Inhibition of placental 11β-hydroxysteroid dehydrogenase type 2 by catecholamines via α-adrenergic signaling

American Journal of Physiology - Regulatory Integrative and Comparative Physiology

Volumn 281, Issue 6 50-6, 2001, Pages

  Sarkar, Sumita ^a   Tsai, Shu Whei ^a   Nguyen, Tien T ^a   Plevyak, Michael ^b,c   Padbury, James F ^a,c   Rubin, Lewis P ^a,c  

^a Departments of Pediatrics   (United States)

^b Departments of Obstetrics and Gynecology

^c WOMEN AND INFANTS HOSPITAL   (United States)

Author keywords

Epinephrine; Gene transcription; Norepinephrine; Pregnancy complications; Trophoblast

Indexed keywords

11BETA HYDROXYSTEROID DEHYDROGENASE; ADRENALIN; ALPHA 1 ADRENERGIC RECEPTOR; ALPHA 2 ADRENERGIC RECEPTOR; ALPHA ADRENERGIC RECEPTOR; BETA ADRENERGIC RECEPTOR; CATECHOLAMINE; HYDROCORTISONE; NORADRENALIN; RECEPTOR SUBTYPE; 3 ISOPROPYLAMINO 1 (7 METHYL 4 INDANYLOXY) 2 BUTANOL; ALPHA ADRENERGIC RECEPTOR BLOCKING AGENT; AZEPEXOLE; AZEPINE DERIVATIVE; HYDROXYSTEROID DEHYDROGENASE; PRIMER DNA; PROPANOLAMINE DERIVATIVE; RECOMBINANT PROTEIN;

ARTICLE; BLOOD PLACENTA BARRIER; CELL CULTURE; CHORION VILLUS; CONTROLLED STUDY; DOWN REGULATION; ENZYME ACTIVITY; ENZYME INHIBITION; FETOPLACENTAL UNIT; GENE EXPRESSION REGULATION; GENETIC TRANSCRIPTION; HUMAN; HUMAN CELL; PLACENTA; PLACENTA DEVELOPMENT; PREGNANCY COMPLICATION; PRIORITY JOURNAL; PROMOTER REGION; PROTEIN EXPRESSION; STEADY STATE; STRESS; TRANSCRIPTION REGULATION; TROPHOBLAST; CELL LINE; CESAREAN SECTION; DRUG ANTAGONISM; DRUG EFFECT; ENZYMOLOGY; FEMALE; FIRST TRIMESTER PREGNANCY; GENETICS; GESTATIONAL AGE; PHYSIOLOGY; POLYMERASE CHAIN REACTION; PREGNANCY; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; SIGNAL TRANSDUCTION;

ADRENERGIC ALPHA-ANTAGONISTS; AZEPINES; CELL LINE; CELLS, CULTURED; CESAREAN SECTION; CHORIONIC VILLI; DNA PRIMERS; FEMALE; GENE EXPRESSION REGULATION, ENZYMOLOGIC; GESTATIONAL AGE; HUMANS; HYDROXYSTEROID DEHYDROGENASES; NOREPINEPHRINE; PLACENTA; POLYMERASE CHAIN REACTION; PREGNANCY; PREGNANCY TRIMESTER, FIRST; PROPANOLAMINES; RECEPTORS, ADRENERGIC, ALPHA; RECOMBINANT PROTEINS; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; SIGNAL TRANSDUCTION; TRANSCRIPTION, GENETIC; TROPHOBLASTS;

EID: 0035654628     PISSN: 03636119     EISSN: None     Source Type: Journal    
DOI: 10.1152/ajpregu.2001.281.6.r1966     Document Type: Article

References (53)

1. + dependent 11β-hydroxysteroid dehydrogenase (HSD 11K) gene in JEG-3 human choriocarcinoma cells
2. Expression of 11βhydroxysteroid dehydrogenase in early pregnancy: Implications in human trophoblast-endometrial interactions
3. 11β-hydroxysteroid dehydrogenase expression in first trimester human trophoblasts
4. Maternal stress and obstetric and infant outcomes: Epidemiological findings and neuroendocrine mechanisms
5. Ontogeny of imidazoline binding sites in the human placenta
6. Maternal glucocorticoid secretion mediates long-term effects of prenatal stress
7. Fetal nutrition and cardiovascular disease in adult life
8. β-adrenergic receptors and their regulation
9. Cloning and production of antisera to human placental 11β-hydroxysteroid dehydrogenase type 2
10. Dual function of 11β-hydroxysteroid dehydrogenase in placenta: Modulating placental glucocorticoid passage and local steroid action
11. International Union of Pharmacology nomenclature of adrenoceptors
12. The maternal-fetal cortisol gradient during pregnancy and delivery
13. Single-step method of RNA isolation by acid guanidinium thiocyanate-phenol-chloroform extraction
14. 2-adrenoceptors
15. 2C2
16. Dysfunction of placental glucocorticoid barrier: Link between fetal environment and adult hypertension?
17. Determination of adrenergic receptor mRNAs by quantitative reverse transcriptase-polymerase chain reactions
18. 2-adrenergic receptor subtypes in human placenta: Evidence from direct binding studies
19. Correlation between β and α adrenergic receptor concentrations in human placenta
20. β-adrenergic regulation of cyclic AMP synthesis in cultured human syncytiotrophoblast
21. Hormonal control of plasminogen activator inhibitor-1 gene expression and production in human adipose tissue: Stimulation by glucocorticoids and inhibition by catecholamines
22. Serious life events and congenital malformations: A national study with complete follow-up
23. Exogenous and endogenous catecholamines inhibit the production of macrophage inflammatory protein (MIP) 1α via a β adrenoceptor mediated mechanism
24. Enzymes for epinephrine synthesis and metabolism in the myometrium, endometrium, red blood cells, and plasma of pregnant human subjects
25. Catecholamines, sympathomimetic drugs, and adrenergic receptor antagonists
26. i interaction and is independent of receptor signaling and regulation
27. The effect of labor on maternal and fetal circulating catecholamines
28. Identification of three cationic transporters in placental trophoblast: Cloning, expression and identification of hCAT- 1
29. Apparent mineralocorticoid excess due to 11β-hydroxysteroid dehydrogenase deficiency: A possible cause of intrauterine growth retardation
30. The 11β-hydroxysteroid dehydrogenases: Functions and physiological effects
31. Immunohistochemical localization of the 11β-hydroxysteroid dehydrogenase type II enzyme in human kidney and placenta
32. Hypertension induced by foetal exposure to a maternal low-protein diet, in the rat, is prevented by pharmacological blockade of maternal glucocorticoid synthesis
33. LLC-PK1 cells model 11β-hydroxysteroid dehydrogenase type 2 regulation of glucocorticoid access to renal mineralocorticoid receptors
34. Inhibition of 11-β-hydroxysteroid dehydrogenase in pregnant rats and the programming of blood pressure in the offspring
35. Effect of labor and prostaglandins on phenylethanolamine N-methyltransferase in human fetal membranes
36. Human hypertension caused by mutations in the kidney isozyme of 11β-hydroxysteroid dehydrogenase
37. Ontogeny of cortisol-cortisone interconversion in human tissues: A role for cortisone in human fetal development
38. Ontogenesis of β-adrenergic receptors in the ovine placenta
39. 2c-adrenoceptors in human neuroblastoma SH-SY5Y cells
40. Regulation of 11β-hydroxysteroid dehydrogenase type 2 activity and mRNA in human choriocarcinoma cells
41. Localization and developmental regulation of 11β-hydroxysteroid dehydrogenase-1 and -2 in the baboon syncytiotrophoblast
42. Elevated plasma cortisol concentrations: A link between low birth weight and the insulin resistance syndrome?
43. Evidence for human placental synthesis of 25-dihydroxyvitamin D3 and 23,25-dihydroxyvitamin D3
44. Effects of mechanical forces on lung specific gene expression
45. The human placenta - A rich source of β-adrenergic receptors: Characterization of the receptors in particulate and solubilized preparations
46. 11β-hydroxysteroid dehydrogenase type 2 in human pregnancy and reduced expression in intrauterine growth restriction
47. Regulation of 11β-hydroxysteroid dehydrogenase type-2 by progesterone, estrogen and cyclic-AMP pathway in cultured human placental trophoblasts
48. Differential regulation of 11β-hydroxysteroid dehydrogenase type 1 and type 2 by nitric oxide in cultured human placental trophoblast and chorionic cell population
49. Retinoic acid stimulates the expression of 11β-hydroxysteroid dehydrogenase type 2 in human choriocarcinoma JEG-3 cells
50. 1-adrenergic receptor subtypes in human monocytes
51. Differential effects of maternal stress on circulating levels of corticosterone, progesterone, and testosterone in male and female rat fetuses and their mothers
52. Changes in the hormonal concentrations of pregnant rats and their fetuses following multiple exposures to a stressor during the third trimester
53. Cloning, expression, and tissue distribution of the rat nicotinamide adenine dinucleotide-dependent 11βhydroxysteroid dehydrogenase