Glucocorticoid exposure in late gestation permanently programs rat hepatic phosphoenolpyruvate carboxykinase and glucocorticoid receptor expression and causes glucose intolerance in adult offspring

Journal of Clinical Investigation

Volumn 101, Issue 10, 1998, Pages 2174-2181

  Nyirenda, Moffat J ^a   Lindsay, Robert S ^a   Kenyon, Chris J ^a   Burchell, Ann ^b   Seckl, Jonathan R ^a  

^a WESTERN GENERAL HOSPITAL   (United Kingdom)

^b UNIVERSITY OF DUNDEE   (United Kingdom)

Author keywords

11 hydroxysteroid dehydrogenase; Birth weight; Glucocorticoids; Gluconeogenesis; Non insulin dependent diabetes mellitus

Indexed keywords

11BETA HYDROXYSTEROID DEHYDROGENASE; CORTICOSTERONE; DEXAMETHASONE; GLUCOCORTICOID; GLUCOCORTICOID RECEPTOR; GLUCOSE; LIVER ENZYME; PHOSPHOENOLPYRUVATE CARBOXYKINASE (GTP);

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; BINDING AFFINITY; BODY WEIGHT; CONTROLLED STUDY; ENZYME ACTIVITY; ENZYME INHIBITION; FEMALE; GLUCONEOGENESIS; GLUCOSE BLOOD LEVEL; GLUCOSE HOMEOSTASIS; GLUCOSE INTOLERANCE; HYPERGLYCEMIA; HYPERINSULINEMIA; LOW BIRTH WEIGHT; NON INSULIN DEPENDENT DIABETES MELLITUS; NONHUMAN; PRENATAL DRUG EXPOSURE; PRIORITY JOURNAL; PROTEIN EXPRESSION; RAT;

EID: 0032524014     PISSN: 00219738     EISSN: None     Source Type: Journal    
DOI: 10.1172/JCI1567     Document Type: Article

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