DNA oxidation products, antioxidant, and cancer prevention

Journal of Nutrition

Volumn 134, Issue 11, 2004, Pages

  Thompson, Henry J ^a  

^a Department of Environmental and Radiological Health Sciences   (United States)

Author keywords

8 hydroxy 2 deoxyguanosine; Antioxidant; Biomarkers; Cancer; DNA oxidation

Indexed keywords

8 HYDROXYDEOXYGUANOSINE; BIOLOGICAL MARKER; DNA; DNA GLYCOSYLTRANSFERASE; ENDONUCLEASE; OXIDIZING AGENT; REACTIVE OXYGEN METABOLITE;

ANTIOXIDANT ACTIVITY; CANCER PREVENTION; CANCER RISK; CARCINOGENESIS; CELL PROTECTION; COMET ASSAY; CONFERENCE PAPER; DIAGNOSTIC VALUE; DNA DETERMINATION; GENE MUTATION; GENETIC POLYMORPHISM; GENOTYPE; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; HUMAN; OXIDATIVE STRESS; SEPARATION TECHNIQUE; SITE DIRECTED MUTAGENESIS; TANDEM MASS SPECTROMETRY;

ANIMALS; ANTIOXIDANTS; BIOLOGICAL MARKERS; DEOXYGUANOSINE; DNA; DNA DAMAGE; HUMANS; NEOPLASMS; OXIDATION-REDUCTION;

EID: 7944219981     PISSN: 00223166     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Conference Paper

References (11)

1. Halliwell, B. & Gutteridge, J.M.C. (1999) Free Radical in Biology and Medicine. Oxford Science Publications, New York, NY.
2. Institute of Medicine, National Academy of Sciences, Food and Nutrition Board Panel on Dietary Antioxidants and Related Compounds (2000) Dietary Reference Intakes for Vitamin C, Vitamin E, Selenium, and Carotenoids. National Academies Press, Washington, DC.
3. Mayne, S. T. (2003) Antioxidant nutrients and chronic disease: use of biomarkers of exposure and oxidative stress status in epidemiologic research. J. Nutr. 133: 933S-940S.
4. Cadet, J., Douki, T., Frelon, S., Sauvaigo, S., Pouget, J. P. & Ravanat, J. L. (2002) Assessment of oxidative base damage to isolated and cellular DNA by HPLC-MS/MS measurement. Free Radic. Biol. Med. 33: 441-449.
5. Hazra, T. K., Izumi, T., Kow, Y. W. & Mitra, S. (2003) The discovery of a new family of mammalian enzymes for repair of oxidatively damaged DNA, and its physiological implications. Carcinogenesis 24: 155-157.
6. Hamilton, M. L., Guo, Z., Fuller, C. D., Van Remmen, H., Ward, W. F., Austad, S. N., Troyer, D. A., Thompson, I. & Richardson, A. (2001) A reliable assessment of 8-oxo-2-deoxyguanosine levels in nuclear and mitochondrial DNA using the sodium iodide method to isolate DNA. Nucl. Acids Res. 29: 2117-2126.
7. Henderson, P. T., Delaney, J. C., Gu, F., Tannenbaum, S. R. & Essigmann, J. M. (2002) Oxidation of 7,8-dihydro-8-oxoguanine affords lesions that are potent sources of replication errors in vivo. Biochemistry 41: 914-921.
8. Hussain, S. P., Raja, K., Amstad, P. A., Sawyer, M., Trudel, L. J., Wogan, G. N., Hofseth, L. J., Shields, P. G., Billiar, T. R., et al. (2000) Increased p53 mutation load in nontumorous human liver of Wilson disease and hemochromatosis: oxyradical overload diseases. Proc. Natl. Acad. Sci. U.S.A. 97: 12770-12775.
9. Halliwell, B. (2000) Why and how should we measure oxidative DNA damage in nutritional studies? How far have we come? Am. J. Clin. Nutr. 72: 1082-1087.
10. Ravanat, J. L., Douki, T., Duez, P., Gremaud, E., Herbert, K., Hofer, T., Lasserre, L., Saint-Pierre, C., Favier, A. & Cadet, J. (2002) Cellular background level of 8-oxo-7,8-dihydro-2'-deoxyguanosine: an isotope based method to evaluate artefactual oxidation of DNA during its extraction and subsequent work-up. Carcinogenesis 23: 1911-1918.
11. Sauvaigo, S., Petec-Calin, C., Caillat, S., Odin, F. & Cadet, J. (2002) Comet assay coupled to repair enzymes for the detection of oxidative damage to DNA induced by low doses of gamma-radiation: use of YOYO-1, low-background slides, and optimized electrophoresis conditions. Anal. Biochem. 303: 107-109.