The PIK-related kinases intercept conventional signaling pathways

Chemistry and Biology

Volumn 6, Issue 5, 1999, Pages

  Kuruvilla, Finny G ^a   Schreiber, Stuart L ^a  

^a HARVARD UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CELL CYCLE; PHOSPHOTRANSFERASE; SIGNAL TRANSDUCTION;

MAMMALIA;

EID: 0033133990     PISSN: 10745521     EISSN: None     Source Type: Journal    
DOI: 10.1016/S1074-5521(99)80070-2     Document Type: Article

References (70)

1. 1. Syllaba, L. & Henner, K. (1926). Contribution à l'indépedance de l'athétose double idiopathique et congénitale [Contributions to the independence of idiopathic and congenital double athetosis]. Rev. Neurol. 1, 541-562.
2. 2. Boder, E. & Sedgwick, R.P. (1957). Ataxia-telangiectasia. A familial syndrome of progressive cerebellar ataxia, oculocutaneous telangiectasia and frequent pulmonary infection. USC Med. Bull. 9, 15-28.
3. 3. Sehgal, S.N., Baker, H. & Vezina, C. (1975). Rapamycin (AY-22,989), a new antifungal antibiotic. II. Fermentation, isolation and characterization. J. Antibiot (Tokyo) 28, 727-732.
4. 4. Vezina, C., Kudelski, A. & Sehgal, S.N. (1975). Rapamycin (AY-22,989), a new antifungal antibiotic. I. Taxonomy of the producing streptomycete and isolation of the active principle. J. Antibiot. (Tokyo) 28, 721-726.
5. 5. Schreiber, S.L. (1991). Chemistry and biology of the immunophilins and their immunosuppressive ligands. Science 251, 283-287.
6. 6. Cafferkey, R., et al., & Livi, G.P. (1993). Dominant missense mutations in a novel yeast protein related to mammalian phosphatidylinositol 3-kinase and VPS34 abrogate rapamycin cytotoxicity. Mol. Cell. Biol. 13, 6012-6023.
7. 7. Kunz, J., Henriquez, R., Schneider, U., Deuter-Reinhard, M., Movva, N.R. & Hall, M.N. (1993). Target of rapamycin in yeast, TOR2, is an essential phosphatidylinositol kinase homolog required for G1 progression. Cell 73, 585-596.
8. 8. Brown, E.J., et al., & Schreiber S.L. (1994). A mammalian protein targeted by G1-arresting rapamycin-receptor complex. Nature 369, 756-758.
9. 9. Sabatini, D.M., Erdjument-Bromage, H., Lui, M., Tempst, P. & Snyder, S.H. (1994). RAFT1: a mammalian protein that binds to FKBP12 in a rapamycin-dependent fashion and is homologous to yeast TORs. Cell 78, 35-43.
10. 10. Savitsky, K., et al., & Shiloh Y. (1995). A single ataxia telangiectasia gene with a product similar to Pl-3 kinase. Science 268, 1749-1753.
11. 11. Helliwell, S.B., Wagner, P., Kunz, J., Deuter-Reinhard, M., Henriquez, R. & Hall, M.N. (1994). TOR1 and TOR2 are structurally and functionally similar but not identical phosphatidylinositol kinase homologues in yeast. Mol. Biol. Cell. 5, 105-118.
12. 12. Keith, C.T. & Schreiber, S.L. (1995). PIK-related kinases: DNA repair, recombination, and cell cycle checkpoints. Science 270, 50-51.
13. 13. Hartley, K.O., et al., & Jackson S.P. (1995). DNA-dependent protein kinase catalytic subunit: a relative of phosphatidylinositol 3-kinase and the ataxia telangiectasia gene product. Cell 82, 849-856.
14. 14. Hari, K.L., Santerre, A., Sekelsky, J.J., McKim, K.S., Boyd, J.B. & Hawley, R.S. (1995). The mei-41 gene of D. melanogaster is a structural and functional homolog of the human ataxia telangiectasia gene. Cell 82, 815-821.
15. 15. Bentley, N.J., et al., & Carr A.M. (1996). The Schizosaccharomyces pombe rad3 checkpoint gene. EMBO J 15, 6641-6651.
16. 16. Weinert, T.A., Kiser, G.L. & Hartwell, L.H. (1994). Mitotic checkpoint genes in budding yeast and the dependence of mitosis on DNA replication and repair. Genes Dev. 8, 652-665.
17. 17. Kato, R. & Ogawa, H. (1994). An essential gene, ESR1, is required for mitotic cell growth, DNA repair and meiotic recombination in Saccharomyces cerevisiae. Nucleic Acids Res. 22, 3104-3112.
18. 18. Greenwell, P.W., Kronmal, S.L., Porter, S.E., Gassenhuber, J., Obermaier, B. & Petes, T.D. (1995). TEL1, a gene involved in controlling telomere length in S. cerevisiae, is homologous to the human ataxia telangiectasia gene. Cell 82, 823-829.
19. 19. Morrow, D.M., Tagle, D.A., Shiloh, Y., Collins, F.S. & Mieter, P. (1995). TEL1, an S. cerevisiae homolog of the human gene mutated in ataxia telangiectasia, is functionally related to the yeast checkpoint gene MEC1. Cell 82, 831-840.
20. 20. Cimprich, K.A., Shin, T.B., Keith, C.T. & Schreiber, S.L. (1996). cDNA cloning and gene mapping of a candidate human cell-cycle checkpoint protein. Proc. Natl Acad. Sci. USA 93, 2850-2855.
21. 21. McMahon, S.B., Van Buskirk, H.A., Dugan, K.A., Copeland, T.D. & Cole, M.D. (1998). The novel ATM-related protein TRRAP is an essential cofactor for the c-Myc and E2F oncoproteins. Cell 94, 363-374.
22. 22. Vassilev, A., et al., & Nakatani Y. (1998). The 400 kDa subunit of the PCAF histone acetylase complex belongs to the ATM superfamily. Mol. Cell 2, 869-875.
23. 23. Grant, P.A., Schieltz, D., Pray-Grant, M.G., Yates, J.R. III & Workman, J.L. (1998). The ATM-related cofactor Tra1 is a component of the purified SAGA complex. Mol. Cell 2, 863-867.
24. 24. Saleh, A., et al., & Brandl C.J. (1998). Tra1p is a component of the yeast Ada. Spt transcriptional regulatory complexes. J. Biol. Chem. 273, 26559-26565.
25. s6k. FEBS Lett. 410, 78-82.
26. 26. Weng, Q.P., Andrabi, K., Kozlowski, M.T., Grove, J.R. & Avruch, J. (1995). Multiple independent inputs are required for activation of the p70 S6 kinase. Mol. Cell. Biol. 15, 2333-2340.
27. 27. Westphal, R.S., Coffee, R.L. Jr., Marotta, A., Pelech, S.L. & Wadzinski, B.E. (1999). Identification of kinase-phosphatase signaling modules composed of p70 S6 kinase-protein phosphatase 2A (PP2A) and p21-activated kinase-PP2A. J. Biol. Chem. 274, 687-692.
28. 28. Di Como, C.J. & Arndt, K.T. (1996). Nutrients, via the Tor proteins, stimulate the association of Tap42 with type 2A phosphatases. Genes Dev. 10, 1904-1916.
29. 29. Chen, J., Peterson, R.T. & Schreiber, S.L. (1998). Alpha 4 associates with protein phosphatases 2A, 4 and 6. Biochem. Biophys. Res. Commun. 247, 827-832.
30. 30. Murata, K., Wu, J. & Brautigan, D.L. (1997). B cell receptor-associated protein alpha4 displays rapamycin-sensitive binding directly to the catalytic subunit of protein phosphatase 2A. Proc. Natl Acad. Sci. USA 94, 10624-10629.
31. 31. Inui, S., Sanjo, H., Maeda, K., Yamamoto, H., Miyamoto, E. & Sakaguchi, N. (1998). Ig receptor binding protein 1 (alpha4) is associated with a rapamycin-sensitive signal transduction in lymphocytes through direct binding to the catalytic subunit of protein phosphatase 2A. Blood 92, 539-546.
32. 32. Peterson, R.T., Desai, B.N., Hardwick, J.S. & Schreiber, S.L. (1999). Protein phosphatase 2A interacts with the 70-kDa S6 kinase and is activated by inhibition of FKBP12-rapamycin associated protein. Proc. Natl Acad. Sci. USA 96, 4438-4442.
33. 33. Beretta, L., Gingras, A.C., Svitkin, Y.V., Hall, M.N. & Sonenberg, N. (1996). Rapamycin blocks the phosphorylation of 4E-BP1 and inhibits cap-dependent initiation of translation. EMBO J. 15, 658-664.
34. 34. Schmidt, A., Beck, T., Koller, A., Kunz, J. & Hall, M.N. (1998). The TOR nutrient signalling pathway phosphorylates NPR1 and inhibits turnover of the tryptophan permease. EMBO J. 17, 6924-6931.
35. 35. Nourse, J., et al., & Roberts J.M. (1994). Interleukin-2-mediated elimination of the p27Kip1 cyclin-dependent kinase inhibitor prevented by rapamycin. Nature 372, 570-573.
36. Kip1. Mol. Cell. Biol. 16, 6744-6751.
37. 37. Berset, C., Trachsel, H. & Altmann, M. (1998). The TOR (target of rapamycin) signal transduction pathway regulates the stability of translation initiation factor elF4G in the yeast Saccharomyces cerevisiae. Proc. Natl Acad. Sci. USA 95, 4264-4269.
38. 38. Barbet, N.C., Schneider, U., Helliwell, S.B., Stansfield, I., Tuite, M.F. & Hall, M.N. (1996). TOR controls translation initiation and early G1 progression in yeast. Mol. Biol. Cell. 7, 25-42.
39. 39. Zaragoza, D., Ghavidel, A., Heitman, J. & Schultz, M.C. (1998). Rapamycin induces the GO program of transcriptional repression in yeast by interfering with the TOR signaling pathway. Mol. Cell. Biol. 18, 4463-4470.
40. 40. Chung, J., Kuo, C.J., Crabtree, G.R. & Blenis, J. (1992). Rapamycin-FKBP specifically blocks growth-dependent activation of and signaling by the 70 kd S6 protein kinases. Cell 69, 1227-1236.
41. 41. Banin, S., et al., & Ziv Y. (1998). Enhanced phosphorylation of p53 by ATM in response to DNA damage. Science 281, 1674-1677.
42. 42. Canman, C.E., et al., & Siliciano J.D. (1998). Activation of the ATM kinase by ionizing radiation and phosphorylation of p53. Science 281, 1677-1679.
43. 43. Levine, A.J. (1997). p53, the cellular gatekeeper for growth and division. Cell 88, 323-331.
44. 44. Tibbetts, R.S., et al., & Abraham R.T. (1999). A role for ATR in the DNA damage-induced phosphorylation of p53. Genes Dev. 13, 152-157.
45. 45. Woo, R.A., McLure, K.G., Lees-Miller, S.P., Rancourt, D.E. & Lee, P.W. (1998). DNA-dependent protein kinase acts upstream of p53 in response to DNA damage. Nature 394, 700-704.
46. 46. Brown, L & McCarthy, N. (1997). DNA repair. A sense-abl response? Nature 387, 450-451.
47. 47. Pendergast, A.M. (1996). Nuclear tyrosine kinases: from Abl to WEE1. Curr. Opin. Cell Biol. 8, 174-181.
48. 48. Walworth, N.C. & Bernards, R. (1996). rad-dependent response of the chk1-encoded protein kinase at the DNA damage checkpoint. Science 271, 353-356.
49. 49. Furnari, B., Rhind, N. & Russell, P. (1997). Cdc25 mitotic inducer targeted by chk1 DNA damage checkpoint kinase. Science 277, 1495-1497.
50. 50. Waterman, M.J., Stavridi, E.S., Waterman, J.L. & Halazonetis, T.D. (1998). ATM-dependent activation of p53 involves dephosphorylation and association with 14-3-3 proteins. Nat. Genet. 19, 175-178.
51. 51. Bertram, P.G., Zeng, C., Thorson, J., Shaw, A.S. & Zheng, X.F. (1998). The 14-3-3 proteins positively regulate rapamycin-sensitive signaling. Curr. Biol. 8, 1259-1267.
52. 52. Andrade, M.A. & Bork, P. (1995). HEAT repeats in the Huntington's disease protein [letter]. Nat. Genet. 11, 115-116.
53. 53. Groves, M.R., Hanlon, N., Turowski, P., Hemmings, B.A. & Barford, D. (1999). The structure of the protein phosphatase 2A PR65/A subunit reveals the conformation of its 15 tandemly repeated HEAT motifs. Cell 96, 99-110.
54. 54. Fox, H.L., Kimball, S.R., Jefferson, L.S. & Lynch, C.J. (1998). Amino acids stimulate phosphorylation of p70S6k and organization of rat adipocytes into multicelluiar clusters. Am. J. Physiol. 274, C206-213.
55. 55. Hara, K., Yonezawa, K., Weng, Q.P., Kozlowski, M.T., Belham, C. & Avruch, J. (1998). Amino acid sufficiency and mTOR regulate p70 S6 kinase and elF-4E BP1 through a common effector mechanism. J. Biol. Chem. 273, 14484-14494.
56. 56. Noda, T. & Ohsumi, Y. (1998). Tor, a phosphatidylinositol kinase homologue, controls autophagy in yeast. J. Biol. Chem. 273, 3963-3966.
57. 57. liboshi, Y., et al., & Terada N. (1999). Amino acid-dependent control of p70(s6k). Involvement of tRNA aminoacylation in the regulation. J. Biol. Chem. 274, 1092-1099.
58. 58. Xu, Y., Ashley, T., Brainerd, E.E., Bronson, R.T., Meyn, M.S. & Baltimore, D. (1996). Targeted disruption of ATM leads to growth retardation, chromosomal fragmentation during meiosis, immune defects, and thymic lymphoma. Genes Dev. 10, 2411-2422.
59. 59. Barlow, C., et al., & Wynshaw-Boris A. (1996). Atm-deficient mice: a paradigm of ataxia telangiectasia. Cell 86, 159-171.
60. 60. Cliby, W.A., et al., & Friend S.H. (1998). Overexpression of a kinase-inactive ATR protein causes sensitivity to DNA-damaging agents and defects in cell cycle checkpoints. EMBO J. 17, 159-169.
61. 61. Keegan, K.S., et al., & Hoekstra M.F. (1996). The Atr and Atm protein kinases associate with different sites along meiotically pairing chromosomes. Genes Dev. 10, 2423-2437.
62. 62. Kirchgessner, C.U., et al., & Brown J.M. (1995). DNA-dependent kinase (p350) as a candidate gene for the murine SCID defect. Science 267, 1178-1183.
63. 63. Blunt, T., et al., & Jeggo, P.A. (1995). Defective DNA-dependent protein kinase activity is linked to V(D)J recombination and DNA repair defects associated with the murine scid mutation. Cell 80, 813-823.
64. 64. Leuther, K.K., Hammarsten, O., Kornberg, R.D. & Chu, G. (1999). Structure of DNA-dependent protein kinase: implications for its regulation by DNA. EMBO J. 18, 1114-1123.
65. 65. Gottlieb, T.M. & Jackson, S.P. (1993). The DNA-dependent protein kinase: requirement for DNA ends and association with Ku antigen. Cell 72, 131-142.
66. 66. Schmidt, A., Kunz, J. & Hall, M.N. (1996). TOR2 is required for organization of the actin cytoskeleton in yeast. Proc. Natl Acad. Sci. USA 93, 13780-13785.
67. 67. Zheng, X.F., Florentino, D., Chen, J., Crabtree, G.R. & Schreiber, S.L. (1995). TOR kinase domains are required for two distinct functions, only one of which is inhibited by rapamycin. Cell 82, 121-130.
68. 68. Xu, Y. & Baltimore, D. (1996). Dual roles of ATM in the cellular response to radiation and in cell growth control. Genes Dev. 10, 2401-2410.
69. 69. Zhao, X., Muller, E.G. & Rothstein, R. (1998). A suppressor of two essential checkpoint genes identifies a novel protein that negatively affects dNTP pools. Mol. Cell 2, 329-340.
70. 70. Choi, J., Chen, J., Schreiber, S.L. & Clardy, J. (1996). Structure of the FKBP12-rapamycin complex interacting with the binding domain of human FRAP. Science 273, 239-242.