Glucocorticoid programming of pituitary-adrenal function: Mechanisms and physiological consequences

Seminars in Neonatology

Volumn 6, Issue 4, 2001, Pages 319-329

  O'Regan, David ^a   Welberg, Leonie L A M ^a   Holmes, Megan C ^a   Seckl, Jonathan R ^a  

^a UNIVERSITY OF EDINBURGH   (United Kingdom)

Author keywords

11 hydroxysteroid dehydrogenase; Fetal programming; Glucocorticoid; Hypertension; Hypothalamicpituitary adrenal axis; Non insulin dependent diabetes mellitus

Indexed keywords

11BETA HYDROXYSTEROID DEHYDROGENASE; DEXAMETHASONE; GLUCOCORTICOID;

ANIMAL BEHAVIOR; DRUG EFFECT; FETUS LUNG MATURATION; HUMAN; HYPERGLYCEMIA; HYPERINSULINEMIA; HYPERTENSION; HYPOPHYSIS ADRENAL SYSTEM; HYPOTHALAMUS HYPOPHYSIS ADRENAL SYSTEM; LOW BIRTH WEIGHT; NEUROENDOCRINE SYSTEM; NONHUMAN; PRENATAL DRUG EXPOSURE; RAT; REVIEW; STEROID THERAPY;

EID: 0035740678     PISSN: 10842756     EISSN: None     Source Type: Journal    
DOI: 10.1053/siny.2001.0067     Document Type: Article

References (132)

1. Fetal and infant origins of adult disease
2. Fetal nutrition and cardiovascular disease in adult life
3. Type 2 (non-insulin dependent) diabetes mellitus, hypertension and hyperlipidaemia (syndrome X): Relation to reduced fetal growth
4. Birth-weight and adult hypertension and obesity in women
5. Birth weight and adult hypertension, diabetes mellitus, and obesity in US men
6. Size at birth and plasma insulin-like growth factor-1 concentrations
7. Relation of size at birth to noninsulin dependent diabetes and insulin concentrations in men aged 50-60 years
8. Failure to realise growth potential in utero and adult obesity in relation to blood pressure in 50 year old Swedish men
9. Mother's weight in pregnancy and coronary heart disease in a cohort of Finnish men: Follow up study
10. Birth weight and risk of cardiovascular disease in a cohort of women followed up since 1976
11. Placental weight, birth measurements, and blood pressure at age 8 years
12. Fetal growth and glucose and insulin metabolism in four-year-old Indian children
13. Blood pressure in prospective population based cohort of newborn and infant twins
14. Testing the fetal origins hypothesis in twins: The Birmingham twin study
15. Adult cardiovascular risk factors in premature babies
16. Early growth and death from cardiovascular disease in women
17. Fetal and placental size and risk of hypertension in adult life
18. Thinness at birth and glucose tolerance in seven-year-old children
19. Dysfunction of the placental glucocorticoid barrier: A link between the foetal environment and adult hypertension?
20. Association of the INS VNTR with size at birth
21. Mutations in the glucokinase gene of the fetus result in reduced birth weight
22. Glucocorticoids, 11β-hydroxysteroid dehydrogenase and fetal programming
23. Physiologic programming of the fetus
24. Prenatal stress, glucocorticoids and the programming of the brain
25. Critical exposure time for androgenization of the developing hypothalamus in the female rat
26. Sex steroid-induced changes in hepatic enzymes
27. Prenatal exposure to prednisone in humans and animals retards intra-uterine growth
28. Dexamethasone and estradiol treatment in pregnant rhesus macaques: Effects on gestation length, maternal plasma hormones and fetal growth
29. Disproportionate growth of organs and body weight following glucocorticoid treatment of the rat fetus
30. Preterm newborn lamb renal and cardiovascular responses after fetal or maternal antenatal betamethasone
31. Glucocorticoids and small babies
32. Elevated levels of umbilical cord plasma corticotropin-releasing hormone in growth-retarded fetuses
33. Concentrations of corticotropin-releasing hormone in the umbilical-cord blood of pregnancies complicated by preeclampsia
34. Pharmacologic enhancement of fetal lung maturation
35. Promotional role for glucocorticoids in the development of intracellular signalling: Enhanced cardiac and renal adenylate cyclase reactivity to β-adrenergic and non-adrenergic stimuli after low-dose fetal dexamethasone exposure
36. Fetal dexamethasone exposure interferes with establishment of cardiac noradrenergic innervation and sympathetic activity
37. Inhibition of renal growth by prenatal dexamethasone and the programming of blood pressure in the offspring
38. Prenatal dexamethasone causes oligonephronia, sodium retention, and higher blood pressure in the offspring
39. Hypothalamic-pituitary-adrenal function in chronic intermittently cold-stressed neonatally handled and non handled rats
40. Neonatal handling alters adrenocortical negative feedback sensitivity and hippocampal type II glucocorticoid receptor binding in the rat
41. Early environmental regulation of forebrain glucocorticoid receptor gene expression: Implications for adrenocortical responses to stress
42. Progeny of mothers drinking corticosterone during lactation has lower stress-induced corticosterone secretion and better cognitive performance
43. Adoption reverses the long-term impairment in glucocorticoid feedback induced by prenatal stress
44. Effect of cortisol on blood pressure and vascular reactivity in the ovine fetus
45. Prenatal dexamethasone treatment in conjunction with rescue therapy of human surfactant: A randomized placebo-controlled multicenter study
46. Molecular genetic analysis of glucocorticoid signaling during mouse development
47. The ontogeny of 11βhydroxysteroid dehydrogenase type 2 and mineralo-corticoid receptor gene expression reveal intricate control of glucocorticoid action in development
48. Differential expression of 11beta-hydroxysteroid dehydrogenase types 1 and 2 in human placenta and fetal membranes
49. Glucocorticoid exposure in utero: A new model for adult hypertension
50. Dexamethasone in the last week of pregnancy attenuates hippocampal glucocorticoid receptor gene expression and elevates blood pressure in the adult offspring in the rat
51. Glucocorticoid exposure in late gestation permanently programmes rat hepatic phosphoenolpyruvate carboxykinase and glucocorticoid receptor expression and causes glucose intolerance in adult offspring
52. An early prenatal exposure to excess glucocorticoid leads to hypertensive offspring in sheep
53. Differential timing for programming of glucose homoeostasis, sensitivity to insulin and blood pressure by in utero exposure to dexamethasone in sheep
54. The metabolic clearance rate, blood production, interconversion and transplacental passage of cortisol and cortisone in pregnancy near term
55. Isolation and cloning of human placental 11βhydroxysteroid dehydrogenase-2 cDNA
56. 11β-hydroxysteroid dehydrogenase type 1: A tissue-specific amplifier of glucocorticoid action
57. Type 2 11βhydroxysteroid dehydrogenase messenger RNA and activity in human placenta and fetal membranes: Its relationship to birth weight and putative role in fetal steroidogenesis
58. No correlation in human placenta between activity or mRNA for the K (type 2) isozyme of 11β-hydroxysteroid dehydrogenase and fetal or placental weight
59. 11 Beta-hydroxysteroid dehydrogenase type 2 is the predominant isozyme in the guinea pig placenta: Decreases in messenger ribonucleic acid and activity at term
60. Fetal osteocalcin levels are related to placental 11β-hydroxysteroid dehydrogenase activity
61. Extensive personal experience - Examination of genotype and phenotype relationships in 14 patients with apparent mineralocorticoid excess
62. Cloning and tissue distribution of the human 11βhydroxysteroid dehydrogenase type 2 enzyme
63. Inhibition of 11β-hydroxysteroid dehydrogenase in pregnant rats and the programming of blood pressure in the offspring
64. Programming of glucose tolerance in the rat: Role of placental 11β-hydroxysteroid dehydrogenase
65. Hypertension in mice lacking 11β-hydroxysteroid dehydrogenase type 2
66. Developmental increase in expression of the messenger ribonucleic acid and protein levels of 11β-hydroxysteroid dehydrogenase types 1 and 2 in the baboon placenta
67. Type 2 11βhydroxysteroid dehydrogenase in human fetal tissues
68. Ontogeny of mRNAs encoding glucocorticoid and mineralocorticoid receptors and 11β-hydroxysteroid dehydrogenases in prenatal rat brain development reveal complex control of glucocorticoid action
69. The role of the hippocampus in feedback regulation of the hypothalamic-pituitaryadrenal axis
70. The excitatory effects of the amygdala on hypothalamo-pituitary-adrenocortical responses are mediated by hypothalamic norepinephrine, serotonin, and CRF-41
71. Early, postnatal experience alters hypothalamic corticotropin-releasing factor (CRF) mRNA, median eminence CRF content and stress-induced release in adult rats
72. Maternal care, hippocampal glucocorticoid receptors, and hypothalamic-pituitary-adrenal responses to stress
73. Postnatal handling alters glucocorticoid but not mineralocorticoid receptor mRNA expression in the hippocampus of adult rats
74. Neonatal maternally deprived rats have as adults elevated basal pituitary-adrenal activity and enhanced susceptibility to apomorphine
75. Prenatal stress selectively alters the reactivity of the hypothalamic-pituitary adrenal system in the female rat
76. Sex-specific effects of prenatal stress on hypothalamic-pituitary-adrenal responses to stress and brain glucocorticoid receptor density in adult rats
77. Prenatal stress increases the hypothalamo-pituitary-adrenal axis response in young and adult rats
78. Brain corticosteroid receptor balance and homeostatic control
79. Morphologic and behavioral effects of perinatal glucocorticoid administration
80. Prenatal glucocorticoid programming of brain corticosteroid receptors and corticotrophin-releasing hormone: Possible implications for behaviour
81. Unique sequences in the guinea pig glucocorticoid receptor induce constituitive transactivation and decrease steroid sensitivity
82. Prenatal glucocorticoid modifies hypothalamo-pituitary-adrenal regulation in prepubertal guinea pigs
83. Maternal glucocorticoid treatment programs HPA regulation in adult offspring: Sex-specific effects
84. Dynamic changes in glucocorticoid and mineralocorticoid receptor mRNA in the developing guinea pig brain
85. Inhibition of 11β-hydroxysteroid dehydrogenase, the feto-placental barrier to maternal glucocorticoids, permanently programs amygdala glucocorticoid receptor mRNA expression and anxiety-like behavior in the offspring
86. Regulation of glucocorticoid receptor mRNA and heat shock protein 70 mRNA in the developing sheep brain
87. Fetal hypothalamic-pituitary adrenal (HPA) development and activation as a determinant of the timing of birth, and of postnatal disease
88. Glucocorticoid-biogenic amine interactions in relation to mood and behaviour
89. Prenatal stress alters brain catecholaminergic activity and potentiates stress-induced behavior in adult rats
90. Maternal stress induces synaptic loss and developmental disabilities of offspring
91. Serotonin regulates type II corticosteroid receptor binding in hippocampal cell cultures
92. Postnatal handling induces changes in the hippocampal expression of NGFIA and AP2 transcription factors in the rat: Effects of thyroid hormones and serotonin
93. Postnatal handling increases the expression of cAMP-inducible transcription factors in the rat hippocampus: The effects of thyroid hormones and serotonin
94. The genomic structure of the human glucocorticoid receptor
95. 5′heterogeneity of glucocorticoid receptor mRNA is tissue-specific; differential regulation of variant promoters by early life events
96. Prenatal dexamethasone exposure alters brain monoamine metabolism and adrenocortical response in rat offspring
97. Programming of brainstem serotonin transporter development by prenatal glucocorticoids
98. Neonatal handling reverses behavioral abnormalities induced in rats by prenatal stress
99. The interaction between prenatal stress and neonatal handling on nociceptive response latencies in male and female rats
100. Does prenatal stress impair coping and regulation of hypothalamic-pituitary-adrenal axis?
101. Prenatal and perinatal risk factors for autism
102. Low weight gain in infancy and suicide in adult life
103. Glucose tolerance in adults after prenatal exposure to famine
104. Schizophrenia after prenatal famine
105. Cellular growth during early malnutrition
106. The influence of early malnutrition on subsequent behavioral development. 1. Degree of impairment in intellectual performance
107. A follow-up-study of the influence of early malnutrition on development - Behavior at home and at school
108. The association between prenatal stress and infant birth weight and gestational age at birth: A prospective investigation
109. Psychosocial support for maternal stress during pregnancy - Effect on birth-weight
110. Preterm delivery effects of socioeconomic factors, psychological stress, smoking, alcohol, and caffeine
111. The preterm prediction study: Maternal stress is associated with spontaneous preterm birth at less than thirty-five weeks' gestation
112. Prenatal loss of father and psychiatric disorders
113. Prenatal exposure to maternal stress and subsequent schizophrenia - The May 1940 invasion of The Netherlands
114. Prenatal stress and childhood psychopathology
115. Follow-up study from birth of the effects of prenatal stresses
116. Maternal anxiety during pregnancy: Effect on fetal behavior at 38 to 40 weeks of gestation
117. Maternal stress responses and anxiety during pregnancy: Effects on fetal heart rate
118. Child psychiatric sequelae of maternal war stress
119. Size at birth and adrenocortical function in childhood
120. Impaired glucose tolerance and elevated blood pressure in low birth weight, non-obese young South African adults: Early programming of the cortisol axis
121. Elevated plasma cortisol concentrations: An explanation for the relationship between low birthweight and adult cardiovascular risk factors
122. Low birth weight predicts elevated plasma cortisol concentrations in adults from 3 populations
123. Altered control of cortisol secretion in adult men with low birth weight and cardiovascular risk factors
124. Neurotoxicity of glucocorticoids in the primate brain
125. Prenatal diagnosis and management of congenital adrenal-hyperplasia
126. Prenatal diagnosis and treatment of 21-hydroxylase deficiency
127. Prenatal treatment and diagnosis of congential adrenal hyperplasia owing to 21-hydroxylase deficiency
128. Effects of early prenatal dexamethasone on the cognitive and behavioral development of young children: Results of a pilot study
129. Long-term somatic follow-up of prenatally treated children with congenital adrenal hyperplasia
130. Antenatal corticosteroid therapy and blood pressure at 14 years of age in preterm children