Potential significance of physiological and pharmacological glucocorticoids in early pregnancy

Human Reproduction Update

Volumn 14, Issue 5, 2008, Pages 497-517

  Michael, Anthony E ^a   Papageorghiou, Aris T ^a  

^a ST GEORGE'S UNIVERSITY OF LONDON   (United Kingdom)

Author keywords

11 hydroxysteroid dehydrogenase; Cortisol; Glucocorticoid; Placenta; Trophoblast

Indexed keywords

11BETA HYDROXYSTEROID DEHYDROGENASE; BETAMETHASONE; CHORIONIC GONADOTROPIN; CYTOKINE; DEXAMETHASONE; GLUCOCORTICOID; HYDROCORTISONE; ISOENZYME; METHYLPREDNISOLONE; PLASMINOGEN ACTIVATOR INHIBITOR; PREDNISOLONE; PROSTAGLANDIN; STEROID RECEPTOR; TRIAMCINOLONE ACETATE;

ANTIINFLAMMATORY ACTIVITY; APOPTOSIS; CELL GROWTH; CELL INVASION; CHORIOAMNIONITIS; CLINICAL TRIAL; DECIDUA; DRUG MECHANISM; DRUG SAFETY; EMBRYO DEVELOPMENT; ENDOMETRIUM; ENZYME ACTIVITY; FERTILIZATION IN VITRO; FETOTOXICITY; FIRST TRIMESTER PREGNANCY; GROWTH REGULATION; HORMONE ACTION; HORMONE DETERMINATION; HORMONE SYNTHESIS; HUMAN; HYDATIDIFORM MOLE; IMMUNE DEFICIENCY; INFERTILITY; INFLAMMATION; INTRACYTOPLASMIC SPERM INJECTION; INTRAUTERINE GROWTH RETARDATION; MEDICAL LITERATURE; NATURAL KILLER CELL; NIDATION; OVULATION INDUCTION; PATHOGENESIS; PLACENTA DEVELOPMENT; PREECLAMPSIA; PREGNANCY COMPLICATION; PREGNANCY DISORDER; PREMATURE LABOR; PRENATAL DRUG EXPOSURE; PRIORITY JOURNAL; PROTEIN INTERACTION; REVIEW; SIGNAL TRANSDUCTION; TROPHOBLAST; UPREGULATION;

11-BETA-HYDROXYSTEROID DEHYDROGENASES; ANIMALS; CHORIONIC GONADOTROPIN; DECIDUA; EMBRYO IMPLANTATION; EMBRYONIC DEVELOPMENT; FEMALE; FERTILIZATION IN VITRO; GLUCOCORTICOIDS; HUMANS; IMMUNOSUPPRESSIVE AGENTS; ISOENZYMES; MATERNAL-FETAL EXCHANGE; PLACENTA; PREGNANCY; PREGNANCY COMPLICATIONS; TROPHOBLASTS;

EID: 49649095455     PISSN: 13554786     EISSN: 14602369     Source Type: Journal    
DOI: 10.1093/humupd/dmn021     Document Type: Review

References (365)

1. Achache H, Revel A. Endometrial receptivity markers, the journey to successful embryo implantation. Hum Reprod Update 2006;12 731-746.
2. Adcock IM, Caramori G. Cross-talk between pro-inflammatory transcription factors and glucocorticoids. Immunol Cell Biol 2001;79 376-384.
3. Addison RS, Maguire DJ, Mortimer RH, Cannell GR. Metabolism of preditisolone by the isolated perfused human placental lobule. J Ster Biochem Mol Biol 1991;39:83-90.
4. Addison RS, Maguire DJ, Mortimer RH, Roberts MS, Cannell GR. Pathway and kinetics of prednisolone metabolism in the human placenta. J Ster Biochem Mol Biol 1993;44:315-320.
5. +-dependent isoform of 11β-hydroxysteroid dehydrogenase. Cloning and characterization cDNA from sheep kidney. J Biol Chem 1994;269:25959-25962.
6. Ain R, Canham LN, Soares MJ. Dexamethasone-induced intrauterine growth restriction impacts the placental prolactin family, insulin-like growth factor-II and the Akt signaling pathway. J Endocrinol 2005;185 253-263.
7. Albiston AL, Obeyesekere VR, Smith RE, Krozowski ZS. Cloning and tissue distribution of the human 11β-hydroxysteroid dehydrogenase type 2 enzyme. Mol Cell Endocrinol 1994;105:R11-R17.
8. Alfaidy N, Xiong ZG, Myatt L, Lye SJ, MacDonald JF, Challis JR. Prostaglandin F2α potentiates cortisol production by stimulating 11β-hydroxysteroid dehydrogenase 1: A novel feedback loop that may contribute to human labour. J Clin Endocrinol Metab 2001;86: 5585-5592.
9. Alfaidy N, Gupta S, DeMarco C, Caniggia I, Challis JRG. Oxygen regulation of placental 11β-hydroxysteroid dehydrogenase 2: physiological and pathological implications. J Clin Endocrinol Metab 2002;87:4797-4805.
10. Alfaidy N, Li W, Macintosh T, Yang K, Challis J. Late gestation increase in 11β-hydroxysteroid dehydrogenase 1 expression in human fetal membranes: A novel intrauterine source of cortisol. J Clin Endocrinol Metab 2003;88:5033-5038.
11. Anderson AB, Gennser G, Jeremy TY, Ohrlander S, Sayers L, Tumbull AC. Placental transfer and metabolism of betamethasone in human pregnancy. Obstet Gynecol 1977;49:471-474.
12. Antonow-Schlorke I, Schwab M, Li C, Nathanielsz PW. Glucocorticoid exposure at the dose used clinically alters cytoskeletal proteins and presynaptic terminals in the fetal baboon brain. J Physiol 2003; 547: 117-123.
13. Arcuri F, Monder C, Lockwood CJ, Schatz F. Expression of 11β-hydroxysteroid dehydrogenase during decidualization of human endometrial stromal cells. Endocrinology 1996;137:595-600.
14. Arcuri F, Battistini S, Hausknecht V, Cintorino M, Lockwood CJ, Schatz F. Human endometrial decidual cell-associated 11β-hydroxysteroid dehydrogenase expression: Its potential role in implantation. Early Pregnancy 1997;3:259-264.
15. Arcuri F, Sestini S, Paulesu L, Bracci L, Carducci A, Manzoni F, Cardone C, Cintorino M. 11β-hydroxysteroid dehydrogenase expression in first trimester human trophoblasts. Mol Cell Endocrinol 1998;141 13-20.
16. Arcuri F, Sestini S, Cintorino M. Expression of 11β-hydroxysteroid dehydrogenase in early pregnancy: Implications in human trophoblast-endometrial interactions. Semin Reprod Endocrinol 1999;17:53-61.
17. Arriza JL, Weinberger C, Cerelli G, Glaser TM, Handelin BL, Housman DE, Evans RM. Cloning of human mineralocorticoid receptor complementary DNA: structural and functional kinship with the glucocorticoid receptor. Science 1987;237:268-275.
18. Baggia S, Albrecht ED, Babischkin JS, Pepe GJ. Interconversion of cortisol and cortisone in baboon trophoblast and decidua cells in culture. Endocrinology 1990;127:1735-1741.
19. Bailey JM. New mechanisms for effects of anti-inflammatory glucocorticoids. Biofactors 1991;3:97-102.
20. Banjanin S, Kapoor A, Matthews SG. Prenatal glucocorticoid exposure alters hypothalamic-pituitary-adrenal function and blood pressure in mature male guinea pigs. J Physiol 2004;558:305-318.
21. Barbera A, Wilkening RB, Teng C, Battaglia FC, Meschia G. Metabolic alterations in the fetal hepatic and umbilical circulations during glucocorticoid-induced parturition in sheep. Ped Res 1997;41 242-248.
22. Barnes PJ. Anti-inflammatory actions of glucocorticoids: Molecular mechanisms. Clin Sci (Lond) 1998;94:557-572.
23. Barnes PJ. Corticosteroid effects on cell signalling. Eur Respir J 2006;27: 413-426.
24. Beitins IZ, Bayard F, Ances IG, Kowarski A, Migeon CJ. The transplacental passage of prednisone and prednisolone in pregnancy near term. J Pediatr 1972;81:936-945.
25. Benediktsson R, Edwards CR. Apparent mineralocorticoid excess. J Hum Hypertension 1994;8:371-375.
26. Benediktsson R, Lindsay RS, Noble J, Seckl JR, Edwards CRW. Glucocorticoid exposure in utero: New model for adult hypertension. Lancet 1993;341:339-341.
27. Benediktsson R, Calder AA, Edwards CRW, Seckl JR. Placental 11β-hydroxysteroid dehydrogenase: A key regulator of fetal glucocorticoid exposure. Clin Endocrinol 1997;46:161-166.
28. Bertram CE, Hanson MA. Prenatal programming of postnatal endocrine responses by glucocorticoids. Reproduction 2002;124:459-467.
29. Beshay VE, Carr BR, Rainey WE. The human fetal adrenal gland, corticotrophin-releasing hormone, and parturition. Semin Reprod Med 2007;25:14-20.
30. Blanford AT, Murphy BEP. In vitro metabolism of prednisolone, dexamethasone, betamethasone, and cortisol by the human placenta. Am J Obstet Gynecol 1977;127:264-267.
31. Blondeau B, Lesage J, Czernichow P, Dupouy JP, Breant B. Glucocorticoids impair fetal β-cell development in rats. Am J Physiol Endocrinol Metab 2001;281:E592-E599.
32. Bloom SL, Sheffield JS, McIntire DD, Leveno KJ. Antenatal dexamethasone and decreased birth weight. Obstet Gynecol 2001;97:485-490.
33. Boomsma CM, Keay SD, Macklon NS. Peri-implantation glucocorticoid administration for assisted reproductive technology cycles. Cochrane Database Syst Rev 2007;24:CD005996.
34. Breant B, Gesina E, Blondeau D. Nutrition, glucocorticoids and pancreas development. Horm Res 2006;65(Suppl. 3):98-104.
35. Brown RW, Chapman KE, Edwards CRW, Seckl JR. Human placental 11β-hydroxysteroid dehydrogenase: Evidence for and partial purification of a distinct NAD-dependent iosform. Endocrinology 1993;132 2614-2621.
36. Brown RW, Chapman KE, Kotelevtsev Y, Yau JL, Lindsay RS, Brett L, Leckie C, Murad P, Lyons V, Mullins JJ et al. Cloning and production of antisera to human placental 11β-hydroxysteroid dehydrogenase type 2. Biochem J 1996a;313:1007-1017.
37. Brown RW, Diaz R, Robson AC, Kotelevtsev YV, Mullins JJ, Kaufman MH, Seckl JR. The ontogeny of 11β-hydroxysteroid dehydrogenase type 2 and mineralocorticoid receptor gene expression reveal intricate control of glucocorticoid action in development. Endocrinology 1996b;137 794-797.
38. Burrows TD, King A, Loke YW. Trophoblast migration during human placental implantation. Hum Reprod Update 1996;2:307-321.
39. Burton PJ, Waddell BJ. 11β-Hydroxysteroid dehydrogenase in the rat placenta: Developmental changes and the effects of altered glucocorticoid exposure. J Endocrinol 1994;143:505-513.
40. Burton PJ, Waddell BJ. Dual function of 11β-hydroxysteroid dehydrogenase in placenta: Modulating glucocorticoid passage and local steroid action. Biol Reprod 1999;60:234-240.
41. Burton PJ, Smith RE, Krozowski ZS, Waddell BJ. Zonal distribution of 11β-hydroxysteroid dehydrogenase types 1 and 2 messenger ribonucleic acid expression in the rat placenta and decidua during late pregnancy. Biol Reprod 1996;55:1023-1028.
42. Canlon B, Erichsen S, Nemlander E, Chen M, Hossain A, Celsi G, Ceccatelli S. Alterations in the intrauterine environment by glucocorticoids modifies the developmental programme of the auditory system. Eur J Neurosci 2003;17:2035-2041.
43. Causevic M, Mohaupt M. 11β-Hydroxysteroid dehydrogenue type 2 in pregnancy and preeclampsia. Mol Aspects Med 2007;28:220-226.
44. Chan CC, Lao TT, Ho PC, Sung EO, Cheung AN. The effect of mifepristone on the expression of steroid hormone receptors in human decidua and placenta: A randomized placebo-controlled double-blind study. J Clin Endocrinol Metab 2003;88:5846-5850.
45. Chan J, Rabbitt EH, Innes BA, Bulmer JN, Stewart PM, Kilby MD, Hewison M. Glucocorticoid-induced apoptosis in human decidua: A novel role for 11β-hydroxysteroid dehydrogenase in late gestation. J Endocrinol 2007;195:7-15.
46. Chard T. Cytokines in implantation. Hum Reprod Update 1995;1 385-396.
47. Challis JRG, Matthews SG, Gibb W, Lye SJ. Endocrine and paracrine regulation of birth at term and preterm. Endocr Rev 2000;21 514-550.
48. Cheng YH, Nicholson RC, King B, Chan EC, Fitter JT, Smith R. Glucocorticoid stimulation of corticotropin-releasing hormone gene expression requires a cyclic adenosine 3′,5′-monophosphate regulatory element in human primary placental cytotrophoblast cells. J Clin Endocrinol Metab 2000;85:1937-1945.
49. Chisaka H, Johnstone JF, Premyslova M, Manduch Z, Challis JR. Effect of pro-inflammatory cytokines on expression and activity of 11β-hydroxysteroid dehydrogenase type 2 in cultured human term placental trophoblast and human choriocarcinoma JEG-3 cells. J Soc Gynecol Investig 2005;12:303-309.
50. Clark PM. Programming of the hypothalamo-pituitary-adrenal axis and the fetal origins of adult disease hypothesis. Eur J Pediatr 1998; 157:S7-S10.
51. Clarke KA, Ward JW, Forhead AJ, Giussani DA, Fowden AL. Regulation of 11β-hydroxysteroid dehydrogenase type 2 activity in ovine placenta by fetal cortisol. J Endocrinol 2002;172:527-534.
52. Clifton VL, Rennie N, Murphy VE. Effect of inhated glucocorticoid treatment on placental 11β-hydroxysteroid dehydrogenase type 2 activity and neonatal birthweight in pregnancies and complicated by asthma. Aust N Z J Obstet Gynaecol 2006;46:136-140.
53. Condon J, Gosden C, Gardener D, Nickson P, Hewison M, Howie AJ, Stewart PM. Expression of type 2 11β-hydroxysteroid dehydrogenase and corticosteroid hormone receptors in early human fetal life. J Clin Endocrinol Metab 1998;83:4490-4497.
54. Crocker IP, Barratt S, Kaur M, Baker PN. The in-vitro characterization of induced apoptosis in placental cytotrophoblasts and syncytiotrophoblasts. Placenta 2001;22:822-830.
55. Crocker IP, Cooper S, Ong SC, Baker PN. Differences in apoptotic susceptibility of cytotrophoblasts and syncytiotrophoblasts in normal pregnancy to those complicated with preeclampsia and intrauterine growth restriction. Am J Pathol 2003;162:637-643.
56. Cross JC, Nakano H, Natale DR, Simmons DG, Watson ED. Branching morphogenesis during development of placental villi. Differentiation 2006;74:393-401.
57. Crowther CA, Harding JE. Repeat doses of prenatal corticosteroids for women at risk of preterm birth for preventing neonatal respiratory disease. Cochrane Database Syst Rev 2007;3:CD003935.
58. Darnel AD, Archer K, Yang K. Regulation of 11β-hydroxysteroid dehydrogenase type 2 by steroid hormones and epidermal growth factor in the Ishikawa human endometrial cell line. J Ster Biochem Mol Biol 1999;70:203-210.
59. De Blasio MJ, Dodic M, Jefferies AJ, Moritz KM, Wintour EM, Owens JA. Maternal exposure to dexamethasone or cortisol in early pregnancy differentially alters insulin secretion and glucose homeostasis in adult male sheep offspring. Am J Physiol Endocrinol Metab 2007;293 75-82.
60. de Vries A, Holmes MC, Heijnis A, Seier JV, Heerden J, Louw J, Wolfe-Coote S, Meaney MJ, Levitt NS, Seckl JR. Prenatal dexamethasone exposure induces changes in nonhuman primate offspring cardiometabolic and hypothalamic-pituitary-adrenal axis function. J Clin Invest 2007;117:1058-1067.
61. de Weerth C, van Hees Y, Buitelaar JK. Prenatal maternal cortisol levels and infant behavior during the first 5 months. Early Hum Dev 2003;74: 139-151.
62. d'Hauterive SP, Berndt S, Tsamplas M, Charlet-Renard C, Dubois M, Bourgain C, Hazout A, Foidart JM, Geenen V. Dialogue between blastocyst hCG and endometrial LH/hCG receptor: Which role in implantation? Gynecol Obstet Invest 2007;64:156-160.
63. Demoly P, Piette V, Daures JP. Asthma therapy during pregnancy. Expert Opin Pharmacother 2003;4:1019-1023.
64. Dodic M, May CN, Wintour EM, Coghlan JP. An early prenatal exposure to excess glucocorticoid leads to hypertensive offspring in sheep. Clin Sci (Lond) 1998;94:149-155.
65. Dodic M, Peers A, Coghlan JP, May CN, Lumbers E, Yu Z, Wintour EM. Altered cardiovascular haemodynamics and baroreceptor-heart rate reflex in adult sheep after prenatal exposure to dexamethasone. Clin Sci (Lond) 1999;97:103-109.
66. Dodic M, Samuel C, Moritz K, Wintour EM, Morgan J, Grigg L, Wong J. Impaired cardiac functional reserve and left ventricular hypertrophy in adult sheep after prenatal dexamethasone exposure. Circ Res 2001;89:623-629.
67. Dodic M, Abouantoun T, O'Connor A, Wintour EM, Moritz KM. Programming effects of short prenatal exposure to dexamethasone in sheep. Hypertension 2002a;40:729-734.
68. Dodic M, Hantzis V, Duncan J, Rees S, Koukoulas I, Johnson K, Wintour EM, Moritz K. Programming effects of short prenatal exposure to cortisol. FASEB J 2002b;16:1017-1026.
69. Doyle LW, Ford GW, Davis NM, Callanan C. Antenatal corticosteroid therapy and blood pressure at 14 years of age in preterm children. Clin Sci (Lond). 2000;98:137-142.
70. Drake AJ, Tang JI, Nyirenda MI. Mechanisms underlying the role of glucocorticoids in the early life programming of adult disease. Clin Sci (Lond) 2007;113:219-232.
71. Draper N, Stewart PM. 11β-Hydroxysteroid dehydrogenase and the pre-receptor regulation of corticosteroid hormone action. J Endocrinol 2005;186:251-271.
72. Driver PM, Kilby MD, Bujalska I, Walker EA, Hewison M, Stewart PM. Expression of 11β-hydroxysteroid dehydrogenase isozymes and corticosteroid hormone receptors in primary cultures of human trophoblast and placental bed biopsies. Mol Hum Reprod 2001;7 357-363.
73. Driver PM, Rauz S, Walker EA, Hewison M, Kilby MD, Stewart PM. Characterization of human trophoblast as a mineralocorticoid target tissue. Mol Hum Reprod 2003;9:793-798.
74. Eberhart CO, Argani P. Wnt signaling in human development: Beta-catenin nuclear translocation in fetal lung, kidney, placenta, capillaries, adrenal, and cartilage. Pediart Dev Pathol 2001;4:351-357.
75. Economopoulos P, Sun M, Purgina B, Gibb W. Glucocorticoids stimulate prostaglandin H synthase type-2 (PGHS-2) in the fibroblast cells in human amnion cultures. Mol Cell Endocrinol 1996;25:141-147.
76. Edwards CRW, Benediktsson R, Lindsay RS, Seckl JR. Dysfunction of placental glucocorticoid barrier: Link between fetal environment and adult hypertension. Lancet 1993;341:355-357.
77. Edwards CRW, Benediktsson R, Lindsay RS, Seckl JR. 11β-hydroxysteroid dehydrogenases: Key enzymes in determining tissue-specific glucocorticoid effects. Steroids 1996;61:263-269.
78. Emgard M, Paradisi M, Pirondi S, Fernandez M, Giardino L, Calza L. Prenatal glucocorticoid exposure affects learning and vulnerability of cholinergic neurons. Neurobiol Aging 2007;28:112-121.
79. Empson M, Lassere M, Craig J, Scott J. Prevention of recurrent miscarriage for women with antiphospholipid antibody or lupus anticoagulant. Cochrane Database Syst Rev 2005;2:CD002859.
80. Erickson K, Thorsen P, Chrousos G, Grigoriadis DE, Khongsaly O, McGregor J, Schulkin J. Preterm birth: Associated neuroendocrine, medical, and behavioural risk factors. J Clin Endocrinol Metab 2001;86 2544-2552.
81. Ericsson A, Hamark B, Jansson N, Johansson BR, Powell TL, Jansson T. Hormonal regulation of glucose and system A amino acid transport in first trimester placental villous fragments. Am J Physiol Regul Integr Comp Physiol 2005;288:R656-R662.
82. Estelles A, Gilabert J, Keeton M, Eguchi Y, Amar J, Grancha S, Espna F, Loskutoff DJ, Schleef RR. Altered expression of plasminogen activator inhibitor type 1 in placentas from pregnant women with preeclampsia and/ or intrauterine fetal growth retardation. Blood 1994;84 143-150.
83. Feroze-Zaidi F, Fusi L, Takano M, Higham J, Salker MS, Goto T, Edassery S, Klingel K, Boini KM, Palmada M et al. Role and regulation of the serum-and glucocorticoid-regulated kinase 1 in fertile and infertile human endometrium. Endocrinology 2007;148:5020-5029.
84. Feinberg RF, Kao LC, Haimowitz JE, Queenan JT, Jr, Wun TC, Strauss JF, Kliman HJ. Plasminogen activator inhibitor types 1 and 2 in human trophoblasts. PAI-1 is an immunocytochemical marker of invading trophoblasts. Lab Invest 1989;61:20-26.
85. Field T, Diego M, Hernandez-Reif M, Gil K, Vera Y. Prenatal maternal cortisol, fetal activity and growth. Int J Neurosci 2005;115 423-429.
86. Field T, Hernandez-Reif M, Diego M, Figueiredo B, Schanberg S, Kuhn C. Prenatal cortisol, prematurity and low birthweight. Infant Behav Dev 2006;29:268-275.
87. Florio P, Imperatore A, Sanseverino F, Torricelli M, Reis FM, Lowry PJ, Petraglia F. The measurement of maternal plasma corticotropin-releasing factor (CRF) and CRF-binding protein improves the early prediction of preeclampsia. J Clin Endocrinol Metab 2004;89:4673-4677.
88. Flower RJ, Rothwell NJ. Lipocortin-1: Cellular mechanisms and clinical relevance. Trends Pharmacol Sci 1994;15:71-76.
89. Fowden AL. The insulin-like growth factors and feto-placental growth. Placenta 2003;24:803-812.
90. Fowden AL, Forhead AJ. Endocrine mechanisms of intrauterine programming. Reproduction 2004;127:515-526.
91. Fowden AL, Szemere J, Hughes P, Gilmour RS, Forhead AJ. The effects of cortisol on the growth rate of the sheep fetus during late gestation. J Endocrinol 1996;151:97-105.
92. Fowden AL, Ward JW, Wooding FP, Forhead AJ, Constancia M. Programming placental nutrient transport capacity. J Physiol 2006;572 5-15.
93. French NP, Hagan R, Evans SF, Godfrey M, Newnham JP. Repeated antenatal corticosteroids: Size at birth and subsequent development. Am J Obstet Gynecol 1999;180:114-121.
94. Funder JW. Apparent mineralocorticoid excess, 11β-hydroxysteroid dehydrogenase and aldosterone action: Closing one loop, opening another. Trends Endocrinol Metab 1995;6:248-251.
95. Funder JW. Glucocorticoid and mineralocorticoid receptors: Biology and clinical relevance. Annu Rev Med 1997;48:231-240.
96. Gesina E, Tronche F, Herrera P, Duchene B, Tales W, Czernichow P, Breant B. Dissecting the role of glucocorticoids on pancreas development. Diabetes 2004;53:2322-2329.
97. Gesina E, Blondeau B, Milet A, Le Nin I, Duchene B, Czernichow P, Scharfmann R, Tronche F, Breant B. Glucocorticoid signalling affects pancreatic development through both direct and indirect effects. Diabetologia 2006;49:2939-2947.
98. Gharraee Z, Beharry KD, Valencia AM, Cho S, Guajardo L, Nageotte MP, Modanlou HD. Effects of antenatal betamethasone on maternal and fetoplacental matrix metalloproteinases 2 and 9 activities in human singleton pregnancies. J Investig Med 2006;54:245-254.
99. Giannopoulos G, Jackson K, Tulchinsky D. Glucocorticoid metabolism in human placenta, decidua, myometrium and fetal membranes. J Steroid Biochem 1982;17:371-374.
100. Gibb W, Breton R. Studies on the action of dexamethasone on prostaglandin production by freshly dispersed amnion cells. Acta Endocrinol (Copenh) 1993;128:563-567.
101. Giraud GD, Louey S, Jonker S, Schultz J, Thornburg KL. Cortisol stimulates cell cycle activity in the cardiomyocyte of the sheep fetus. Endocrinology 2006;147:3641-3642.
102. Goland RS, Tropper P, Warren W, Stark R, Jozak S, Conwell I. Concentrations of corticotropin-releasing hormone in the umbilical cord blood of pregnancies complicated by preeclampsia. Reprod Fertil Dev 1995;7:1227-1230.
103. Graf R, Gossrau R, Frank HG. Placental toxicity in rats after administration of synthetic glucocorticoids. A morphological, histochemical and immunohistochemical investigation. Anat Embryol (Berl). 1989;180:121-130.
104. Grancha S, Estelles A, Gilabert J, Chirivella M, Espana F, Aznar J. Decreased expression of PAI-2 mRNA and protein in pregnancies complicated with intrauterine fetal growth retardation. Thromb Haemost 1996;76:761-767.
105. Gravanis A, Makrigiannakis A, Zoumakis E, Margioris AN. Endometrial and myometrial corticotropin-releasing hormone (CRH): Its regulation and possible roles. Peptides 2001;22:785-793.
106. Guller S, Markiewicz L, Wozniak R, Burnham JM, Wang EY, Kaplan P, Lockwood CJ. Developmental regulation of glucocorticoid-mediated effects on extracellular matrix protein expression in the human placenta. Endocrinology 1994;134:2064-2071.
107. Gullet S, Kong L, Wozniak R, Lockwood CJ. Reduction of extracellular matrix protein expression in human amnion epithelial cells by glucocorticoids: A potential role in preterm rupture of the fetal membranes. J Clin Endocr Metab 1995a;80:2244-2250.
108. Gullet S, Kong L, Wozniak R, Lockwood CJ. Opposing actions of transforming growth factor-β and glucocorticoids in the regulation of fibronectin expression in the human placenta. J Clin Endocr Metab 1995b; 80:3273-3278.
109. Gur C, Diav-Citrin O, Shechtman S, Amon J, Ornoy A. Pregnancy outcome after first trimester exposure to corticosteroids: A prospective controlled study. Reprod Toxicol 2004;18:93-101.
110. Hahn T, Barth S, Graf R, Engelmann M, Beslagic D, Reul JM, Holsboer F, Dohr G, Desoye G. Placental glucose transporter expression is regulated by glucocorticoids. J Clin Endocr Metab 1999;84:1445-1452.
111. Handschuh K, Guibourdenche J, Tsatsaris V, Guesnon M, Laurendeau I, Evain-Brion D, Fournier T. Human chorionic gonadotropin produced by the invasive trophoblast but not the villous trophoblast promotes cell invasion and is down-regulated by peroxisome proliferator-activated receptor-γ. Endocrinology 2007;148:5011-5019.
112. Hanson FW, Powell JE, Stevens VC. Effects of HCG and human pituitary LH on steroid secretion and functional life of the human corpus luteum. J Clin Endoctinol Metab 1971;32:211-215.
113. Hardy DB, Yang K. The expression of 11β-hydroxysteroid dehydrogenase type 2 is induced during trophoblast differentiation: Effects of hypoxia. J Clin Endocrinol Metab 2002;87:3696-3701.
114. Hardy DB, Pereria LE, Yang K. Prostaglandins and leukotriene B4 are potent inhibitors of 11β-hydroxysteroid dehydrogenase type 2 activity in human choriocarcinoma JEG-3 cells. Biol Reprod 1999;61 40-45.
115. Hardy DB, Dixon SJ, Narayan N, Yang K. Calcium inhibits human placental 11β-hydroxysteroid dehydrogenase type 2 activity. Biochem Biophys Res Comm 2001;283:756-761.
116. Hayashi R, Wada H, Ito K, Adcock IM. Effects of glucocorticoids on gene transcription. Eur J Pharm 2004;500:51-62.
117. Heilmann P, Buchheim E, Wacker J, Ziegler R. Alteration of the activity of the 11β-hydroxysteroid dehydrogenase in pregnancy: Relevance for the development of pregnancy-induced hypertension? J Clin Endocr Metab 2001;86:5222-5226.
118. Henderson TA, Saunders PT, Moffett-King A, Groome NP, Critchley HO. Steroid receptor expression in uterine natural killer cells. J Clin Endocr Metab 2003;88:440-449.
119. Hewitt DP, Mark PJ, Waddell BJ. Placental expression of peroxisome proliferator-activated receptors in rat pregnancy and the effect of increased glucocorticoid exposure. Biol Reprod 2006a;74 23-28.
120. Hewitt DP, Mark PJ, Dharmarajan AM, Waddell BJ. Placental expression of secreted frizzled related protein-4 in the rat and the impact of glucocorticoid-induced fetal and placental growth restriction. Biol Reprod 2006b;75:75-81.
121. Hirasawa G, Sasano H, Suzuki T, Takeyama J, Muramatu Y, Fukushima K, Hiwatashi N, Toyota T, Nagura H, Krozowski ZS. 11β-hydroxysteroid dehydrogenase type 2 and mineralocorticoid receptor in human fetal development. J Clin Endocrinol Metab 1999;84:1453-1458.
122. Hirasawa G, Takeyama J, Sasano H, Fukushima K, Suzuki T, Muramatu Y, Darnel AD, Kaneko C, Hiwatashi N, Toyota T et al. 11β-hydroxysteroid dehydrogenase type II and mineralocorticoid receptor in human placenta. J Clin Endocrinol Metab 2000;85:1306-1309.
123. Hobel CJ, Dunkel-Schetter C, Roesch SC, Castro LC, Arora CP. Maternal plasma corticotropin-releasing hormone associated with stress at 20 weeks' gestation in pregnancies ending in preterm delivery. Am J Obstet Gynecol 1999;180:257-263.
124. Hofmann GE, Glatstein I, Schatz F, Heller D, Deligdisch L. Immunohistochemical localization of urokinase-type plasminogen activator and the plasminogen activator inhibitors 1 and 2 in early human implantation sites. Am J Obstet Gynecol 1994;170:671-676.
125. Hofmann M, Pollow K, Bahlmann F, Casper F, Steiner E, Brockerhoff P. 11β-hydroxysteroid dehydrogenase (11β-HSD-II) activity in human placenta: Its relationship to placental weight and birth weight and its possible role in hypertension. J Perinat Med 2001;29:23-30.
126. Holmes MC, Abrahamsen CT, French KL, Paterson JM, Mullins JJ, Seckl JR. The mother or the fetus? 11β-hydroxysteroid dehydrogenase type 2 null mice provide evidence for direct fetal programming of behavior by endogenous glucocorticoids. J Neurosci 2006;26:3840-3844.
127. Homan A, Guan H, Hardy DB, Gratton RJ, Yang K. Hypoxia blocks 11β-hydroxysteroid dehydrogenase type 2 induction in human trophoblast cells during differentiation by a time-dependent mechanism that involves both translation and transcription. Placenta 2006;27: 832-840.
128. Huang WL, Beazley LD, Quinlivan JA, Evans SF, Newnham JP, Dunlop SA. Effect of corticosteroids on brain growth in fetal sheep. Obstet Gynecol 1999;94:213-218.
129. Huang WL, Harper CG, Evans SF, Newnham JP, Dunlop SA. Repeated prenatal corticosteroid administration delays myelination of the corpus callosum in fetal sheep. Int J Dev Neurosci 2001;19:415-425.
130. Hundertmark S, Buhler H, Fromm M, Kruner-Gareis B, Kruner M, Ragosch V, Kuhlmann K, Seckl JR. Ontogeny of 11β-hydroxysteroid dehydrogenase: activity in the placenta, kidney, colon of fetal rats and rabbits. Horm Metab Res 2001;33:78-83.
131. Ikegami M, Jobe AH, Newnham J, Polk DH, Willet KE, Sly P. Repetitive prenatal glucocorticolds improve lung function and decrease growth in preterm lambs. Am J Respir Crit Care Med 1997;156:178-184.
132. Imseis HM, Zimmerman PD, Samuels P, Kniss DA, Tumour necrosis factor-α induces cyclo-oxygenase-2 gene expression in first trimester trophoblasts: Suppression by glucocorticoids and NSAIDs. Placenta 1997;18:521-526.
133. Islami D, Mock P, Bischof P. Effects of human chorionic gonadotropin on trophoblast invasion. Semin Reprod Med 2001;19:49-53.
134. Jaggers DC, Collins WP, Milligan SR. Potent inhibitory effects of steroids in an in vitro model of angiogenesis. J Endocrinol 1996;150:457-464.
135. Jansson T, Powell TL. Role of the placenta in fetal programming: underlying mechanisms and potential interventional approaches. Clin Sci (Lond) 2007;113:1-13.
136. Jaquiery AL, Oliver MH, Bloomfield FH, Connor KL, Challis JR, Harding JE. Fetal exposure to excess glucocorticoid is unlikely to explain the effects of periconceptional undernutrition in sheep. J Physiol 2006;572:109-118.
137. Jellyman JK, Gardner DS, Fowden AL, Giussani DA. Effects of dexamethasone on the uterine and umbilical vascular beds during basal and hypoxemic conditions in sheep. Am J Obstet Gynecol 2004;190 825-835.
138. Jensen EC, Gallaher BW, Breier BH, Harding JE. The effect of a chronic maternal cortisol infusion on the late-gestation fetal sheep. J Endocrinol 2002;174:27-36.
139. Johnstone JF, Bocking AD, Unlugedik E, Challis JR. The effects of chorioamnionitis and betamethasone on 11β-hydroxysteroid dehydrogenase types 1 and 2 and the glucocorticoid receptor in preterm human placenta. J Soc Gynecol Investig 2005;12:238-245.
140. Jones HN, Ashworth CJ, Page KR, McArdle HJ. Cortisol stimulates system A amino acid transport and SNAT2 expression in a human placental cell line (BeWo). Am J Physiol Endociinol Metab 2006;291:E596-E603.
141. Jones SA, Brooks AN, Challis JR. Steroids modulate corticotropin-releasing hormone production in human fetal membranes and placenta. J Clin Endocrinol Metab 1989;68:825-830.
142. Julan L, Guan H, van Beek JP, Yang K. Peroxisome proliferator-activated receptor δ suppresses 11β-hydroxysteroid dehydrogenase type 2 gene expression in human placental trophoblast cells. Endocrinology 2005;146:1482-1490.
143. Jung SP, Siegrist B, Wade MR, Anthony CT, Woltering EA. Inhibition of human angiogenesis with heparin and hydrocortisone. Angiogenesis 2001;4:175-186.
144. Kajantie E, Dunkel L, Turpeinen U, Stenman UH, Wood PJ, Nuutila M, Andersson S. Placental 11β-hydroxysteroid dehydrogenase-2 and fetal cortisol/cortisone shuttle in small preterm infants. J Clin Endocrinol Metab 2003;88:493-500.
145. Kajantie E, Dunkel L, Turpeinen U, Stenman U-H, Andersson S. Placental 11βHSD2 activity, early postnatal clinical course and adrenal function in extremely low birth weight infants. Ped Res 2006;59 575-578.
146. Kalantaridou S, Makrigiannakis A, Zoumakis E, Chrousos GP. Peripheral corticotropin-releasing hormone is produced in the immune and reproductive systems: Actions, potential roles and clinical implications. Front Biosci 2007;12:572-580.
147. Kapoor A, Dunn E, Kostaki A, Andrews MH, Matthews SG. Fetal programming of hypothalamo-pituitary-adrenal function: Prenatal stress and glucocorticoids. J Physiol 2006;572:31-44.
148. Keay SD, Harlow CR, Wood PJ, Jenkins JM, Cahill DJ. Higher cortisol: cortisone ratios in the preovulatory follicle of completely unstimulated IVF cycles indicate oocytes with increased pregnancy potential. Hum Reprod 2002;17:2410-2414.
149. Kelly RW, King AE, Critchley HOD. Cytokine control in human endometrium. Reproduction 2001;121:3-19.
150. Kerzner LS, Stonestreet BS, Wu K-Y, Sadowska G, Malee MP. Antenatal dexamethasone: Effect on ovine placental 11β-hydroxysteroid dehydrogenase type 2 expression and fetal growth. Ped Res 2002; 52:706-712.
151. Kino T, Chrousos GP. Glucocorticoid and mineralocorticoid receptors and associated diseases. Essays Biochem 2004;40:137-155.
152. Klemcke HG, Sarnpath-Kumar R, Yang K, Vallett JL, Christenson RK. 11β-hydroxysteroid dehydrogenase and glucocorticoid receptor mRNA expression in porcine placentae: Effects of stage of gestation, breed, and uterine environment. Biol Reprod 2003;69:1945-1950.
153. Klemcke HG, Vallett JL, Christenson RK. Lack of effect of metyrapone and exogenous cortisol on early porcine conceptus development. Exp Physiol 2006;91:521-530.
154. Knaggs P, Lambert A, Proudfoot F, Nickson I, Hooper MAK, Lemon E, Robertson WR. A rapid method for the measurement of the oxoreductase activity of 11β-hydroxysteroid dehydrogenase in granulosa-lutein cells from patients undergoing in-vitro fertilization. Mol Hum Reprod 1998;4:147-151.
155. 2+ and cAMP pathways. Am J Physiol Endocrinol Metab 2006;290:E282-E288.
156. Kossmann JC, Bard H, Gibb W. Characterization of specific steroid binding in human amnion at term. Biol Reprod 1982;27:320-326.
157. Koyama K, Krozowski ZS. Modulation of 11β-hydroxysteroid dehydrogenase type 2 activity in Ishikawa cells is associated with changes in cellular proliferation. Mol Cell Endocrinol 2001;183:165-170.
158. Kranendonk G, Hopster H, Fillerup M, Ekkel ED, Mulder EJ, Wiegant VM, Taverne MA. Lower birth weight and attenuated adrenocortical response to ACTH in offspring from sows that orally received cortisol during gestation. Dom Anim Endocrinol 2006a;30:218-238.
159. Kranendonk G, Hopster H, Fillerup M, Ekkel ED, Mulder EJ, Taverne MA. Cortisol administration to pregnant sows affects novelty-induced locomotion, aggressive behaviour, and blunts gender differences in their offspring. Horm Behav 2006b;49:663-672.
160. Krozowski ZS. The 11β-hydroxysteroid dehydrogenases: Functions and physiological effects. Mol Cell Endocrinol 1999;151:121-127.
161. Krozowski ZS, Maguire JA, Stein-Oakley AN, Dowling J, Smith RE, Andrews RK. Immunohistochemical localization of the 11β-hydroxysteroid dehydrogenase type II enzyme in human kidney and placenta. J Clin Endocrinol Metab 1995;80:2203-2209.
162. Laatikainen T, Virtanen T, Kaaja R, Salminen-Lappalainen K. Corticotropin-releasing hormone in maternal and cord plasma in pre-eclampsia. Eur J Obstet Gynecol Reprod Biol 1991;39 19-24.
163. Lang F, Bohmer C, Palmada M, Seebohm G, Strutz-Seebohm N, Vallon V. (Patho)physiological significance of the serum- and glucocorticoid-inducible kinase isoforms. Physiol Rev 2006;86 1151-1178.
164. Langdown ML, Sugden MC. Enhanced placental GLUT1 and GLUT3 expression in dexamethasone-induced fetal growth retardation. Mol Cell Endocrinol 2001;185:109-117.
165. Langley-Evans SC. Intrauterine programming of hypertension by glucocorticoids. Life Sci 1997a;60:1213-1221.
166. Langley-Evans SC. Maternal carbenoxolone treatment lowers birthweight and induces hypertension in the offspring of rats fed a protein-replete diet. Clin Sci 1997b;93:423-429.
167. Langlois DA, Matthews SG, Yu M, Yang K. Differential expression of 11β-hydroxysteroid dehydrogenase 1 and 2 in the developing ovine fetal liver and kidney. J Endocrinol 1995;147:405-411.
168. Lakshini V, Nath N, Muneyyirci-Delale O. Characterization of 11β-hydroxysteroid dehydrogenase of human placenta: Evidence for the existence of two species of 11β-hydroxysteroid dehydrogenase. J Ster Biochem Mol Biol 1993;45:391-397.
169. Laskin CA, Bombardier C, Hannah ME, Mandel FP, Ritchie JW, Farewell V, Farine D, Spitzer K, Fielding L, Soloninka CA et al. Prednisone and aspirin in women with autoantibodies and unexplained recurrent fetal loss. N Engl J Med 1997;337:148-153.
170. Lee MJ, Ma Y, LaChapelle L, Kadner SS, Guller S. Glucocorticoid enhances transforming growth factor-β effects on extracellular matrix protein expression in human placental mesenchymal cells. Biol Reprod 2004;70:1246-1252.
171. Lee MJ, Wang Z, Yee H, Ma Y, Swenson N, Yang L, Kadner SS, Baergen RN, Logan SK, Garabedian MJ et al. Expression and regulation of glucocorticoid receptor in human placental villous fibroblasts. Endocrinology 2005;146:4619-4626.
172. Lesage J, Blondeau B, Grino M, Breant B, Dupouy JP. Maternal undernutrition during late gestation induces fetal overexposure to glucocorticoids and intrauterine growth retardation, and disturbs the hypothalamo-pituitary adrenal axis in the newborn rat. Endocrinology 2001;142:1692-1702.
173. Leung TN, Chung TKH, Madsen G, Lam PKW, Sabota D, Smith R. Rate of rise in maternal plasma corticotropin-releasing hormone and its relation to gestational length. Br J Obstet Gynaecol 2001;108:527-532.
174. Levitt NS, Lindsay RS, Holmes MC, Seckl JR. Dexamethasone in the last week of pregnancy attenuates hippocampal glucocorticoid receptor gene expression and elevates blood pressure in the adult offspring in the rat. Neuroendocrinology 1996;64:412-418.
175. Levitz M, Jansen V, Dancis J. The transfer and metabolism of corticosteroids in the perfused human placenta. Am J Obstet Gynecol 1978;132:363-366.
176. Lewicka S, von Hagens C, Hettinger U, Grunwald K, Vecsei P, Runnebaum B, Rabe T. Cortisol and cortisone in human follicular fluid and serum and the outcome of IVF treatment. Hum Reprod 2003;18: 1613-1617.
177. Li K, Smith RE, Ferrari P, Funder JW, Krozowski ZS. Rat 11β-hydroxysteroid dehydrogenase type 2 enzyme is expressed at low levels in the placenta and is modulated by adrenal steroids in the kidney. Mol Cell Endocrinol 1996;120:67-75.
178. Li X, Wong J, Tsai SY, Tsai MJ, O'Malley BW. Progesterone and glucocorticoid receptors recruit distinct coactivator complexes and promote distinct patterns of local chromatin modification. Mol Cell Biol 2003;23:3763-3773.
179. Li W, Gao L, Wang Y, Duan T, Myatt L, Sun K. Enhancement of cortisol-induced 11β-hydroxysteroid dehydrogenase type 1 expression by interleukin 1β in cultured human chorionic trophoblast cells. Endocrinology 2006;147:2490-2495,
180. Librach CL, Feigenbaum SL, Bass KE, Cui TY, Verastas N, Sadovsky Y, Quigley JP, French DL, Fisher SJ. Interleukin-1b regulates human cytotrophoblast metalloproteinase activity and invasion in vitro. J Biol Chem 1994;269:17125-17131.
181. Licht P, Russu V, Lehmeyer S, Wildt L. Molecular aspects of direct LH/ hCG effects on human endometrium - lessons from intrauterine microdialysis in the human female in vivo. Reprod Biol 2001;1 10-19.
182. Lindsay RS, Lindsay RM, Edwards CRW, Seckl JR. Inhibition of 11β-hydroxysteroid dehydrogenase in pregnant rats and the programming of blood pressure in the offspring. Hypertension 1996a;27 1200-1204.
183. Lindsay RS, Lindsay RM, Waddell BJ, Seckl JR. Prenatal glucocorticoid exposure leads to offspring hyperglycaemia in the rat: Studies with the 11β-hydroxysteroid dehydrogenase inhibitor carbenoxolone. Diabetologia 1996b;39:1299-1305.
184. Liu Y, Li A, Matthews SG. Maternal glucocorticoid treatment programs HPA regulation in adult offspring: Sex-specific effects. Am J Physiol Endocrinol Metab 2001;280:E729-E739.
185. Lopez-Bernal A, Craft IL. Corticosteroid metabolism in vitro by human placenta, fetal membranes and decidua in early and late gestation. Placenta 1981;2:279-285.
186. Lopez-Bernal A, Anderson AB, Turnbull AC. The measurement of glucocorticoid receptors in human placental cytosol. Placenta 1984;5:105-116.
187. Loskutoff DJ, Sawdey M, Keeton M, Schneiderman J. Regulation of PAI-1 gene expression in vivo. Thromb Haemost 1993;70:135-137.
188. Lu NZ, Wardell SE, Burnstein KL, Defranco D, Fuller PJ, Giguere V, Hochberg RB, McKay L, Renoir JM, Weigel NL et al. International Union of Pharmacology. LXV. The pharmacology and classification of the nuclear receptor superfamily: Glucocorticoid, mineralocorticoid, progesterone, and androgen receptors. Pharmacol Rev 2006;58 782-797.
189. Ma Y, Ryu JS, Dulay A, Segal M, Guller S. Regulation of plasminogen activator inhibitor (PAI)-1 expression in a human trophoblast cell line by glucocorticoid (GC) and transforming growth factor (TGF)-β. Placenta 2002;23:727-734.
190. Ma XH, Wu WX, Nathanielsz PW. Gestation-related and betamethasone-induced changes in 11β-hydroxysteroid dehydrogenase types 1 and 2 in the baboon placenta. Am J Obstet Gynecol 2003;188 13-21.
191. Ma Y, Kadner SS, Guller S. Differential effects of lipopolysaccharide and thrombin on interleukin-8 expression in syncytiotrophoblasts and endothelial cells: Implications for fetal survival. Ann N Y Acad Sci 2004;1034:236-244.
192. Ma Y, Mor G, Abrahams VM, Buhimschi IA, Buhimschi CS, Guller S. Alterations in syncytiotrophoblast cytokine expression following treatment with lipopolysaccharide. Am J Reprod Immunol 2006;55 12-18.
193. Makrigiannakis A, Zoumakis E, Margioris AN, Stournaras C, Chrousos GP, Gravanis A. Regulation of the promoter of the human corticotropin-releasing hormone gene in transfected human endometrial cells. Neuroendocrinology 1996;64:85-92.
194. Makrigiannakis A, Margioris AN, Chatzaki E, Zoumakis E, Chrousos GP, Gravanis A. The decidualizing effect of progesterone may involve direct transcriptional activation of corticotrophin-releasing hormone from human endometrial stromal cells. Mol Hum Reprod 1999;5 789-796.
195. Makrigiannakis A, Zoumakis E, Kalantaridou S, Chrousos G, Gravanis A. Participation of maternal and fetal CRH in early phases of human implantation: The role of antalarmin. Curr Drug Targets Immune Endocr Metabol Disord 2004;4:75-78.
196. Makrigiannakis A, Minas V, Kalantaridou SN, Nikas G, Chrousos GP. Hormonal and cytokine regulation of early implantation. Trends Endocrinol Metab 2006;17:178-185.
197. Malassine A, Cronier L. Hormones and human trophoblast differentiation: a review. Endocrine 2002;19:3-11.
198. Mandl M, Ghaffari-Tabrizi N, Haas J, Nöhammer G, Desoye G. Differential glucocorticoid effects on proliferation and invasion of human trophoblast cell lines. Reproduction 2006;132:159-167.
199. Mantero F, Palermo M, Petrelli MD, Tedde R, Stewart PM, Shackleton CH. Apparent mineralocorticoid excess: Type I and type II. Steroids 1996;61:193-196.
200. Martins JP, Monteiro JC, Paixao AD. Renal function in rats subjected to prenatal dexamethasone. Clin Exp Pharmacol Physiol 2003;30 32-37.
201. Matthews SG. Antenatal glucocorticoids and programming of the developing CNS. Pediatr Res 2000;47:291-300.
202. Matthews SG. Early programming of the hypothalamo-pituitary-adrenal axis. Trends Endocrinol Metab 2002;13:373-380.
203. Matthews SG, Owen D, Kalabis G, Banjanin S, Setiawan EB, Dunn EA, Andrews MH. Fetal glucocorticoid exposure and hypothalamo-pituitary-adrenal (HPA) function after birth. Endocr Res 2004;30:827-836.
204. McCalla CO, Nacharaju VL, Muneyyirci-Delale O, Glasgow S, Feldman JG. Placental 11β-hydroxysteroid dehydrogenase activity in normotensive and pre-eclamptic pregnancies. Steroids 1998;63:511-515.
205. McDonald SE, Henderson TA, Gomez-Sanchez CE, Critchley HOD, Mason JI. 11β-hydroxysteroid dehydrogenases in human endometrium. Mol Cell Endocrinol 2006;248:72-78.
206. McLean M, Bistis A, Davies JJ, Woods R, Lowry PJ, Smith R. A placental clock controlling the length of human pregnancy. Nat Med 1995;1 460-463.
207. McMullen S, Osgerby JC, Thurston LM, Gadd TS, Wood PJ, Wathes DC, Michael AE. Alterations in placental 11β-hydroxysteroid dehydrogenase (11βHSD) activities and fetal cortisol:cOrtisone ratios induced by nutritional restriction prior to conception and at defined stages of gestation in ewes. Reproduction 2004127:717-725.
208. McNatt LG, Lane D, Clark AF. Angiostatic activity and metabolism of cortisol in the chorioallantoic membrane (CAM) of the chick embryo. J Steroid Biochem Mol Biol 1992;42:687-693.
209. McNeil CJ, Nwagwu MO, Finch AM, Page KR, Thain A, McArdle HJ, Ashworth CJ. Glucocorticoid exposure and tissue gene expression of 11βHSD-1, 11βHSD-2, and glucocorticoid receptor in a porcine model of differential fetal growth. Reproduction 2007;133:653-661.
210. McTernan CL, Draper N, Nicholson H, Chalder SM, Driver P, Hewison M, Kilby MD, Stewart PM. Reduced placental 11β-hydroxysteroid dehydrogenase type 2 mRNA levels in human pregnancies complicated by intrauterine growth restriction: An analysis of possible mechanisms. J Clin Endocrinol Metab 2001;86:4979-4983.
211. Meaney MJ, Szyf M, Seckl JR. Epigenetic mechanisms of perinatal. programming of hypothalamic-pituitary-adrenal function and health. Trends Mol Med 2007;13:269-277.
212. Michael AE. Life after liquorice: The link between cortisol and conception. Reprod Biomed Online 2003;7:683-690.
213. Michael AE, Gregory L, Walker SM, Antoniw JW, Shaw RW, Edwards CR, Cooke BA. Ovarian 11β-hydroxysteroid dehydrogenase: Potential predictor of conception by in-vitro fertilisation and embryo transfer. Lancet 1993;342:711-712.
214. Michael AE, Gregory L, Piercy EC, Walker SM, Shaw RW, Cooke BA. Ovarian 11β-hydroxysteroid dehydrogenase activity is inversely related to the outcome of in vitro fertilization-embryo transfer treatment cycles. Fertil Steril 1995;64:590-598.
215. Michael AE, Collins TD, Norgate DP, Gregory L, Wood PJ, Cooke BA. Relationship between ovarian cortisol:cOrtisone ratios and the clinical outcome of in vitro fertilization and embryo transfer (IVF-ET). Clin Endocrinol 1999;51:535-540.
216. Michael AE, Thurston LM, Rae MT. Glucocorticoid metabolism and reproduction: A tale of two enzymes. Reproduction 2003;126 425-441.
217. Mirazi N, Alfaidy N, Martin R, Challis JR. Effects of dexamethasone and sulfasalazine on prostaglandin E2 output by human placental cells in vitro. J Soc Gynecol Invest 2004;11:22-26.
218. Moritz KM, Johnson K, Douglas-Denton R, Wintour EM, Dodic M. Maternal glucocorticoid treatment programs alterations in the renin-angiotensin system of the ovine fetal kidney. Endocrinology 2002;143 4455-4463.
219. Moritz KM, Jefferies AJ, Wintour EM, Dodic M. Fetal renal and blood pressure responses to steroid infusion after early prenatal treatment with dexamethasone. Am J Physiol 2005;288:R62-R66.
220. Morrish DW, Dakour J, Li H. Functional regulation of human trophoblast differentiation. J Reprod Immunol 1998;39:179-195.
221. Moss TJ, Nitsos I, Harding R, Newnham. JP. Differential effects of maternal and fetal betamethasone injections in late-gestation fetal sheep. J Soc Gynecol Investig 2003;10:474-479.
222. Muller T, Nanan R, Dietl J. Effect of antenatal corticosteroid administration on Doppler flow velocity parameters in pregnancies with absent or reverse end-diastolic flow in the umbilical artery. Acta Obstet Gynecol Scand 2003;82:794-796.
223. Muneoka K, Mikuni M, Ogawa T, Kitera K, Kamei K, Takigawa M, Takahashi K. Prenatal dexamethasone exposure alters brain monoamine metabolism and adrenocortical response in rat offspring. Am J Physiol Regal Integr Comp Physiol 1997;273:R1669-R1675.
224. Muneyyirci-Delale O, Lakshmi V, McCalla CO, Karacan M, Neil G, Camilien L. Variations in human placental 11β-dehydrogenase and 11-oxoreductase activities of 11β-hydroxysteroid dehydrogenase enzyme during pregnancy. Early Pregnancy 1996;2:201-206.
225. Muneyyirci-Delale O, Nacharaju VL, Sidell J, Neil G, Karacan M, Camilien L, Temkin S, Abulafia O. 11β-hydroxysteroid dehydrogenase activity in pregnancies complicated by hydatidiform mole. Am J Reprod Immunol 2006;55:415-419.
226. Murphy BEP. Ontogeny of cortisol-cortisone interconversion in human tissues: A role for cortisone in human fetal development. J Steroid Biochem 1981;14:811-817.
227. Murphy VE, Clifton VL. Alterations in human placental 11β-hydroxysteroid dehydrogenase type 1 and 2 with gestational age and labour. Placenta 2003;24:739-744.
228. Murphy VE, Zakar T, Smith R, Giles WB, Gibson PG, Clifton VL. Reduced 11β-hydroxysteroid dehydrogenase type 2 activity is associated with decreased birth weight centile in pregnancies complicated by asthma. J Clin Endocr Metab 2002;87:1660-1668.
229. Murphy VE, Smith R, Giles WB, Clifton VL. Endocrine regulation of human fetal growth: The role of the mother, placenta, and fetus. Endocr Rev 2006;27:141-169.
230. Murphy VE, Fittock RJ, Zarzycki PK, Delahunty MM, Smith R, Clifton VL. Metabolism of synthetic steroids by the human placenta. Placenta 2007;28:39-46.
231. Nacharaju VL, Divald A, McCalla CO, Yang L, Muneyyirci-Delale O. 11β-hydroxysteroid dehydrogenase inhibitor carbenoxolone stimulates chorionic gonadotropin secretion from human term cytotrophoblast cells differentiated in vitro. Am J Reprod Immunol 2004;52:133-138.
232. Namazy JA, Schatz M. Update in the treatment of asthma during pregnancy. Clin Rev Allergy Immunol 2004;26:139-148.
233. Nepomnaschy PA, Welch KB, McConnell DS, Low BS, Strassmann BI, England BG. Cortisol levels and very early pregnancy loss in humans. Proc Natl Acad Sci USA 2006;103:3938-3942.
234. Newnham JP. Is prenatal glucocorticoid administration another origin of adult disease? Clin Exp Pharmacol Physiol 2001;28:957-961.
235. Newnham JP, Moss TJ. Antenatal glucocorticoids and growth: Single versus multiple doses in animal and human studies. Semin Neonatol 2001; 6:285-292.
236. Newnham JP, Evans SF, Godfrey M, Huang W, Ikegami M, Jobe A. Maternal, but not fetal, administration of corticosteroids restricts fetal growth. J Matern Fetal Med 1999;8:81-87.
237. Nicholson RC, King BR, Smith R. Complex regulatory interactions control CRH gene expression. Front Biosci 2004;9:32-39.
238. Nyirenda MJ, Seckl JR. Intrauterine events and the programming of adulthood disease: The role of fetal glucocorticoid exposure. Int J Mol Med 1998;2:607-614.
239. Nyirenda MJ, Lindsay RS, Kenyon CJ, Burchell A, Seckl JR. Glucocorticoid exposure in late gestation permanently programmes rat hepatic phosphoenolpyruvate carboxykinase and glucocorticoid receptor expression and causes glucose intolerance in adult offspring. J Clin Invest 1998;101:2174-2181.
240. Ogasawara M, Aoki K. Successful uterine steroid therapy in a case with a history of ten miscarriages. Am J Reprod Immunol 2000;44 253-255.
241. O'Regan D, Welberg LL, Holmes MC, Seckl JR. Glucocorticoid programming of pituitary-adrenal function: Mechanisms and physiological consequences. Semin Neonatol 2001;6:319-329.
242. Ortiz LA, Quan A, Weinberg A, Baum M. Effect of prenatal dexamethasone on rat renal development. Kidney Int 2001;59:1663-1669.
243. Ortiz LA, Quan A, Zarzar F, Weinberg A, Baum M. Prenatal dexamethasone programs hypertension and renal injury in the rat. Hypertension 2003;41:328-334.
244. Osur SL. The management of asthma and rhinitis during pregnancy. J Womens Health (Larchmt) 2005;14:263-276.
245. Papageorghiou AT, Campbell S. First trimester screening for preeclampsia. Curr Opin Obstet Gynecol 2006;18:594-600.
246. Pasqualini JR. Enzymes involved in the formation and transformation of steroid hormones in the fetal and placental compartments. J Ster Biochem Mol Biol 2005;97:401-415.
247. Pasquarette MM, Stewart PM, Ricketts ML, Imaishi J, Mason JI. Regulation of 11β-hydroxysteroid dehydrogenase type 2 activity and mRNA in human choriocarcinoma cells. J Mol Endocrinol 1996;16:269-275.
248. Patel FA, Challis JRG. Cortisol/progesterone antagonism in regulation of 15-hydroxysteroid dehydrogenase activity and mRNA levels in human chorion and placental trophoblast cells at term. J Clin Endocrinol Metab 2002;87:700-708.
249. Patel FA, Clifton VL, Chwalisz K, Challis JRG. Steroid regulation of prostaglandin dehydrogenase activity and expression in human term placenta and chorio-decidua in relation to labour. J Clin Endocrinol Metab 1999a;84:291-299.
250. Patel FA, Sun K, Challis JRG. Local modulation by 11β-hydroxysteroid dehydrogenase of glucocorticoid effects on the activity of 15-hydroxyprostaglandin dehydrogenase in human chorion and placental trophoblast cells. J Clin Endocrinol Metab 1999b;84:395-400.
251. Patel FA, Funder JW, Challis JRG. Mechanism of cortisol/progesterone antagonism in the regulation of 15-hydroxyprostaglandin dehydrogenase activity and messenger ribonucleic acid levels in human chorion and placental trophoblast cells at term. J Clin Endocrinol Metab 2003;88:2922-2933.
252. Pepe GJ, Babischkin JS, Burch MMG, Leavitt MG, Albrecht ED. Developmental increase in expression of the messenger ribonucleic acid and protein levels of 11β-hydroxysteroid dehydrogenase types 1 and 2 in the baboon placenta. Endocrinology 1996a;137:5678-5684.
253. Pepe GJ, Waddell BJ, Burch MG, Albrecht ED. Interconversion of cortisol and cortisone in the baboon placenta at midgestation: Expression of 11β-hydroxysteroid dehydrogenase type 1 messenger RNA. J Ster Biochem Mol Biol 1996b;58:403-410.
254. Pepe GJ, Burch MG, Albrecht ED. Expression of the 11beta-hydroxysteroid dehydrogenase types 1 and 2 proteins in human and baboon placental syncytiotrophoblast. Placenta 1999;20:575-582.
255. Pepe GJ, Burch MG, Albrecht ED. Estrogen regulates 11β-hydroxysteroid dehydrogenase-1 and -2 localization in placental syncitiotrophoblast in the second half of primate pregnancy. Endocrinology 2001;142 4496-4503.
256. Petrelli MD, Lim-Tio SS, Condon J, Hewison M, Stewart PM. Differential expression of nuclear 11β-hydroxysteroid dehydrogenase type 2 in mineralocorticoid receptor positive and negative tissues. Endocrinology 1997;138:3077-3080.
257. Phillips GD, Whitehead RA, Knighton DR. Inhibition by methylprednisolone acetate suggests an indirect mechanism for TGF-β induced angiogenesis. Growth Factors 1992;6:77-84.
258. Potter SM, Dennedy MC, Morrison JJ. Corticosteroids and fetal vasculature: Effects of hydrocortisone, dexamethasone and betamethasone on human umbilical artery. Br J Obst Gynaecol 2002;109 1126-1131.
259. Pountain GD, Keogan MT, Hazleman BL, Brown DL. Effects of single dose compared with three days' prednisolone treatment of healthy volunteers: contrasting effects on circulating lymphocyte subsets. J Clin Pathol 1993;46:1089-1092.
260. Quenby S, Farquharson R. Uterine natural killer cells, implantation failure and recurrent miscarriage. Reprod Biomed Online 2006;13 24-28.
261. Quenby S, Farquharson R, Young M, Vince G. Successful pregnancy outcome following 19 consecutive miscarriages: Case report. Hum Reprod 2003;18:2562-2564.
262. Quenby S, Kalumbi C, Bates M, Farquharson R, Vince G. Prednisolone reduces preconceptual endometrial natural killer cells in women with recurrent miscarriage. Fertil Steril 2005;84:980-984.
263. Rahimi R, Nikfar S, Abdollahi M. Increased morbidity and mortality in acute human organophosphate-poisoned patients treated by oximes: A meta-analysis of clinical trials. Hum Exp Toxicol 2006;25 447-452.
264. Reinisch JM, Simon NG, Karow WG, Gandelman R. Prenatal exposure to prednisone in humans and animals retards intrauterine growth. Science 1978;202:436-438.
265. Ricketts ML, Verhaeg JM, Bujalska I, Howie AJ, Rainey WE, Stewart PM. Immunohistochemical localization of type 1 11β-hydroxysteroid dehydrogenase in human tissues. J Clin Endocr Metab 1998;83 1325-1335.
266. Ringler GE, Kallen CB, Strauss JF. Regulation of human trophoblast function by glucocorticoids: Dexamethasone promotes increased secretion of chorionic gonadotropin. Endocrinology 1989;124:1625-1631.
267. Roberts D, Dalziel S. Antenatal corticosteroids for accelerating fetal lung maturation for women at risk of preterm birth. Cochrane Database Syst Rev 2006;3: CD004554.
268. Robinson BG, Emanuel RL, Frim DM, Majzoub JA. Glucocorticoid stimulates corticotropin-releasing hormone gene in human placenta. Proc Natl Acad Sci USA 1988;85:5244-5248.
269. Rodriguez JJ, Montaron MF, Petry KG, Aurousseau C, Marinelli M, Premier S, Rougon G, Le Moal M, Abrous DN. Complex regulation of the expression of the polysialylated form of the neuronal cell adhesion molecule by glucocorticoids in the rat hippocampus. Eur J Neurosci 1998;10 2994-3006.
270. Rogerson FM, Kayes KM, White PC. Variation in placental type 2 11β-hydroxysteroid dehydrogenase activity is not related to birth weight or placental weight. Mol Cell Endocrinol 1997;128 103-109.
271. Roghair RD, Lamb FS, Miller FJ, Jr, Scholz TD, Segar JL. Early gestation dexamethasone programs enhanced postnatal ovine coronary artery vascular reactivity. Am J Physiol Regul Integr Comp Physiol 2005;289 R1169-R1176.
272. Rosen T, Krikun G, Ma Y, Wang EY, Lockwood CJ, Gullet S. Chronic antagonism of nuclear factor-kappaB activity in cytotrophoblasts by dexamethasone: A potential mechanism for antiinflammatory action of glucocorticoids in human placenta. J Clin Endocrinol Metab 1998;3647-3652.
273. 2 integrin expression in cytotrophoblasts by glucocorticoids. Endocrinology 1999;140: 3904-3908.
274. Sampath-Kumar R, Matthews SG, Yang K. 11β-hydroxysteroid dehydrogenase type 2 is the predominant isozyme in the guinea pig placenta: Decreases in messenger ribonucleic acid and activity at term. Biol Reprod 1998;59:1378-1384.
275. Sandman CA, Glynn L, Schetter CD, Wadhwa P, Garite T, Chicz-DeMet A, Hobel C. Elevated maternal cortisol early in pregnancy predicts third trimester levels of placental corticotropin releasing hormone (CRH): priming the placental clock. Peptides 2006;27:1457-1463.
276. Sarkar S, Tsai S-W, Nguyen TT, Plevyak M, Padbury JF, Rubin LP. Inhibition of placental 11β-hydroxysteroid dehydrogenase type 2 by catecholamines via α-adrenergic signalling. Am J Physiol Regul Integr Comp Physiol 2001;281:R1966-R1974.
277. Schaiff WT, Barak Y, Sadovsky Y. The pleiotropic function of PPAR gamma in the placenta. Mol Cell Endocrinol 2006;249:10-15.
278. Schoof E, Girstl M, Frobenius W, Kirschbaum M, Repp R, Knerr I, Rascher W, Dotsch J. Course of placental 11β-hydroxysteroid dehydrogenase type 2 and 15-hydroxyprostaglandin dehydrogenase mRNA expression during human gestation. Eur J Endocrinol 2001a;145:187-192.
279. Schoof E, Girstl M, Frobenius W, Kirschbaum M, Dorr HG, Rascher W, Dotsch J. Decreased gene expression of 11β-hydroxysteroid dehydrogenase type 2 and 15-hydroxyprostaglandin dehydrogenase in human placenta of patients with preeclampsia. J Clin Endocrinol Metab 2001b;86 1313-1317.
280. Seckl JR. Glucocorticoids, feto-placental 11β-hydroxysteroid dehydrogenase type 2, and the early life origins of adult disease. Steroids 1997;62: 89-94.
281. Seckl JR. Glucocorticoids programming of the fetus. Mol Cell Endocrinol 2001;185:61-71.
282. Seckl JR. Prenatal glucocorticoids and long-term programming. Eur J Endocrinol 2004;151:U49-U62.
283. Seckl JR. Glucocorticoids, feto-placental 11β-hydroxysteroid dehydrogenase type 2, and the early life origins of adult disease. Steroids 2007;62: 89-94.
284. Seckl JR, Walker BR. 11β-hydroxysteroid dehydrogenase type 1 - a tissue-specific amplifier of glucocorticoid action. Endocrinology 2001;142:1371-1376.
285. Seckl JR, Meaney MJ. Glucocorticoid programming. Ann N Y Acad Sci 2004;1032:63-84.
286. Seckl JR, Benediktsson R, Lindsay RS, Brown RW. Placental 11β-hydroxysteroid dehydrogenase and the programming of hypertension. J Steroid Biochem Mol Biol 1995;55:447-455.
287. Segar JL, Roghair RD, Segar EM, Bailey MC, Scholz TD, Lamb FS. Early gestation dexamethasone alters baroreflex and vascular responses in newborn lambs before hypertension. Am J Physiol Regul Integr Comp Physiol 2006;291:R481-R488.
288. Schoneveld OJ, Gaemers IC, Lamers WH. Mechanisms of glucocorticoid signalling. Biochim Biophys Acta 2004;1680:114-128.
289. Shams M, Kilby MD, Somerset DA, Howie AJ, Gupta A, Wood PJ, Afnan M, Stewart PM. 11β-hydroxysteroid dehydrogenase type 2 in human pregnancy and reduced expression in intrauterine growth restriction. Hum Reprod 1998;13:799-804.
290. Sharkey A. Cytokines and implantation. Rev Reprod 1998;3 52-61.
291. Sheppard KE, Funder JW. Equivalent affinity of aldosterone and corticosterone for type I receptors in kidney and hippocampus: Direct binding studies. J Steroid Biochem 2001;28:737-742.
292. Shimojo M, Stewart PM. Apparent mineralocorticoid excess syndromes. J Endocrinol Invest 1995;18:518-532.
293. Shoener JA, Baig R, Page KC. Prenatal exposure to dexamethasone alters hippocampal drive on hypothalamic-pituitary-adrenal axis activity in adult male rats. Am J Physiol Regul Integr Comp Physiol 2006; 290:R1366-R1373.
294. Sloboda DM, Newnham JP, Challis JR. Effects of repeated maternal betamethasone administration on growth and hypothalamic-pituitary-adrenal function of the ovine fetus at term. J Endocrinol 2000;172:79-91.
295. Sloboda DM, Moss TJ, Gurrin LC, Newnham JP, Challis JR. The effect of prenatal betamethasone administration on postnatal ovine hypothalamic-pituitary-adrenal function. J Endocrinol 2002;172 71-81.
296. Smith R, Nicholson RC. Corticotrophin releasing hormone and the timing of birth. Front Biosci 2007;12:912-918.
297. Smith MA, Thomford PJ, Mattison DR, Slikker W, Jr. Transport and metabolism of dexamethasone in the dually perfused human placenta. Reprod Toxicol 1988;2:37-43.
298. Smith RE, Salamonsen LA, Komesaroff PA, Li KXZ, Myles KM, Lawrence M, Krozowski Z. 11β-Hydroxysteroid dehydrogenase type II in the human endometrium: Localization and activity during the menstrual cycle. J Clin Endocrinol Metab 1997;82:4252-4257.
299. Speirs HJ, Seckl JR, Brown RW. Ontogeny of glucocorticoid receptor and 11β-hydroxysteroid dehydrogenase type-1 gene expression identifies potential critical periods of glucocorticoid susceptibility during development. J Endocrinol 2004;181:105-116.
300. Srisuparp S, Strakova Z, Fazleabas AT. The role of chorionic gonadotropin (CG) in blastocyst implantation. Arch Med Res 2001; 32:627-634.
301. Stand F, Mazancova K, Miksik I, Pavek P, Fendrich Z, Pacha J. Corticosterone transfer and metabolism in the dually perfused rat placenta: Effect of 11β-hydroxysteroid dehydrogenase type 2. Placenta 2006;27:171-180.
302. Staun-Ram E, Shalev E. Human trophoblast function during the implantation process. Reprod Biol Endocrinol 2005;3:56.
303. Stevens VC. Human chorionic gonadotrophin: Properties and potential immunological manipulation for clinical application. Clin Obstet Gynaecol 1979;6:549-566.
304. Stewart PM, Corrie JE, Shackleton CH, Edwards CR. Syndrome of apparent mineralocorticoid excess. A defect in the cortisol-cortisone shuttle. J Clin Invest 1988;82:340-349.
305. Stewart PM, Murray BA, Mason JI. Type 2 11β-hydroxysteroid dehydrogenase in human fetal tissues. J Clin Endocrirol Metab 1994;78:1529-1532.
306. Stewart PM, Rogerson FM, Mason JI. Type 2 11β-hydroxysteroid dehydrogenase messenger ribonucleic acid and activity in human placenta and fetal membranes: Its relationship to birthweight and putative role in fetal adrenal steroidogenesis. J Clin Endocrinol Metab 1995; 80:885-890.
307. Struwe E, Berzl GM, Schild RL, Beckmann MW, Dorr HG, Rascher W, Dotsch J. Simultaneously reduced gene expression of cortisol-activating and cortisol-inactivating enzymes in placentas of small-for-gestational-age neonates. Am J Obstet Gynecol 2007;197:43e.1-43e.6.
308. Sugden MC, Langdown ML, Munns MJ, Holness MJ. Maternal glucocorticoid treatment modulates placental leptin and leptin receptor expression and materno-fetal leptin physiology during late pregnancy, and elicits hypertension associated with hyperleptinaemia in the early-growth-retarded adult offspring. Eur J Endocrinol 2001; 145:529-539.
309. Sun K, Myatt L. Enhancement of glucocorticoid-induced 11β-hydroxysteroid dehydrogenases type 1 expression by proinflammatory cytokines in cultured human amnion fibroblasts. Endocrinology 2003;144: 5568-5577.
310. Sun M, Ramirez M, Challis JR, Gibb W. Immunohistochemical localization of the glucocorticoid receptor in human fetal membranes and decidua at term and preterm delivery. J Endocrinol 1996;149:243-248.
311. Sun K, Yang K, Challis JRG. Differential expression of 11β-hydroxysteroid dehydrogenase types 1 and 2 in human placental and fetal membranes. J Clin Endocr Metab 1997a;82:300-305.
312. Sun K, Yang K, Challis JRG. Differential regulation of 11β-hydroxysteroid dehydrogenase type 1 and 2 by nitric oxide in cultured human placental trophoblast and chorionic cell preparation. Endocrinology 1997b; 138:4912-4920.
313. Sun K, Yang K, Challis JR. Glucocorticoid actions and metabolism in pregnancy: Implications for placental function and fetal cardiovascular activity. Placenta 1998a;19:353-360.
314. Sun K, Yang K, Challis JRG. Regulation of 11β-hydroxysteroid dehydrogenase type 2 by progesterone, estrogen, and the cyclic adenosine 5′-monophosphate pathway in cultured human placental and chorionic trophoblasts. Biol Reprod 1998b;58:1379-1384.
315. Sun K, He P, Yang K. Intracrine induction of 11β-hydroxysteroid dehydrogenase type 1 expression by glucocorticoid potentiates prostaglandin production in the human chorionic trophoblast. Biol Reprod 2002;67:1450-1455.
316. Sun K, Ma R, Cui X, Campos B, Webster R, Brockman D, Myatt L. Glucocorticoids induce cytosolic phospholipase A2 and prostaglandin H synthase type 2 but not microsomal prostaglandin E synthase (PGES) and cytosolic PGES expression in cultured primary human amnion cells. J Clin Endocrinol Metab 2003;88:5564-5571.
317. Tangalakis K, Lumbers ER, Moritz KM, Towstoless MK, Wintour EM. Effect of cortisol on blood pressure and vascular reactivity in the ovine fetus. Exp Physiol 1992;77:709-717.
318. Tanswell AK, Worthingon D, Smith BT. Human amniotic membrane corticosteroid 11-oxidoreductase activity. J Clin Endocrinol Metab 1977;45:721-725.
319. Tauber SC, Schlumbohm C, Schilg L, Fuchs E, Nau R, Gerber J. Intrauterine exposure to dexamethasone impairs proliferation but not neuronal differentiation in the dentate gyrus of newborn common marmoset monkeys. Brain Pathol 2006;16:209-217.
320. Thomas FJ, Thomas MJ, Tetsuka M, Mason JI, Hillier SG. Corticosteroid metabolism in human granulosa-lutein cells. Clin Endocrinol (Oxf) 1998;48:509-513.
321. Thompson A, Han VKM, Yang K. Spatial and temporal patterns of expression of 11β-hydroxysteroid dehydrogenase types 1 and 2 messenger RNA and glucocorticoid receptor protein in the murine placenta and uterus during late pregnancy. Biol Reprod 2002;67:1708-1718.
322. Thompson A, Han VKM, Yang K. Differential expression of 11β-hydroxysteroid dehydrogenase types 1 and 2 mRNA and glucocorticoid receptor protein during mouse embryo development. J Ster Biochem Mol Biol 2004;88:367-375.
323. Thurston LM, Norgate DP, Jonas KC, Gregory L, Wood PJ, Cooke BA, Michael AE. Ovarian modulators of type 1 11β-hydroxysteroid dehydrogenase (11βHSD) activity and intra-follicular cortisol:cOrtisone ratios correlate with the clinical outcome of IVF. Hum Reprod 2003;18 1603-1612.
324. Timmerman M, Teng C, Wilkening RB, Chung M, Battaglia FC. Net amino acid flux across the fetal liver and placenta during spontaneous ovine parturition. Biol Neonate 2001;79:54-60.
325. Trainer PJ. Corticosteroids and pregnancy. Sem Reprod Med 2002; 20:375-380.
326. Tremblay J, Hardy DB, Pereira LE, Yang K. Retinoic acid stimulates the expression of 11β-hydroxysteroid dehydrogenase type 2 in human choriocarcinoma JEG-3 cells. Biol Reprod 1999;60:541-545.
327. Ulick S, Levine LS, Gunczler P, Zanconato G, Ramirez LC, Rauh W, Rosier A, Bradlow HL, New MI. A syndrome of apparent mineralocorticoid excess associated with defects in the peripheral metabolism of cortisol. J Clin Endocrinol Metab 1979;49:757-764.
328. Uno H, Eisele S, Sakai A, Shelton S, Baker E, DeJesus O, Holden J. Neurotoxicity of glucocorticoids in the primate brain. Horm Behav 1994;28:336-348.
329. Urban R, Lemancewicz A, Przepiesc J, Urban J, Kretowska M. Antenatal corticosteroid therapy: A comparative study of dexamethasone and betamethasone effects on fetal Doppler flow velocity waveforms. Eur J Obstet Gynecol Reprod Biol 2005;120:170-174.
330. van Beek JP, Guan H, Julan L, Yang K. Glucocorticoids stimulate the expression of 11β-hydroxysteroid dehydrogenase type 2 in cultured human placental trophoblast cells. J Clin Endocrinol Metab 2004;89 5614-5621.
331. van der Burg B, van der Saag PT. Nuclear factor-kappa-B/steroid hormone receptor interactions as a functional basis of anti-inflammatory action of steroids in reproductive organs. Mol Hum Reprod 1996;2 433-438.
332. van Runnard Heimel PJ, Schobben AF, Huisjes AJ, Franx A, Bruinse HW. The transplacental passage of prednisolone in pregnancies complicated by early-onset HELLP syndrome. Placenta 2005;26:842-845.
333. Vassalli JD, Sappino AP, Belin D. The plasminogen activator/plasmin system. J Clin Invest 1991;88:1067-1072.
334. Waddell BJ, Benediktsson R, Brown RW, Seckl JR. Tissue-specific messenger ribonucleic acid expression of 11β-hydroxysteroid dehydrogenase types 1 and 2 and the glucocorticoid receptor within rat placenta suggests exquisite local control of glucocorticoid action. Endocrinology 1998;139:1517-1523.
335. Waddell BJ, Hisheh H, Dharmarajan AM, Burton PJ. Apoptosis in rat placenta is zone-dependent and stimulated by glucocorticoids. Biol Reprod 2000;63:1913-1917.
336. Wadhwa PD, Porto M, Garite TJ, Chicz-DeMet A, Sandman CA. Maternal corticotropin-releasing hormone levels in the early third trimester predict length of gestation in human pregnancy. Am J Obstet Gynecol 1998;179:1079-1085.
337. Walker BR, Aggarwal I, Stewart PM, Padfield PL, Edwards CR. Endogenous inhibitors of 11β-hydroxysteroid dehydrogenase in hypertension. J Clin Endocrinol Metab 1995;80:529-533.
338. Ward JW, Wooding FB, Fowden AL. Ovine feto-placental metabolism. Placenta 2002;23:451-458.
339. Ward JW, Wooding FB, Fowden AL. Ovine feto-placental metabolism. J Physiol 2004;554:529-541.
340. Ward JW, Forhead AJ, Wooding FB, Fowden AL. Functional significance and cortisol dependence of the gross morphology of ovine placentomes during late gestation. Biol Reprod 2006;74:137-145.
341. Weisbart M, Huntley FM. The presence of cortisol receptors in the human amnion. J Ster Biochem Mol Biol 1997;63:339-344.
342. Welberg LAM, Seckl JR. Prenatal stress, glucocorticoids and the programming of the brain. J Neuroendocrinol 2001;13:113-128.
343. Welberg LA, Seckl JR, Holmes MC. Inhibition of 11β-hydroxysteroid dehydrogenase, the foeto-placental barrier to maternal glucocorticoids, permanently programs amygdala GR mRNA expression and anxiety-like behaviour in the offspring. Eur J Neurosci 2000;12:1047-1054.
344. Welberg LAM, Seckl JR, Holmes MC. Prenatal glucocorticoid programming of brain corticosteroid receptors and corticotrophin-releasing hormone: possible implications for behaviour. Neuroscience 2001;104 71-79.
345. White PC, Mune T, Agarwal AK. 11β-Hydroxysteroid dehydrogenase and the syndrome of apparent mineralcorticoid excess. Endocr Rev 1997; 18: 135-156.
346. Whittle WL, Holloway AC, Lye SJ, Gibb W, Challis JR. Prostaglandin production at the onset of ovine parturition is regulated by both estrogen-independent and estrogen-dependent pathways. Endocrinology 2000;141:3783-3791.
347. Whittle WL, Patel FA, Alfaidy N, Holloway AC, Fraser M, Gyomorey S, Lye SJ, Gibb W, Challis JR. Glucocorticoid regulation of human and ovine parturition: The relationship between fetal hypothalamic-pituitary-adrenal axis activation and intrauterine prostaglandin production. Biol Reprod 2001;64:1019-1032.
348. Whorwood CB, Firth KM, Budge H, Symonds ME. Maternal undernutrition during early to midgestation programs tissue-specific alterations in the expression of the glucocorticoid receptor, 11β-hydroxysteroid dehydrogenase isoforms, and type 1 angiotensin II receptor in neonatal sheep. Endocrinology 2001;142:2854-2864.
349. Wilson RC, Nimkam S, New MI. Apparent mineralocorticoid excess. Trends Endocrinol Metab 2001;12:104-111.
350. Wintour EM, Alcorn D, McFarlane A, Moritz K, Potocnik SJ, Tangalakis K. Effect of maternal glucocorticoid treatment on fetal fluids in sheep at 0.4 gestation. Am J Physiol 1994;266:R1174-R1181.
351. Wintour EM, Moritz KM, Johnson K, Ricardo S, Samuel CS, Dodic M. Reduced nephron number in adult sheep, hypertensive as a result of prenatal glucocorticoid treatment. J Physiol 2003;549:929-935.
352. Wirbelauer J, Schmidt B, Klingel K, Cao L, Lang F, Speer CP. Serum and glucocorticoid-inducible kinase in pulmonary tissue of preterm fetuses exposed to chorioamnionitis. Neonatology 2007;93:257-262.
353. Woods LL, Weeks DA. Prenatal programming of adult blood pressure: Role of maternal corticosteroids. Am J Physiol Regal Integr Comp Physiol 2005;289:R955-R962.
354. Xiao DL, Huang XH, Bae S, Ducsay CA, Zhang L. Cortisol-mediated potentiation of uterine artery contractility: Effect of pregnancy. Am J Physiol Heart Circ Physiol 2002;283:H238-H246.
355. Xiao DL, Huang XH, Pearce WJ, Longo LD, Zhang L. Effect of cortisol on norepinephrine-mediated contractions in ovine uterine arteries. Am J Physiol Heart Circ Physiol 2003;284:H1142-H1151.
356. Xu B, Makris A, Thornton C, Hennessy A. Glucocorticoids inhibit placental cytokines from cultured normal and preeclamptic placental explants. Placenta 2005;26:654-660.
357. Yang K. Co-expression of two distinct isoforms of 11β-hydroxysteroid dehydrogenase in the ovine placenta. J Steroid Biochem Mol Biol 1995;52:337-343.
358. Yang K. Placental 11 beta-hydroxysteroid dehydrogenase; barrier to maternal glucocorticoids. Rev Reprod 1997;2:129-132.
359. Yang K, Langlois DA, Campbell LE, Challis JRG, Krkosek M, Yu M. Cellular localization and developmental regulation of 11β-hydroxysteroid dehydrogenase type 1 (11β-HSD1) gene expression in the ovine placenta. Placenta 1997;18:503-509.
360. Yang K, Hardy DB, Doumouras MA, van Beek JP, Rocha E. ATP stimulates human placental 11β-hydroxysteroid dehydrogenase type 2 activity by a novel mechanism independent of phosphorylation. J Cell Biochem 2002;84:295-300.
361. Yang K, Julan L, Rubio F, Sharma A, Guan H. Cadmium reduces 11β-hydroxysteroid dehydrogenase type 2 activity and expression in human placental trophoblast cells. Am J Physiol Endocrinol Metab 2006;290:E135-E142.
362. Yang Z, Guo C, Zhu P, Li W, Myatt L, Sun K. Role of glucocorticoid receptor and CCAAT/enhancer-binding protein α in the feed-forward induction of 11β-hydroxysteroid dehydrogenase type 1 expression by cortisol in human amnion fibroblasts. J Endocrinol 2007;195 241-253.
363. Zakar T, Hirst JJ, Mijovic JE, Olson DM. Glucocorticoids stimulate the expression of prostaglandin endoperoxide H synthase-2 in amnion cells. Endocrinology 1995;136:1610-1619.
364. Zhang Q, Collins V, Chakrabarty K, Wolf RF, Unno N, Howe D, Rose JC, Wu WX. Regulation of membrane-associated prostaglandin E2 synthase 1 in pregnant sheep intrauterine tissues by glucocorticoid and estradiol. Endocrinology 2006;147:3719-3726.
365. Zhou M-Y, Gomez-Sanchez EP, Cox DL, Cosby D, Gomez-Sanchez CE. Cloning, expression and tissue distribution of the rat nicotinamide adenine dinucleotide-dependent isoform of 11β-hydroxysteroid dehydrogenase. Endocrinology 1995;136:3729-3734.