Epidermal growth factor stimulation of RPE cell survival: Contribution of phosphatidylinositol 3-kinase and mitogen-activated protein kinase pathways

Experimental Eye Research

Volumn 79, Issue 1, 2004, Pages 51-59

  Defoe, Dennis M ^a   Grindstaff, Rachel D ^a  

^a East Tennessee State University   (United States)

Author keywords

Akt; apoptosis; cell survival; epidermal growth factor; extracellular signal regulated kinase; phosphatidylinositol 3 kinase; retinal pigment epithelium; tyrosine phosphorylation

Indexed keywords

1,4 DIAMINO 1,4 BIS(2 AMINOPHENYLTHIO) 2,3 DICYANOBUTADIENE; 2 MORPHOLINO 8 PHENYLCHROMONE; 4 (3 CHLOROANILINO) 6,7 DIMETHOXYQUINAZOLINE; EPIDERMAL GROWTH FACTOR; EPIDERMAL GROWTH FACTOR RECEPTOR; MITOGEN ACTIVATED PROTEIN KINASE; MITOGEN ACTIVATED PROTEIN KINASE 1; MITOGEN ACTIVATED PROTEIN KINASE INHIBITOR; PHOSPHATIDYLINOSITOL 3 KINASE; PHOSPHATIDYLINOSITOL 3 KINASE INHIBITOR; PHOSPHOTYROSINE; PROTEIN KINASE B; PROTEIN TYROSINE KINASE INHIBITOR;

APOPTOSIS; ARTICLE; CELL DEATH; CELL PROLIFERATION; CELL PROTECTION; CELL SURVIVAL; CELL SUSPENSION; CELL VIABILITY; CONTROLLED STUDY; DRUG EFFECT; DRUG EXPOSURE; ENZYME PHOSPHORYLATION; EPITHELIUM CELL; HUMAN; HUMAN CELL; HUMAN CELL CULTURE; IMMUNOPRECIPITATION; MEDIATOR; PIGMENT EPITHELIUM; PRIORITY JOURNAL; REGULATORY MECHANISM; SERUM; SIGNAL TRANSDUCTION; SUSPENSION CELL CULTURE; WESTERN BLOTTING;

1-PHOSPHATIDYLINOSITOL 3-KINASE; ANALYSIS OF VARIANCE; BLOTTING, WESTERN; CELL LINE; CELL SURVIVAL; EPIDERMAL GROWTH FACTOR; HUMANS; MAP KINASE SIGNALING SYSTEM; PHOSPHORYLATION; PIGMENT EPITHELIUM OF EYE; PRECIPITIN TESTS; STIMULATION, CHEMICAL;

EID: 2942528976     PISSN: 00144835     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.exer.2004.02.017     Document Type: Article

References (47)

1. Alroy I., Yarden Y. The ErbB signaling network in embryogenesis and oncogenesis: signal diversification through combinatorial ligand-receptor interactions. FEBS Lett. 410:1997;83-86
2. Assoian R.K., Schwartz M.A. Coordinate signaling by integrins and receptor tyrosine kinases in the regulation of G1 phase cell-cycle progression. Curr. Opin. Genet. Dev. 11:2001;48-53
3. Ballif B.A., Blenis J. Molecular mechanisms mediating mammalian mitogen-activated protein kinase (MAPK) kinase (MEK)-MAPK cell survival signals. Cell Growth Differ. 12:2001;397-408
4. Bjorge J.D., Chan T.O., Antczak M., Kung H.J., Fujita D.J. Activated type I phosphatidylinositol kinase is associated with the epidermal growth factor (EGF) receptor following EGF stimulation. Proc. Nat. Acad. Sci. USA. 87:1990;3816-3820
5. Bonni A., Brunet A., West A.E., Datta S.R., Takasu M.A., Greenberg M.E. Cell survival promoted by the Ras-MAPK signaling pathway by transcription- dependent and -independent mechanisms. Science. 286:1999;1358-1362
6. Bryckaert M., Guillonneau X., Hecquet C., Courtois Y., Mascarelli F. Both FGF1 and bcl-x synthesis are necessary for the reduction of apoptosis in retinal pigmented epithelial cells by FGF2: role of the extracellular signal-regulated kinase 2. Oncogene. 18:1999;7584-7593
7. Carpenter G. Receptors for epidermal growth factor and other peptide mitogens. Ann. Rev. Biochem. 56:1987;881-914
8. Cobb M.H. MAP kinase pathways. Prog. Biophys. Mol. Biol. 71:1999;479-500
9. Datta S.R., Brunet A., Greenberg M.E. Cellular survival: a play in three Akts. Genes Dev. 13:1999;2905-2927
10. Davis A.A., Bernstein P.S., Bok D., Turner J., Nachtigal M., Hunt R.C. A human retinal pigment epithelial cell line that retains epithelial characteristics after prolonged culture. Invest. Ophthalmol. Vis. Sci. 36:1995;955-964
11. D'Mello S.R., Borodezt K., Soltoff S.P. Insulin-like growth factor and potassium depolarization maintain neuronal survival by distinct pathways: possible involvement of PI 3-kinase in IGF-1 signaling. J. Neurosci. 17:1997;1548-1560
12. Dorey C.K., Wu G., Ebenstein D., Garsd A., Weiter J.J. Cell loss in the aging retina. Relationship to lipofuscin accumulation and macular degeneration. Invest. Ophthalmol. Vis. Sci. 30:1989;1691-1699
13. Dudek H., Datta S.R., Franke T.F., Birnbaum M.J., Yao R., Cooper G.M., Segal R.A., Kaplan D.R., Greenberg M.E. Regulation of neuronal survival by the serine-threonine protein kinase Akt. Science. 275:1997;661-665
14. Dudley D.T., Pang L., Decker S.J., Bridges A.J., Saltiel A.R. A synthetic inhibitor of the mitogen-activated protein kinase cascade. Proc. Nat. Acad. Sci. USA. 92:1995;7686-7689
15. Favata M.F., Horiuchi K.Y., Manos E.J., Daulerio A.J., Stradley D.A., Feeser W.S., Van Dyk D.E., Pitts W.J., Earl R.A., Hobbs F., Copeland R.A., Magolda R.L., Scherle P.A., Trzaskos J.M. Identification of a novel inhibitor of mitogen-activated protein kinase kinase. J. Biol. Chem. 273:1998;18623-18632
16. Franke T.F., Yang S.I., Chan T.O., Datta K., Kazlauskas A., Morrison D.K., Kaplan D.R., Tsichlis P.N. The protein kinase encoded by the Akt proto-oncogene is a target of the PDGF-activated phosphatidylinositol 3-kinase. Cell. 81:1995;727-736
17. Franke T.F., Kaplan D.R., Cantley L.C., Toker A. Direct regulation of the Akt proto-oncogene product by phosphatidylinositol-3, 4-bisphosphate. Science. 275:1997;665-668
18. Fruman D.A., Meyers R.E., Cantley L.C. Phosphoinositide kinases. Ann. Rev. Biochem. 67:1998;481-507
19. Gao H., Hollyfield J.G. Aging of the human retina. Differential loss of neurons and retinal pigment epithelial cells. Invest. Ophthalmol. Vis. Sci. 33:1992;1-17
20. Gavrieli Y., Sherman Y., Ben-Sasson S.A. Identification of programmed cell death in situ via specific labeling of nuclear DNA fragmentation. J. Cell Biol. 119:1992;493-501
21. Guillonneau X., Bryckaert M., Launay-Longo C., Courtois Y., Mascarelli F. Endogenous FGF1-induced activation and synthesis of extracellular signal-regulated kinase 2 reduce cell apoptosis in retinal-pigmented epithelial cells. J. Biol. Chem. 273:1998;22367-22373
22. Hollyfield J.G., Anderson R.E., LaVail M.M. Retinal Degenerative Diseases and Experimental Therapy. 1999;Kluwer/Plenum Academic, New York, NY
23. Kauffmann-Zeh A., Rodriguez-Viciana P., Ulrich E., Gilbert C., Coffer P., Downward J., Evan G. Suppression of c-Myc-induced apoptosis by Ras signalling through PI(3)K and PKB. Nature. 385:1997;544-548
24. Kennedy S.G., Wagner A.J., Conzen S.D., Jordan J., Bellacosa A., Tsichlis P.N., Hay N. The P.I.3-k.i.n., nase/Akt signaling pathway delivers an anti-apoptotic signal. Genes Dev. 11:1997;701-713
25. Korte G.E., Perlman J.I., Pollack A. Regeneration of mammalian pigment epithelium. Int. Rev. Cytol. 152:1994;223-263
26. Khwaja A., Rodriguez-Viciana P., Wennstrom S., Warne P.H., Downward J. Matrix adhesion and Ras transformation both activate a phosphoinositide 3-OH kinase and protein kinase B/Akt cellular survival pathway. EMBO J. 16:1997;2783-2793
27. Kulik G., Klippel A., Weber M.J. Antiapoptotic signalling by the insulin-like growth factor I receptor, phosphatidylinositol 3-kinase, and Akt. Mol. Cell Biol. 17:1997;1595-1606
28. Marmor M.F., Wolfensberger T.J. The Retinal Pigment Epithelium. 1998;Oxford University Press, Oxford
29. Moghal N., Sternberg P.W. Multiple positive and negative regulators of signaling by the EGF-receptor. Curr. Opin. Cell Biol. 11:1999;190-196
30. Morris D.A., Henkind P. Pathological responses of the human retinal pigment epithelium. Zinn K.M., Marmor M.F. In The Retinal Pigment Epithelium. 1979;247-266 Harvard University Press, Cambridge, MA
31. Mosmann T. Rapid colorimetric assay for cellular growth and survival: application to proliferation and cytotoxicity assays. J. Immunol. Methods. 65:1983;55-63
32. Olayioye M.A., Neve R.M., Lane H.A., Hynes N.E. The ErbB signaling network: receptor heterodimerization in development and cancer. EMBO J. 19:2000;3159-3167
33. Párrizas M., Saltiel A.R., LeRoith D. Insulin-like growth factor 1 inhibits apoptosis using the phosphatidylinositol 3′-kinase and mitogen-activated protein kinase pathways. J. Biol. Chem. 272:1997;154-161
34. Powis G., Bonjouklian R., Berggren M.M., Gallegos A., Abraham R., Ashendel C., Zalkow L., Matter W.F., Dodge J., Grindey G., et al. Wortmannin, a potent and selective inhibitor of phosphatidylinositol-3-kinase. Cancer Res. 54:1994;2419-2423
35. Rodrigues G.A., Falasca M., Zhang Z., Ong S.H., Schlessinger J. A novel positive feedback loop mediated by the docking protein Gab1 and phosphatidylinositol 3-kinase in epidermal growth factor receptor signaling. Mol. Cell. Biol. 20:2000;1448-1459
36. Rodriguez-Tarduchy G., Collins M., Lopez-Rivas A. Regulation of apoptosis in interleukin-3-dependent hemopoietic cells by interleukin-3 and calcium ionophores. EMBO J. 9:1990;2997-3002
37. Sadek C.M., Allen-Hoffmann B.L. Cytochrome P450IA1 is rapidly induced in normal human keratinocytes in the absence of xenobiotics. J. Biol. Chem. 269:1994;16067-16074
38. Sarks S.H., Sarks J.P. Ryan S.J. Age-related macular degeneration: atrophic form. vol. 2:1994;1071-1102 Mosby, St. Louis, MO
39. Ts'o M.O.M. Developmental, reactive, and neoplastic proliferation of the retinal pigment epithelium. Zinn K.M., Marmor M.F. In The Retinal Pigment Epithelium. 1979;267-276 Harvard University Press, Cambridge, MA
40. Uebersax E.D., Grindstaff R.D., Defoe D.M. Survival of the retinal pigment epithelium in vitro: comparison of freshly isolated and subcultured cells. Exp. Eye Res. 70:2000;381-390
41. van der Geer P., Hunter T., Lindberg R.A. Receptor protein-tyrosine kinases and their signal transduction pathways. Ann. Rev. Cell Biol. 10:1994;251-337
42. Vemuri G.S., McMorris F.A. Oligodendrocytes and their precursors require phosphatidylinositol 3-kinase signaling for survival. Development. 122:1996;2529-2537
43. Vlahos C.J., Matter W.F., Hui K.Y., Brown R.F. A specific inhibitor of phosphatidylinositol 3-kinase, 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one (LY294002). J. Biol. Chem. 269:1994;5241-5248
44. Xia Z., Dickens M., Raingeaud J., Davis R.J., Greenberg M.E. Opposing effects of ERK and JNK-p38 MAP kinases on apoptosis. Science. 270:1995;1326-1331
45. Yao R., Cooper G.M. Requirement for phosphatidylinositol-3 kinase in the prevention of apoptosis by nerve growth factor. Science. 267:1995;2003-2006
46. Yao R., Cooper G.M. Growth factor-dependent survival of rodent fibroblasts requires phosphatidylinositol 3-kinase but is independent of pp70S6K activity. Oncogene. 13:1996;343-351
47. Yoon H.S., Rho S.H., Jeong J.H., Yoon S., Yoo K.S., Yoo Y.H. Genistein produces reduction in growth and induces apoptosis of rat RPE-J cells. Curr. Eye Res. 20:2000;215-224