Insulin receptor substrate 1 binds two novel splice variants of the regulatory subunit of phosphatidylinositol 3-kinase in muscle and brain

Molecular and Cellular Biology

Volumn 16, Issue 5, 1996, Pages 2195-2203

  Antonetti, David A ^b   Algenstaedt, Petra ^b   Kahn, C Ronald ^a  

^a JOSLIN DIABETES CENTER   (United States)

^b NONE

Author keywords

[No Author keywords available]

Indexed keywords

INSULIN RECEPTOR; PHOSPHATIDYLINOSITOL 3 KINASE;

ALTERNATIVE RNA SPLICING; AMINO ACID SEQUENCE; AMINO TERMINAL SEQUENCE; ARTICLE; AUTOPHOSPHORYLATION; GENE CLUSTER; GENE EXPRESSION; GLUCOSE TRANSPORT; HUMAN; HUMAN CELL; HUMAN TISSUE; IMMUNOBLOTTING; INSULIN BINDING; NEUROTRANSMISSION; NORTHERN BLOTTING; NUCLEOTIDE SEQUENCE; PRIORITY JOURNAL; PROTEIN PHOSPHORYLATION; RECEPTOR BINDING; SKELETAL MUSCLE;

UNIDENTIFIED BACULOVIRUS;

EID: 0029913340     PISSN: 02707306     EISSN: None     Source Type: Journal    
DOI: 10.1128/MCB.16.5.2195     Document Type: Article

References (42)

1. Ahn, A. H., and L. M. Kunkel. 1993. The structural and functional diversity of dystrophin. Nat. Genet 3:283-291.
2. Araki, E., M. A. Lipes, M. E. Patti, J. C. Bruning, B. Haag III, R. S. Johnson, and C. R. Kahn. 1994. Alternative pathway of insulin signalling in mice with targeted disruption of the IRS-1 gene. Nature (London) 372:186-110.
3. Araki, E., X. Sun, B. L. Haag, Y. Zhang, L. M. Chuang, T. Yang-Feng, M. F. White, and C. R. Kahn. 1993. Human skeletal muscle insulin receptor substrate-1: characterization of the cDNA, gene and chromosomal localization. Diabetes 42:1041-1054.
4. Ausubel, F. M., R. Brent, R. E. Kinston, D. D. Moore, J. G. Seidman, J. A. Smith, and K. Struhl (ed.). 1993. Current protocols in molecular biology. Wiley-Interscience, New York.
5. Baltensperger, K., L. M. Kozma, S. R. Jaspers, and M. P. Czech. 1994 Regulation by insulin of phosphatidylinositol 3′-kinase bound to α- and β-isoforms of p85 regulatory subunit. J. Biol. Chem. 269:28937-28946
6. Cheatham, B., and C. R. Kahn. 1995 Insulin action and the insulin signaling network. Endocrine Rev. 16:117-142.
7. Dhand, R., K. Hara, I. Hiles, B. Bax, I. Gout, G. Panayotou, M. J. Fry, K. Yonezawa, M. Kasuga, and M. D. Waterfield. 1994. PI 3-kinase: structural and functional analysis of intersubunit interactions. EMBO J. 13:511-521.
8. Dhand, R., I. Hiles, G. Panayotou, S. Roche, M. J. Fry, I. Gout, N. F. Totty, O. Truong, P. Vicendo, K. Yonezawa, M. Kasuga, S. A. Courtneidge, and M. D. Waterfield. 1994. PI-3-kinase is a dual specificity enzyme - autoregulation by an intrinsic protein-serine kinase activity. EMBO J. 13:522-533.
9. Divecha, M., and R. F. Irvine. 1995. Phospholipid signaling Cell 80:269-278.
10. Escobedo, J. A., S. Navankasattusas, W. M. Kavanaugh, D. Milfay, V. A. Fried, and L. T. Williams. 1991. cDNA cloning of a novel 85 kd protein that has SH2 domains and regulates binding of PI3-kinase to the PDGF β-receptor. Cell 65:75-82.
11. Hu, P., B. Margolis, E. Y. Skolnik, R. Lammers, A. Ullrich, and J. Schlessinger. 1992. Interactions of phosphatidylinositol 3-kinase-associated p85 with epidermal growth factor and platelet-derived growth factor receptors. Mol. Cell. Biol 12:981-990.
12. Hu, Q., A. Klippel, A. J. Muslin, W. J. Fantl, and L. T. Williams. 1995. Ras-dependent induction of cellular responses by constitutively active phosphatidylinositol-3 kinase Science 268:100.
13. Kasuya, J., H. Goko, and Y. Fujita-Yamaguchi. 1995. Multiple transcripts for the human cardiac form of the cGMP-inhibited cAMP phosphodieterase. J. Biol. Chem. 270:14305-14312
14. Kennelly, P. J., and E. G. Krebs. 1991. Consensus sequences as substrate specificity determinants for protein kinases and protein phosphatases. J Biol. Chem. 266:15555-15558.
15. Klippel, A., J. A. Escobedo, M. Hirano, and L. T. Williams. 1994. The interaction of small domains between the subunits of phosphatidylinositol 3-kinase determines enzyme activity Mol. Cell. Biol. 14:2675-2685
16. Lam, K., C. L. Carpenter, N. B. Ruderman, J. C. Friel, and K. L. Kelly. 1994. The phosphatidylinositol 3-kinase serine kinase phosphorylates IRS-1. J. Biol. Chem. 269:20648-20652.
17. Lamphere, L., C. L. Carpenter, Z. F. Sheng, R. G. Kallen, and G. E. Lienhard. 1994. Activation of PI-kinase in 3T3-L1 adipocytes by association with insulin receptor substrate-1. Am. J. Physiol. 266:E486-E494.
18. Lee, A. D., P. A. Hansen, and J. O. Holloszy. 1995. Wortmannin inhibits insulin-stimulated but not contraction-stimulated glucose transport activity in skeletal muscle. Growth Regul. 361:51-54.
19. Ling, L. E., B. J. Druker, L. C. Cantley, and T. M. Roberts. 1992 Transformation-defective mutants of polyomavirus middle T antigen associate with phosphatidylinositol 3-kinase (PI 3-kinase) but are unable to maintain wild-type levels of PI 3-kinase products in intact cells. J Virol. 66:1702-1708
20. Martin Zanca, D., S. H. Hughes, and M. Barbacid. 1986 A human oncogene formed by the fusion of truncated tropomyosin and protein tyrosine kinase sequences. Nature (London) 319:743-748.
21. McGlade, C. J., C. Ellis, M. Reedijk, D. J. Anderson, G. Mbamulu, A. D. Reith, G. Panauotou, P. End, A. Bernstien, A. Kazlauskas, M. D. Waterfield, and T. Pawson. 1992. SH2 domains of the p85α subunit of phosphatidylinositol 3-kinase regulate binding to growth factor receptors. Mol. Cell. Biol 12:991-097.
22. Okada, T., Y. Kawano, T. Sakakibara, O. Hazeki, and M. Ui. 1994. Essential role of phosphatidylinositol 3-kinase in insulin-induced glucose transport and antilipolysis in rat adipocytes - studies with a selective inhibitor wortmannin. J. Biol. Chem. 269:3568-3573
23. c-src complexes and PI3-kinase. Cell 65:91-104.
24. PIK reveal a new regulatory subunit for the phosphatidylinositol 3-kinase. Mol. Cell Biol. 15:4453-4465.
25. Roche, S., M. Koegl, and S. A. Courtneidge. 1994. The phosphatidylinositol 3-kinase a is required for DNA synthesis induced by some, but not all, growth factors. Proc Natl. Acad Sci. USA 91:9185-9189.
26. Sambrook, J., E. F. Fritsch, and T. Maniatis. 1989 Molecular cloning: a laboratory manual, 2nd ed. Cold Spring Harbor laboratory Press, Cold Spring Harbor, N.Y.
27. Shepherd, P. R., B. T. Nave, and K. Siddle. 1995 Insulin stimulation of glycogen synthesis and glycogen synthase activity is blocked by wortmannin and rapamycin in 3T3-L1 adipocytes: evidence for the involvement of phosphoinositide 3-kinase and p70 ribosomal protein-S6 kinase. Biochem. J 305:25-28.
28. Sims, R. E., F. E. Rushford, D. P. Huston, and G. R. Cunningham. 1987. Successful immunosuppressive therapy in a patient with autoantibodies to insulin receptors and immune complex glomerulonephritis. South Med. J. 80:903-906.
29. Skolnik, E. Y., B. Margolis, M. Mohammadi, E. Lowenstein, R. Fischer, A. Drepps, A. Ullrich, and J. Schlessinger. 1991 Cloning of PI3 kinase-associated p85 utilizing a novel method for expression/cloning of target proteins for receptor tyrosine kinases. Cell 65:83-90.
30. Stoyanov, B., S. Volinia, T. Hanck, I. Rubio, M. Loubtchenkov, D. Malek, S. Stoyanova, B. Vanhaesebroeck, R. Dhand, B. Nurnberg, P. Gierschik, K. Seedorf, J. J. Hsuan, M. D. Waterfield, and R. Wetzker. 1995 Cloning and characterization of a G protein-activated human phosphoinositide-3 kinase. Science 269:690-693.
31. Sun, X., D. L. Crimmins, M. G. Myers, Jr., M. Miralpeix, and M. F. White. 1993. Pleiotropic insulin signals are engaged by multisite phosphorylation of IRS-1. Mol. Cell Biol. 13:7418-7428.
32. Tanizawa, Y., A. Matsutani, K. C. Chiu, and M. A. Permutt. 1992. Human glucokinase gene: isolation, structural characterization, and identification of a microsatellite repeat polymorphism. Mol. Endocrinol. 6:1070-1081.
33. Varticovski, L., D. Harrison-Findik, M. L. Keeler, and M. Susa. 1994. Role of PI 3-kinase in mitogenesis. Biochim. Biophys. Acta 1226:1-11.
34. Wang, J., K. R. Auger, L. Jarvis, Y. Shi, and T. M. Roberts. 1995. Direct association of Grb2 with the p85 subunit of phosphatidylinositol 3-kinase. J. Biol. Chem. 270:12774-12780.
35. 34a. White, M. Personal communication.
36. White, M. F. 1990. The insulin receptor tyrosine kinase, p. 223-250. In K. Siddle and J. C. Hutton (ed.). Peptide hormone action, a practical approach. IRL Press, Oxford.
37. White, M. F. 1994 The IRS-1 signaling system. Curr. Opin. Genet. Dev. 4:47-54.
38. White, M. F., and C. R. Kahn. 1994. The insulin signaling system. J. Biol. Chem. 269:1-4.
39. White, M. F., S. E. Shoelson, H. Keutmann, and C. R. Kahn. 1988. A cascade of tyrosine autophosphorylation in the b-subunit activates the insulin receptor. J Biol. Chem. 263:2969-2980.
40. Yeh, J. I., E. A. Gulve, L. Rameh, and M. J. Birnbaum. 1995 The effects of wortmannin on rat skeletal muscle: dissociation of signaling pathways for insulin- and contraction-activated hexose transport. J. Biol. Chem. 270:2107-2111.
41. Zheng, Y., S. Bagrodia, and R. A. Cerione. 1994. Activation of phosphoinositide 3-kinase activity by CDC42HS binding to p85. J. Biol. Chem. 269: 18727-18730.
42. Zhu, J., P. J. Bilan, J. S. Moyers, D. A. Antonetti, and C. R. Kahn. 1996. Rad, a novel ras-related GTPase, interacts with skeletal muscle β-tropomyosin. J. Biol Chem. 271:768-773