Positive and Negative Roles of p85α and p85β Regulatory Subunits of Phosphoinositide 3-Kinase in Insulin Signaling

Journal of Biological Chemistry

Volumn 278, Issue 48, 2003, Pages 48453-48466

  Ueki, Kohjiro ^a   Fruman, David A ^a,b   Yballe, Claudine M ^a,b   Fasshauer, Mathias ^a   Klein, Johannes ^a   Asano, Tomoichiro ^c   Cantley, Lewis C ^a,b   Kahn, C Ronald ^a,d  

^a HARVARD MEDICAL SCHOOL   (United States)

^b BETH ISRAEL DEACONESS MEDICAL CENTER   (United States)

^c UNIVERSITY OF TOKYO   (Japan)

^d JOSLIN DIABETES CENTER   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CATALYST ACTIVITY; CELLS; INSULIN; PROTEINS;

APOPTOSIS;

BIOCHEMISTRY;

GLUCOSE; GLYCOGEN SYNTHASE; INSULIN; INSULIN RECEPTOR SUBSTRATE 2; PHOSPHATIDYLINOSITOL 3 KINASE; PROTEIN KINASE B; PROTEIN P110; PROTEIN P85; PROTEIN P85ALPHA; PROTEIN P85BETA; UNCLASSIFIED DRUG;

ANIMAL CELL; APOPTOSIS; ARTICLE; ENZYME ACTIVATION; ENZYME ACTIVITY; ENZYME REGULATION; ENZYME SUBUNIT; GLUCOSE TRANSPORT; MOUSE; NEWBORN; NONHUMAN; PRIORITY JOURNAL; PROTEIN BINDING; PROTEIN EXPRESSION; PROTEIN PHOSPHORYLATION; REGULATORY MECHANISM; SIGNAL TRANSDUCTION;

1-PHOSPHATIDYLINOSITOL 3-KINASE; ADENOVIRIDAE; ADIPOCYTES; ANIMALS; APOPTOSIS; BLOTTING, NORTHERN; CATALYTIC DOMAIN; DEOXYGLUCOSE; ENZYME ACTIVATION; GLYCOGEN SYNTHASE; INSULIN; JNK MITOGEN-ACTIVATED PROTEIN KINASES; MICE; MITOGEN-ACTIVATED PROTEIN KINASES; MODELS, BIOLOGICAL; MUTATION; PHOSPHORYLATION; PRECIPITIN TESTS; PROTEIN ISOFORMS; PROTEIN STRUCTURE, TERTIARY; PROTEIN-SERINE-THREONINE KINASES; PROTO-ONCOGENE PROTEINS; PROTO-ONCOGENE PROTEINS C-AKT; RIBOSOMAL PROTEIN S6 KINASES, 90-KDA; SIGNAL TRANSDUCTION;

ANIMALIA;

EID: 0346220260     PISSN: 00219258     EISSN: None     Source Type: Journal    
DOI: 10.1074/jbc.M305602200     Document Type: Article

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