Inhibition of 11β-hydroxysteroid dehydrogenase, the foetoplacental barrier to maternal glucocorticoids, permanently programs amygdala GR mRNA expression and anxiety-like behaviour in the offspring

European Journal of Neuroscience

Volumn 12, Issue 3, 2000, Pages 1047-1054

  Welberg, Leonie A M ^a   Seckl, Jonathan R ^a   Holmes, Megan C ^a  

^a UNIVERSITY OF EDINBURGH   (United Kingdom)

Author keywords

Birth weight; Body weight; Corticosterone; Prenatal stress; Rat

Indexed keywords

11BETA HYDROXYSTEROID DEHYDROGENASE; CARBENOXOLONE; CORTICOSTERONE; CORTICOTROPIN RELEASING FACTOR; GLUCOCORTICOID; GLUCOCORTICOID RECEPTOR; MESSENGER RNA; MINERALOCORTICOID RECEPTOR; ENZYME INHIBITOR; HYDROXYSTEROID DEHYDROGENASE;

AFFECTIVE NEUROSIS; AMYGDALOID NUCLEUS; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; BEHAVIOR; BIRTH WEIGHT; BLOOD PLACENTA BARRIER; BODY WEIGHT; CONTROLLED STUDY; CORTICOSTERONE BLOOD LEVEL; ENZYME INHIBITION; FEMALE; FETUS; GROOMING; HIPPOCAMPUS; HYPERTENSION; HYPOTHALAMUS HYPOPHYSIS ADRENAL SYSTEM; LOW BIRTH WEIGHT; MESSENGER RNA SYNTHESIS; NON INSULIN DEPENDENT DIABETES MELLITUS; NONHUMAN; PRIORITY JOURNAL; RAT; REARING; STRESS; SWIMMING; THALAMUS MIDLINE NUCLEUS; ANIMAL; ANIMAL BEHAVIOR; ANXIETY; BIOSYNTHESIS; BRAIN LEVEL; CHEMICALLY INDUCED DISORDER; DEPRESSION; DRUG ANTAGONISM; DRUG EFFECT; FETOMATERNAL TRANSFUSION; HYPOTHALAMUS HYPOPHYSIS SYSTEM; IN SITU HYBRIDIZATION; METABOLISM; PHYSIOLOGY; PREGNANCY; PRENATAL EXPOSURE; PSYCHOLOGICAL ASPECT; WISTAR RAT;

11-BETA-HYDROXYSTEROID DEHYDROGENASES; AMYGDALA; ANIMALS; ANXIETY; BEHAVIOR, ANIMAL; BRAIN CHEMISTRY; CARBENOXOLONE; CORTICOSTERONE; DEPRESSION; ENZYME INHIBITORS; FEMALE; GLUCOCORTICOIDS; HYDROXYSTEROID DEHYDROGENASES; HYPOTHALAMO-HYPOPHYSEAL SYSTEM; IN SITU HYBRIDIZATION; MATERNAL-FETAL EXCHANGE; PREGNANCY; PRENATAL EXPOSURE DELAYED EFFECTS; RATS; RATS, WISTAR; RECEPTORS, GLUCOCORTICOID; RNA, MESSENGER; SWIMMING;

EID: 0033624912     PISSN: 0953816X     EISSN: None     Source Type: Journal    
DOI: 10.1046/j.1460-9568.2000.00958.x     Document Type: Article

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