Cell signaling by receptor tyrosine kinases

Cell

Volumn 103, Issue 2, 2000, Pages 211-225

  Schlessinger, Joseph ^a  

^a NEW YORK UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

PROTEIN TYROSINE KINASE;

CELL ACTIVITY; CELL CYCLE; CELL METABOLISM; CELL MIGRATION; CELL PROLIFERATION; CELL SURFACE; CELL SURVIVAL; CYTOPLASM; ENZYME ACTIVITY; EUKARYOTE; PRIORITY JOURNAL; REVIEW; SIGNAL PROCESSING;

EUKARYOTA;

EID: 0034644539     PISSN: 00928674     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0092-8674(00)00114-8     Document Type: Review

References (109)

1. Characterization of a 3-phosphoinositide-dependent protein kinase which phosphorylates and activates protein kinase B alpha
2. Translocation of PDK-1 to the plasma membrane is important in allowing PDK-1 to activate protein kinase B
3. Epidermal growth factor (EGF)-induced generation of hydrogen peroxide
4. Platelet-derived growth factor-induced H(2)O(2) production requires the activation of phosphatidylinositol 3-kinase
5. Ras and Rho GTPases: A family reunion
6. SHIP modulates immune receptor responses by regulating membrane association of Btk
7. Structure and function of sphongolipid- and cholesterol-rich membrane rafts
8. Akt promotes cell survival by phosphorylating and inhibiting a fork-head transcription factor
9. Employment of the epidermal growth factor receptor in growth factor-independent signaling pathways
10. A Neu acquaintance for ErbB3 and ErbB4: A role for receptor heterodimerization in growth signaling
11. Control of FGF receptor signaling: Lessons from fruitflies
12. C-kinase phosphorylates the epidermal growth factor receptor and reduces its epidermal growth factor-stimulated tyrosine protein kinase activity
13. PIP2 and PIP3: Complex roles at the cell surface
14. Jak-STAT pathways and transcriptional activation in response to IFNs and other extracellular signaling proteins
15. Cellular survival: A play in three Akts
16. Signal transduction by the JNK group of MAP kinases
17. Tumor-promoting phorbol esters cause the phosphorylation of epidermal growth factor receptors in normal human fibroblasts at threonine 654
18. Smad2 transduces common signals from receptor serine-threonine and tyrosine kinases
19. Lipid microdomains in cell surface membrane
20. Increased insulin sensitivity and obesity resistance in mice lacking the protein tyrosine phosphatase-1B gene
21. Socs-3 is an insulin-induced negative regulator of insulin signaling
22. Activation of phospholipase Cγ by PI-3 kinase induced PH domain mediated membrane targeting
23. Diverse signaling pathways activated by growth factor receptors induce broadly overlapping, rather than independent, sets of genes
24. Structure of the high affinity complex of inositol trisphosphate with a phospholipase C-pleckstrin homology domain
25. Extracellular domains drive homo- but not heterodimerization of ErbB receptors
26. The protein kinase encoded by the Akt proto-oncogene is a target of the PDGF-activated phosphatidylinositol 3-kinase
27. High affinity binding of inositol phosphates and phosphoinositides to the pleckstrin homology domain of RAC/protein kinase B and their influence on kinase activity
28. Phosphoinositide binding domains: Embracing 3-phosphate
29. Secondary dimerization between members of the epidermal growth factor receptor family
30. Organization and regulation of mitogen-activated protein kinase signaling pathways
31. Clustering membrane proteins: It's all coming together with the PSD-95/SAP90 protein family
32. Epidermal growth factor receptor:critical mediators of multiple receptor pathways
33. Dimerization of cell surface receptors in signal transduction
34. Twenty proteins containing a C-terminal SOCS box form five structural classes
35. Evidence for epidermal growth factor (EGF)-induced intermolecular autophosphorylation in living cells
36. Proxy activation of protein ErbB2 by heterologous ligands implies a heterotetrameric mode of receptor tyrosine kinase interaction
37. Crystal structure of the activated insulin receptor tyrosine kinase in complex with peptide substrate and ATP analog
38. Crystal structure of the tyrosine kinase domain of the human insulin receptor
39. Autoregulatory mechanisms in protein-tyrosine kinases
40. The Croonian lecture, 1997. The phosphorylation of proteins on tyrosine: Its role in cell growth and disease
41. Signaling - 2000 and beyond
42. Transforming gene product of Rous sarcoma virus phosphorylates tyrosine
43. Cytokine receptor signaling
44. Fibroblast growth factor receptor tyrosine kinases: Molecular analysis and signal transduction
45. Receptor activation: When a dimer is not enough
46. The interaction between the Drosophila secreted protein argos and the epidermal growth factor receptor inhibits dimerization of the receptor and binding of secreted spitz to the receptor
47. The tyrosine kinase negative regulate c-Cbl as a RING-type, E2-dependent ubiquitin-protein ligase
48. Signaling networks: The origins of cellular multitasking
49. JNK2 contains a specificity-determining region responsible for efficient c-Jun binding and phosphorylation
50. Transcriptional control by protein phosphorylation: Signal transmission from the cell surface to the nucleus
51. PDGF stimulation of inositol phospholipid hydrolysis requires PLC-γ phosphorylation on residues 783 and 1254
52. EGF binding to its receptor triggers a rapid tyrosine phosphorylation of the ErbB-2 protein in the mammary tumor cell line SKBR-3
53. Src family kinases are required for integrin but not PDGFR signal transduction
54. Opposite BMP and EGF signaling pathways converge on the TGF-β family mediator Smad1
55. Structural basis for cytokine hormone-receptor recognition and receptor activation
56. A lipid-anchored Grb2-binding protein that links FGF-receptor activation to the Ras/MAP kinase signaling pathway
57. Modular peptide recognition domains in eukaryotic signaling
58. Reversible inactivation of protein-tyrosine phosphase 1B in A431 cells stimulated with epidermal growth factor
59. Signal-dependent membrane targeting by pleckstrin homology (PH) domains
60. Regulation of signal transduction and signal diversity by receptor oligomerization
61. Specific and high-affinity binding of inositol phosphates to an isolated pleckstrin homology domain
62. PH domains: Diverse sequences with a common fold recruit signaling molecules to the cell surface
63. Two EGF molecules contribute additively to stabilization of the EGFR dimer
64. Scaffold proteins may biphasically affect the levels of mitogen-activated protein kinase signaling and reduce its threshold properties
65. Regulation of tyrosine kinase cascades by G-protein-coupled receptors
66. The riddle of MAP kinase signaling specificity
67. The tumor suppressor, PTEN/MMac1, dephosphorylates the lipid second messenger, phosphatidylinositol 3,4,5-trisphosphate
68. Angiopoietin-2, a natural antagonist for Tie2 that disrupts in vivo angiogenesis
69. The PTB domain: The name doesn't say it all
70. Specificity of receptor tyrosine kinase signaling: Transient versus sustained extracellular signal-regulated kinase activation
71. FGF signaling in skeletal development
72. TGFβ signaling in growth control, cancer and heritable disorders
73. Structure of the FGF receptor tyrosine kinase domain reveals a novel autoinhibitory mechanism for receptor tyrosine kinases
74. The ErbB signaling network: Receptor heterodimerization in development and cancer
75. Protein modules and signaling networks
76. SH2 and SH3 domains
77. Signaling through scaffold, anchoring and adaptor proteins
78. Structural basis for FGF receptor dimerization and activation
79. Crystal structures of two FGF-FGFR complexes reveal the determinants of ligand-receptor specificity
80. Heterodimerization of epidermal growth factor receptor and wild-type or kinase-deficient Neu: A mechanism of interreceptor kinase activation and transphosphorylation
81. The role of phosphoinositide 3-kinase lipid products in cell function
82. A novel positive feedback loop mediated by the docking protein Gab1 and PI-3 kinase in EGF receptor signaling
83. FGF signaling inhibits chondrocythe proliferation and regulates bone development through the STAT-1 pathway
84. Signal transduction by allosteric receptor oligomerization
85. SH2/SH3 signaling proteins
86. Crystal structure of a ternary FGF-FGFR-heparin complex reveals a dual role for heparin in FGFR binding and dimerization
87. Functional rafts in cell membranes
88. SH2 domains recognize specific phosphopeptide sequences
89. Heparin-induced oligomerization of FGF molecules is responsible for FGF receptor dimerization, activation, and cell proliferation
90. EGF-stimulated tyrosine phosphorylation of p185(neu): A potential model for receptor interactions
91. Pleiotropic insulin signals are engaged by multisite phosphorylation of IRS-1
92. Targeted disruption of FGF8 causes failure of cell migration in gastrulating mouse embryo
93. Translocation and reversible localization of signaling proteins: A dynamic future for signal transduction
94. Cellular functions regulated by src family kinases
95. Akt/protein kinase B is regulated by autophosphorylation at the hypothetical PDK-2 site
96. Cellular signaling: Pivoting around PDK-1
97. Bivalence of EGF-like ligands drive the ErbB signaling network
98. Signal transduction by receptors with tyrosine kinase activity
99. Signaling through the insulin receptor and the insulin-like growth factor-1 receptor
100. Intermolecular association of the p185(neu) protein and EGF modulates EGF receptor function
101. Alternatively spliced NH2-terminal immunoglobulin like loop I in the ectodomain of the fibroblast growth factor (FGF) receptor 1 lowers affinity for both heparin and FFI
102. Mitogen and stress response pathways: MAP-kinase cascades and phosphatase regulation in mammals and yeast
103. Structural organization of MAP-kinase signaling modules by scaffold proteins in yeast and mammals
104. Crystal structure at 1.7 Å resolution of VEGF in complex with domain 2 of the Flt-1 receptor
105. Crystal structures of c-Src reveal features of its autoinhibitory mechanism
106. FGFR1 is required for embryonic growth and mesodermal patterning during mouse gastrulation
107. Cell surface, heparin-like molecules are required for binding of basic fibroblast growth factor to its high affinity receptor
108. LAT: The ZAP-70 tyrosine kinase substrate that links T cell receptor to cellular activation
109. Smad3 and Smad4 cooperate with c-Jun/c-Fos to mediate TGFβ-induced transcription