Oxidative Stress Affects the Junctional Integrity of Retinal Pigment Epithelial Cells

Investigative Ophthalmology and Visual Science

Volumn 45, Issue 2, 2004, Pages 675-684

  Bailey, Tracey A ^a,b   Kanuga, Nabeed ^a   Romero, Ignacio A ^a,c   Greenwood, John ^a   Luthert, Philip J ^a   Cheetham, Michael E ^a,d  

^a UNIVERSITY COLLEGE LONDON   (United Kingdom)

^b CRANFIELD UNIVERSITY   (United Kingdom)

^c OPEN UNIVERSITY   (United Kingdom)

^d UNIVERSITY COLLEGE LONDON   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

BETA CATENIN; HEAT SHOCK PROTEIN 27; HEAT SHOCK PROTEIN 70; HYDROGEN PEROXIDE; NERVE CELL ADHESION MOLECULE; OCCLUDIN; PROTEIN ZO1;

ARTICLE; BLOOD RETINA BARRIER; CELL FRACTIONATION; CELL JUNCTION; CELL VIABILITY; CONTROLLED STUDY; HUMAN; HUMAN CELL; IMMUNOFLUORESCENCE; OXIDATIVE STRESS; PIGMENT EPITHELIUM; PRIORITY JOURNAL; RETINA; RETINA MACULA AGE RELATED DEGENERATION; RETINA MACULA DEGENERATION; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; TIGHT JUNCTION; WESTERN BLOTTING;

BETA CATENIN; BLOOD-RETINAL BARRIER; BLOTTING, WESTERN; CADHERINS; CELL DIFFERENTIATION; CELL LINE; CELL SURVIVAL; CYTOSKELETAL PROTEINS; FLUORESCENT ANTIBODY TECHNIQUE, INDIRECT; HEAT-SHOCK PROTEINS; HEME OXYGENASE (DECYCLIZING); HEME OXYGENASE-1; HSP70 HEAT-SHOCK PROTEINS; HUMANS; HYDROGEN PEROXIDE; MEMBRANE PROTEINS; NEOPLASM PROTEINS; OXIDANTS; OXIDATIVE STRESS; PHOSPHOPROTEINS; PIGMENT EPITHELIUM OF EYE; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; TIGHT JUNCTIONS; TRANS-ACTIVATORS;

EID: 0942287243     PISSN: 01460404     EISSN: None     Source Type: Journal    
DOI: 10.1167/iovs.03-0351     Document Type: Article

References (41)

1. Bressler NM, Bressler SB, Fine SL. Age related macular degeneration. Surv Ophthalmol. 1998;32:375-413.
2. Winkler BS, Boulton ME, Gottsch JD, Sternberg P. Oxidative damage and age-related macular degeneration. Mol Vis. 1999;5:32.
3. Tate DR, Miceli MV, Newsome DA. Phagocytosis and H2O2 induce catalase and metallothionein gene expression in human retinal pigment epithelial cells. Invest Ophthalmol Vis Sci. 1995;36:1271-1279.
4. Rozanowska M, Jarvis-Evans J, Korytowski W, et al. Blue light-induced reactivity of retinal age pigment: in vitro generation of oxygen-reactive species. J Biol Chem. 1995;270:18825-18830.
5. Handa JT, Verzijl N, Matsunaga H, et al. Increase in the advanced glycation end product pentosidine in Bruch's membrane with age. Invest Ophthalmol Vis Sci. 1999;40:775-779.
6. Kerendian J, Enomoto H, Wong CD. Induction of stress proteins in SV-40 transformed human RPE-derived cells by organic oxidants. Curr Eye Res. 1992;11:385-396.
7. Wong CG, Lin NG. Induction of stress proteins in cultured human RPE-derived cells. Curr Eye Res. 1989;8:537-545.
8. Hackett SF, Schoenfeld CL, Freund J, Goettsch JD, Bhargave S, Campochiaro PA. Neurotrophic factors, cytokines and stress increase expression of basic fibroblast growth factor in retinal pigmented epithelial cells. Exp Eye Res. 1997;64:865-873.
9. Alizadeh M, Wada M, Gelfman CM, Handa JT, Hjelmeland LM. Downregulation of differentiation specific gene expression by oxidative stress in ARPE-19 cells. Invest Ophthalmol Vis Sci. 2001;42:2706-2713.
10. Konari K, Sawada N, Zhong Y, Isomura H, Nakagawa T, Mori M. Development of the blood-retinal barrier in vitro: formation of tight junctions as revealed by occludin and ZO-1 correlates with the barrier function of chick retinal epithelial cells. Exp Eye Res. 1995;61:99-108.
11. Kanuga N, Winton HL, Beauchene L, et al. Characterization of genetically modified human retinal pigment epithelial cells developed for in vitro and transplantation studies. Invest Ophthalmol Vis Sci. 2002;43:546-555.
12. Ban Y, Rizzolo LJ. A culture model of development reveals multiple properties of RPE tight junctions. Mol Vis. 1997;3:18.
13. Marrs JA, Andersson-Fisone C, Jeong MC, et al. Plasticity in epithelial cell phenotype: modulation by expression of different cadherin cell adhesion molecules. J Cell Biol. 1995;129:507-519.
14. McKay BS, Irving PE, Skumatz CMB, Burke JM. Cell-cell adhesion molecules and the development of an epithelial phenotype in cultured human retinal pigment epithelial cells. Exp Eye Res. 1997;65:661-671.
15. Liou GI, Matragoon S, Sameul S, et al. MAP kinase and β-catenin signaling in HGF induced RPE migration. Mol Vis. 2002;8:483-494.
16. Basuroy S, Sheth P, Kuppuswamy D, Balasubramian S, Ray RM, Rao RK. Expression of kinase-inactive c-Src delays oxidative stress-induced disassembly and accelerates calcium-mediated reassembly of tight junctions in Caco-2 cell monolayer. J Cell Biol. 2003;278:11916-11944.
17. Kevil CG, Ohno N, Gute DC, et al. Role of cadherin internalization in hydrogen peroxide-mediated endothelial permeability. Free Rad Biol Med. 1998;24:1015-1022.
18. 2-mediated permeability: role of MAPK and occludin. Am J Physiol. 2000;279:C21-C30.
19. Dunn KC, Aotaki-Keen AE, Putkey FR, Hjelmeland LM. ARPE-19, a human retinal pigment epithelial cell line with differentiated properties. Exp Eye Res. 1996;62:155-169.
20. Chapple JP, Hardcastle AJ, Grayson C, Willison KR, Cheetham ME. Delineation of the plasma membrane targeting domain of the X-linked retinitis pigmentosa protein, RP2. Invest Ophthalmot Vis Sci. 2002;43:2015-2020.
21. Bunt-Milam AH, Saari JC. Immunocytochemical localization of two retinoid-binding proteins in vertebrate retina. J Cell Biol. 1983;97:703-712.
22. Hamel CP, Tsilou E, Harris E, et al. A developmentally regulated microsomal protein specific for the pigment epithelium of the vertebrate retina. J Neurosci Res. 1993;34:414-425.
23. Guilloneau X, Brychaert M, Launay-Longo C, Coutois Y, Mascarelli F. Endogenous FGF1-induced activation and synthesis of extracellular signal-related kinase 2 reduce cell apoptosis in retinal-pigmented epithelial cells. J Biol Chem. 1998;273:22367-22373.
24. Strunnikova N, Baffi J, Gonzalez A, Silk W, Cousins SW, Csaky KG. Regulated heat shock protein 27 expression in human retinal pigment epithelium. Invest Ophthalmol Vis Sci. 2001;42:2130-2138.
25. Mehlen P, Kretz-Remy C, Preville X, Arrigo AP. Human Hsp27, Drosophila Hsp27 and human alphaB-crystallin expression-mediated increase in glutathione is essential for the protective activity of these proteins against TNFalpha-induced cell death. EMBO J. 1996;15:2695-2706.
26. Guzhova IV Lasunskaia EB, Nilsson K Darieva ZA, Margulis BA. Effect of heat shock on cell differentiation and apoptosis in U-937 cells. Tsitologiia. 2000;42:653-658.
27. Alge CS, Priglinger SG, Neubauer AS, et al. Retinal pigment epithelium is protected against apoptosis by αB-crystallin. Invest Ophthalmol Vis Sci. 2002;43:3575-3582.
28. Ding L, Candido EP. HSP25, A small heat shock protein associated with dense bodies and M-lines of body wall muscle in Caenorhabditis elegans. J Biol Chem. 2000;275:9510-9517.
29. Vincent M, Tanguay RM. Heat-shock induced proteins present in the cell nucleus of Chironomus tentans salivary gland. Nature. 1979;281:501-503.
30. Nollen EA, Salomons FA, Brunsting JF, Want JJ, Sibon OC, Kampinga HH. Dynamic changes in the localization of thermally unfolded nuclear proteins associated with chaperone-dependent protection. Proc Natl Acad Sci USA. 2001;98:12038-12043.
31. Wissing D, Jaattela M. HSP27 and HSP70 increase the survival of WEHI-S cells exposed to hyperthermia. Int J Hyperthermia. 1996;12:125-138.
32. Williams CD, Rizzolo LJ. Remodeling of junctional complexes during the development of the outer blood-retinal barrier. Anat Rec. 1997;249:380-388.
33. Hinck L, Nathke S, Papkoff J, Nelson WJ. Beta-catenin: a common target for the regulation of cell adhesion by wnt-1 and src signalling pathways. Trends Biochem Sci. 1994;19:538-542.
34. Eastman Q, Grosschedl R. Regulation of LEF-1/TCF transcription factors by wnt and other signals. Curr Opin Cell Biol. 1999;11:233-240.
35. Vinores SA, Derevjanik NL, Ozaki H, Okamoto N, Campochiaro PA. Cellular mechanisms of blood-retinal barrier dysfunction in macular edema. Doc Ophthalmol. 1999;97:217-228.
36. Hageman GS, Luthert PJ, Victor Chong NH, Johnson LV, Anderson DH, Mullins RF. An integrated hypothesis that considers drusen as biomarkers of immune-mediated processes at the RPE-Bruch's membrane interface in aging and age-related macular degeneration. Prog Retin Eye Res. 2001;20:705-732.
37. Henkind P. Some observations about retinal vascular-neuronal interrelationships. Br J Ophthalmol. 1978;62:361-364.
38. Green WR, Wilson DJ. Choroidal neovascularization. Ophthalmology. 1986;93:1169-1176.
39. Kaida M, Cao F, Schumatz CMB, Irving PE, Burke JM. Time at confluence for human RPE cells: effects on the adherens junction and in vitro wound closure. Invest Ophthalmol Vis Sci. 2000;41:3215-3224.
40. Dale TC. Signal transduction by the Wnt family of ligands. Biochem J. 1998;329:209-223.
41. Brown JD, Moon, RT. Wnt signaling: why is everything so negative? Curr Opin Cell Biol. 1998;10:182-187.