Association between Variation in the Actin-Binding Gene Caldesmon and Diabetic Nephropathy in Type 1 Diabetes

Diabetes

Volumn 53, Issue 4, 2004, Pages 1162-1165

  Conway, Bryan R ^a,e   Maxwell, A Peter ^a   Savage, David A ^a   Patterson, Chris C ^a   Doran, Peter P ^b,c,d   Murphy, Madeline ^b,c,d   Brady, Hugh R ^b,c,d   Fogarty, Damian G ^a  

^a QUEEN'S UNIVERSITY BELFAST   (United Kingdom)

^b MATER MISERICORDIAE UNIVERSITY HOSPITAL   (Ireland)

^c UNIVERSITY COLLEGE DUBLIN   (Ireland)

^d Dublin Molecular Medicine Centre   (Ireland)

^e BELFAST CITY HOSPITAL   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

ACTIN BINDING PROTEIN; CALDESMON;

ACTIN BINDING GENE; ADULT; ARTICLE; CHROMOSOME 7Q; CONTROLLED STUDY; CYTOSKELETON; DENATURING HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; DIABETIC NEPHROPATHY; EXTRACELLULAR MATRIX; FEMALE; GENE; GENE DISRUPTION; GENE LOCATION; GENETIC ANALYSIS; GENETIC ASSOCIATION; GENETIC VARIABILITY; GLUCOSE BLOOD LEVEL; HAPLOTYPE; HUMAN; INSULIN DEPENDENT DIABETES MELLITUS; KIDNEY FAILURE; MAJOR CLINICAL STUDY; MALE; MESANGIUM CELL; MULTIGENE FAMILY; PRIORITY JOURNAL; SINGLE NUCLEOTIDE POLYMORPHISM;

BASE SEQUENCE; CALMODULIN-BINDING PROTEINS; DIABETES MELLITUS, TYPE 1; DIABETIC NEPHROPATHIES; GENETIC PREDISPOSITION TO DISEASE; GENOTYPE; HUMANS; IRELAND; NORTHERN IRELAND; ODDS RATIO; POLYMORPHISM, SINGLE NUCLEOTIDE; PROMOTER REGIONS (GENETICS); VARIATION (GENETICS);

EID: 1842422848     PISSN: 00121797     EISSN: None     Source Type: Journal    
DOI: 10.2337/diabetes.53.4.1162     Document Type: Article

References (22)

1. U.S. Renal Data System: USRDS 2002 Annual Data Report: Atlas of End-Stage Renal Disease in the United States. Bethesda, MD, National Institutes of Health, National Institute of Diabetes and Digestive and Kidney Diseases, 2002
2. Krolewski AS, Warram JH, Christlieb AR, Busick EJ, Kahn CR: The changing natural history of nephropathy in type 1 diabetes. Am J Med 87:785-794, 1985
3. Seaquist ER, Goetz FC, Rich S, Barbosa J. Familial clustering of diabetic kidney disease: evidence for genetic susceptibility to diabetic nephropathy. N Engl J Med 320:1161-1165, 1989
4. Borch-Johnsen K, Norgaard K, Hommel E, Mathiesen ER, Jensen JS, Deckert T, Parving H-H: Is diabetic nephropathy an inherited complication? Kidney Int 41:719-722, 1992
5. Quinn M, Angelico MC, Warram JH, Krolewski AS: Familial factors determining the development of diabetic nephropathy in patients with IDDM. Diabetologia 39:940-945, 1996
6. Murphy M, Godson C, Cannon S, Kato S, Mackenzie HS, Martin F, Brady HR: Suppression subtractive hybridization identifies high glucose levels as a stimulus for expression of connective tissue growth factor and other genes in human mesangial cells. J Biol Chem 274:5830-5834, 1999
7. Clarkson MR, Murphy M, Gupta S, Lambe T, Mackenzie HS, Godson C, Martin F, Brady HR: High glucose-altered gene expression in mesangial cells. J Biol Chem 277:9707-9712, 2002
8. Zhou X, Hurst RD, Templeton D, Whiteside CI: High glucose alters actin assembly in glomerular mesangial and epithelial cells. Lab Invest 73:372-383, 1995
9. Cortes P, Mendez M, Riser BL, Guerin CJ, Rodriguez-Barbero A, Hassett C, Yee J: F-actin fibre distribution in glomerular cells: structural and functional implications. Kidney Int 58:2452-2461, 2000
10. Zatz R, Brenner BM: Pathogenesis of diabetic microangiopathy: the haemodynamic view. Am J Med 80:443-453, 1986
11. Imperatore G, Hanson RL, Pettitt DJ, Kobes S, Bennett PH, Knowler WC, Pima Diabetes Genes Group: Sib-pair linkage analysis for susceptibility genes for microvascular complication among Pima Indians with type 2 diabetes. Diabetes 47:821-830, 1998
12. Fogarty DG, Moczulski DK, Makita Y, Araki S, Rogus JJ, Warram JH, Krolewski A: Evidence for susceptibility locus to diabetic nephropathy on chromosome 7q in Caucasian families with type 2 diabetes (Abstract). Diabetes 48 (Suppl. 1):A47, 1999
13. Helfman DM, Levy ET, Berthier C, Shtutman M, Riveline D, Grosheva I, Lachish-Zalait A, Elbaum M, Bershadsky AD: Caldesmon inhibits non-muscle cell contractility and interferes with the formation of focal adhesions. Mol Biol Cell 10:3097-3112, 1999
14. Yamashiro S, Chern H, Yamakita Y, Matsumura F: Mutant caldesmon lacking cdc2 phosphorylation sites delays M-phase entry and inhibits cytokinesis. Mol Biol Cell 12:239-250, 2001
15. Matsumura F, Yamashiro S: Caldesmon. Curr Opin Cell Biol 5:70-76, 1993
16. Hayashi K, Yano H, Hashida T, Takeuchi R, Takeda O, Asada K, Takahashi E-I, Kato I, Sobue K: Genomic structure of the human caldesmon gene. Proc Natl Acad Sci U S A 89:12122-12126, 1992
17. Fogarty DG, Harron JC, Hughes AE, Nevin NC, Doherty CC, Maxwell AP: A molecular variant of angiotensinogen is associated with diabetic nephropathy in IDDM. Diabetes 45:1204-1208, 1996
18. Lewontin RC: The interaction of selection and linkage. I: general considerations; heterotic models. Genetics 49:49-67, 1964
19. Johnson GCL, Esposito L, Barratt BJ, Smith AN, Heward J, Di Genova G, Ueda H, Cordell HJ, Eaves IA, Dudbridge F, Twells RCJ, Payne F, Hughes W, Nutland S, Stevens H, Carr P, Tuomilehto-Wolf E, Toumilehto J, Gough SCL, Clayton DG, Todd JA: Haplotype tagging for the identification of common disease genes. Nat Genet 29:233-237, 2001
20. Stephens M, Smith NJ, Donnelly P: A new statistical method for haplotype reconstruction from population data. Am J Hum Genet 68:978-989, 2001
21. Schneider S, Roessli D, Excofier L: Arlequin: a software for population genetics data analysis. Version 2.000. Geneva, Genetics and Biometry Lab, Department of Anthropology, University of Geneva, 2000
22. Zhao JH, Sham PC: Faster allelic association analysis using unrelated subjects. Hum Hered 53:36-41, 2002