Prenatal glucocorticoid exposure leads to offspring hyperglycaemia in the rat: Studies with the 11 β-hydroxysteroid dehydrogenase inhibitor carbenoxolone

Diabetologia

Volumn 39, Issue 11, 1996, Pages 1299-1305

  Lindsay, R S ^a   Lindsay, R M ^a   Waddell, B J ^a   Seckl, J R ^a  

^a UNIVERSITY OF EDINBURGH   (United Kingdom)

Author keywords

11 hydroxysteroid dehydrogenase; Birthweight; Carbenoxolone; Diabetes mellitus; Glucocorticoids

Indexed keywords

CARBENOXOLONE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CONTROLLED STUDY; DIABETES MELLITUS; FEMALE; FETUS; HYPERGLYCEMIA; LOW BIRTH WEIGHT; NEWBORN; NONHUMAN; PRENATAL DEVELOPMENT; PRIORITY JOURNAL; RAT; SUBCUTANEOUS DRUG ADMINISTRATION;

11-BETA-HYDROXYSTEROID DEHYDROGENASES; ADMINISTRATION, ORAL; ADRENALECTOMY; ANIMALS; BIRTH WEIGHT; BLOOD GLUCOSE; CARBENOXOLONE; ENZYME INHIBITORS; FEMALE; GLUCOSE; HYDROXYSTEROID DEHYDROGENASES; INSULIN; MALE; MATERNAL EXPOSURE; MATERNAL-FETAL EXCHANGE; PREGNANCY; PRENATAL EXPOSURE DELAYED EFFECTS; RATS; RATS, WISTAR;

EID: 0029989854     PISSN: 0012186X     EISSN: None     Source Type: Journal    
DOI: 10.1007/s001250050573     Document Type: Article

References (62)

1. Barker D, Osmond C, Simmonds S, Wield G (1993) The relation of small head circumference and thinness at birth to death from cardiovascular disease in adult life. BMJ 306: 422-426
2. Osmond C, Barker D, Winter P, Fall C, Simmonds S (1993) Early growth and death from cardiovascular disease in women. BMJ 307: 1524-1527
3. Barker DJP, Bull AR, Osmond C, Simmonds SJ (1990) Fetal and placental size and risk of hypertension in adult life. BMJ 301: 259-263
4. Barker DJP, Osmond C, Goldings J, Kuh D, Wadsworth MEJ (1989) Growth in utero, blood pressure in childhood and adult life, and mortality from cardiovascular disease. BMJ 298: 564-567
5. Hales CN, Barker DJP, Clark PMS, et al (1991) Fetal and infant growth and impaired glucose tolerance at age 64. BMJ 303: 1019-1022
6. Kolacek S, Kapetenovic T, Luzar V (1993) Early determinants of cardiovascular risk factors in adults. Acta Pediatr 82: 377-382
7. Phipps K, Barker D, Hales C, Fall C, Clark P (1993) Fetal growth and impaired glucose tolerance in men and women. Diabetologia 36: 225-228
8. Barker DJP, Gluckman PD, Godfrey KM, Harding JE, Owens JA, Robinson JS (1993) Fetal nutrition and cardiovascular disease in adult life. Lancet 341: 938-941
9. Barker DJP (1991) Fetal and infant origins of adult disease. BMJ (publications). London
10. Robinson S, Wallon R, Clark P, Barker D, Hales C, Osmond C (1992) The relation of fetal growth to plasma glucose in young men. Diabetologia 35: 444-446
11. McCance D, Pettitt D, Hanson R, Jacobsson L, Knowler W, Bennett P (1994) Birthweight and non-insulin-dependent diabetes: thrifty genotype, thrifty phenotype, or surviving small baby genotype? BMJ 308: 942-945
12. Valdez R, Athens MA, Thompson GH, Bradshaw BS, Stern MP (1994) Birthweight and adult health outcomes in a biethnic population in the USA. Diabetologia 37: 624-631
13. McKeigue P, Leon D, Berglund L, Mohsen R, Lithell H (1994) Relationship of birthweight and ponderal index to non-insulin-dependent diabetes and insulin response to glucose challenge in men aged 50-60 years. Diabet Med 11 [Suppl 2]: S17 (Abstract)
14. Yajnik CS, Fall C, Vaidya U, et al. (1995) Fetal growth and glucose and insulin metabolism in four-year-old Indian children. Diabet Med 12: 330-336
15. Edwards CRW, Benediktsson R, Lindsay R, Seckl JR (1993) Dysfunction of the placental glucocorticoid barrier: a link between the foetal environment and adult hypertension? Lancet 341: 355-357
16. Ross E, Marshall-Jones P, Friedman M (1966) Cushing's syndrome: diagnostic criteria. Q J Med 35: 149-193
17. Garvey D, Scott J (1981) Placental and foetal contraindications of dexamethasone administration to pregnant rats. Experientia 37: 757-759
18. Gunberg D (1957) Some effects of exogenous hydrocortisone on pregnancy in the rat. Anat Rec 129: 133-149
19. Reinisch JM, Simon NG, Karwo WG, Gandleman R (1978) Prenatal exposure to prednisone in humans and animals retards intra-uterine growth. Science 202: 436-438
20. Slotkin TA, Seidler FJ, Kavlock RJ, Gray JA (1992) Fetal dexamethasone exposure accelerates development of renal function: relationship to dose, cell differentiation and growth inhibition. J Dev Physiol 17: 55-61
21. LaBorde JB, Hansen DK, Young JF, Sheehan DM, Holson RR (1992) Prenatal dexamethasone exposure in rats: effects of dose, age at exposure, and drug-induced hypophagia on malformations and fetal organ weights. Fundam Appl Toxicol 19: 545-554
22. Fowden AL, Mijovic J, Silver M (1993) The effects of cortisol in hepatic and renal gluconeogenic enzyme activities in the sheep fetus during late gestation. J Endocrinol 137: 213-222
23. Meaney MJ, Aitken DH, van Berkel C, Bhatnagar S, Sapolsky RM (1988) Effect of neonatal handling on age-related impairments associated with the hippocampus. Science 239: 766-768
24. Harris G (1964) Sex hormones, brain development and brain function. Endocrinology 75: 627-648
25. Benediktsson R, Lindsay RS, Noble J, Seckl JR, Edwards C (1993) Glucocorticoid exposure in utero: a new model for adult hypertension. Lancet 341: 339-341
26. Brown R, Chapman K, Kotoletsev Y, et al (1996) Cloning and production of antisera to human placental 11β-hydrocysteroid dehydrogenase type 2. Biochem J 313: 1007-1017
27. Murphy BEP, Clark SJ, Donald IR, Pinsky M, Vedady DL (1974) Conversion of maternal cortisol to cortisone during placental transfer to the human fetus. Am J Obstet Gynecol 118: 538-541
28. Stewart P, Rogerson F, Mason J (1995) Type 2 11 β-hydroxysteroid dehydrogenase messenger RNA and activity in human placenta and fetal membranes: its relationship to birthweight and putative role in fetal steroidogenesis. JC Clin Endocrinol Metab 80: 885-890
29. Benediktsson R, Noble J, Calder A, Edwards C, Seekl J (1995) 11 β-hydroxysteroid dehydrogenase efficiency in the intact placenta and birthweight in humans. American Endocrine Society Abstracts P3: 641 (Abstract)
30. Mune T, Rogerson F, Nikkila H, Agarwal A, White P (1995) Human hypertension caused by mutations in the kidney isozyme of 11 β-hydroxysteroid dehydrogenase. Nature Genetics 10: 394-399
31. Low SC, Chapman KE, Edwards CRW, et al (1994) Sexual dimorphism of hepatic 11 β hydroxysteroid dehydrogenase in the rat: the role of growth hormone patterns. J Endocrinol 143: 541-548
32. Ashby J, Speake R (1975) Insulin and glucagon secretion from isolated islets of Langerhans: effects of calcium ionophores. Biochem J 150: 89-96
33. Al-Dujaili E, Williams B, Edwards C (1981) The development and application of a direct immunoassay for corticosterone. Steroids 37: 157-176
34. Albiston AL, Obeyesekere VR, Smith RE, Krozowski ZS (1994) Cloning and tissue distribution of the human 11 beta-hydroxysteroid dehydrogenase type 2 enzyme. Mol Cell Endocrinol 105: R11-R17
35. Lopez Bernal A, Craft IL (1981) Corticosteroid metabolism in vitro by human placenta, foetal membranes and decidua in early and late gestation. Placenta 2: 279-285
36. Freinkel N (1980) The Banting Lecture 1980: Of Pregnancy and Progeny. Diabetes 1023-1035
37. Pettitt DJ, Aleck KA, Baird HR, Carraher MJ, Bennett PH, Knowler WC (1987) Congenital susceptibility to NIDDM - Role of the intrauterine environment. Diabetes 37: 622-628
38. Alcolado J, Alcolado R (1992) Importance of maternal history of non-insulin dependent diabetic patients. BMJ 302: 1178-1180
39. Martin A, Simpson J, Ober C, Freinkel N (1985) Frequency of diabetes mellitus in mothers of probands with gestational diabetes: possible maternal influence on the predisposition to gestational diabetes. Am J Obstet Gynecol 151: 471-475
40. Linn T, Leowk E, Schneider K, Federlin K (1993) Spontaneous glucose intolerance in the progeny of low dose streptozotocin-induced diabetic mice. Diabetologia 36: 1245-1251
41. Bihoreau MT, Ktorza A, Kinebanyan MF, Picon L (1986) Impaired glucose homeostasis in adult rats from hyperglycaemic mothers. Diabetes 35: 979-984
42. Grill V, Johansson B, Jalkanen P, Eriksson U (1991) Influence of severe diabetes mellitus early in pregnancy in the rat: effects on insulin sensitivity and insulin secretion in the offspring. Diabetologia 34: 373-378
43. Aerts I, Sodoyez Goffaux F, Sodoyez J, Malaisse W, van Asche F (1988) The diabetic intrauterine milieu has a long lasting effect on insulin secretion by beta cells and on insulin uptake by target tissues. Am J Obstet Gynecol 159: 1287-1292
44. Monder C (1991) Corticosteroids, kidneys, sweet roots and dirty drugs. Mol Cell Endocrinol 78: C95-C98
45. Baker ME, Fanestil DD (1991) Liquorice, computer-based analyses of dehydrogenase sequences, and the regulation of steroid and protaglandin action. Mol Cell Endocrinol 78: C99-C102
46. Teelucksingh S, Benediktsson R, Lindsay RS et al (1991) Liquorice. Lancet 337: 1549
47. Billaudel B, Mathias P, Sutter P, Malaisse W (1984) Inhibition by corticosterone of calcium inflow and insulin release in rat pancreatic islets. J Endocrinol 100: 227-233
48. Chick W (1973) Beta cell replication in pancreatic monolayer cultures. Effects of glucose, tolbutamide, glucocorticoid, growth hormone and glucagon. Diabetes 22: 687-693
49. Andersson A (1975) Synthesis of DNA in isolated pancreatic islets maintained in tissue culture. Endocrinology 96: 1051-1054
50. Bian X, Seidler F, Bartolome J, Kavlock R, Bartolome M, Slotkin T (1990) Dose-dependent effect of prenatal dexamethasone treatment on beta-adrenergic receptor coupling to ornithine decarboxylase and cyclic AMP. J Dev Physiol 14: 125-130
51. Bian XP, Seidler FJ, Slotkin TA (1991) Promotional role for glucocorticoids in the development of intracellular signalling: enhanced cardiac and renal adenylate cyclase reactivity to beta-adrenergic and non-adrenergic stimuli after low-dose fetal dexamethasone exposure 1. J Dev Physiol 16: 331-339
52. Henning S (1981) Postnatal development: coordination of feeding, digestion and metabolism. Am J Physiol 4(3) G199-G214
53. Iynedjian P, Aubergen P, Guigoz Y, Le Cam A (1985) Pretranslational regulation of tyrosine aminotransferase and phosphoenol (GTP) synthesis by glucagon and dexamethasone in adult rat hepatocytes. Biochem J 225: 77-84
54. Levine S (1962) Plasma free corticosteroid response to electric shock in rats simulated in infancy. Science 135: 795-796
55. Henry C, Kabbaj M, Simon H, LeMoal M, Maccari S (1994) Prenatal stress increases the hypothalamo-pituitary-adrenal axis response in young and adult rats. J Neuroendocrinol 6: 341-345
56. Levitt N, Lindsay R, Holmes M, Seckl J (1995) Prenatal dexamethasone programmes attenuated hippocampal glucocorticoid receptor gene expression and elevated basal corticosterone levels in adult life. American Endocrine Society Abstracts P1: 451 (Abstract)
57. Jones J, Clemmons D (1995) Insulin-like growth factors and their binding proteins: biological actions. Endocr Rev 16: 3-34
58. Price WA, Stiles AD, Moats-Staats BM, D'Ercole AJ (1992) Gene expression of the insulin-like growth factors (IGFs), the type 1 IGF receptor, and IGF-binding proteins in dexamethasone-induced fetal growth retardation. Endocrinology 130: 1424-1432
59. Phillips D, Barker D, Hales C, Hirst S, Osmond C (1994) Thinness at birth and insulin resistance in later life. Diabetologia 37: 150-154
60. Snoek A, Remacle C, Reusens B, Hoet J (1990) Effect of a low protein diet during pregnancy on the foetal rat endocrine pancreas. Biol Neonate 57: 107-118
61. Swenne I, Crace C, Milner D (1987) Persistent impairment of insulin secretory response to glucose in adult rats after a limited period of protein-caloric malnutrition early in life. Diabetes 36: 454-458
62. Langley-Evans S, Phillips GJ, Benediktsson R et al. (1996) Protein intake in pregnancy, placental glucocorticoid metabolism and the programming of hypertension in the rat. Placenta 17: 169-172