An evolutionarily conserved function of the drosophila insulin receptor and insulin-like peptides in growth control

Current Biology

Volumn 11, Issue 4, 2001, Pages 213-221

  Brogiolo, Walter ^a   Stocker, Hugo ^a   Ikeya, Tomoatsu ^a   Rintelen, Felix ^a   Fernandez, Rafael ^b   Hafen, Ernst ^a  

^a UNIVERSITY OF ZURICH   (Switzerland)

^b UNIVERSITY OF PENNSYLVANIA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ANIMALIA; INSECTA;

EID: 0035916357     PISSN: 09609822     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0960-9822(01)00068-9     Document Type: Article

References (46)

1. The developmental basis for allometry in insects
2. Environmental control of the cell cycle in Drosophila: Nutrition activates mitotic and endoreplicative cells by distinct mechanisms
3. Evolution and development of body size and cell size in Drosophila melanogaster in response to temperature
4. Studies in quantitative inheritance. XII. Cell size and number in relation to genetic and environmental variation of body size in Drosophila
5. Size control in animal development
6. Genetics of mouse growth
7. Autonomous control of cell and organ size by CHICO, a Drosophila homolog of vertebrate IRS1-4
8. The Drosophila phosphoinositide 3-kinase Dp110 promotes cell growth
9. Regulation of imaginal disc cell size, cell number and organ size by Drosophila class I(A) phosphoinositide 3-kinase and its adaptor
10. Drosophila tumor suppressor PTEN controls cell size and number by antagonizing the Chico/P13-kinase signaling pathway
11. PTEN affects cell size, cell proliferation and apoptosis during Drosophila eye development
12. Drosophila PTEN regulates cell growth and proliferation through P13K-dependent and independent pathways
13. Cell-autonomous regulation of cell and organ growth in Drosophila by Akt/PKB
14. Drosophila S6 kinase: A regulator of cell size
15. The Drosophila insulin receptor homolog: A gene essential for embryonic development encodes two receptor isoforms with different signaling potential
16. The Drosophila insulin receptor is required for normal growth
17. Analysis of Drosophila photoreceptor axon guidance in eye-specific mosaics
18. The Drosophila insulin receptor activates multiple signaling pathways but requires insulin receptor substrate proteins for DNA synthesis
19. Tinman and bagpipe: Two homeo box genes that determine cell fates in the dorsal mesoderm of Drosophila
20. Molecular mechanisms of inherited insulin resistance
21. Crystal structure of the tyrosine kinase domain of the human insulin receptor
22. A homozygous kinase-defective mutation in the insulin receptor gene in a patient with leprechaunism
23. Targeted gene expression as a means of altering cell fates and generating dominant phenotypes
24. The genome sequence of Drosophila melanogaster
25. Hormone families: Pancreatic hormones and homologous growth factors
26. Eukaryotic protein processing: Endoproteolysis of precursor proteins
27. Pancreatic development and maturation of the islet B cell: Studies of pluripotent islet cultures
28. Structure and organization of four clustered genes that encode bombyxin, an insulin-related brain secretory peptide of the silkmoth Bombyx mori
29. Isolation and structural characterization of an insulin-related molecule, a predominant neuropeptide from Locusta migratoria
30. Growth-controlling molluscan neurons produce the precursor of an insulin-related peptide
31. Glucose stimulates the release of bombyxin, an insulin-related peptide of the silkworm Bombyx mori
32. Insulin as a growth factor
33. Relation of birthweight to maternal plasma glucose and insulin concentrations during normal pregnancy
34. Clinical features and natural history of Beckwith-Wiedemann syndrome: Presentation of 74 new cases
35. Nesidioblastosis unravelled
36. Analysis of genetic mosaics in developing and adult Drosophila tissues
37. Eyeless initiates the expression of both sine oculis and eyes absent during Drosophila compound eye development
38. Prediction of complete gene structures in human genomic DNA
39. Identification of prokaryotic and eukaryotic signal peptides and prediction of their cleavage sites
40. Double-label in situ hybridization using biotin and digoxigenin-tagged RNA probes
41. In situ hybridization to RNA
42. The Drosophila SHC adaptor protein is required for signaling by a subset of receptor tyrosine kinases
43. A putative Ras GTPase activating protein acts as a negative regulator of signaling by the sevenless receptor tyrosine kinase
44. Expression of baculovirus P35 prevents cell death in Drosophila
45. The human insulin receptor cDNA: The structural basis for hormone-activated transmembrane signalling
46. New insulin-like proteins with atypical disulfide bond pattern characterized in Caenorhabditis elegans by comparative sequence analysis and homology modeling