the larval tiger salamander
117. Equivalence of background and bleaching desensitization in isolated rod photoreceptors of the larval tiger salamander
118. Retinoid requirements for recovery of sensitivity after visual-pigment bleaching in isolated photoreceptors
119. Visual pigment bleaching in isolated salamander retinal cones. Microspectrophotometry and light adaptation
120. Detailed localization of photoreceptor guanylate cyclase activating protein-1 and -2 in mammalian retinas using light and electron microscopy
121. Distribution and axial diffusion of retinol in bleached rod outer segments of frogs (Rana pipiens)
122. Rhodopsin phosphorylation as a mechanism of cyclic GMP phosphodiesterase regulation by S-modulin
123. Recoverin has S-modulin activity in frog rods
124. Calcium-dependent regulation of cyclic GMP phosphodiesterase by a protein from frog retinal rods
125. Occupancy of the chromophore binding site of opsin activates visual transduction in rod photoreceptors
126. Transient activation of transduction by 11-cis retinal during pigment regeneration in bleach-adapted rods
127. Structure-function relationships and localization of the Na/Ca-K exchanger in rod photoreceptors
128. Intracellular recordings from gecko photoreceptors during light and dark adaptation
129. 2+ fluxes and channel regulation in rods of the albino rat
130. Highly cooperative feedback control of retinal rod guanylate cyclase by calcium ions
131. Cytoplasmic free calcium concentration in dark-adapted retinal rod outer segments
132. Characterization of guanylate cyclase activity in single retinal rod outer segments
133. The cGMP-phosphodiesterase and its contribution to sensitivity regulation in retinal rods
134. Regulation of sensitivity in vertebrate rod photoreceptors by calcium
135. Visual transduction in human rod photoreceptors
136. Compartmentalization of calcium extrusion mechanisms in the outer and inner segments of photoreceptors
137. Mechanism of quenching of phototransduction
138. Light-dependent phosphorylation of rhodopsin in living frogs
139. Light-regulated binding of rhodopsin kinase and other proteins to cattle photoreceptor membranes
140. Light- and GTP-regulated interaction of GTPase and other proteins with bovine photoreceptor membranes
141. Phosphorylation of rhodopsin in bovine photoreceptor membranes. A dark reaction after illumination
142. Light dependent phosphorylation of rhodopsin by ATP
143. Light-induced binding of 48-kDa protein to photoreceptor membranes is highly enhanced by phosphorylation of rhodopsin
144. Phosphorylation of rhodopsin as a possible mechanism of adaptation
145. Calcium controls light-triggered formation of catalytically active rhodopsin
146. Calcium homeostasis in the outer segments of retinal rods from the tiger salamander
147. Spontaneous quantal events induced in toad rods by pigment bleaching
148. The involvement of rod photoreceptors in dark adaptation
149. Dark adaptation: A re-examination
150. External and internal actions in the response of salamander retinal rods to altered external calcium concentration
151. Incorporation of analogues of GTP and GDP into rod photoreceptors isolated from the tiger salamander
152. Spatial spread of activation and background desensitization in toad rod outer segments
153. A quantitative account of the activation steps involved in phototransduction in amphibian photoreceptors
154. Responses of the phototransduction cascade to dim light
155. Background and bleaching equivalence in steady-state adaptation of vertebrate rods
156. Effect of hydroxylamine on photon-like events during dark adaptation in toad rod photoreceptors
157. Dark adaptation of toad rod photoreceptors following small bleaches
158. Molecular basis of dark adaptation in rod photoreceptors
159. 2+-binding protein related to mammalian guanylate-cyclase-activating proteins
160. 2+ levels
161. Calcium modulation of cyclic GMP synthesis in rat visual cells
162. Cloning and expression of a second photoreceptor-specific membrane retina guanylyl cyclase (RetGC), RetGC-2
163. The mechanism of dark-adaptation
164. 2+
165. Existence of a beta-ionone ring-binding site in the rhodopsin molecule
166. Messengers of transduction and adaptation in vertebrate photoreceptors
167. Incorporation of chelator into guinea-pig rods shows that calcium mediates mammalian photoreceptor light adaptation
168. 2+ in the light adaptation of rods isolated from the tiger salamander retina
169. Effects of lowered cytoplasmic calcium concentration and light on the responses of salamander rod photoreceptors
170. 2+ in the adaptation of responses to saturating flashes in salamander rods
171. 2+ concentration during the bright flash response
172. Prolongation by phytic acid of the time constant that dominates bright flash response recovery in rods isolated from the tiger salamander
173. Persistent activation of transducin by bleached rhodopsin in salamander rods
174. Role of cytoplasmic calcium concentration in the bleaching adaptation of salamander cone photoreceptors
175. Light adaptation in cone photoreceptors of the salamander: A role for cytoplasmic calcium
176. Photoreceptor light adaptation is mediated by cytoplasmic calcium concentration
177. Free calcium concentrations in bullfrog rods determined in the presence of multiple forms of Fura-2
178. Dynamic, spatially nonuniform calcium regulation in frog rods exposed to light
179. Light response of vertebrate photoreceptors
180. Rods, cones and calcium
181. Measurement of the intracellular free calcium concentration in salamander rods
182. A comparison of the efficiency of G protein activation by ligand-free and light-activated forms of rhodopsin
183. Light-activated rhodopsin phosphorylation may control light sensitivity in isolated rod outer segments
184. Control of light-activated phosphorylation in frog photoreceptor membranes
185. Differences in calcium homeostasis between retinal rod and cone photoreceptors revealed by the effects of voltage on the cGMP-gated conductance in intact cells
186. Calmodulin regulation of cyclic-nucleotide-gated channels
187. Photoreceptor membrane proteins, phototransduction, and retinal degenerative diseases. The Friedenwald Lecture
188. Calcium extrusion from mammalian photoreceptor terminals
189. Kinetics of desensitization induced by saturating flashes in toad and salamander rods
190. 2+ modulation of the cGMP-gated channel of bullfrog retinal rod photoreceptors
191. Light adaptation in retinal rods of the rabbit and two other nonprimate mammals
192. Calcium and light adaptation in retinal rods and cones
193. Calcium and magnesium fluxes across the plasma membrane of the toad rod outer segment
194. Guanosine 3′,5′-cyclic monophosphate-activated conductance studied in a truncated rod outer segment of the toad
195. Sodium-dependent calcium extrusion and sensitivity regulation in retinal cones of the salamander
196. Molecular genetics of human color vsion: The genes encoding blue, green, and red pigments
197. Heterotrimeric G proteins: Organizers of transmembrane signals
198. Activation of transducin guanosine triphosphatase by two proteins of the RGS family
199. Regulation of protein kinase C
200. Calcium regulates some, but not all, aspects of light adaptation in rod photoreceptors
201. Kinetics of recovery of the dark-adapted salamander rod photoresponse
202. Rhodopsin phosphorylation and dephosphorylation in vivo
203. Transducin activation by molecular species of rhodopsin other than metarhodopsin II
204. Interphotoreceptor retinoid-binding protein promotes rhodopsin regeneration in toad photoreceptors
205. Molecular cloning and characterization of the G protein gamma subunit of cone photoreceptors
206. Phosphorylation of photolyzed rhodopsin is calcium-insensitive in retina permeabilized by alpha-toxin
207. The catalytic subunit of phosphatase 2A dephosphorylates phosphoopsin
208. Rod outer segment retinol dehydrogenase: Substrate specificity and role in phototransduction
209. The influence of arrestin (48K protein) and rhodopsin kinase on visual transduction
210. Activation and inactivation steps in the visual transduction pathway
211. Molecular cloning and characterization of retinal photoreceptor guanylyl cyclase-activating protein
212. Kinetics of visual pigment regeneration in excised mouse eyes and in mice with a targeted disruption of the gene encoding interphotoreceptor retinoid-binding protein or arrestin
213. Activation of rhodopsin phosphorylation is triggered by the lumirhodopsin-metarhodopsin I transition
214. Identification of components of a phosphoinositide signaling pathway in retinal rod outer segments
215. Signal transmission along retinal rods and the origin of the electroretinographic a-wave
216. Rhodopsin and visual adaptation: Analysis of photoreceptor thresholds in the isolated skate retina
217. Light-dependent delay in the falling phase of the retinal rod photoresponse
218. Modulation of transduction gain in light adaptation of retinal rods
219. Visual adaptation: Effects of externally applied retinal on the light-adapted, isolated skate retina
220. Light adaptation and sensitivity controlling mechanisms in vertebrate photoreceptors
221. Response properties of cones from the retina of the tiger salamander
222. 2+ with cGMP-gated ion channels differ in retinal rod and cone photoreceptors
223. 2+-binding proteins in the retina
224. Photoreceptor guanylate cyclases: A review
225. Amplification and kinetics of the activation steps in phototransduction
226. Molecular mechanisms of vertebrate photoreceptor light adaptation
227. Functional differences in the interaction of arrestin and its splice variant, p44, with rhodopsin
228. Activating mutations of rhodopsin and other G protein-coupled receptors
229. The concentration of cytosolic free calcium in vertebrate rod outer segments measured with fura-2
230. 2+-dependent, diffusable factor modulates the cGMP-gated ion channels differently than in rods
231. Origin of reproducibility in the responses of retinal rods to single photons
232. Computer analysis of photochemical changes in the human retina
233. Rhodopsin regeneration in man
234. Single cyclic nucleotide-gated channels locked in different ligand-bound states
235. Rhodopsin measurement and dark adaptation in a subject deficient in cone vision
236. Visual pigments in man
237. Cone pigment kinetics in the protanope
238. The Ferrier Lecture, 1962
239. Measurement of rhodpsin in the living human eye
240. Bleaching and regeneration of cone pigments in man
241. Retinol esterification in bovine retinal pigment epithelium: Reversibility of lecithin: Retinol acyltransferase
242. Reduction of all-trans-retinal limits regeneration of visual pigment in mice
243. The action of cytoplasmic calcium on the cGMP-activated channel in salamander rod photoreceptors
244. G-protein deactivation is rate-linuting for shut-off of the phototransduction cascade
245. 2+ concentration in salamander cone photoreceptors
246. 2+ in salamander rods
247. Intracellular biochemical manipulation of phototransduction in detached rod outer segments
248. Projection structure of frog rhodopsin in two crystal forms
249. The photovoltage of macaque cone photoreceptors: Adaptation, noise, and kinetics
250. Calcium homeostasis in vertebrate retinal rod outer segments
251. 2+ sequestration and release in intact bovine retinal rod outer segments. Role in inactivation of Na-Ca+K exchange
252. Calcium translocation and storage of isolated intact cattle rod outer segments in darkness
253. 2+
254. 2+ sequestration and release in intact bovine retinal rod outer segments
255. Light-dependent calcium release from photoreceptors measured by laser micro-mass analysis
256. Rhodopsin activation blocked by metal-ion-binding sites linking transmembrane helices C and F
257. Molecular cloning of a retina-specific membrane guanylyl cyclase
258. A splice variant of arrestin. Molecular cloning and localization in bovine retina
259. Elemental distribution in Rana pipiens retinal rods: Quantitative electron probe analysis
260. Equivalent adaptation levels in localized retinal areas
261. Transducin activation by the bovine opsin apoprotein
262. Light adaptation in cat retinal rods
263. Calcium feedback and sensitivity regulation in primate rods
264. Role of calcium in regulating the cyclic GMP cascade of phototransduction in retinal rods
265. Role for the target enzyme in deactivation of photoreceptor G protein in vivo
266. Phosphorylation of an inhibitory subunit of cGMP phosphodiesterase in Rana catesbeiana rod photoreceptors. I. Characterization of the phosphorylation
267. Phosphorylation of an inhibitory subunit of cGMP phosphodiesterase in Rana catesbeiana rod photoreceptors. II. A possible mechanism for the turnoff of cGMP phosphodiesterase without GTP hydrolysis
268. Arrangement of rhodopsin transmembrane alpha-helices
269. Subsecond deactivation of transducin by endogenous GTP hydrolysis
270. Millisecond activation of transducin in the cyclic nucleotide cascade of vision
271. Carotenoids and the visual cycle
272. Photo-sensitive reactions in the foveae of normal and cone monochromatic observers
273. Light and dark adaptation in the isolated rat retina
274. The retinal specific protein RGS-r competes with the gamma subunit of cGMP phosphodiesterase for the alpha subunit of transducin and facilitates signal termination
275. Light-dependent phosphorylation of rhodopsin: Number of phosphorylation sites
276. Amplitude, kinetics, and reversibility of a light-induced decrease in guanosine 3′,5′-cyclic monophosphate in frog photoreceptor membranes
277. Protein kinase C activity and light sensitivity of single amphibian rods
278. Prolonged photoresponses in transgenic mouse rods lacking arrestin
279. Possible stimulation of retinal rod recovery to dark state by cGMP release from a cGMP phosphodiesterase noncatalytic site
280. Cyclic GMP-specific, high affinity, noncatalytic binding sites on light-activated phosphodiesterase
281. Two membrane forms of guanylyl cyclase found in the eye
282. Two eye guanylyl cyclases are expressed in the same photoreceptor cells and form homomers in preference to heteromers
283. Cyclic GMP-activated conductance of retinal photoreceptor cells
284. Effect of ions on the light-sensitive current in retinal rods
285. Cation selectivity of light-sensitive conductance in retinal rods
286. Electrogenic Na-Ca exchange in retinal rod outer segment
287. Light-induced reduction of cytoplasmic free calcium in retinal rod outer segment
288. Light-activated phosphodiesterase of the rod outer segment. Kinetics and parameters of activation and de-activation
289. Technique for introducing retinol analogs into the isolated retina
290. Light-dependent control of calcium in intact rods of the bullfrog Rana catesbeiana
291. Guanylyl cyclase-linked receptors
292. Structure and function of cyclic nucleotide-gated channels
293. Cyclic nucleotide gated channels