Maternal undernutrition during late gestation induces fetal overexposure to glucocorticoids and intrauterine growth retardation, and disturbs the hypothalamo-pituitary adrenal axis in the newborn rat

Endocrinology

Volumn 142, Issue 5, 2001, Pages 1692-1702

  Lesage, J ^a   Blondeau, B ^b   Grino, M ^b   Breant B ^b   Dupouy, J P ^a  

^a UNIV LILLE   (France)

^b INSERM   (France)

Author keywords

[No Author keywords available]

Indexed keywords

ARTICLE; CORTICOSTEROID THERAPY; CORTICOSTERONE BLOOD LEVEL; DIETARY INTAKE; FETOPLACENTAL UNIT; HYPOTHALAMUS HYPOPHYSIS ADRENAL SYSTEM; INTRAUTERINE GROWTH RETARDATION; NEWBORN; NONHUMAN; PRIORITY JOURNAL; RAT;

EID: 0035047054     PISSN: 00137227     EISSN: None     Source Type: Journal    
DOI: 10.1210/endo.142.5.8139     Document Type: Article

References (52)

1. Fetal nutrition and cardiovascular disease in adult life
2. Type 2 (non-insulin dependent) diabetes mellitus, hypertension and hyperipidaemia (syndrome X): Relation to reduced fetal growth
3. Birth weight and the future development of diabetes
4. Diet in pregnancy and the offsprings blood pressure 40 years later
5. In utero exposure to maternal low protein diets induces hypertension in weanling rats independently of maternal blood pressure changes
6. Adult glucose and lipid metabolism may be programmed during fetal life
7. Chronic maternal undernutrition in the rat leads to delayed postnatal growth and elevated blood pressure of offspring
8. Endocrine regulation of fetal growth
9. Elevated levels of umbilical cord plasma corticotropin-releasing hormone in growth-retarded fetuses
10. Glucocorticoid exposure in utero: New model for adult hypertension
11. Glucocotiold exposure in late gestation permanently programs rat hepatic phoshoenolpyruvate carboxykinase and glucocorticoid receptor expression and causes glucose intolerance in the adult offspring
12. Conversion of maternal cortisol to cortisone during placental transfer to the human fetus
13. Cloning and production of antisera to human placental 11β-hydroxysteroid dehydrogenase type 2
14. Type2 11β-hydroxysteroid dehydrogenase messenger RNA and activity, in human placenta and fetal memranes: Its relationship to birth weight and putative role in fetal steroidogensis
15. Effects of chronic maternal dexamethasone treatment on the hormones of the hypothalamo-pituitary-adrenal axis in the rat fetus
16. Consequences of prenatal morphine exposure on the hypothalamo-pituitarydrenal axis in the newborn rat: Effect of maternal adrenalectomy
17. Subcutaeous implantation method for chronic glucocorticoid replacement therapy
18. Rat corticotropin-releasing hormone gene: Sequence and tissue-specific expression
19. Structure of the rat pro-opiomelanocortin (POMC) gene
20. Cloning, expression, and tissue distribution of the rat nicotinamide adenine dinucletide-dependent 11β-hydroxysteroid dehydrogenase
21. An in situ hybridization histochemistry technique allowing simultaneous visualization by the use of confocal microscopy of three cellular mRNA species in individual neurons
22. Quantitative in situ hybridization hisochemistry reveals increased levels of corficotropin-releasing factor in RNA after adrenalectomy in rats
23. 18-36) and peptide YY (PYY) on the rat adrenal capsule/ zona glomerulosa
24. Effects of rat corticotropin-releasing factor, arginine vasopressin and oxytocin on the secretions of adrenocorticorophic hormone and corticosterone in the fetal rat in late gestation: In vivo and in vitro studies
25. A versatile method for the determiation of serum cortisol binding globulin and sex hormone binding globulin binding capacities
26. The attraction of proteins for small molecules and ions
27. Central hypogonadism in burned men
28. Effect of experimental and pathological weight loss upon the hypothalamo-pituitary-adrenal axis
29. Abormal hypothalamic-pituitary-adrenal function in anorexia nervosa
30. The endocrine response to dietary restriction in the rat
31. The effects of acute and life-long food restriction on basal and stress-induced serum corticosterone levels in young and aged rats
32. Fasting, feeding and regulation of the sympahetic nervous system
33. Regulation of energy balance
34. Facilitation and feedback in the hypothalamo-pituitary-adrenal axis during food restriction in rats
35. Feeding and the diurnal variation of the hypohalamic-pituitary-adrenal axis and its responses to CRH and ACTH in rats
36. Protein malnutrition increases plasma adrenocorticotropin and anterior pituitary proopiomelanocortin mesenger ribonucleic acid in the rat
37. Adrenocortical responsiveness to adreocorticotropic hormone is enhanced in chronically food-restricted rats
38. Maternal dietary protein restriction, placental glucocorticoid metabolism and the programming of hypertension
39. The adrenal cortex
40. Passage of 14C-4 corticosterone from the mother to the foetus and neonate
41. Maternal and fetal cortecosterone levels during late pregnancy in rats
42. Fetal-maternal adrenocorticotropin and corticosterone relationship in the rat: Effects of maternal adrenalectomy
43. Corticosterone regulation of type I and type II adrenal steroid receptors in brain, pituitary and immune tissue
44. Editorial: Glucocorticoids and small babies
45. Prenatal glucocorticoid exposure leads to offspring hyperglycaemia in the rat: Studies with the 11β-hydroxysteroid dehydrogenase inhibitor carbenoxolone
46. Inhibition of 11β-hydroxysteroid dehydrogenase in pregnant rats and the programming of blood pressure in the offspring
47. Sex-specific effects of prenatal stress on hypothalamic-pituitary-adrenal responses to stress and brain glucocorticoid receptor density in adult rats
48. Median eminence corticoropin-releasing hormone content following prenatal stress and neonatal hanling
49. Age-dependent inbility of the endocrine pancreas to adapt to pregnancy: A long-term conseuence of perinatal malnutrition in the rat
50. Hypertension induced by foetal exposure to a lowrotein diet, in the rat, is prevented by pharmacological blockade of maternal glucocorticoid synthesis
51. Dexamethasone in the lastweek of pregnancy attenuates hippocampal glucocorticoid receptor gene exression and elevates blood pressure in the adult offspring in the rat