Placental 11β-hydroxysteroid dehydrogenase: A key regulator of fetal glucocorticoid exposure

Clinical Endocrinology

Volumn 46, Issue 2, 1997, Pages 161-166

  Benediktsson, Rafn ^a   Calder, Andrew A ^b   Edwards, Christopher R W ^a   Seckl, Jonathan R ^a  

^a WESTERN GENERAL HOSPITAL   (United Kingdom)

^b UNIVERSITY OF EDINBURGH   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

11BETA HYDROXYSTEROID DEHYDROGENASE; CORTISONE; GLUCOCORTICOID; HYDROCORTISONE;

ARTICLE; CORTICOSTEROID METABOLISM; ELECTRON MICROSCOPY; ENZYME ACTIVITY; FETUS; HUMAN; HUMAN TISSUE; IN VITRO STUDY; INTRAUTERINE GROWTH RETARDATION; ISOTOPE LABELING; PLACENTA; PRIORITY JOURNAL;

EID: 0030940457     PISSN: 03000664     EISSN: None     Source Type: Journal    
DOI: 10.1046/j.1365-2265.1997.1230939.x     Document Type: Article

References (31)

1. Addison, R.S., MaGuire, D.J., Mortimer, R.H. & Cannell, G.R. (1991) Metabolism of prednisolone by the isolated perfused human placental lobule. Journal of Steroid Biochemistry and Molecular Biology, 39, 83-90.
2. Addison, R.S., MaGuire, D.J., Mortimer, R.H., Roberts, M.S. & Cannell, G.R. (1993) Pathway and kinetics of prednisolone metabolism in the human placenta. Journal of Steroid Biochemistry and Molecular Biology, 44, 315-320.
3. Arai, Y. & Gorski, R.A. (1968) Critical exposure time for androgenization of the developing hypothalamus in the female rat. Endocrinology, 82, 1010-1014.
4. Barker, D.J.P., Bull, A.R., Osmond, C. & Simmonds, S.J. (1990) Fetal and placental size and risk of hypertension in adult life. British Medical Journal, 301, 259-262.
5. Beitins, I.Z., Bayard, F., Ances, I.G., Kiwarski, A. & Migeon, C.J. (1973) The metabolic clearance rate, blood production, interconversion and transplacental passage of cortisol and cortisone in pregnancy near term. Pediatric Research, 7, 509-519.
6. Benediktsson, R. (1995) The Role of 11β-Hydroxysteroid Dehydrogenase in Controlling Foetal Glucocorticoid Exposure. 1-232.(PhD thesis, University of Edinburgh)
7. Benediktsson, R., Lindsay, R.S., Noble, J., Seckl, J.R. & Edwards, C.R.W. (1993) Glucocorticoid exposure in utero: new model for adult hypertension. Lancet, 341, 339-341.
8. Blasco, M.J., López Bernal, A. & Turnbull, A.C. (1986) 11-beta-Hydroxysteroid dehydrogenase activity of the human placenta during pregnancy. Hormone and Metabolic Research, 18, 638-641.
9. Brown, R.W., Chapman, K.E., Edwards, C.R.W. & Seckl, J.R. (1993) Human placental 11β-hydroxysteroid dehydrogenase: evidence for and partial purification of a distinct NAD-dependent isoform. Endocrinology, 132, 2614-2621.
10. Brown, R.W., Chapman, K.E., Kotelevtsev, Y., Yau, J.L.W., Lindsay, R.S., Brett, L.P., Leckie, C., Murad, P., Lyons, V., Mullins, J.J., Edwards, C.R.W. & Seckl, J.R. (1996) Cloning and production of antisera to human placental 11β-hydroxysteroid dehydrogenase type 2. Biochemical Journal, 313, 1007-1017.
11. Campbell, A.L. & Murphy, B.E.P. (1977) The maternal-fetal cortisol gradient during pregnancy and at delivery. Journal of Clinical Endocrinology and Metabolism, 45, 435-440.
12. 18 cartridges. Clinica Chimica Acta, 122, 419-422.
13. Dancis, J., Jansen, V., Levitz, M. & Rosner, W. (1978) Effect of protein binding on transfer and metabolism of cortisol in perfused human placenta. Journal of Clinical Endocrinology and Metabolism, 46, 863-868.
14. Dodds, H., MaGuire, D.J., Addison, R.S., Johnson, L., Mortimer, R.H. & Cannell, G.R. (1993) Metabolism of cortisol in the perfused human placental lobule. Placenta, 14, A17.
15. Dormer, R.A. & France, J.T. (1973) Cortisol and cortisone levels in umbilical cord plasma and maternal plasma of normal pregnancies. Steroids, 21, 497-510.
16. Edwards, C.R.W., Benediktsson, R., Lindsay, R.S. & Seckl, J.R. (1993) Dysfunction of placental glucocorticoid barrier: link between fetal environment and adult hypertension? The Lancet, 341, 355-357.
17. Gustafsson, G.A. & Stenberg, A. (1974) Irreversible androgenic programming at birth of microsomal and soluble rat liver enzymes active on 4-androstene-3,17-dione and 5-alpha, androstane-3-alpha, 17-beta-diol. Journal of Biological Chemistry, 249, 711-718.
18. Hales, C.N., Barker, D.J.P., Clark, P.M.S., Cox, L.J., Fall, C., Osmond, C. & Winter, P.D. (1991) Fetal and infant growth and impaired glucose tolerance at age 64. British Medical Journal, 303, 1019-1022.
19. Jamieson, P.M., Chapman, K.E., Edwards, C.R.W. & Seckl, J.R. (1995) 11β-hydroxysteroid dehydrogenase is an exclusive 11β-reductase in primary cultures of rat hepatocytes: effect of physicochemical and hormonal manipulations. Endocrinology, 136, 4754-4761.
20. Kaufmann, P. (1985) Influence of ischemia and artificial perfusion on placental ultrastructure and morphometry. Contributions in Gynecology and Obstetrics, 13, 18-26.
21. Lakshmi, V., Nath, N. & Muneyyirchi-Delale, O. (1993) Characterisation of 11β-hydroxysteroid dehydrogenase of human placenta: evidence for the existence of two species of 11β-hydroxysteroid dehydrogenase. Journal of Steroid Biochemistry and Molecular Biology, 45, 391-397.
22. Law, C.M., De Swiet, M., Osmond, C., Fayers, P.M., Barker, D.J.P., Cruddas, A.M. & Fall, C.H.D. (1993) Initiation of hypertension in utero and its amplification throughout life. British Medical Journal, 306, 24-27.
23. Meulenberg, P.M. & Hofman, J.A. (1990) Differences between concentrations of salivary cortisol and cortisone and of free cortisol and cortisone in plasma during pregnancy and postpartum. Clinical Chemistry, 36, 70-75.
24. Monder, C., Stewart, P.M., Lakshmi, V., Valentino, R., Burt, D. & Edwards, C.R.W. (1989) Licorice inhibits corticosteroid 11 beta-dehydrogenase of rat kidney and liver: in vivo and in vitro studies. Endocrinology, 125, 1046-1053.
25. Murphy, B.E.P., Clark, S.J., Donald, I.R., Pinsky, M. & Vedady, D.L. (1974) Conversion of maternal cortisol to cortisone during placental transfer to the human fetus. American Journal of Obstetrics and Gynecology, 118, 538-541.
26. Pasqualini, J.R., Nguyen, B.L., Uhrich, F., Wiqvist, N. & Diczfalusy, E. (1970) Cortisol and cortisone metabolism in the human foetoplacental unit at midgestation. Journal of Steroid Biochemistry, 1, 209-219.
27. Reinisch, J.M., Simon, N.G., Karow, W.G. & Gandelman, R. (1978) Prenatal Exposure to Prednisone in Humans and Animals Retards lntrauterine Growth. Science, 202, 436-438.
28. Robinson, S., Walton, R.J., Clark, P.M., Barker, D.J.P., Hales, C.N. & Osmond, C. (1992) The relation of fetal growth to plasma glucose in young men. Diabetologia, 35, 444-446.
29. Schneider, H., Panigel, M. & Dancis, J. (1972) Transfer across the perfused human placenta of antipyrine, sodium and leucine. American Journal of Obstetrics and Gynecology, 114(6), 822-828.
30. Siehe, H., Baude, G., Lichtenstein, I., Wang, D., Buhler, H., Hoyer, G.A. & Hierholzer, K. (1993) Metabolism of dexamethasone: sites and activity in mammalian tissues. Renal Physiology and Biochemistry, 16, 79-88.
31. Stewart, P.M., Rogerson, F.M. & Mason, J.I. (1995) Type 2 11β-hydroxysteroid dehydrogenase messenger ribonucleic acid and activity in human placenta and fetal membranes: its relationship to birth weight and putative role in fetal adrenal steroidogenesis. Journal of Clinical Endocrinology and Metabolism, 80, 885-890.