Chapter 1 Biomedical Agriculture. A Systematic Approach to Food Crop Improvement for Chronic Disease Prevention

Advances in Agronomy

Volumn 102, Issue , 2009, Pages 1-54

  Thompson, Matthew D ^a   Thompson, Henry J ^a  

^a Department of Environmental and Radiological Health Sciences   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

EID: 65449128818     PISSN: 00652113     EISSN: None     Source Type: Book Series    
DOI: 10.1016/S0065-2113(09)01001-3     Document Type: Review

References (208)

1. Aggett P.J., Bresson J., Haschke F., Hernell O., Koletzko B., Lafeber H.N., Michaelsen K.F., Micheli J., Ormisson A., Rey J., Salazar de S.J., and Weaver L. Recommended dietary allowances (RDAs), recommended dietary intakes (RDIs), recommended nutrient intakes (RNIs), and population reference intakes (PRIs) are not "recommended intakes". J. Pediatr. Gastroenterol. Nutr. 25 (1997) 236-241
2. Ahn S., and Tanksley S.D. Comparative linkage maps of the rice and maize genomes. Proc. Natl. Acad. Sci. USA 90 (1993) 7980-7984
3. Ambrosone C.B., Freudenheim J.L., Thompson P.A., Bowman E., Vena J.E., Marshall J.R., Graham S., Laughlin R., Nemoto T., and Shields P.G. Manganese superoxide dismutase (MnSOD) genetic polymorphisms, dietary antioxidants, and risk of breast cancer. Cancer Res. 59 (1999) 602-606
4. American Cancer Society. Cancer Facts and Figures (2008)
5. Ames B.N., Shigenaga M.K., and Hagen T.M. Oxidants, antioxidants, and the degenerative diseases of aging. Proc. Natl. Acad. Sci. USA 90 (1993) 7915-7922
6. Bais H.P., Vepachedu R., Gilroy S., Callaway R.M., and Vivanco J.M. Allelopathy and exotic plant invasion: From molecules and genes to species interactions. Science 301 (2003) 1377-1380
7. Bamia C., Trichopoulos D., Ferrari P., Overvad K., Bjerregaard L., Tjonneland A., Halkjaer J., Clavel-Chapelon F., Kesse E., Boutron-Ruault M.C., Boffetta P., Nagel G., et al. Dietary patterns and survival of older Europeans: The EPIC-Elderly Study (European Prospective Investigation into Cancer and Nutrition). Public Health Nutr. 10 (2007) 590-598
8. Berg C.M., Lappas G., Strandhagen E., Wolk A., Toren K., Rosengren A., Aires N., Thelle D.S., and Lissner L. Food patterns and cardiovascular disease risk factors: The Swedish INTERGENE research program. Am. J. Clin. Nutr. 88 (2008) 289-297
9. Biddinger S.B., and Kahn C.R. From mice to men: Insights into the insulin resistance syndromes. Annu. Rev. Physiol. 68 (2006) 123-158
10. Bjelakovic G., Nikolova D., Gluud L.L., Simonetti R.G., and Gluud C. Mortality in randomized trials of antioxidant supplements for primary and secondary prevention: Systematic review and meta-analysis. JAMA 297 (2007) 842-857
11. Breimer L.H. Molecular mechanisms of oxygen radical carcinogenesis and mutagenesis: The role of DNA base damage. Mol. Carcinogen. 3 (1990) 188-197
12. Brown L., and van der Ouderaa F. Nutritional genomics: Food industry applications from farm to fork. Br. J. Nutr. 97 (2007) 1027-1035
13. Buchner D.A., Burrage L.C., Hill A.E., Yazbek S.N., O'Brien W.E., Croniger C.M., and Nadeau J.H. Resistance to diet-induced obesity in mice with a single substituted chromosome. Physiol. Genomics 35 (2008) 116-122
14. Burke J.M., Burger J.C., and Chapman M.A. Crop evolution: From genetics to genomics. Curr. Opin. Genet. Dev. 17 (2007) 525-532
15. Burlingame B. What is a nutrient?. J. Food Comp. Anal. 14 (2001) 1
16. Burton-Freeman B. Dietary Fibre and energy regulation. J. Nutr. 130 (2000) S272-S275
17. Buxser S., and Chapman D.L. Use of mixture distributions to deconvolute the behavior of "hits" and controls in high-throughput screening data. Anal. Biochem. 361 (2007) 197-209
18. Cadet J., Douki T., Frelon S., Sauvaigo S., Pouget J.P., and Ravanat J.L. Assessment of oxidative base damage to isolated and cellular DNA by HPLC-MS/MS measurement. Free Radic. Biol. Med. 33 (2002) 441-449
19. Cani P.D., and Delzenne N.M. Gut microflora as a target for energy and metabolic homeostasis. Curr. Opin. Clin. Nutr. Metab. Care 10 (2007) 729-734
20. Cani P.D., Amar J., Iglesias M.A., Poggi M., Knauf C., Bastelica D., Neyrinck A.M., Fava F., Tuohy K.M., Chabo C., Waget A., Delmee E., et al. Metabolic endotoxemia initiates obesity and insulin resistance. Diabetes 56 (2007) 1761-1772
21. Cani P.D., Bibiloni R., Knauf C., Waget A., Neyrinck A.M., Delzenne N.M., and Burcelin R. Changes in gut microbiota control metabolic endotoxemia-induced inflammation in high-fat diet-induced obesity and diabetes in mice. Diabetes 57 (2008) 1470-1481
22. Casas J.P., Shah T., Hingorani A.D., Danesh J., and Pepys M.B. C-reactive protein and coronary heart disease: A critical review. J. Intern. Med. 264 (2008) 295-314
23. Centers for Disease Control. Health, United States. Centers for Disease Control 297 14 (2007) 1544
24. Centers for Disease Control. Health Statistics. Centers for Disease Control and Prevention (2008)
25. Cerutti P.A. Prooxidant states and tumor promotion. Science 227 (1985) 375-381
26. Chassy B., Hlywka J.J., Kleter G.A., Kok E.J., Kuiper H.A., McGloughlin M., Munro I.C., Phipps R.H., Reid J.E., Stein J., and Zabik J. Nutritional and safety assessments of foods and feeds nutritionally improved through biotechnology. Food Nutr. Bull. 26 (2005) 436-442
27. Chiuve S.E., and Willett W.C. The 2005 Food Guide Pyramid: An opportunity lost?. Nat. Clin. Pract. Cardiovasc. Med. 4 (2007) 610-620
28. Collins A. Measurement of oxidative DNA damage using the comet assay. In: Lunec J., and Griffiths H.R. (Eds). Measuring In Vivo Oxidative Damage: A Practical Approach (1998), John Wiley & Sons, England 83-94
29. Combs G.F., Duxbury J.M., and Welch R.M. Food systems for improved health: Linking agricultural production and human nutrition. Eur. J. Clin. Nutr. 51 (1997) S32-S33
30. Cooke M.S., Olinski R., and Evans M.D. Does measurement of oxidative damage to DNA have clinical significance?. Clin. Chim. Acta 365 (2006) 30-49
31. Cooper S.A., Whaley-Connell A., Habibi J., Wei Y., Lastra G., Manrique C., Stas S., and Sowers J.R. Renin-angiotensin-aldosterone system and oxidative stress in cardiovascular insulin resistance. Am. J. Physiol. Heart Circ. Physiol. 293 (2007) H2009-H2023
32. Cornblatt B.S., Ye L., Nkova-Kostova A.T., Erb M., Fahey J.W., Singh N.K., Chen M.S., Stierer T., Garrett-Mayer E., Argani P., Davidson N.E., Talalay P., et al. Preclinical and clinical evaluation of sulforaphane for chemoprevention in the breast. Carcinogenesis 28 (2007) 1485-1490
33. Coussens L.M., and Werb Z. Inflammation and cancer. Nature 420 (2002) 860-867
34. Craddick S.R., Elmer P.J., Obarzanek E., Vollmer W.M., Svetkey L.P., and Swain M.C. The DASH diet and blood pressure. Curr. Atheroscler. Rep. 5 (2003) 484-491
35. DeFlora S., Izzotti A., Randerath K., Randerath E., Bartsch H., Nair J., Balansky R., van Schooten F., Degan P., Fronza G., Walsh D., and Lewtas J. DNA adducts and chronic degenerative disease. Pathogenetic relevance and implications in preventive medicine. Mutat. Res. 366 (1996) 197-238
36. DellaPenna D. Nutritional genomics: Manipulating plant micronutrients to improve human health. Science 285 (1999) 375-379
37. Dingkuhn M., Luquet D., Quilot B., and de Reffye P. Environmental and genetic control of morphogenesis in crops: Towards models simulating phenotypic plasticity. Aust. J. Agric. Res. 56 (2005) 1289-1302
38. Dixon R.A., Gang D.R., Charlton A.J., Fiehn O., Kuiper H.A., Reynolds T.L., Tjeerdema R.S., Jeffery E.H., German J.B., Ridley W.P., and Seiber J.N. Perspective-Applications of metabolomics in agriculture. J. Agric. Food Chem. 54 (2006) 8984-8994
39. Drewnowski A. Concept of a nutritious food: Toward a nutrient density score. Am. J. Clin. Nutr. 82 (2005) 721-732
40. Dumas M.E., Barton R.H., Toye A., Cloarec O., Blancher C., Rothwell A., Fearnside J., Tatoud R., Blanc V., Lindon J.C., Mitchell S.C., Holmes E., et al. Metabolic profiling reveals a contribution of gut microbiota to fatty liver phenotype in insulin-resistant mice. Proc. Natl. Acad. Sci. USA 103 (2006) 12511-12516
41. Duthie G.G., Gardner P.T., and Kyle J.A. Plant polyphenols: Are they the new magic bullet?. Proc. Nutr. Soc. 62 (2003) 599-603
42. Dwivedi S.L., Crouch J.H., Mackill D.J., Xu Y., Blair M.W., Ragot M., Upadhyaya H.D., and Ortiz R. The molecularization of public sector crop breeding: Progress, problems, and prospects. Adv. Agron. 95 (2007) 163-318
43. Englyst K.N., and Englyst H.N. Carbohydrate bioavailability. Br. J. Nutr. 94 (2005) 1-11
44. Eyre H., Kahn R., Robertson R.M., Clark N.G., Doyle C., Gansler T., Glynn T., Hong Y., Smith R.A., Taubert K., Thun M.J., and and The ACS/ADA/AHA Collaborative Writing Committee. Preventing cancer, cardiovascular disease, and diabetes: A common agenda for the American Cancer Society, the American Diabetes Association, and the American Heart Association. Circulation 109 (2004) 3244-3255
45. Ezzat V.A., Duncan E.R., Wheatcroft S.B., and Kearney M.T. The role of IGF-I and its binding proteins in the development of type 2 diabetes and cardiovascular disease. Diabetes Obes. Metab. 10 (2008) 198-211
46. Finley J.W. Proposed criteria for assessing the efficacy of cancer reduction by plant foods enriched in carotenoids, glucosinolates, polyphenols and selenocompounds. Ann. Bot. (Lond.) 95 (2005) 1075-1096
47. Fischer S., and Sana S. Metabolomic Profiling of Bacterial Leaf Blight in Rice (2007), Agilent Technologies, Santa Clara, CA
48. Food and Agriculture Organization. The State of the World's Plant Genomic Resources for Food and Agriculture (1998), Food and Agriculture Organization of the United Nations, Rome
49. Food and Agriculture Organization. The State of Food and Agriculture 2003-2004 (2008), World Health Organization, Washington, DC
50. Fowler C., and Hodgkin T. Plant genetic resources for food and agriculture: Assessing global availability. Annu. Rev. Environ. Resour. 29 (2004) 143-179
51. Frary A., Nesbitt T.C., Grandillo S., Knaap E., Cong B., Liu J., Meller J., Elber R., Alpert K.B., and Tanksley S.D. fw2.2: A quantitative trait locus key to the evolution of tomato fruit size. Science 289 (2000) 85-88
52. Frasca F., Pandini G., Sciacca L., Pezzino V., Squatrito S., Belfiore A., and Vigneri R. The role of insulin receptors and IGF-I receptors in cancer and other diseases. Arch. Physiol. Biochem. 114 (2008) 23-37
53. Fung T.T., Chiuve S.E., McCullough M.L., Rexrode K.M., Logroscino G., and Hu F.B. Adherence to a DASH-style diet and risk of coronary heart disease and stroke in women. Arch. Intern. Med. 168 (2008) 713-720
54. Gagarin A., Makarenkov V., and Zentilli P. Using clustering techniques to improve hit selection in high-throughput screening. J. Biomol. Screen. 11 (2006) 903-914
55. Gepts P. Origin and evolution of common bean: Past events and recent trends. Hort. Sci. 33 (1998) 1124-1130
56. Gepts P., and Hancock J. The future of plant breeding. Crop Sci. 46 (2006) 1630-1634
57. Gepts P., and Papa R. Possible effects of (trans)gene flow from crops on the genetic diversity from landraces and wild relatives. Environ. Biosafety Res. 2 (2003) 89-103
58. German J.B., Roberts M.A., and Watkins S.M. Personal metabolomics as a next generation nutritional assessment. J. Nutr. 133 (2003) 4260-4266
59. Gilani G.S., and Nasim A. Impact of foods nutritionally enhanced through biotechnology in alleviating malnutrition in developing countries. J. AOAC Int. 90 (2007) 1440-1444
60. Giugliano D., Ceriello A., and Esposito K. Glucose metabolism and hyperglycemia. Am. J. Clin. Nutr. 87 (2008) 217S-222S
61. Glancey J.L., Kee E., and Wootten T. Technical advances and strategies for future developments in mechanization. HortTechnology 15 (2005) 486-488
62. Grundy S.M., Howard B., Smith Jr. S., Eckel R., Redberg R., and Bonow R.O. Prevention conference VI: Diabetes and cardiovascular disease: Executive summary: Conference proceeding for healthcare professionals from a special writing group of the american heart association. Circulation 105 (2002) 2231-2239
63. Grusak M.A. Genomics-assisted plant improvement to benefit human nutrition and health. Trends Plant Sci. 4 (1999) 164-166
64. Guilford J.M., and Pezzuto J.M. Natural products as inhibitors of carcinogenesis. Expert Opin. Investig. Drugs 17 (2008) 1341-1352
65. Haegele A.D., Gillette C., O'Neill C., Wolfe P., Heimendinger J., Sedlacek S., and Thompson H.J. Plasma xanthophyll carotenoids correlate inversely with indices of oxidative DNA damage and lipid peroxidation. Cancer Epidemiol. Biomarkers Prev. 9 (2000) 421-425
66. Halliwell B., and Gutteridge J.M.C. Free Radical in Biology and Medicine (1999), Oxford Science Publications, New York
67. Hammer G.L., Chapman S., van Oosterom E., and Podlich D.W. Trait physiology and crop modelling as a framework to link phenotypic complexity to underlying genetic systems. Aust. J. Agric. Res. 56 (2005) 947-960
68. Harris S.S. Dietary guidelines for Americans recommendations for the year 2000. Food Aust. 52 (2000) 212-214
69. Hasler C.M. The changing face of functional foods. J. Am. Coll. Nutr. 19 (2000) 499S-506S
70. Hasler C.M. Functional foods: Benefits, concerns and challenges-A position paper from the American council on science and health. J. Nutr. 132 (2002) 3772-3781
71. Hasler C.M. Health claims in the United States: An aid to the public or a source of confusion?. J. Nutr. 138 (2008) 1216S-1220S
72. Hawkes C., and Ruel M. The links between agriculture and health: An intersectoral opportunity to improve the health and livelihoods of the poor. Bull. World Health Organ. 84 (2006) 984-990
73. Holmes E., and Nicholson J.K. Human metabolic phenotyping and metabolome wide association studies. Ernst. Schering. Found. Symp. Proc. (2007) 227-249
74. Holmes E., Wilson I.D., and Nicholson J.K. Metabolic phenotyping in health and disease. Cell 134 (2008) 714-717
75. Huang D., Ou B., and Prior R.L. The chemistry behind antioxidant capacity assays. J. Agric. Food Chem. 53 (2005) 1841-1856
76. Hung H.C., Joshipura K.J., Jiang R., Hu F.B., Hunter D., Smith-Warner S.A., Colditz G.A., Rosner B., Spiegelman D., and Willett W.C. Fruit and vegetable intake and risk of major chronic disease. J. Natl. Cancer Inst. 96 (2004) 1577-1584
77. Hwang E.S., and Kim G.H. Biomarkers for oxidative stress status of DNA, lipids, and proteins in vitro and in vivo cancer research. Toxicology 229 (2007) 1-10
78. IARC. Weight Control and Physical Activity. IARC Handbook of Cancer Prevention Vol. 6 (2002), IARC Press, Lyon 1-355
79. Jacobs D.R., and Tapsell L.C. Food, not nutrients, is the fundamental unit in nutrition. Nutr. Rev. 65 (2007) 439-450
80. Johansson I., Hallmans G., Wikman A., Biessy C., Riboli E., and Kaaks R. Validation and calibration of food-frequency questionnaire measurements in the Northern Sweden Health and Disease cohort. Public Health Nutr. 5 (2002) 487-496
81. Kahn R., Buse J., Ferrannini E., and Stern M. The metabolic syndrome: Time for a critical appraisal. Joint statement from the American Diabetes Association and the European Association for the Study of Diabetes. Diabetologia 48 (2005) 1684-1699
82. Kalra E.K. Nutraceutical-Definition and introduction. AAPS PharmSci. 5 (2003) E25
83. Kami J., Velasquez V.B., Debouck D.G., and Gepts P. Identification of presumed ancestral DNA sequences of phaseolin in Phaseolus vulgaris. Proc. Natl. Acad. Sci. USA 92 (1995) 1101-1104
84. Kaput J. Diet-disease gene interactions. Nutrition 20 (2004) 26-31
85. Kaput J. Decoding the pyramid: A systems-biological approach to nutrigenomics. Ann. NY Acad. Sci. 1055 (2005) 64-79
86. Kaput J. Developing the promise of nutrigenomics through complete science and international collaborations. Forum Nutr. 60 (2007) 209-223
87. Kaput J., Ordovas J.M., Ferguson L., van Ommen B., Rodriguez R.L., Allen L., Ames B.N., Dawson K., German B., Krauss R., Malyj W., Archer M.C., et al. The case for strategic international alliances to harness nutritional genomics for public and personal health. Br. J. Nutr. 94 (2005) 623-632
88. Karamouzis M.V., and Papavassiliou A.G. COX-2 inhibition in cancer therapeutics: A field of controversy or a magic bullet?. Expert Opin. Investig. Drugs 13 (2004) 359-372
89. Keil A.G. Crop wild relatives (2008). http://www.cropwildrelatives.org Accessed 2008
90. Keon J., Curtis R., Cabrera H., and Hargreaves J. A genomics approach to crop pest and disease research. Pest Manag. Sci. 59 (2003) 143-148
91. Kevorkov D., and Makarenkov V. Statistical analysis of systematic errors in high-throughput screening. J. Biomol. Screen. 10 (2005) 557-567
92. Kinghorn A.D., Su B.N., Jang D.S., Chang L.C., Lee D., Gu J.Q., Carcache-Blanco E.J., Pawlus A.D., Lee S.K., Park E.J., Cuendet M., Gills J.J., et al. Natural inhibitors of carcinogenesis. Planta Med. 70 (2004) 691-705
93. Kinney A.J. Metabolic engineering in plants for human health and nutrition. Curr. Opin. Biotechnol. 17 (2006) 130-138
94. Kinross J.M., von Roon A.C., Holmes E., Darzi A., and Nicholson J.K. The human gut microbiome: Implications for future health care. Curr. Gastroenterol. Rep. 10 (2008) 396-403
95. Kochian L.V., and Garvin D.F. Agricultural approaches to improving phytonutrient content in plants: An overview. Nutr. Rev. 57 (1999) S13-S18
96. Kornman K.S., Martha P.M., and Duff G.W. Genetic variations and inflammation: A practical nutrigenomics opportunity. Nutrition 20 (2004) 44-49
97. Kris-Etherton P.M., Lefevre M., Beecher G.R., Gross M.D., Keen C.L., and Etherton T.D. Bioactive compounds in nutrition and health-research methodologies for establishing biological function: The antioxidant and anti-inflammatory effects of flavonoids on atherosclerosis. Annu. Rev. Nutr. 24 (2004) 511-538
98. Lawrence M., and Rayner M. Functional foods and health claims: A public health policy perspective. Public Health Nutr. 1 (1998) 75-82
99. Lenihan E., Duvick S., and White P. Rapid screening to identify unusual thermal starch traits from bulked corn kernels. Cereal Chem. 81 (2004) 527-532
100. Lewis D.F., Ioannides C., and Parke D.V. Cytochromes P450 and species differences in xenobiotic metabolism and activation of carcinogen. Environ. Health Perspect. 106 (1998) 633-641
101. Ley R.E., Turnbaugh P.J., Klein S., and Gordon J.I. Microbial ecology: Human gut microbes associated with obesity. Nature 444 (2006) 1022-1023
102. Li M., Wang B., Zhang M., Rantalainen M., Wang S., Zhou H., Zhang Y., Shen J., Pang X., Zhang M., Wei H., Chen Y., et al. Symbiotic gut microbes modulate human metabolic phenotypes. Proc. Natl. Acad. Sci. USA 105 (2008) 2117-2122
103. Liby K.T., Yore M.M., and Sporn M.B. Triterpenoids and rexinoids as multifunctional agents for the prevention and treatment of cancer. Nat. Rev. Cancer 7 (2007) 357-369
104. Lindsay M.P., Lagudah E.S., Hare R.A., and Munns R. A locus for sodium exclusion (Nax1), a trait for salt tolerance, mapped in durum wheat. Funct. Plant Biol. 31 (2004) 1105-1114
105. Lippman Z., and Tanksley S.D. Dissecting the genetic pathway to extreme fruit size in tomato using a cross between the small-fruited wild species Lycopersicon pimpinellifolium and L. esculentum var. Giant Heirloom. Genetics 158 (2001) 413-422
106. Liu R.H. Potential synergy of phytochemicals in cancer prevention: Mechanism of action. J. Nutr. 134 (2004) 3479S-3485S
107. Loft S., Vistisen K., Ewertz M., Tjonneland A., Overvad K., and Poulsen H.E. Oxidative DNA damage estimated by 8-hydroxydeoxyguanosine excretion in humans: Influence of smoking, gender and body mass index. Carcinogenesis 13 (1992) 2241-2247
108. Londo J.P., Chiang Y.C., Hung K.H., Chiang T.Y., and Schaal B.A. Phylogeography of Asian wild rice, Oryza rufipogon, reveals multiple independent domestications of cultivated rice, Oryza sativa. Proc. Natl. Acad. Sci. USA 103 (2006) 9578-9583
109. Lopez-Garcia E., Schulze M.B., Fung T.T., Meigs J.B., Rifai N., Manson J.E., and Hu F.B. Major dietary patterns are related to plasma concentrations of markers of inflammation and endothelial dysfunction. Am. J. Clin. Nutr. 80 (2004) 1029-1035
110. Lotito S.B., and Frei B. The increase in human plasma antioxidant capacity after apple consumption is due to the metabolic effect of fructose on urate, not apple-derived antioxidant flavonoids. Free Radic. Biol. Med. 37 (2004) 251-258
111. Luesch H. Towards high-throughput characterization of small molecule mechanisms of action. Mol. Biosyst. 2 (2006) 609-620
112. Marshall S. Role of insulin, adipocyte hormones, and nutrient-sensing pathways in regulating fuel metabolism and energy homeostasis: A nutritional perspective of diabetes, obesity, and cancer. Sci. STKE 2006 (2006) re7
113. Martin F.P., Dumas M.E., Wang Y., Legido-Quigley C., Yap I.K., Tang H., Zirah S., Murphy G.M., Cloarec O., Lindon J.C., Sprenger N., Fay L.B., et al. A top-down systems biology view of microbiome-mammalian metabolic interactions in a mouse model. Mol. Syst. Biol. 3 (2007) 112
114. Martindale J.L., and Holbrook N.J. Cellular response to oxidative stress: Signaling for suicide and survival. J. Cell Physiol. 192 (2002) 1-15
115. Masters J.R., and Stacey G.N. Changing medium and passaging cell lines. Nat. Protoc. 2 (2007) 2276-2284
116. Mayer J.E., Pfeiffer W.H., and Beyer P. Biofortified crops to alleviate micronutrient malnutrition. Curr. Opin. Plant Biol. 11 (2008) 166-170
117. Mayo Clinic. Dietary fiber: An essential part of a healthy diet (2007). http://www.mayoclinic.com
118. McCullough M.L., and Willett W.C. Evaluating adherence to recommended diets in adults: The Alternate Healthy Eating Index. Public Health Nutr. 9 (2006) 152-157
119. McCullough M.L., Feskanich D., Rimm E.B., Giovannucci E.L., Ascherio A., Variyam J.N., Spiegelman D., Stampfer M.J., and Willett W.C. Adherence to the Dietary Guidelines for Americans and risk of major chronic disease in men. Am. J. Clin. Nutr. 72 (2000) 1223-1231
120. McDaniel S.M., O'Neill C., Metz R.P., Tarbutton E., Stacewicz-Sapuntzakis M., Heimendinger J., Wolfe P., Thompson H., and Schedin P. Whole-food sources of vitamin A more effectively inhibit female rat sexual maturation, mammary gland development, and mammary carcinogenesis than retinyl palmitate. J. Nutr. 137 (2007) 1415-1422
121. McNally K.L., Bruskiewich R., Mackill D., Buell C.R., Leach J.E., and Leung H. Sequencing multiple and diverse rice varieties. Connecting whole-genome variation with phenotypes. Plant Physiol. 141 (2006) 26-31
122. Metzlaff K. European plant science: A field of opportunities. J. Exp. Bot. 56 (2005) 1699-1709
123. Milne G.L., Sanchez S.C., Musiek E.S., and Morrow J.D. Quantification of F2-isoprostanes as a biomarker of oxidative stress. Nat. Protoc. 2 (2007) 221-226
124. Misciagna G., De M.G., Cisternino A.M., Guerra V., Logroscino G., and Freudenheim J.L. Dietary carbohydrates and glycated proteins in the blood in non diabetic subjects. J. Am. Coll. Nutr. 24 (2005) 22-29
125. Misciagna G., De M.G., and Trevisan M. Non enzymatic glycated proteins in the blood and cardiovascular disease. Curr. Pharm. Des. 13 (2007) 3688-3695
126. Mollet B., and Rowland I. Functional foods: At the frontier between food and pharma. Curr. Opin. Biotechnol. 13 (2002) 483-485
127. Monna L., Ohta R., Masuda H., Koike A., and Minobe Y. Genome-wide searching of single-nucleotide polymorphisms among eight distantly and closely related rice cultivars (Oryza sativa L.) and a wild accession (Oryza rufipogon Griff.). DNA Res. 13 (2006) 43-51
128. Must A., Spadano J., Coakley E.H., Field A.E., Colditz G., and Dietz W.H. The disease burden associated with overweight and obesity. JAMA 282 (1999) 1523-1529
129. Naidu K.A. Vitamin C in human health and disease is still a mystery? An overview. Nutr. J. 2 (2003) 7
130. Nestel P., Bouis H.E., Meenakshi J.V., and Pfeiffer W. Biofortification of staple food crops. J. Nutr. 136 (2006) 1064-1067
131. Nicholson J.K., Holmes E., and Elliott P. The metabolome-wide association study: A new look at human disease risk factors. J. Proteome Res. 7 (2008) 3637-3638
132. O'Connor J.C., McCusker R.H., Strle K., Johnson R.W., Dantzer R., and Kelley K.W. Regulation of IGF-I function by proinflammatory cytokines: At the interface of immunology and endocrinology. Cell Immunol. 252 (2008) 91-110
133. Packard R.R., and Libby P. Inflammation in atherosclerosis: From vascular biology to biomarker discovery and risk prediction. Clin. Chem. 54 (2008) 24-38
134. Park E.J., and Pezzuto J.M. Botanicals in cancer chemoprevention. Cancer Metastasis Rev. 21 (2002) 231-255
135. Pfeiffer W.H., and McClafferty B. HarvestPlus: Breeding crops for better nutrition. Crop Sci. 47 (2007) S88-S105
136. Pickersgill B. Domestication of plants in the Americas: Insights from Mendelian and molecular genetics. Ann. Bot. 100 (2007) 925-940
137. Pirola L., Johnston A.M., and Van O.E. Modulators of insulin action and their role in insulin resistance. Int. J. Obes. Relat. Metab. Disord. 27 Suppl. 3 (2003) S61-S64
138. Potter J.D. Food, Nutrition and the Prevention of Cancer: A Global Perspective. (1997), American Institute for Cancer Research, Washington, DC
139. Prithiviraj B., Weir T., Bais H.P., Schweizer H.P., and Vivanco J.M. Plant models for animal pathogenesis. Cell Microbiol. 7 (2005) 315-324
140. Prochaska H.J., Santamaria A.B., and Talalay P. Rapid detection of inducers of enzymes that protect against carcinogens. Proc. Natl. Acad. Sci. USA 89 (1992) 2394-2398
141. Prosky L. When is dietary fiber considered a functional food?. Biofactors 12 (2000) 289-297
142. Qu H., Madl R.L., Takemoto D.J., Baybutt R.C., and Wang W. Lignans are involved in the antitumor activity of wheat bran in colon cancer SW480 cells. J. Nutr. 135 (2005) 598-602
143. Reeves P.G., Nielsen F.H., and Fahey Jr. G.C. AIN-93 purified diets for laboratory rodents: Final report of the American Institute of Nutrition ad hoc writing committee on the reformulation of the AIN-76A rodent diet. J. Nutr. 123 (1993) 1939-1951
144. Reeves P.G., Rossow K.L., and Lindlauf J. Development and testing of the AIN-93 purified diets for rodents: Results on growth, kidney calcification and bone mineralization in rats and mice. J. Nutr. 123 (1993) 1923-1931
145. Riboli E., and Norat T. Epidemiologic evidence of the protective effect of fruit and vegetables on cancer risk. Am. J. Clin. Nutr. 78 (2003) 559S-569S
146. Rippe J.M., Crossley S., and Ringer R. Obesity as a chronic disease: Modern medical and lifestyle management. J. Am. Diet. Assoc. 98 (1998) S9-S15
147. Robbins R.J. Phenolic acids in foods: An overview of analytical methodology. J. Agric. Food Chem. 51 (2003) 2866-2887
148. Rosenfield P.L. The potential of transdisciplinary research for sustaining and extending linkages between the health and social sciences. Soc. Sci. Med. 35 (1992) 1343-1357
149. Ross-Ibarra J., Morrell P.L., and Gaut B.S. Plant domestication, a unique opportunity to identify the genetic basis of adaptation. Proc. Natl. Acad. Sci. USA 104 Suppl. 1 (2007) 8641-8648
150. Russell J.C., and Proctor S.D. Small animal models of cardiovascular disease: Tools for the study of the roles of metabolic syndrome, dyslipidemia, and atherosclerosis. Cardiovasc. Pathol. 15 (2006) 318-330
151. Sadovsky R., Collins N., Tighe A.P., Brunton S.A., and Safeer R. Patient use of dietary supplements: A clinician's perspective. Curr. Med. Res. Opin. 24 (2008) 1209-1216
152. Schenk S., Saberi M., and Olefsky J.M. Insulin sensitivity: Modulation by nutrients and inflammation. J. Clin. Invest. 118 (2008) 2992-3002
153. Schleicher E., and Friess U. Oxidative stress, AGE, and atherosclerosis. Kidney Int. 72 Suppl. 1 (2007) S17-S26
154. Schwartsburd P.M. Chronic inflammation as inductor of pro-cancer microenvironment: Pathogenesis of dysregulated feedback control. Cancer Metastasis Rev. 22 (2003) 95-102
155. Scrinis G. Functional foods or functionally marketed foods? A critique of, and alternatives to, the category of 'functional foods'. Public Health Nutr. 11 (2008) 541-545
156. Shacter E. Quantification and significance of protein oxidation in biological samples. Drug Metab. Rev. 32 (2000) 307-326
157. Shapiro T.A., Fahey J.W., Nkova-Kostova A.T., Holtzclaw W.D., Stephenson K.K., Wade K.L., Ye L., and Talalay P. Safety, tolerance, and metabolism of broccoli sprout glucosinolates and isothiocyanates: A clinical phase I study. Nutr. Cancer 55 (2006) 53-62
158. Shin C.Y., Jung M.Y., Lee I.K., Son M., Kim D.S., Lim J.I., Kim S.H., Yoo M., Huh T.L., Sohn Y.T., and Kim W.B. Anti-diabetic effects of DA-11004, a synthetic IDPc inhibitor in high fat high sucrose diet-fed C57BL/6J mice. Arch. Pharm. Res. 27 (2004) 48-52
159. Soldatos G., Cooper M.E., and Jandeleit-Dahm K.A. Advanced-glycation end products in insulin-resistant states. Curr. Hypertens. Rep. 7 (2005) 96-102
160. Sporn M.B. Dichotomies in cancer research: Some suggestions for a new synthesis. Nat. Clin. Pract. Oncol. 3 (2006) 364-373
161. Stokols D., Hall K.L., Taylor B.K., and Moser R.P. The Science of Team Science: Overview of the field and introduction to the supplement. Am. J. Prev. Med. 35 (2008) S77-S89
162. Stoner G.D., Wang L.S., Zikri N., Chen T., Hecht S.S., Huang C., Sardo C., and Lechner J.F. Cancer prevention with freeze-dried berries and berry components. Semin. Cancer Biol. 17 (2007) 403-410
163. Stoner G.D., Wang L.S., and Casto B.C. Laboratory and clinical studies of cancer chemoprevention by antioxidants in berries. Carcinogenesis 29 (2008) 1665-1674
164. Stuber C.W., and Hancock J. Sustaining plant breeding-National workshop. Crop Sci. 48 (2008) 25-29
165. Stumvoll M., Goldstein B.J., and van Haeften T.W. Type 2 diabetes: Principles of pathogenesis and therapy. Lancet 365 (2005) 1333-1346
166. Surwit R.S., Kuhn C.M., Cochrane C., McCubbin J.A., and Feinglos M.N. Diet-induced type II diabetes in C57BL/6J mice. Diabetes 37 (1988) 1163-1167
167. Thompson H.J. DNA oxidation products, antioxidant status, and cancer prevention. J. Nutr. 134 (2004) 3186S-3187S
168. Thompson H.J., McGinley J.N., Rothhammer K., and Singh M. Rapid induction of mammary intraductal proliferations, ductal carcinoma in situ and carcinomas by the injection of sexually immature female rats with 1-methyl-1-nitrosourea. Carcinogenesis 16 (1995) 2407-2411
169. Thompson H.J., Heimendinger J., Haegele A., Sedlacek S.M., Gillette C., O'Neill C., Wolfe P., and Conry C. Effect of increased vegetable and fruit consumption on markers of oxidative cellular damage. Carcinogenesis 20 (1999) 2261-2266
170. Thompson H.J., Heimendinger J., Gillette C., Sedlacek S.M., Haegele A., O'Neill C., and Wolfe P. In vivo investigation of changes in biomarkers of oxidative stress induced by plant food rich diets. J. Agric. Food Chem. 53 (2005) 6126-6132
171. Thompson H.J., Heimendinger J., Sedlacek S., Haegele A., Diker A., O'Neill C., Meinecke B., Wolfe P., Zhu Z., and Jiang W. 8-Isoprostane F2alpha excretion is reduced in women by increased vegetable and fruit intake. Am. J. Clin. Nutr. 82 (2005) 768-776
172. Thompson H.J., Heimendinger J., Diker A., O'Neill C., Haegele A., Meinecke B., Wolfe P., Sedlacek S., Zhu Z., and Jiang W. Dietary botanical diversity affects the reduction of oxidative biomarkers in women due to high vegetable and fruit intake. J. Nutr. 136 (2006) 2207-2212
173. Thompson M.D., Brick M.A., McGinley J.N., and Thompson H.J. Chemical composition and cancer inhibitory activity of dry bean market classes. Crop Sci. 49 (2009) 179-186
174. Thompson M.D., Stushnoff C., McGinley J.N., and Thompson H.J. In vitro measures used to predict anticancer activity of apple cultivars and their comparison to outcomes from a rat model of experimentally-induced breast cancer. Nutr. Cancer 61 4 (2009)
175. Thompson M.D., Thompson H.J., Brick M.A., McGinley J.N., Jiang W., Zhu Z., and Wolfe P. Mechanisms associated with dose-dependent inhibition of rat mammary carcinogenesis by dry bean (Phaseolus vulgaris, L.). J. Nutr. 138 (2008) 2091-2097
176. Thompson M.D., Thompson H.J., McGinley J.N., et al. Functional food characteristic of potato cultivars (Solanum tuberosum L.): Phytochemical composition and inhibition of 1-methyl-1-nitrosourea induced breast cancer in rats. J. Food Compos. Anal. (2009) (in press)
177. Tripp R., Louwaars N., and Eaton D. Plant variety protection in developing countries. A report from the field. Food Policy 32 (2007) 354-371
178. Turnbaugh P.J., Ley R.E., Mahowald M.A., Magrini V., Mardis E.R., and Gordon J.I. An obesity-associated gut microbiome with increased capacity for energy harvest. Nature 444 (2006) 1027-1031
179. USDA. Dietary Guidelines (2008), United States Department of Agriculture, Washington, DC
180. van Dooren T. Inventing seed: The nature(s) of intellectual property in plants. Environ. Plan. D Soc. Space 26 (2008) 676-697
181. van Gils C.H., Peeters P.H.T., Bueno-De-Mesquita H.B., Boshuizen H.C., Lahmann P.H., Clavel-Chapelon F., Thiebaut A., Kesse E., Sieri S., Palli D., Tumino R., Panico S., et al. Consumption of vegetables and fruits and risk of breast cancer. J. Am. Med. Assoc. 293 (2005) 183-193
182. vanOmmen B. Nutrigenomics: Exploiting systems biology in the nutrition and health arenas. Nutrition 20 (2004) 4-8
183. Varshney R.K., Hoisington D.A., and Tyagi A.K. Advances in cereal genomics and applications in crop breeding. Trends Biotechnol. 24 (2006) 490-499
184. Vermeir M., Annaert P., Mamidi R.N., Roymans D., Meuldermans W., and Mannens G. Cell-based models to study hepatic drug metabolism and enzyme induction in humans. Expert Opin. Drug Metab. Toxicol. 1 (2005) 75-90
185. Vincent H.K., Innes K.E., and Vincent K.R. Oxidative stress and potential interventions to reduce oxidative stress in overweight and obesity. Diabetes Obes. Metab. 9 (2007) 813-839
186. Walters W.P., and Namchuk M. Designing screens: How to make your hits a hit. Nat. Rev. Drug Discov. 2 (2003) 259-266
187. Watkins S.M., Hammock B.D., Newman J.W., and German J.B. Individual metabolism should guide agriculture toward foods for improved health and nutrition. Am. J. Clin. Nutr. 74 (2001) 283-286
188. Watkins S.M., and German J.B. Metabolomics and biochemical profiling in drug discovery and development. Curr. Opin. Mol. Ther. 4 (2002) 224-228
189. Watkins S.M., and German J.B. Toward the implementation of metabolomic assessments of human health and nutrition. Curr. Opin. Biotechnol. 13 (2002) 512-516
190. WCRF/AICR. Food, Nutrition, Physical Activity, and the Prevention of Cancer: A Global Perspective (2007), AICR, Washington, DC
191. Weir T.L., Park S.W., and Vivanco J.M. Biochemical and physiological mechanisms mediated by allelochemicals. Curr. Opin. Plant Biol. 7 (2004) 472-479
192. Welch R.M. Biotechnology, biofortification, and global health. Food Nutr. Bull. 26 (2005) 419-421
193. Welch R.M., and Graham R.D. Agriculture: The real nexus for enhancing bioavailable micronutrients in food crops. J. Trace Elem. Med. Biol. 18 (2005) 299-307
194. Weller S.C., Bressan R.A., Goldsbrough P.B., Fredenburg T.B., and Hasegawa P.M. The effect of genomics on weed management in the 21st century. Weed Sci. 49 (2001) 282-289
195. Willett W.C., and Hu F.B. The food frequency questionnaire. Cancer Epidemiol. Biomarkers Prev. 16 (2007) 182-183
196. Willett W.C., Reynolds R.D., Cottrell-Hoehner S., Sampson L., and Browne M.L. Validation of a semi-quantitative food frequency questionnaire: Comparison with a 1-year diet record. J. Am. Diet. Assoc. 87 (1987) 43-47
197. Williams R.J., Spencer J.P., and Rice-Evans C. Flavonoids: Antioxidants or signalling molecules?. Free Radic. Biol. Med. 36 (2004) 838-849
198. Wink M. Evolution of secondary metabolites from an ecological and molecular phylogenetic perspective. Phytochemistry 64 (2003) 3-19
199. Wink M. Plant secondary metabolism: Diversity, function and its evolution. Nat. Prod. Commun. 3 (2008) 1205-1216
200. World Health Organization. Diet, Nutrition and the Prevention of Chronic Disease. Report of a Joint WHO/FAO Consultation (2003), World Health Organization, Geneva, Switzerland WHO Technical Report Series No. 916
201. World Health Organization. The World Health Report 2007: A Safer Future, Global Public Health Security in the 21st Century (2007), World Health Organization, Geneva, Switzerland
202. World Health Organization. Chronic Disease (2008), World Health Organization, Geneva, Switzerland
203. World Health Organization Global Report. Preventing Chronic Diseases: A Vital Investment (2008), World Health Organization, Geneva, Switzerland
204. Wu X., Beecher G.R., Holden J.M., Haytowitz D.B., Gebhardt S.E., and Prior R.L. Lipophilic and hydrophilic antioxidant capacities of common foods in the United States. J. Agric. Food Chem. 52 (2004) 4026-4037
205. Wu X.L., Gu L.W., Holden J., Haytowitz D.B., Gebhardt S.E., Beecher G., and Prior R.L. Development of a database for total antioxidant capacity in foods: A preliminary study. J. Food Compos. Anal. 17 (2004) 407-422
206. Wu J.L., Wu C.J., Lei C.L., Baraoidan M., Bordeos A., Madamba M.R.S., Ramos-Pamplona M., Mauleon R., Portugal A., Ulat V.J., Bruskiewich R., Wang G.L., et al. Chemical- and irradiation-induced mutants of indica rice IR64 for forward and reverse genetics. Plant Mol. Biol. 59 (2005) 85-97
207. Yusuf S., Reddy S., Ounpuu S., and Anand S. Global burden of cardiovascular diseases. Part I. General considerations, the epidemiologic transition, risk factors, and impact of urbanization. Circulation 104 (2001) 2746-2753
208. Zieman S.J., and Kass D.A. Advanced glycation endproduct crosslinking in the cardiovascular system: Potential therapeutic target for cardiovascular disease. Drugs 64 (2004) 459-470